Paulo C. Rodrı́guez

21.7k citations

124 papers · 15.2k indexed · 12 hit papers · h-index 52

Immunology top 0.05%
Oncology top 0.2%
Molecular Biology top 2%
Cancer Research top 0.5%
Epidemiology top 2%

Co-authors: Augusto C. Ochoa Jovanny Zabaleta David Quiceno Arnold H. Zea Claudia Hernandez Juan B. Ochoa Suzanne Ostrand‐Rosenberg Amir A. Al-Khami
Topics: Immune cells in cancer (50 papers)Immune Cell Function and Interaction (42 papers)Cancer Immunotherapy and Biomarkers (15 papers)
Cited by: Immunology Oncology Biological Psychiatry
Journals: Proceedings of the National Academy of Sciences Journal of Biological Chemistry Journal of Clinical Investigation
Partner nations: United States Egypt Italy

In The Last Decade

Paulo C. Rodrı́guez

117 papers receiving 15.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

2016 2.0k citations Augusto C. Ochoa, Suzanne Ostrand‐Rosenberg et al. profile →
Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses

2004 974 citations Paulo C. Rodrı́guez, David Quiceno et al. Cancer Research profile →
Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

2009 759 citations Minu K. Srivastava, Pratima Sinha et al. Cancer Research profile →
l-arginine availability regulates T-lymphocyte cell-cycle progression

2006 704 citations Paulo C. Rodrı́guez, David Quiceno et al. profile →
Arginase-Producing Myeloid Suppressor Cells in Renal Cell Carcinoma Patients: A Mechanism of Tumor Evasion

2005 671 citations Arnold H. Zea, Paulo C. Rodrı́guez et al. Cancer Research profile →
Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes

2009 634 citations Paulo C. Rodrı́guez, Marc S. Ernstoff et al. Cancer Research profile →
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

2006 581 citations Paulo C. Rodrı́guez, Augusto C. Ochoa et al. profile →
Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives

2008 568 citations Paulo C. Rodrı́guez, Augusto C. Ochoa profile →
Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies

2015 450 citations Amir A. Al-Khami, Dorota Wyczechowska et al. Cancer Immunology Research profile →
Arginase: A Multifaceted Enzyme Important in Health and Disease

2018 339 citations Paulo C. Rodrı́guez et al. profile →
Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma

2024 142 citations Xiaoqing Yu, Arnold B. Etame et al. profile →
Functional Reprogramming of Neutrophils within the Brain Tumor Microenvironment by Hypoxia-Driven Histone Lactylation

2025 23 citations Xiaoqing Yu, Arnold B. Etame et al. profile →

Peers

Countries citing papers authored by Paulo C. Rodrı́guez

Since Specialization

Citations

This map shows the geographic impact of Paulo C. Rodrı́guez's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Paulo C. Rodrı́guez with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Paulo C. Rodrı́guez more than expected).

Fields of papers citing papers by Paulo C. Rodrı́guez

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Paulo C. Rodrı́guez. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Paulo C. Rodrı́guez. The network helps show where Paulo C. Rodrı́guez may publish in the future.

Co-authorship network of co-authors of Paulo C. Rodrı́guez

This figure shows the co-authorship network connecting the top 25 collaborators of Paulo C. Rodrı́guez. A scholar is included among the top collaborators of Paulo C. Rodrı́guez based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Paulo C. Rodrı́guez. Paulo C. Rodrı́guez is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Engineering synthetic agonists for targeted activation of Notch signaling 2025 ·Nature Chemical Biology ·(unknown),Daniel Antfolk,(unknown),(unknown),(unknown),(unknown),David González-Pérez,Daniel Abate‐Daga,Paulo C. Rodrı́guez,Vincent C. Luca	0
2	Pan-cancer γδ TCR analysis uncovers clonotype diversity and prognostic potential 2024 ·Cell Reports Medicine ·Xiaoqing Yu,Li Song,Ling Cen,Biwei Cao,(unknown),Yuanyuan Shen,Daniel Abate‐Daga,Paulo C. Rodrı́guez,José R. Conejo-García,Xuefeng Wang	2
3	Relationships among Inflammatory Biomarkers and Self-Reported Treatment-Related Symptoms in Patients Treated with Chemotherapy for Gynecologic Cancer: A Controlled Comparison 2023 ·Cancers ·Aasha I. Hoogland,Brent J. Small,Laura B. Oswald,(unknown),(unknown),Brian D. Gonzalez,Xiaoyin Li,Michelle C. Janelsins,Hailey W. Bulls,Brian W. James,(unknown),(unknown),Mary K. Townsend,Shelley S. Tworoger,Paulo C. Rodrı́guez,Julienne E. Bower,Sachin M. Apte,Robert M. Wenham,Heather Jim	5
4	TCR-Independent Metabolic Reprogramming Precedes Lymphoma-Driven Changes in T-cell Fate 2022 ·Cancer Immunology Research ·(unknown),(unknown),(unknown),John M. Koomen,Eric A. Welsh,(unknown),Sujeewa Ranatunga,Chunying Yang,(unknown),Harshani R. Lawrence,Paulo C. Rodrı́guez,Anders Berglund,John L. Cleveland	1
5	Single-Cell Characterization of the Immune Microenvironment of Melanoma Brain and Leptomeningeal Metastases 2021 ·Clinical Cancer Research ·Inna Smalley,Zhihua Chen,Manali Phadke,Jiannong Li,Xiaoqing Yu,(unknown),Brittany Evernden,Jane L. Messina,Amod A. Sarnaik,Vernon K. Sondak,Chaomei Zhang,Vincent Law,Nam Tran,Arnold B. Etame,Robert Macaulay,Zeynep Eroglu,Peter Forsyth,Paulo C. Rodrı́guez,Y. Ann Chen,Keiran S.M. Smalley	96
6	Targeted Therapy Given after Anti–PD-1 Leads to Prolonged Responses in Mouse Melanoma Models through Sustained Antitumor Immunity 2021 ·Cancer Immunology Research ·(unknown),Zhihua Chen,Jiannong Li,Eslam Mohamed,Michael A. Davies,Inna Smalley,Derek R. Duckett,Vinayak Palve,Brian J. Czerniecki,Peter Forsyth,David Noyes,Dennis O. Adeegbe,Zeynep Eroglu,(unknown),Kenneth Y. Tsai,Uwe Rix,Christin E. Burd,Y. Ann Chen,Paulo C. Rodrı́guez,Keiran S.M. Smalley	19
7	Differential PI3Kδ Signaling in CD4+ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy 2017 ·Cancer Research ·Shamim Ahmad,Rasha Abu Eid,Rajeev Shrimali,Mason Webb,Vivek Verma,(unknown),(unknown),Raed Samara,Paulo C. Rodrı́guez,Mikayel Mkrtichyan,Samir N. Khleif	87
8	Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition 2017 ·Cancer Research ·Rasha Abu Eid,Shamim Ahmad,(unknown),Mason Webb,(unknown),Rajeev Shrimali,Takumi Kumai,Sudha Ananth,Paulo C. Rodrı́guez,Esteban Celis,John E. Janik,Mikayel Mkrtichyan,Samir N. Khleif	61
9	ABC294640, A Novel Sphingosine Kinase 2 Inhibitor, Induces Oncogenic Virus–Infected Cell Autophagic Death and Represses Tumor Growth 2017 ·Molecular Cancer Therapeutics ·Lu Dai,Aiping Bai,Charles D. Smith,Paulo C. Rodrı́guez,Fangyou Yu,Zhiqiang Qin	27
10	Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance 2017 ·Cancer Research ·Rosa A. Sierra,Jimena Trillo-Tinoco,Eslam Mohamed,Lolie C. Yu,Bhagelu R. Achyut,Ali S. Arbab,(unknown),Barbara A. Osborne,Lucio Miele,Paulo C. Rodrı́guez	60
11	Sildenafil Suppresses Inflammation-Driven Colorectal Cancer in Mice 2017 ·Cancer Prevention Research ·Bianca N. Islam,(unknown),Yali Hou,(unknown),Nagendra Singh,Sangmi Kim,Ravindra Kolhe,Jimena Trillo-Tinoco,Paulo C. Rodrı́guez,Franklin G. Berger,Subbaramiah Sridhar,Darren D. Browning	64
12	l -Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells 2014 ·Cancer Research ·Matthew Fletcher,María E. Ramírez,Rosa A. Sierra,Patrick Raber,Paul Thevenot,Amir A. Al-Khami,(unknown),Claudia Hernandez,Dorota Wyczechowska,Augusto C. Ochoa,Paulo C. Rodrı́guez	219
13	Rescue of Notch-1 Signaling in Antigen-Specific CD8+ T Cells Overcomes Tumor-Induced T-cell Suppression and Enhances Immunotherapy in Cancer 2014 ·Cancer Immunology Research ·Rosa A. Sierra,Paul Thevenot,Patrick Raber,Yan Cui,Chris Parsons,Augusto C. Ochoa,Jimena Trillo-Tinoco,Luis Del Valle,Paulo C. Rodrı́guez	66
14	Trp53 Inactivation in the Tumor Microenvironment Promotes Tumor Progression by Expanding the Immunosuppressive Lymphoid-like Stromal Network 2013 ·Cancer Research ·Gang Guo,Luis Marrero,Paulo C. Rodrı́guez,Luis Del Valle,Augusto C. Ochoa,Yan Cui	55
15	Targeting Sphingosine Kinase Induces Apoptosis and Tumor Regression for KSHV-Associated Primary Effusion Lymphoma 2013 ·Molecular Cancer Therapeutics ·Zhiqiang Qin,Lu Dai,Jimena Trillo-Tinoco,Can E. Senkal,Wenxue Wang,(unknown),(unknown),Luis Del Valle,Paulo C. Rodrı́guez,Erik K. Flemington,Christina Voelkel‐Johnson,Charles D. Smith,Besim Öğretmen,Chris Parsons	54
16	Polycyclic aromatic hydrocarbons—induced ROS accumulation enhances mutagenic potential of T‐antigen from human polyomavirus JC 2013 ·Journal of Cellular Physiology ·Anna Wilk,Piotr Waligórski,Adam Lassak,Himanshu Vashistha,(unknown),David J. Tate,Arnold H. Zea,Shahriar Koochekpour,Paulo C. Rodrı́guez,Leonard G. Meggs,John J. Estrada,Augusto C. Ochoa,Krzysztof Reiss	37
17	Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteinebreakdown → 2009 ·Cancer Research ·Minu K. Srivastava,Pratima Sinha,Virginia K. Clements,Paulo C. Rodrı́guez,Suzanne Ostrand‐Rosenberg	759
18	Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8+ T Cell Function via l -Arginine Metabolism 2009 ·Cancer Research ·Lyse A. Norian,Paulo C. Rodrı́guez,Leigh A. O’Mara,Jovanny Zabaleta,Augusto C. Ochoa,Marina Cella,Paul M. Allen	216
19	Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytesbreakdown → 2009 ·Cancer Research ·Paulo C. Rodrı́guez,Marc S. Ernstoff,Claudia Hernandez,Michael B. Atkins,Jovanny Zabaleta,Rosa A. Sierra,Augusto C. Ochoa	634
20	Arginase-Producing Myeloid Suppressor Cells in Renal Cell Carcinoma Patients: A Mechanism of Tumor Evasionbreakdown → 2005 ·Cancer Research ·Arnold H. Zea,Paulo C. Rodrı́guez,Michael B. Atkins,Claudia Hernandez,Sabina Signoretti,Jovanny Zabaleta,David F. McDermott,David Quiceno,Amanda Youmans,Anne O’Neill,James W. Mier,Augusto C. Ochoa	671

About Paulo C. Rodrı́guez

Paulo C. Rodrı́guez is a scholar working on Immunology, Physiology and Biochemistry, having authored 124 papers that have together received 15.2k indexed citations. Recurring topics across this work include Immune cells in cancer (50 papers), Immune Cell Function and Interaction (42 papers) and Cancer Immunotherapy and Biomarkers (15 papers). The work is most often cited by research in Immunology (10.6k citations), Oncology (5.1k citations) and Biological Psychiatry (320 citations). Paulo C. Rodrı́guez has collaborated with scholars based in United States, Egypt and Italy. Frequent co-authors include Augusto C. Ochoa, Jovanny Zabaleta, David Quiceno, Arnold H. Zea, Claudia Hernandez, Juan B. Ochoa, Suzanne Ostrand‐Rosenberg, Amir A. Al-Khami, Rosa A. Sierra and Patrick Raber. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Journal of Clinical Investigation.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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