Robert A. Kastelein

44.0k total citations · 17 hit papers
74 papers, 31.0k citations indexed

About

Robert A. Kastelein is a scholar working on Immunology, Dermatology and Molecular Biology. According to data from OpenAlex, Robert A. Kastelein has authored 74 papers receiving a total of 31.0k indexed citations (citations by other indexed papers that have themselves been cited), including 63 papers in Immunology, 17 papers in Dermatology and 15 papers in Molecular Biology. Recurrent topics in Robert A. Kastelein's work include Psoriasis: Treatment and Pathogenesis (29 papers), Immune Cell Function and Interaction (18 papers) and Dermatology and Skin Diseases (17 papers). Robert A. Kastelein is often cited by papers focused on Psoriasis: Treatment and Pathogenesis (29 papers), Immune Cell Function and Interaction (18 papers) and Dermatology and Skin Diseases (17 papers). Robert A. Kastelein collaborates with scholars based in United States, France and United Kingdom. Robert A. Kastelein's co-authors include J. Daniel, Terrill K. McClanahan, Wendy M. Blumenschein, René de Waal Malefyt, Yi Chen, J. Fernando Bazán, Jeanine Mattson, Claire L. Langrish, Daniel M. Gorman and Beth Basham and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and The Lancet.

In The Last Decade

Robert A. Kastelein

73 papers receiving 30.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 3.2k citations Claire L. Langrish, Yi Chen et al. The Journal of Experimental Medicine profile →
IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

2005 3.0k citations Jochen Schmitz, Alexander M. Owyang et al. profile →
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

2003 2.3k citations J. Daniel, Yi Chen et al. profile →
Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP

2002 1.7k citations Vassili Soumelis, Pedro A. Reche et al. profile →
Development, cytokine profile and function of human interleukin 17–producing helper T cells

2007 1.6k citations Katia Boniface, Wendy M. Blumenschein et al. profile →
Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens

2001 1.6k citations René de Waal Malefyt, Robert A. Kastelein et al. The Journal of Experimental Medicine profile →
A family of human receptors structurally related to Drosophila Toll

1998 1.4k citations Jackie C. Timans, Robert A. Kastelein et al. profile →
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

2003 1.3k citations Craig A. Murphy, Claire L. Langrish et al. The Journal of Experimental Medicine profile →
IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6

2006 1.2k citations Terrill K. McClanahan, Melanie A. Kleinschek et al. profile →
IL-23 promotes tumour incidence and growth

2006 792 citations Jeanine Mattson, Terrill K. McClanahan et al. profile →
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells

2012 791 citations Barbara Joyce-Shaikh, Scott Turner et al. profile →
The IL-12 Family of Heterodimeric Cytokines

2003 745 citations Stefan Pflanz, Robert A. Kastelein et al. profile →
Discovery and Biology of IL-23 and IL-27: Related but Functionally Distinct Regulators of Inflammation

2006 626 citations Robert A. Kastelein, Christopher A. Hunter et al. profile →
Understanding the IL-23–IL-17 immune pathway

2005 613 citations Robert A. Kastelein, J. Daniel et al. profile →
IL‐12 and IL‐23: master regulators of innate and adaptive immunity

2004 595 citations Claire L. Langrish, René de Waal Malefyt et al. profile →
WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27

2004 589 citations Stefan Pflanz, Linda Hibbert et al. The Journal of Immunology profile →
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis

2006 565 citations Wendy M. Blumenschein, Caroline Diveu et al. The Journal of Experimental Medicine profile →

Peers

Countries citing papers authored by Robert A. Kastelein

Since Specialization

Citations

This map shows the geographic impact of Robert A. Kastelein's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Robert A. Kastelein with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Robert A. Kastelein more than expected).

Fields of papers citing papers by Robert A. Kastelein

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Robert A. Kastelein. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Robert A. Kastelein. The network helps show where Robert A. Kastelein may publish in the future.

Co-authorship network of co-authors of Robert A. Kastelein

This figure shows the co-authorship network connecting the top 25 collaborators of Robert A. Kastelein. A scholar is included among the top collaborators of Robert A. Kastelein based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Robert A. Kastelein. Robert A. Kastelein is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation 2009 ·The Journal of Experimental Medicine ·Melanie A. Kleinschek, Katia Boniface, Svetlana Sadekova, Jeff Grein, Erin E. Murphy, Scott Turner, (unknown), (unknown), William A. Faubion, René de Waal Malefyt, Robert H. Pierce, Terrill K. McClanahan, Robert A. Kastelein	364
2	IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells 2009 ·The Journal of Immunology ·Caroline Diveu, Mandy J. McGeachy, Katia Boniface, Jason S. Stumhofer, Manjiri Sathe, Barbara Joyce-Shaikh, Yi Chen, Cristina M. Tato, Terrill K. McClanahan, René de Waal Malefyt, Christopher A. Hunter, J. Daniel, Robert A. Kastelein	267
3	Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine 2008 ·The Journal of Experimental Medicine ·Colby Zaph, Yurong Du, Steven A. Saenz, Meera G. Nair, Jacqueline Perrigoue, Betsy C. Taylor, Amy E. Troy, Dmytro Kobuley, Robert A. Kastelein, J. Daniel, Yimin Yu, David Artis	244
4	Protective Immunity to Systemic Infection with Attenuated Salmonella enterica serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17 2008 ·The Journal of Immunology ·(unknown), Gabriele Köhler, Nicole Schütze, Jens Knauer, Reinhard K. Straubinger, Alissa A. Chackerian, Ellen Witte, Kerstin Wolk, Robert Sabat, Yoichiro Iwakura, Christoph Hölscher, Uwe Müller, Robert A. Kastelein, Gottfried Alber	95
5	IL-25 regulates Th17 function in autoimmune inflammation 2007 ·The Journal of Experimental Medicine ·Melanie A. Kleinschek, Alexander M. Owyang, Barbara Joyce-Shaikh, Claire L. Langrish, Yi Chen, Daniel M. Gorman, Wendy M. Blumenschein, Terrill K. McClanahan, Frank Brombacher, Stephen D. Hurst, Robert A. Kastelein, J. Daniel	322
6	IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex 2007 ·The Journal of Immunology ·Alissa A. Chackerian, Elizabeth R. Oldham, Erin E. Murphy, Jochen Schmitz, Stefan Pflanz, Robert A. Kastelein	427
7	Immunological and Antitumor Effects of IL-23 as a Cancer Vaccine Adjuvant 2006 ·The Journal of Immunology ·Willem W. Overwijk, Karin E. de Visser, Felicia H. Tirion, (unknown), Thijs W.H. Pols, Yme U. van der Velden, Jasper G. van den Boorn, Anna M. Keller, Wim A. Buurman, Marc R. Theoret, Bianca Blom, Nicholas P. Restifo, Ada M. Kruisbeek, Robert A. Kastelein, John B.A.G. Haanen	67
8	IL-23 Enhances the Inflammatory Cell Response in Cryptococcus neoformans Infection and Induces a Cytokine Pattern Distinct from IL-12 2006 ·The Journal of Immunology ·Melanie A. Kleinschek, Uwe Müller, Scott J. Brodie, Werner Stenzel, Gabriele Köhler, Wendy M. Blumenschein, Reinhard K. Straubinger, Terrill K. McClanahan, Robert A. Kastelein, Gottfried Alber	184
9	IL-27 Limits IL-2 Production during Th1 Differentiation 2006 ·The Journal of Immunology ·Alejandro V. Villarino, Jason S. Stumhofer, Christiaan J. M. Saris, Robert A. Kastelein, Frédéric J. de Sauvage, Christopher A. Hunter	179
10	Differential Effects of IL-27 on Human B Cell Subsets 2006 ·The Journal of Immunology ·Fréderique Larousserie, (unknown), Émilie Bardel, Josy Froger, Robert A. Kastelein, Odile Devergne	90
11	Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract 2006 ·The Journal of Experimental Medicine ·Alexander M. Owyang, Colby Zaph, Emma H. Wilson, Katherine J. Guild, Terrill K. McClanahan, H. R. P. Miller, J. Daniel, Michael H. Goldschmidt, Christopher A. Hunter, Robert A. Kastelein, David Artis	304
12	IL-23 Provides a Limited Mechanism of Resistance to Acute Toxoplasmosis in the Absence of IL-12 2004 ·The Journal of Immunology ·Linda A. Lieberman, Fabı́ola Cardillo, Alexander M. Owyang, D Rennick, J. Daniel, Robert A. Kastelein, Christopher A. Hunter	129
13	WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27 breakdown → 2004 ·The Journal of Immunology ·Stefan Pflanz, Linda Hibbert, Jeanine Mattson, (unknown), (unknown), J. Fernando Bazán, Joseph H. Phillips, Terrill K. McClanahan, René de Waal Malefyt, Robert A. Kastelein	589
14	IL-27 and IFN- α Signal via Stat1 and Stat3 and Induce T-Bet and IL-12R β 2 in Naive T Cells 2003 ·Journal of Interferon & Cytokine Research ·Linda Hibbert, Stefan Pflanz, René de Waal Malefyt, Robert A. Kastelein	272
15	IL-23 Production by Cosecretion of Endogenous p19 and Transgenic p40 in Keratin 14/p40 Transgenic Mice: Evidence for Enhanced Cutaneous Immunity 2003 ·The Journal of Immunology ·Tamara Kopp, Petra H. Lenz, C Bello-Fernández, Robert A. Kastelein, Thomas S. Kupper, Georg Stingl	106
16	Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation breakdown → 2003 ·The Journal of Experimental Medicine ·Craig A. Murphy, Claire L. Langrish, Yi Chen, Wendy M. Blumenschein, Terrill K. McClanahan, Robert A. Kastelein, Jonathon D. Sedgwick, J. Daniel	1327
17	Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells 2001 ·The Journal of Immunology ·Pedro A. Reche, Vassili Soumelis, Daniel M. Gorman, (unknown), Man-Ru Liu, Marilyn Travis, Sandra Zurawski, (unknown), Yong-Jun Liu, Hergen Spits, René de Waal Malefyt, Robert A. Kastelein, J. Fernando Bazán	338
18	Two Novel IL-1 Family Members, IL-1δ and IL-1ε, Function as an Antagonist and Agonist of NF-κB Activation Through the Orphan IL-1 Receptor-Related Protein 2 2001 ·The Journal of Immunology ·Reno Debets, Jackie C. Timans, Bernhard Homey, Sandra Zurawski, Theodore R. Sana, (unknown), Janet Wagner, (unknown), (unknown), Satish Menon, J. Fernando Bazán, Robert A. Kastelein	212
19	IL-18 Receptors, Their Role in Ligand Binding and Function: Anti-IL-1RAcPL Antibody, a Potent Antagonist of IL-18 2000 ·The Journal of Immunology ·Reno Debets, Jackie C. Timans, (unknown), Sandra Zurawski, René de Waal Malefyt, Kevin W. Moore, John S. Abrams, Anne O’Garra, J. Fernando Bazán, Robert A. Kastelein	66
20	IL-10 enhances NK cell proliferation, cytotoxicity and production of IFN-γ when combined with IL-18 1999 ·European Journal of Immunology ·Guifang Cai, Robert A. Kastelein, Christopher A. Hunter	154

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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