Richard J. Knox

3.8k citations

64 papers · 3.1k indexed · h-index 33

Co-authors: Frank Friedlos J. J. Roberts David Lydall Roger G. Melton Marion P. Boland Shiuan Chen Kebin Wu Philip J. Burke
Topics: Bioactive Compounds and Antitumor Agents (14 papers)Cancer therapeutics and mechanisms (14 papers)Biochemical and Molecular Research (13 papers)
Cited by: Toxicology Biotechnology Organic Chemistry
Journals: JAMA Journal of Biological Chemistry Journal of Personality and Social Psychology
Partner nations: United Kingdom United States Slovakia

In The Last Decade

Richard J. Knox

63 papers receiving 3.0k citations

Peers

Countries citing papers authored by Richard J. Knox

Since Specialization

Citations

This map shows the geographic impact of Richard J. Knox's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Richard J. Knox with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Richard J. Knox more than expected).

Fields of papers citing papers by Richard J. Knox

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Richard J. Knox. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Richard J. Knox. The network helps show where Richard J. Knox may publish in the future.

Co-authorship network of co-authors of Richard J. Knox

This figure shows the co-authorship network connecting the top 25 collaborators of Richard J. Knox. A scholar is included among the top collaborators of Richard J. Knox based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Richard J. Knox. Richard J. Knox is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Phronesis in medical decision making:medical leadership, virtue ethics and practical wisdom 2018 ·University of Birmingham Research Portal (University of Birmingham) ·(unknown),Deborah Biggerstaff,(unknown),(unknown),Richard J. Knox,Aisha Malik,Chris Turner,Catherine Weir	2
2	Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugs 2016 ·Bioorganic & Medicinal Chemistry Letters ·Philip J. Burke,(unknown),Terence C. Jenkins,Richard J. Knox,(unknown),Stephen P. Stanforth	2
3	Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: Effects of combining beneficial single mutations 2009 ·Biochemical Pharmacology ·Mansooreh Jaberipour,(unknown),Christopher P. Guise,Jane I. Grove,Richard J. Knox,Longqin Hu,Eva I. Hyde,Peter F. Searle	27
4	Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs 2007 ·Dalton Transactions ·O.R. Allen,A.L. Gott,John A. Hartley,Janet M. Hartley,Richard J. Knox,Patrick C. McGowan	51
5	NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs 2006 ·Biochemical Pharmacology ·(unknown),NamPhuong Tran,Richard J. Knox,Anil K. Jaiswal	56
6	Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase 2003 ·Oncogene ·Alan Bilsland,(unknown),(unknown),Fiona McGregor,T.R. Jeffry Evans,Ian Ganly,Richard J. Knox,Jane A. Plumb,W. Nicol Keith	64
7	CB 1954: From the Walker Tumor to NQO2 and VDEPT 2003 ·Current Pharmaceutical Design ·Richard J. Knox,Philip J. Burke,Shiuan Chen,Rachel Kerr	31
8	Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954 2001 ·Oncogene ·Jane A. Plumb,Alan Bilsland,(unknown),Jiangqin Zhao,Rosalind Glasspool,Richard J. Knox,T.R. Jeffry Evans,W. Nicol Keith	82
9	Involvement of NADPH: cytochrome P450 reductase in the activation of indoloquinone EO9 to free radical and DNA damaging species56Abbreviations: EORTC, European Organisation for the Research and Treatment of Cancer; DMPO, 5,5-dimethyl-1-pyrroline-1-oxide; and AN and AH, hyperfine-splitting constants for nitrogen and hydrogen, respectively. 2001 ·Biochemical Pharmacology ·Susan M. Bailey,(unknown),Laurence H. Patterson,(unknown),Richard J. Knox,Paul Workman	30
10	Targeting enzymes to cancers - new developments 1999 ·Expert Opinion on Investigational Drugs ·Kenneth D. Bagshawe,Philip J. Burke,Richard J. Knox,Roger G. Melton,Surinder K. Sharma	6
11	Developments with targeted enzymes in cancer therapy 1999 ·Current Opinion in Immunology ·Kenneth D. Bagshawe,Surinder K. Sharma,Philip J. Burke,Roger G. Melton,Richard J. Knox	35
12	KW-2149 (7-N-[2-[γ-l-glutamylamino]ethyldithio-ethyl] mitomycin C): DNA Interactions and Drug Uptake Following Serum Activation 1998 ·Biochemical Pharmacology ·Simon McAdam,Richard J. Knox,John A. Hartley,John R. Masters	11
13	Virtual cofactors for an Escherichia coli nitroreductase enzyme: Relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT) 1995 ·Biochemical Pharmacology ·Richard J. Knox,Frank Friedlos,Michael Jarman,Lawrence Davies,Phyllis M. Goddard,(unknown),(unknown),Roger F. Sherwood	29
14	Identification, synthesis and properties of 5-(aziridin-1-YL)-2-nitro-4-nitrosobenzamide, A novel DNA crosslinking agent derived from CB1954 1993 ·Biochemical Pharmacology ·Richard J. Knox,Frank Friedlos,Patrick J. Biggs,William D. Flitter,Margaret Gaskell,Phyllis M. Goddard,Lawrence Davies,Michael Jarman	23
15	The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT) 1993 ·Cancer and Metastasis Reviews ·Richard J. Knox,Frank Friedlos,Marion P. Boland	87
16	Identification of novel reduced pyridinium derivatives as synthetic co-factors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2) 1992 ·Biochemical Pharmacology ·Frank Friedlos,Michael Jarman,Lawrence Davies,Marion P. Boland,Richard J. Knox	41
17	The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—I 1992 ·Biochemical Pharmacology ·(unknown),Roger G. Melton,Roger F. Sherwood,Brian Coles,Frank Friedlos,Richard J. Knox	183
18	Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in walker cells 1989 ·Biochemical Pharmacology ·J. J. Roberts,Tania Marchbank,(unknown),Marion P. Boland,Frank Friedlos,Richard J. Knox	13
19	The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2) 1988 ·Biochemical Pharmacology ·Richard J. Knox,Marion P. Boland,Frank Friedlos,Brian Coles,Christopher Southan,J. J. Roberts	115
20	A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in walker carcinoma cells 1988 ·Biochemical Pharmacology ·Richard J. Knox,Frank Friedlos,Michael Jarman,J. J. Roberts	127

About Richard J. Knox

Richard J. Knox is a scholar working on Toxicology, Physiology and Biotechnology, having authored 64 papers that have together received 3.1k indexed citations. Recurring topics across this work include Bioactive Compounds and Antitumor Agents (14 papers), Cancer therapeutics and mechanisms (14 papers) and Biochemical and Molecular Research (13 papers). The work is most often cited by research in Toxicology (411 citations), Biotechnology (449 citations) and Organic Chemistry (924 citations). Richard J. Knox has collaborated with scholars based in United Kingdom, United States and Slovakia. Frequent co-authors include Frank Friedlos, J. J. Roberts, David Lydall, Roger G. Melton, Marion P. Boland, Shiuan Chen, Kebin Wu, Philip J. Burke, Roger F. Sherwood and Brian Coles. Their work appears in journals such as JAMA, Journal of Biological Chemistry and Journal of Personality and Social Psychology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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