Ruth Lehr

3.2k citations

20 papers · 1.8k indexed · 1 hit paper · h-index 14

Impact in

Immunology top 5%
- IL-33, ST2, and ILC Pathways
- Psoriasis: Treatment and Pathogenesis
- Immune Response and Inflammation
- Immune Cell Function and Interaction
Molecular Biology top 10%
- TGF-β signaling in diseases
- Inflammasome and immune disorders
- PI3K/AKT/mTOR signaling in cancer

Papers in

Immunology and Allergy 2
Genetics 3
- Chronic Lymphocytic Leukemia Research 2

Co-authors: James A. Fornwald John D. Harling James F. Callahan Barbara A. Olson Laramie M. Gaster Nicholas J. Laping Anil Mathur Eugene T. Grygielko
Journals: Biochemistry (3 papers)Gene (2 papers)Journal of Biological Chemistry (2 papers)Bioorganic & Medicinal Chemistry Letters (1 paper)Biochemical Journal (1 paper)
Partner nations: United States United Kingdom

In The Last Decade

Ruth Lehr

20 papers receiving 1.8k citations

Hit Papers

align trajectories log scale

Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542 2002 · 544 citations

Peers

Countries citing papers authored by Ruth Lehr

Since Specialization

Citations

This map shows the geographic impact of Ruth Lehr's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ruth Lehr with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ruth Lehr more than expected).

Fields of papers citing papers by Ruth Lehr

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ruth Lehr. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ruth Lehr. The network helps show where Ruth Lehr may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Ruth Lehr, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Ruth Lehr Line = papers co-authored together Ruth Lehr links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome Bioorganic & Medicinal Chemistry Letters ·Philip A. Harris, Chaya Duraiswami, S.W. Cho, James A. Fornwald, Sandra J. Hoffman, Glenn A. Hofmann, Ming Jiang, Ruth Lehr, Virgil G. Casten, Zoe Mrozek, Benjamin J. Schwartz, Zining Wu, Guofeng Zhang, Robert W. Marquis, John Bertin, Peter J. Gough	2015	16
2	On the Catalytic Mechanism of Human ATP Citrate Lyase Biochemistry ·Fan Fan, Howard J. Williams, J. Gregory Boyer, Irene Solanich Sanglas, Huizhen Zhao, Ruth Lehr, Hongwei Qi, Benjamin Schwartz, Frank M. Raushel, Thomas D. Meek	2012	31
3	Kinetic Mechanism and Rate-Limiting Steps of Focal Adhesion Kinase-1 Biochemistry ·Jessica L. Schneck, Jacques Briand, Stephanie Chen, Ruth Lehr, Patrick McDevitt, Baoguang Zhao, Angela Smallwood, N.O. Concha, Flora E. Cook, Robert B. Kirkpatrick, Kang Yan, Abedin Karalic, Thomas D. Meek, Sara H. Thrall	2010	11
4	Characterization of PI3K class IA isoforms with regulatory subunit p55α using a scintillation proximity assay Analytical Biochemistry ·Glenn S. Van Aller, Leticia Machado Ribeiro, Christine Fernandes, Ruth Lehr, Robert H. Sinnamon, Robert B. Kirkpatrick, Peter J. Tummino, Lusong Luo	2008	9
5	ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism Nature Chemical Biology ·Lusong Luo, Cynthia A. Parrish, Neysa Nevins, Dean E. McNulty, Omoboriowo A.O, Sandra Sánchez Sarasúa de la Bárcena, Valery Sudakin, Antony N. Shaw, Ruth Lehr, Huizhen Zhao, Sharon Sweitzer, Latesh Lad, Kenneth W. Wood, Roman Sakowicz, Roland S. Annan, Pearl S. Huang, Jeffrey R. Jackson, Dashyant Dhanak, Robert A. Copeland, Kurt R. Auger	2007	92
6	Crystal structure of the kinase domain of serum and glucocorticoid‐regulated kinase 1 in complex with AMP–PNP Protein Science ·Baoguang Zhao, Ruth Lehr, Angela Smallwood, Thau Ho, 山口晃, Petrus Rüdiger, Martha S. Head, Kristin K. Koretke, Christine G. Schnackenberg	2007	45
7	Effects of oncogenic p110α subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase Biochemical Journal ·Jeffrey D. Carson, Marten Sepus Fatem, Ruth Lehr, Robert H. Sinnamon, Robert B. Kirkpatrick, Kurt R. Auger, Dashyant Dhanak, Robert A. Copeland, Richard R. Gontarek, Peter J. Tummino, Lusong Luo	2007	100
8	Selective Binding and Oligomerization of the Murine Granulocyte Colony-stimulating Factor Receptor by a Low Molecular Weight, Nonpeptidyl Ligand Journal of Biological Chemistry ·Michael L. Doyle, Shin‐Shay Tian, Stephen G. Miller, Linda Kessler, Audrey Baker, Michael Brigham‐Burke, Susan B. Dillon, Kevin J. Duffy, Richard M. Keenan, Ruth Lehr, Jon Rosen, Lumelle A. Schneeweis, John J. Trill, Peter R. Young, Juan I. Luengo, Peter Lamb	2003	13
9	Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542 Molecular Pharmacology ·Nicholas J. Laping, Eugene T. Grygielko, Anil Mathur, Abdul Latif Faridah, Jennifer M. Bomberger, Christopher Tweed, W. Martin, James A. Fornwald, Ruth Lehr, John D. Harling, Laramie M. Gaster, James F. Callahan, Barbara A. Olson Hit paper breakdown →	2002	544
10	INTERLEUKIN-1F7B (IL-1H4/IL-1F7) IS PROCESSED BY CASPASE-1 AND MATURE IL-1F7B BINDS TO THE IL-18 RECEPTOR BUT DOES NOT INDUCE IFN-γ PRODUCTION Cytokine ·Sanjay Kumar, Charles R. Hanning, Michael Brigham‐Burke, David J. Rieman, Ruth Lehr, Sanjay Khandekar, Robert B. Kirkpatrick, Gilbert Scott, John C. Lee, Frank J. Lynch, Wentao Gao, Andrea Gambotto, Michael T. Lotze	2002	218
11	Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5) Journal of Medicinal Chemistry ·James F. Callahan, Joelle L. Burgess, James A. Fornwald, Laramie M. Gaster, John D. Harling, Frank P. Harrington, Jag Heer, Chet Kwon, Ruth Lehr, Anil Mathur, Barbara A. Olson, Joseph Weinstock, Nicholas J. Laping	2002	267
12	Identification and Initial Characterization of Four Novel Members of the Interleukin-1 Family Journal of Biological Chemistry ·Sanjay Kumar, Peter McDonnell, Ruth Lehr, Lauren A. Tierney, Maritsa N. Tzimas, Don E. Griswold, Mario Michaud, Ruth Tal‐Singer, Grace I. Wells, Michael L. Doyle, Peter R. Young	2000	281
13	The structure of ribonuclease P protein from Staphylococcus aureus reveals a unique binding site for single-stranded RNA Journal of Molecular Biology ·Claus Spitzfaden, Neville Nicholson, Jo J. Jones, Sabine Guth, Ruth Lehr, C. Prescott, Lisa A. Hegg, Drake S. Eggleston	2000	81
14	A Modified Metal-Ion Affinity Chromatography Procedure for the Purification of Histidine-Tagged Recombinant Proteins Expressed in Drosophila S2 Cells Protein Expression and Purification ·Ruth Lehr, James H. Farmer, Kristine Kikly, S. O'Brien, Robert B. Kirkpatrick	2000	28
15	Production, purification and characterization of non-myristylated human T-cell protein tyrosine kinase in a baculovirus expression system Gene ·Ruth Lehr, Филоненко Надежда Сергеевна, Liangliang Liu, Miriam Araña Ciordia, Su Wang, Connie R. Faltynek, Xinmin Wang, Panayiotis E. Stevis	1996	2
16	Inhibition of T Lymphocyte Actnation by a Novel p56^lckTyrosine Kinase Inhibitor Journal of enzyme inhibition ·Connie R. Faltynek, Su Wang, Deborah Miller, 이누리샘, 郭文岭, Kelvin Rambik, Collective work, 淳志小林, Paul E. Juniewicz, Jay Sarup, Ruth Lehr, David G. Sawutz, Dennis J. Murphy	1995	19
17	Damnacanthal Is a Highly Potent, Selective Inhibitor of p56lck Tyrosine Kinase Activity Biochemistry ·Connie R. Faltynek, Joseph A. Schroeder, 이누리샘, Deborah Miller, Su Wang, Dennis J. Murphy, Ruth Lehr, Marian Kelley, Alan L. Maycock	1995	66
18	Hydrophobic interactions and the design of receptor mimetic peptides. PubMed ·Alfredo Izquierdo-Hernández, Ruth Lehr, L Benhmidoune, ابراهیم دورانی	1995	4
19	p56lck Interactions Accelerate Autophosphorylation and Enhance Activity toward Exogenous Substrates Archives of Biochemistry and Biophysics ·Shu Wang, Ruth Lehr, 由記子西原, Jagdeep Singh, James M. Trevillyan, Connie R. Faltynek	1994	8
20	Production of active human interleukin-1β-converting enzyme in a baculovirus expression system Gene ·Xinmin Wang, Carla T. Helaszek, Laurie A. Winter, Ronald P. Lirette, M. Passatore, Richard B. Ciccarelli, Marian Kelley, John Malinowski, Hans Michael Piper, Song TieShan, James A. Koehn, Liangliang Liu, R. Brückner, Todd L. Graybill, Mark A. Ator, Ruth Lehr, Panayiotis E. Stevis	1994	8

About Ruth Lehr

Ruth Lehr is a scholar working on Immunology and Allergy, Genetics, Immunology, Molecular Biology and Biotechnology, having authored 20 papers that have together received 1.8k indexed citations. Recurring topics across this work include Viral Infectious Diseases and Gene Expression in Insects (3 papers), Protein Kinase Regulation and GTPase Signaling (3 papers), Chronic Lymphocytic Leukemia Research (2 papers), Protein Tyrosine Phosphatases (2 papers), TGF-β signaling in diseases (2 papers), Immune Cell Function and Interaction (2 papers), Protein Degradation and Inhibitors (2 papers) and Inflammasome and immune disorders (2 papers). The work is most often cited by research in Immunology (490 citations), Molecular Biology (1.2k citations), Dermatology (138 citations), Oncology (325 citations) and Immunology and Allergy (66 citations). Ruth Lehr has collaborated with scholars based in United States and United Kingdom. Frequent co-authors include James A. Fornwald, John D. Harling, James F. Callahan, Barbara A. Olson, Laramie M. Gaster, Nicholas J. Laping, Anil Mathur, Eugene T. Grygielko, W. Martin and Christopher Tweed. Their work appears in journals such as Biochemistry, Gene, Journal of Biological Chemistry, Bioorganic & Medicinal Chemistry Letters and Biochemical Journal.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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