Olaf Kinzel

1.9k citations

42 papers · 964 indexed · h-index 17

Impact in

Virology top 10%
- HIV Research and Treatment
Hepatology top 5%
- Liver Diseases and Immunity

Papers in ⓘ

Biological Psychiatry 3
- Tryptophan and brain disorders 3
Oncology 19
- Drug Transport and Resistance Mechanisms 10

Co-authors: Claus Kremoser (14 shared papers)Andreas Schulz (8 shared papers)Michael Rowley (13 shared papers)Christian Gege (9 shared papers)H. Budzikiewicz (2 shared papers)Eva Hambruch (9 shared papers)Ulrich Deuschle (8 shared papers)Thomas Schlüter (7 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (15 papers)Journal of Medicinal Chemistry (4 papers)Journal of Hepatology (3 papers)Tetrahedron Letters (3 papers)Journal of Pharmacology and Experimental Therapeutics (2 papers)
Partner nations: Italy United States Germany

In The Last Decade

Olaf Kinzel

42 papers receiving 928 citations

Peers

Countries citing papers authored by Olaf Kinzel

Since Specialization

Citations

This map shows the geographic impact of Olaf Kinzel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Olaf Kinzel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Olaf Kinzel more than expected).

Fields of papers citing papers by Olaf Kinzel

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Olaf Kinzel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Olaf Kinzel. The network helps show where Olaf Kinzel may publish in the future.

Co-authors

The 25 scholars most cited alongside Olaf Kinzel, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Olaf Kinzel Line = papers co-authored together Olaf Kinzel links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 42 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Synthetic Farnesoid X Receptor Agonists Induce High-Density Lipoprotein-Mediated Transhepatic Cholesterol Efflux in Mice and Monkeys and Prevent Atherosclerosis in Cholesteryl Ester Transfer Protein Transgenic Low-Density Lipoprotein Receptor (−/−) Mice Journal of Pharmacology and Experimental Therapeutics ·Eva Hambruch, Shinobu Miyazaki‐Anzai, Ulrike K. Hahn, Silke Matysik, Alfred Boettcher, Sanja Perović‐Ottstadt, Thomas Schlüter, Olaf Kinzel, Helen Desiree Krol, Ulrich Deuschle, Michael Burnet, Moshe Levi, Gerd Schmitz, Makoto Miyazaki, Claus Kremoser	2012	87
2	Tetrazole thioacetanilides: Potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant Bioorganic & Medicinal Chemistry Letters ·Ester Muraglia, Olaf Kinzel, Ralph Laufer, Michael D. Miller, Gregory Moyer, Vandna Munshi, Federica Orvieto, Maria Cecilia Palumbi, Giovanna Pescatore, Michael Rowley, Peter D. Williams, Vincenzo Summa	2006	74
3	FXR Controls the Tumor Suppressor NDRG2 and FXR Agonists Reduce Liver Tumor Growth and Metastasis in an Orthotopic Mouse Xenograft Model PLoS ONE ·Ulrich Deuschle, Julia Schüler, Andreas Schulz, Thomas Schlüter, Olaf Kinzel, Ulrich Abel, Claus Kremoser	2012	72
4	Nonsteroidal FXR Ligands: Current Status and Clinical Applications Handbook of experimental pharmacology ·Christian Gege, Eva Hambruch, Nina Hambruch, Olaf Kinzel, Claus Kremoser	2019	67
5	Knocking on FXR's Door:The "Hammerhead"-Structure Series of FXRs Agonists - Amphiphilic Isoxazoles with Potent In Vitro and In Vivo Activities Current Topics in Medicinal Chemistry ·Christian Gege, Olaf Kinzel, Christoph Steeneck, Andreas Schulz, Claus Kremoser	2014	52
6	The Synthesis and Antibacterial Activity of two Pyoverdin-ampicillin Conjugates, Entering Pseudomonas aeruginosa via the Pyoverdin-mediated Iron Uptake Pathway. The Journal of Antibiotics ·Olaf Kinzel, Robert Tappe, Igor I. Gerus, H. Budzikiewicz	1998	51
7	Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists Bioorganic & Medicinal Chemistry Letters ·Ulrich Abel, Thomas Schlüter, Andreas Schulz, Eva Hambruch, Christoph Steeneck, Martin Hornberger, Thomas K. Hoffmann, Sanja Perović‐Ottstadt, Olaf Kinzel, Michael Burnet, Ulrich Deuschle, Claus Kremoser	2010	47
8	A Novel Series of Potent and Selective Ketone Histone Deacetylase Inhibitors with Antitumor Activity in Vivo Journal of Medicinal Chemistry ·Philip Jones, Sergio Altamura, Raffaele De Francesco, Odalys Gonzalez Paz, Olaf Kinzel, Giuseppe Mesiti, Edith Monteagudo, Giovanna Pescatore, Michael Rowley, Maria Verdirame, Christian Steinkühler	2008	47
9	Design and Synthesis of Bicyclic Pyrimidinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors Journal of Medicinal Chemistry ·Ester Muraglia, Olaf Kinzel, Cristina Gardelli, Benedetta Crescenzi, Monica Donghi, Marco Ferrara, Emanuela Nizi, Federica Orvieto, Giovanna Pescatore, Ralph Laufer, Odalys Gonzalez-Paz, Annalise Di Marco, Fabrizio Fiore, Edith Monteagudo, Massimiliano Fonsi, Peter J. Felock, Michael Rowley, Vincenzo Summa	2008	42
10	Discovery of a Potent Class I Selective Ketone Histone Deacetylase Inhibitor with Antitumor Activity in Vivo and Optimized Pharmacokinetic Properties Journal of Medicinal Chemistry ·Olaf Kinzel, Laura Llauger-Bufi, Giovanna Pescatore, Michael Rowley, Carsten Schultz‐Fademrecht, Edith Monteagudo, Massimiliano Fonsi, Odalys Gonzalez Paz, Fabrizio Fiore, Christian Steinkühler, Philip Jones	2009	40
11	Synthesis and biological evaluation of a pyoverdin‐β‐lactam conjugate: a new type of arginine‐specific cross‐linking in aqueous solution Journal of Peptide Research ·Olaf Kinzel, H. Budzikiewicz	1999	31
12	Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534 Scientific Reports ·Xiaohua Xue, Aimee De Leon-Tabaldo, Rosa Luna-Roman, Glenda Castro, M. Albers, Freddy Schoetens, Samuel E. DePrimo, Damayanthi Devineni, Thomas Wilde, Steve Goldberg, Olaf Kinzel, Thomas K. Hoffmann, Anne M. Fourie, Robin L. Thurmond	2021	28
13	Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties Bioorganic & Medicinal Chemistry Letters ·Olaf Kinzel, Christoph Steeneck, Thomas Schlüter, Andreas Schulz, Christian Gege, Ulrike K. Hahn, Eva Hambruch, Martin Hornberger, Adriana Spalwisz, Katharina Frick, Sanja Perović‐Ottstadt, Ulrich Deuschle, Michael Burnet, Claus Kremoser	2016	27
14	Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 1 Bioorganic & Medicinal Chemistry Letters ·Savina Malancona, Sergio Altamura, Gessica Filocamo, Olaf Kinzel, José Ignacio Martı́n Hernando, Michael Rowley, Rita Scarpelli, Christian Steinkühler, Philip Jones	2011	26
15	3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates—A new class of HIV-1 integrase inhibitors Bioorganic & Medicinal Chemistry Letters ·Monica Donghi, Olaf Kinzel, Vincenzo Summa	2009	24
16	Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway Bioorganic & Medicinal Chemistry Letters ·Gabriella Dessole, Danila Branca, Federica Ferrigno, Olaf Kinzel, Ester Muraglia, Maria Cecilia Palumbi, Michael Rowley, Sergio Serafini, Christian Steinkühler, Philip Jones	2009	17
17	Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) Bioorganic & Medicinal Chemistry Letters ·Giovanna Pescatore, Danila Branca, Fabrizio Fiore, Olaf Kinzel, Laura Llauger Bufi, Ester Muraglia, Federica Orvieto, Michael Rowley, Carlo Toniatti, Caterina Torrisi, Philip Jones	2009	17
18	Identification and biological evaluation of thiazole-based inverse agonists of RORγt Bioorganic & Medicinal Chemistry Letters ·Christian Gege, Maxwell D. Cummings, M. Albers, Olaf Kinzel, Gerald Kleymann, Thomas Schlüter, Christoph Steeneck, Marina I. Nelen, Cindy Milligan, John Spurlino, Xiaohua Xue, Kristi Leonard, James P. Edwards, Anne M. Fourie, Steven D. Goldberg, Thomas K. Hoffmann	2018	16
19	A Structure-Guided Approach to an Orthogonal Estrogen-Receptor-Based Gene Switch Activated by Ligands Suitable for in Vivo Studies Journal of Medicinal Chemistry ·Olaf Kinzel, Daniela Fattori, Ester Muraglia, Paola Gallinari, Maria Chiara Nardi, Chantal Paolini, Giuseppe Roscilli, Carlo Toniatti, Odalys Gonzalez Paz, Ralph Laufer, Armin Lahm, Anna Tramontano, Riccardo Cortese, Raffaele De Francesco, Gennaro Ciliberto, Uwe Koch	2006	16
20	Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation ACS Medicinal Chemistry Letters ·Christoph Steeneck, Olaf Kinzel, Simon Anderhub, Martin Hornberger, Sheena Pinto, Barbara Morschhaeuser, Floriane Braun, Gerald Kleymann, Thomas K. Hoffmann	2020	15

About Olaf Kinzel

Olaf Kinzel is a scholar working on Biological Psychiatry, Oncology, Virology, Physiology and Infectious Diseases, having authored 42 papers that have together received 964 indexed citations. Recurring topics across this work include Drug Transport and Resistance Mechanisms (10 papers), HIV/AIDS drug development and treatment (6 papers), Histone Deacetylase Inhibitors Research (4 papers), Psoriasis: Treatment and Pathogenesis (4 papers), Protein Degradation and Inhibitors (3 papers), Tryptophan and brain disorders (3 papers), Asthma and respiratory diseases (3 papers) and Click Chemistry and Applications (3 papers). The work is most often cited by research in Virology (72 citations), Hepatology (120 citations), Oncology (345 citations), Biological Psychiatry (23 citations) and Organic Chemistry (255 citations). Olaf Kinzel has collaborated with scholars based in Italy, United States and Germany. Frequent co-authors include Claus Kremoser, Andreas Schulz, Michael Rowley, Christian Gege, H. Budzikiewicz, Eva Hambruch, Ulrich Deuschle, Thomas Schlüter, Giovanna Pescatore and Christoph Steeneck. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Journal of Hepatology, Tetrahedron Letters and Journal of Pharmacology and Experimental Therapeutics.

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