Robert A. Kastelein

44.0k total citations · 17 hit papers
74 papers, 31.0k citations indexed

About

Robert A. Kastelein is a scholar working on Immunology, Dermatology and Molecular Biology. According to data from OpenAlex, Robert A. Kastelein has authored 74 papers receiving a total of 31.0k indexed citations (citations by other indexed papers that have themselves been cited), including 63 papers in Immunology, 17 papers in Dermatology and 15 papers in Molecular Biology. Recurrent topics in Robert A. Kastelein's work include Psoriasis: Treatment and Pathogenesis (29 papers), Immune Cell Function and Interaction (18 papers) and Dermatology and Skin Diseases (17 papers). Robert A. Kastelein is often cited by papers focused on Psoriasis: Treatment and Pathogenesis (29 papers), Immune Cell Function and Interaction (18 papers) and Dermatology and Skin Diseases (17 papers). Robert A. Kastelein collaborates with scholars based in United States, France and United Kingdom. Robert A. Kastelein's co-authors include J. Daniel, Terrill K. McClanahan, Wendy M. Blumenschein, René de Waal Malefyt, Yi Chen, J. Fernando Bazán, Jeanine Mattson, Claire L. Langrish, Daniel M. Gorman and Beth Basham and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and The Lancet.

In The Last Decade

Robert A. Kastelein

73 papers receiving 30.3k citations

Hit Papers

IL-23 drives a pathogenic... 1998 2026 2007 2016 2005 2005 2003 2002 2007 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    2005 3.2k citations Claire L. Langrish, Yi Chen et al. The Journal of Experimental Medicine profile →
  2. IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines
    2005 3.0k citations Jochen Schmitz, Alexander M. Owyang et al. profile →
  3. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    2003 2.3k citations J. Daniel, Yi Chen et al. profile →
  4. Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
    2002 1.7k citations Vassili Soumelis, Pedro A. Reche et al. profile →
  5. Development, cytokine profile and function of human interleukin 17–producing helper T cells
    2007 1.6k citations Katia Boniface, Wendy M. Blumenschein et al. profile →
  6. Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens
    2001 1.6k citations René de Waal Malefyt, Robert A. Kastelein et al. The Journal of Experimental Medicine profile →
  7. A family of human receptors structurally related to Drosophila  Toll
    1998 1.4k citations Gary Hardiman, Jackie C. Timans et al. profile →
  8. Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
    2003 1.3k citations Craig A. Murphy, Claire L. Langrish et al. The Journal of Experimental Medicine profile →
  9. IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6
    2006 1.2k citations Terrill K. McClanahan, Melanie A. Kleinschek et al. profile →
  10. IL-23 promotes tumour incidence and growth
    2006 792 citations Jeanine Mattson, Terrill K. McClanahan et al. profile →
  11. IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells
    2012 791 citations Barbara Joyce-Shaikh, Scott Turner et al. profile →
  12. The IL-12 Family of Heterodimeric Cytokines
    2003 745 citations Stefan Pflanz, Robert A. Kastelein et al. profile →
  13. Discovery and Biology of IL-23 and IL-27: Related but Functionally Distinct Regulators of Inflammation
    2006 626 citations Robert A. Kastelein, Christopher A. Hunter et al. profile →
  14. Understanding the IL-23–IL-17 immune pathway
    2005 613 citations Robert A. Kastelein, J. Daniel et al. profile →
  15. IL‐12 and IL‐23: master regulators of innate and adaptive immunity
    2004 595 citations Claire L. Langrish, René de Waal Malefyt et al. profile →
  16. WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27
    2004 589 citations Stefan Pflanz, Linda Hibbert et al. The Journal of Immunology profile →
  17. IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis
    2006 565 citations Wendy M. Blumenschein, Caroline Diveu et al. The Journal of Experimental Medicine profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
Robert A. Kastelein 24.0k 4.4k 4.1k 3.8k 3.5k 74 31.0k
René de Waal Malefyt 25.5k 1.1× 4.3k 1.0× 5.8k 1.4× 4.5k 1.2× 4.8k 1.4× 150 38.3k
Sergio Romagnani 20.6k 0.9× 3.3k 0.7× 4.9k 1.2× 4.7k 1.2× 6.2k 1.8× 350 36.0k
Enrico Maggi 15.6k 0.7× 2.6k 0.6× 3.9k 0.9× 3.6k 1.0× 4.5k 1.3× 367 27.2k
J. Daniel 26.8k 1.1× 3.6k 0.8× 5.6k 1.4× 8.3k 2.2× 2.9k 0.8× 129 38.8k
Terrill K. McClanahan 17.5k 0.7× 2.5k 0.6× 7.3k 1.8× 4.3k 1.1× 1.7k 0.5× 82 25.1k
Steven F. Ziegler 20.4k 0.9× 5.1k 1.2× 4.3k 1.0× 4.2k 1.1× 5.6k 1.6× 240 30.7k
Mohamed Oukka 21.5k 0.9× 1.6k 0.4× 4.2k 1.0× 4.8k 1.3× 2.0k 0.6× 92 29.3k
Chen Dong 27.8k 1.2× 2.2k 0.5× 8.4k 2.0× 8.6k 2.3× 3.5k 1.0× 330 39.9k
Casey T. Weaver 18.6k 0.8× 1.5k 0.3× 3.5k 0.9× 5.2k 1.4× 2.1k 0.6× 172 26.8k
Susumu Nakae 14.4k 0.6× 2.2k 0.5× 1.9k 0.5× 3.0k 0.8× 4.0k 1.2× 194 20.2k

Countries citing papers authored by Robert A. Kastelein

Since Specialization
Citations

This map shows the geographic impact of Robert A. Kastelein's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Robert A. Kastelein with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Robert A. Kastelein more than expected).

Fields of papers citing papers by Robert A. Kastelein

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Robert A. Kastelein. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Robert A. Kastelein. The network helps show where Robert A. Kastelein may publish in the future.

Co-authorship network of co-authors of Robert A. Kastelein

This figure shows the co-authorship network connecting the top 25 collaborators of Robert A. Kastelein. A scholar is included among the top collaborators of Robert A. Kastelein based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Robert A. Kastelein. Robert A. Kastelein is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Kleinschek, Melanie A., Katia Boniface, Svetlana Sadekova, et al.. (2009). Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. The Journal of Experimental Medicine. 206(3). 525–534. 364 indexed citations
2.
Diveu, Caroline, Mandy J. McGeachy, Katia Boniface, et al.. (2009). IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells. The Journal of Immunology. 182(9). 5748–5756. 267 indexed citations
3.
Zaph, Colby, Yurong Du, Steven A. Saenz, et al.. (2008). Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine. The Journal of Experimental Medicine. 205(10). 2191–2198. 244 indexed citations
4.
Köhler, Gabriele, Nicole Schütze, Jens Knauer, et al.. (2008). Protective Immunity to Systemic Infection with Attenuated Salmonella enterica serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17. The Journal of Immunology. 181(11). 7891–7901. 95 indexed citations
5.
Kleinschek, Melanie A., Alexander M. Owyang, Barbara Joyce-Shaikh, et al.. (2007). IL-25 regulates Th17 function in autoimmune inflammation. The Journal of Experimental Medicine. 204(1). 161–170. 322 indexed citations
6.
Chackerian, Alissa A., Elizabeth R. Oldham, Erin E. Murphy, et al.. (2007). IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex. The Journal of Immunology. 179(4). 2551–2555. 427 indexed citations
7.
Overwijk, Willem W., Karin E. de Visser, Felicia H. Tirion, et al.. (2006). Immunological and Antitumor Effects of IL-23 as a Cancer Vaccine Adjuvant. The Journal of Immunology. 176(9). 5213–5222. 67 indexed citations
8.
Kleinschek, Melanie A., Uwe Müller, Scott J. Brodie, et al.. (2006). IL-23 Enhances the Inflammatory Cell Response in Cryptococcus neoformans Infection and Induces a Cytokine Pattern Distinct from IL-12. The Journal of Immunology. 176(2). 1098–1106. 184 indexed citations
9.
Villarino, Alejandro V., Jason S. Stumhofer, Christiaan J. M. Saris, et al.. (2006). IL-27 Limits IL-2 Production during Th1 Differentiation. The Journal of Immunology. 176(1). 237–247. 179 indexed citations
10.
Larousserie, Fréderique, et al.. (2006). Differential Effects of IL-27 on Human B Cell Subsets. The Journal of Immunology. 176(10). 5890–5897. 90 indexed citations
11.
Owyang, Alexander M., Colby Zaph, Emma H. Wilson, et al.. (2006). Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. The Journal of Experimental Medicine. 203(4). 843–849. 304 indexed citations
12.
Lieberman, Linda A., Fabı́ola Cardillo, Alexander M. Owyang, et al.. (2004). IL-23 Provides a Limited Mechanism of Resistance to Acute Toxoplasmosis in the Absence of IL-12. The Journal of Immunology. 173(3). 1887–1893. 129 indexed citations
13.
Pflanz, Stefan, Linda Hibbert, Jeanine Mattson, et al.. (2004). WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27. The Journal of Immunology. 172(4). 2225–2231. 589 indexed citations breakdown →
14.
Hibbert, Linda, Stefan Pflanz, René de Waal Malefyt, & Robert A. Kastelein. (2003). IL-27 and IFN- α Signal via Stat1 and Stat3 and Induce T-Bet and IL-12R β 2 in Naive T Cells. Journal of Interferon & Cytokine Research. 23(9). 513–522. 272 indexed citations
15.
Kopp, Tamara, Petra H. Lenz, C Bello-Fernández, et al.. (2003). IL-23 Production by Cosecretion of Endogenous p19 and Transgenic p40 in Keratin 14/p40 Transgenic Mice: Evidence for Enhanced Cutaneous Immunity. The Journal of Immunology. 170(11). 5438–5444. 106 indexed citations
16.
Murphy, Craig A., Claire L. Langrish, Yi Chen, et al.. (2003). Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation. The Journal of Experimental Medicine. 198(12). 1951–1957. 1327 indexed citations breakdown →
17.
Reche, Pedro A., Vassili Soumelis, Daniel M. Gorman, et al.. (2001). Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells. The Journal of Immunology. 167(1). 336–343. 338 indexed citations
18.
Debets, Reno, Jackie C. Timans, Bernhard Homey, et al.. (2001). Two Novel IL-1 Family Members, IL-1δ and IL-1ε, Function as an Antagonist and Agonist of NF-κB Activation Through the Orphan IL-1 Receptor-Related Protein 2. The Journal of Immunology. 167(3). 1440–1446. 212 indexed citations
19.
Debets, Reno, Jackie C. Timans, Sandra Zurawski, et al.. (2000). IL-18 Receptors, Their Role in Ligand Binding and Function: Anti-IL-1RAcPL Antibody, a Potent Antagonist of IL-18. The Journal of Immunology. 165(9). 4950–4956. 66 indexed citations
20.
Hardiman, Gary, Robert A. Kastelein, & J. Fernando Bazán. (1997). Isolation, characterization and chromosomal localization of human WNT10B. Cytogenetic and Genome Research. 77(3-4). 278–282. 24 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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