Philippe Roche

2.6k citations

62 papers · 2.0k indexed · h-index 27

Impact in

Computational Theory and Mathematics top 1%
- Computational Drug Discovery Methods
Developmental Biology top 5%

Papers in

Computational Theory and Mathematics 12
- Computational Drug Discovery Methods 12
Hardware and Architecture 4

Co-authors: Xavier Morelli Raphaël Bourgeas Yue Zhao S. Betzi Mario Leclerc Véronique Hamon Laurent Hoffer Frédéric Debellé
Journals: Journal of Medicinal Chemistry (6 papers)Nucleic Acids Research (3 papers)Polymer (2 papers)ACS Chemical Biology (2 papers)European Journal of Medicinal Chemistry (2 papers)
Partner nations: France United States Canada

In The Last Decade

Philippe Roche

59 papers receiving 1.9k citations

Peers

Countries citing papers authored by Philippe Roche

Since Specialization

Citations

This map shows the geographic impact of Philippe Roche's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Philippe Roche with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Philippe Roche more than expected).

Fields of papers citing papers by Philippe Roche

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Philippe Roche. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Philippe Roche. The network helps show where Philippe Roche may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Philippe Roche, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Philippe Roche Line = papers co-authored together Philippe Roche links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	NanoDSF Screening for Anti-tubulin Agents Uncovers New Structure–Activity Insights Journal of Medicinal Chemistry ·Viktoriia E. Baksheeva, M. Galeazzi, Diane Allegro, Carine Derviaux, Eddy Pasquier, Philippe Roche, Xavier Morelli, François Devred, Andrey V. Golovin, Philipp O. Tsvetkov	2025	0
2	ChemoDOTS: a web server to design chemistry-driven focused libraries Nucleic Acids Research ·Laurent Hoffer, N. L. Levchenko, Sarah Barelier, S. Betzi, Thomas W. Miller, Xavier Morelli, Philippe Roche	2024	0
3	Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread European Journal of Medicinal Chemistry ·Erik Höchel, Laurent Hoffer, Raphaël Leblanc, Tey Tsun Hang, Mikaël Feracci, Carine Derviaux, Antonio Luis Egea-Jiménez, Philippe Roche, Pascale Zimmermann, Xavier Morelli, Karine Barral	2021	9
4	Rational Design of PDZ Domain Inhibitors: Discovery of Small Organic Compounds Targeting PDZ Domains Methods in molecular biology ·Laurent Hoffer, Philippe Roche, Xavier Morelli	2021	4
5	CovaDOTS: In Silico Chemistry-Driven Tool to Design Covalent Inhibitors Using a Linking Strategy Journal of Chemical Information and Modeling ·Laurent Hoffer, Magalí Sáez‐Ayala, Dragos Horvath, Alexandre Varnek, Xavier Morelli, Philippe Roche	2019	11
6	Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach Journal of Medicinal Chemistry ·Laurent Hoffer, L.M. Kokolova, 李娅娟, Gustavo Labarca Garat, Christophe Müller, Alexey Yu. Fedorov, Carine Derviaux, Agnès Amouric, S. Betzi, Dragos Horvath, Alexandre Varnek, Yves Collette, Sébastien Combes, Philippe Roche, Xavier Morelli	2018	51
7	Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors European Journal of Medicinal Chemistry ·Jessica Hernández-Rodríguez, Laurent Hoffer, Bruno Coutard, Gilles Quérat, Philippe Roche, Xavier Morelli, Étienne Decroly, Karine Barral	2018	20
8	Paraganglioma of the organ of Zuckerkandl associated with a somatic HIF2α mutation: A case report Oncology Letters ·M. Baldini, Carole Guérin, Alessio Impériale, Anne Barlier, De Salvador A, Morgane Pertuit, Philippe Roche, K Yomemasu, B. Vaı̈sse, Karel Pacák, F. Sébag, David Taïeb	2017	4
9	Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis PLoS Genetics ·Danielle DuBose, Anne-Laure Bailly, S. Betzi, Xiaoli Shi, Jean‐Claude Lissitzky, Ana Zarubica, Arnauld Sergé, Philippe Roche, Adrien Lugari, Véronique Hamon, Florence Bardin, Carine Derviaux, Frédérique Lembo, Stéphane Audebert, Sylvie Marchetto, Bénédicte Durand, Jean‐Paul Borg, Ning Shi, Xavier Morelli, Michel Aurrand‐Lions	2017	31
10	Modulation of Re-initiation of Measles Virus Transcription at Intergenic Regions by PXD to NTAIL Binding Strength PLoS Pathogens ·Louis-Marie Bloyet, Joanna Brunel, Marion Dosnon, Véronique Hamon, Jenny Erales, Antoine Gruet, João Pedro F Arbache, Christophe Bignon, Philippe Roche, Sonia Longhi, Denis Gerlier	2016	43
11	2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein–protein interactions Database ·肖炜静, S. Betzi, Xavier Morelli, Philippe Roche	2016	56
12	Pathological and Genetic Characterization of Bilateral Adrenomedullary Hyperplasia in a Patient with Germline MAX Mutation Endocrine Pathology ·Pauline Romanet, Carole Guérin, S. M. (Sarah) Juliana, K Yomemasu, Frédéric Castinetti, F. Sébag, Philippe Roche, Alberto Cascón, Arthur S. Tischler, Karel Pacák, Anne Barlier, David Taïeb	2016	25
13	Heavy ions test result on a 65nm sparc-v8 radiation-hard microprocessor HAL (Le Centre pour la Communication Scientifique Directe) ·R. W. Shorrock, (unknown), Gilles Gasiot, Lírida Naviner, Philippe Roche	2014	1
14	Chemical and structural lessons from recent successes in protein–protein interaction inhibition (2P2I) Current Opinion in Chemical Biology ·Xavier Morelli, Raphaël Bourgeas, Philippe Roche	2011	164
15	Initiation of pre-B cell receptor signaling: Common and distinctive features in human and mouse Seminars in Immunology ·Marion Espéli, Benjamín Rossi, Stéphane J.C. Mancini, Philippe Roche, Laurent Gauthier, Claudine Schiff	2005	33
16	Modeling study of human renal chloride channel (hCLC-5) mutations suggests a structural-functional relationship Kidney International ·Mathias Twahirwa, Philippe Roche, Paul T. Christie, Nellie Y. Loh, Adam J. Reed, Robert Esnouf, Rajesh V. Thakker	2003	46
17	Symbiotic and Taxonomic Diversity of Rhizobia Isolated from Acacia tortilis subsp. raddiana in Africa Systematic and Applied Microbiology ·G Morganti, Anne Willems, Philippe de Lajudie, Philippe Roche, Habib Jeder, Paola Quatrini, Marc Neyra, Myriam Ferro, Jean‐Claude Promé, Monique Gillis, Catherine Boivin-Masson, Jean Lorquin	2002	55
18	Molecular dynamics of the FixJ receiver domain: movement of the β4–α4 loop correlates with the in and out flip of Phe101 Protein Science ·Philippe Roche, Liliane Mouawad, David Pérahia, Jean‐Pierre Samama, Daniel Kahn	2002	24
19	The common nodABC genes of Rhizobium meliloti are host-range determinants SPIRE - Sciences Po Institutional REpository ·Philippe Roche, Fabienne Maillet, Moira F. Erickson-Lawrence, Frederic Debellé, Myriam Ferro, G. Truchet, J. C. Promé, Jean Dénarié	1996	2
20	*The NodA proteins of Rhizobium meliloti* and Rhizobium tropici specify the N‐acylation of Nod factors by different fatty acids** Molecular Microbiology ·Frédéric Debellé, Moira F. Erickson-Lawrence, Philippe Roche, Céline Pujol, Arlette Savagnac, Charles Rosenberg, Jean‐Claude Promé, Jean Dénarié	1996	51

About Philippe Roche

Philippe Roche is a scholar working on Computational Theory and Mathematics, Hardware and Architecture, Molecular Biology, Developmental Biology and Virology, having authored 62 papers that have together received 2.0k indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (12 papers), Chemical Synthesis and Analysis (10 papers), Click Chemistry and Applications (8 papers), Adrenal and Paraganglionic Tumors (5 papers), Cancer, Hypoxia, and Metabolism (5 papers), Protein Degradation and Inhibitors (5 papers), Legume Nitrogen Fixing Symbiosis (5 papers) and Protein Structure and Dynamics (4 papers). The work is most often cited by research in Computational Theory and Mathematics (383 citations), Developmental Biology (43 citations), Molecular Biology (1.1k citations), Polymers and Plastics (163 citations) and Organic Chemistry (229 citations). Philippe Roche has collaborated with scholars based in France, United States and Canada. Frequent co-authors include Xavier Morelli, Raphaël Bourgeas, Yue Zhao, S. Betzi, Mario Leclerc, Véronique Hamon, Laurent Hoffer, Frédéric Debellé, Jean Dénarié and Sonia Longhi. Their work appears in journals such as Journal of Medicinal Chemistry, Nucleic Acids Research, Polymer, ACS Chemical Biology and European Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact