Roel A. Ophoff

69.6k total citations · 3 hit papers
166 papers, 9.6k citations indexed

About

Roel A. Ophoff is a scholar working on Genetics, Molecular Biology and Psychiatry and Mental health. According to data from OpenAlex, Roel A. Ophoff has authored 166 papers receiving a total of 9.6k indexed citations (citations by other indexed papers that have themselves been cited), including 76 papers in Genetics, 64 papers in Molecular Biology and 43 papers in Psychiatry and Mental health. Recurrent topics in Roel A. Ophoff's work include Genetic Associations and Epidemiology (38 papers), Genomic variations and chromosomal abnormalities (25 papers) and Bipolar Disorder and Treatment (19 papers). Roel A. Ophoff is often cited by papers focused on Genetic Associations and Epidemiology (38 papers), Genomic variations and chromosomal abnormalities (25 papers) and Bipolar Disorder and Treatment (19 papers). Roel A. Ophoff collaborates with scholars based in Netherlands, United States and United Kingdom. Roel A. Ophoff's co-authors include René S. Kahn, Marco P. Boks, Rune R. Frants, Michel D. Ferrari, Gisela M. Terwindt, Monique N. Vergouwe, Ronald van Eijk, Dick Lindhout, Joost Haan and Steve Horvath and has published in prestigious journals such as New England Journal of Medicine, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Roel A. Ophoff

165 papers receiving 9.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4

1996 1.8k citations Roel A. Ophoff, Gisela M. Terwindt et al. Cell profile →
Aging effects on DNA methylation modules in human brain and blood tissue

2012 469 citations Steve Horvath, René S. Kahn et al. Genome biology profile →
Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

2018 293 citations Alexander Gusev, Nicholas Mancuso et al. Nature Genetics profile →

Peers

Roel A. Ophoff

PMH

GENET

CMN

Dawna L. Armstrong United States

Rainer Rupprecht Germany

Frank A. Middleton United States

Károly Mirnics United States

Cheryl A. Frye United States

Markus M. Nöthen Germany

Eitan Friedman Israel

Dale R. Nyholt Australia

Gerome Breen United Kingdom

Sven Cichon Germany

Dawna L. Armstrong United States

Roel A. Ophoff

4.1k ×1.0

1.5k ×0.5

PMH

2.1k ×0.9

GENET

2.3k ×1.6

CMN

1.3k ×1.2

Citations per year, relative to Roel A. Ophoff Roel A. Ophoff (= 1×) peers Dawna L. Armstrong

Countries citing papers authored by Roel A. Ophoff

Since Specialization

Citations

This map shows the geographic impact of Roel A. Ophoff's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Roel A. Ophoff with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Roel A. Ophoff more than expected).

Fields of papers citing papers by Roel A. Ophoff

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Roel A. Ophoff. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Roel A. Ophoff. The network helps show where Roel A. Ophoff may publish in the future.

Co-authorship network of co-authors of Roel A. Ophoff

This figure shows the co-authorship network connecting the top 25 collaborators of Roel A. Ophoff. A scholar is included among the top collaborators of Roel A. Ophoff based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Roel A. Ophoff. Roel A. Ophoff is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Reus, Lianne M., N Ramesh, Maria Koromina, et al.. (2025). Quantitative trait loci mapping of circulating metabolites in cerebrospinal fluid to uncover biological mechanisms involved in brain-related phenotypes. Molecular Psychiatry. 30(8). 3478–3490. 1 indexed citations

Hou, Kangcheng, Marco P. Boks, René S. Kahn, et al.. (2024). Cell-type deconvolution of bulk-blood RNA-seq reveals biological insights into neuropsychiatric disorders. The American Journal of Human Genetics. 111(2). 323–337. 2 indexed citations

Klumpers, Ursula M. H., Annemiek Dols, Nicole Korten, et al.. (2023). Accelerated brain aging as a biomarker for staging in bipolar disorder: an exploratory study. Psychological Medicine. 54(5). 1016–1025. 2 indexed citations

Ori, Anil P. S., Ake T. Lu, Steve Horvath, & Roel A. Ophoff. (2022). Significant variation in the performance of DNA methylation predictors across data preprocessing and normalization strategies. Genome biology. 23(1). 225–225. 10 indexed citations

Poels, Eline M. P., Annabel Vreeker, Marco P. Boks, et al.. (2021). Bipolar episodes after reproductive events in women with bipolar I disorder, A study of 919 pregnancies. Journal of Affective Disorders. 295. 72–79. 18 indexed citations

Kowalec, Kaarina, Eilís Hannon, Georgina Mansell, et al.. (2019). Methylation age acceleration does not predict mortality in schizophrenia. Translational Psychiatry. 9(1). 157–157. 13 indexed citations

Ori, Anil P. S., et al.. (2018). A Longitudinal Model of Human Neuronal Differentiation for Functional Investigation of Schizophrenia Polygenic Risk. Biological Psychiatry. 85(7). 544–553. 4 indexed citations

Gusev, Alexander, Nicholas Mancuso, Hyejung Won, et al.. (2018). Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. Nature Genetics. 50(4). 538–548. 293 indexed citations breakdown →

Schilham, Marco W., Sylvia Kamphuis, P Müller, et al.. (2018). An amino acid motif in HLA-DRβ1 distinguishes patients with uveitis in juvenile idiopathic arthritis. Arthritis & Rheumatism. 59(9). 3492–3492. 1 indexed citations

10.

Verkooijen, Sanne, et al.. (2018). Sleep Disturbances, Psychosocial Difficulties, and Health Risk Behavior in 16,781 Dutch Adolescents. Academic Pediatrics. 18(6). 655–661. 27 indexed citations

11.

Sul, Jae Hoon, Towfique Raj, Simone de Jong, et al.. (2015). Accurate and Fast Multiple-Testing Correction in eQTL Studies. The American Journal of Human Genetics. 96(6). 857–868. 20 indexed citations

12.

Jong, Steven de, Jurjen J. Luykx, E Strengman, et al.. (2014). Seasonal changes in gene expression represent cell-type composition in whole blood. Human Molecular Genetics. 23(10). 2721–2728. 30 indexed citations

13.

Stringer, Sven, René S. Kahn, Lot D. de Witte, Roel A. Ophoff, & Eske M. Derks. (2014). Genetic liability for schizophrenia predicts risk of immune disorders. Schizophrenia Research. 159(2-3). 347–352. 30 indexed citations

14.

Knol, Wilma, Rob J. van Marum, Paul A. F. Jansen, et al.. (2013). Genetic Variation and the Risk of Haloperidol-Related Parkinsonism in Elderly Patients. Journal of Clinical Psychopharmacology. 33(3). 405–410. 12 indexed citations

15.

Vinkers, Christiaan H., Willemijn A. van Gastel, Kristel R. van Eijk, et al.. (2013). The effect of childhood maltreatment and cannabis use on adult psychotic symptoms is modified by the COMT Val158Met polymorphism. Schizophrenia Research. 150(1). 303–311. 54 indexed citations

16.

Ophoff, Roel A., Guido H. Dolmans, & Cisca Wijmenga. (2011). Wnt Signaling and Dupuytren's Disease REPLY. New England Journal of Medicine. 365(18). 1740–1740. 2 indexed citations

17.

Freimer, Nelson B., Susan K. Service, Roel A. Ophoff, et al.. (2007). A quantitative trait locus for variation in dopamine metabolism mapped in a primate model using reference sequences from related species. Proceedings of the National Academy of Sciences. 104(40). 15811–15816. 24 indexed citations

18.

Fairbanks, Lynn A., Timothy K. Newman, Julia N. Bailey, et al.. (2004). Genetic contributions to social impulsivity and aggressiveness in vervet monkeys. Biological Psychiatry. 55(6). 642–647. 88 indexed citations

19.

Vergouwe, Monique N., Roel A. Ophoff, Susan L. Naylor, et al.. (1998). Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients.. PubMed. 77(5). 415–20. 19 indexed citations

20.

Ophoff, Roel A., Gisela M. Terwindt, Monique N. Vergouwe, et al.. (1996). Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4. Cell. 87(3). 543–552. 1758 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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