John Spurlino

4.0k citations

42 papers · 2.8k · h-index 24

Impact in

Molecular Biology top 5%
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
Cancer Research top 5%
- Protease and Inhibitor Mechanisms

Papers in

Molecular Biology 19
- Chemical Synthesis and Analysis 8
Organic Chemistry 12
- Click Chemistry and Applications 4

Co-authors: Florante A. Quiocho (6 shared papers)Lynn E. Rodseth (4 shared papers)Andrew Sharff (1 shared paper)Roger Bone (11 shared papers)Robert C. Wahl (4 shared papers)Douglas L. Smith (4 shared papers)Tracey M. Banks (2 shared papers)Bruce E. Tomczuk (11 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (18 papers)Journal of Medicinal Chemistry (3 papers)Journal of Biological Chemistry (3 papers)Structure (2 papers)Journal of Molecular Biology (2 papers)
Partner nations: United States United Kingdom Belgium

In The Last Decade

John Spurlino

42 papers receiving 2.7k citations

Peers

Countries citing papers authored by John Spurlino

Since Specialization

Citations

This map shows the geographic impact of John Spurlino's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Spurlino with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Spurlino more than expected).

Fields of papers citing papers by John Spurlino

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Spurlino. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Spurlino. The network helps show where John Spurlino may publish in the future.

Co-authors

The 25 scholars most cited alongside John Spurlino, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John Spurlino Line = papers co-authored together John Spurlino links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Showing the 20 most-cited of 42 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis Biochemistry ·Andrew Sharff, Lynn E. Rodseth, John Spurlino, Florante A. Quiocho	1992	415
2	THE 2.3-ANGSTROMS RESOLUTION STRUCTURE OF THE MALTOSE- OR MALTODEXTRIN-BINDING PROTEIN, A PRIMARY RECEPTOR FOR BACTERIAL ACTIVE TRANSPORT AND CHEMOTAXIS PubMed* ·John Spurlino, Guang-Ying Lu, Florante A. Quiocho	1990	414
3	The 2.3-A resolution structure of the maltose- or maltodextrin-binding protein, a primary receptor of bacterial active transport and chemotaxis. Journal of Biological Chemistry ·John Spurlino, Guan Yu Lu, Florante A. Quiocho	1991	410
4	Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor Structure ·Florante A. Quiocho, John Spurlino, Lynn E. Rodseth	1997	281
5	1.56 Å structure of mature truncated human fibroblast collagenase Proteins Structure Function and Bioinformatics ·John Spurlino, Angela Smallwood, Dennis Carlton, Tracey M. Banks, Karen J. Vavra, Jeffrey S. Johnson, Ewell R. Cook, Joseph Falvo, Robert C. Wahl, Tricia A. Pulvino, John J. Wendoloski, Douglas L. Smith	1994	159
6	Structure of human neutrophil collagenase reveals large S1′ specificity pocket Nature Structural & Molecular Biology ·Travis Stams, John Spurlino, Douglas L. Smith, Robert C. Wahl, Thau Ho, M. Walid Qoronfleh, Tracey M. Banks, Byron Rubin	1994	133
7	Synthesis of thiophene-2-carboxamidines containing 2-amino-thiazoles and their biological evaluation as urokinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Kenneth J. Wilson, Carl R. Illig, Nalin L. Subasinghe, James B. Hoffman, Matthias Rudolph, Richard Söll, Christopher J. Molloy, Roger Bone, David Green, Troy D. Randall, Marie Zhang, Frank Lewandowski, Zhao Zhou, Celia Sharp, Diane Maguire, Bruce Grasberger, Renée L. DesJarlais, John Spurlino	2001	88
8	Proposed mechanisms for binding of apo[a] kringle type 9 to apo B-100 in human lipoprotein[a] Biophysical Journal ·Juan Guevara, John Spurlino, A.Y. Jan, Chao Yang, A. Tulinsky, B. V. Venkataram Prasad, John W. Gaubatz, Joel D. Morrisett	1993	60
9	Crystal Structure of the Tyrosine Kinase Domain of Colony-stimulating Factor-1 Receptor (cFMS) in Complex with Two Inhibitors Journal of Biological Chemistry ·Carsten J. Schubert, Céline Schalk‐Hihi, Geoffrey T. Struble, Hongchang Ma, Ioanna P. Petrounia, Benjamin Brandt, Ingrid C. Deckman, Raymond J. Patch, Mark R. Player, John Spurlino, Barry A. Springer	2006	56
10	Genetic approach to the role of tryptophan residues in the activities and fluorescence of a bacterial periplasmic maltose-binding protein Journal of Molecular Biology ·Pierre Martineau, S Szmelcman, John Spurlino, F A Quiocho, Maurice Hofnung	1990	53
11	Serendipity meets precision: the integration of structure-based drug design and combinatorial chemistry for efficient drug discovery Structure ·F. Raymond Salemme, John Spurlino, Roger Bone	1997	53
12	Structural determination of estrogen-related receptor γ in the presence of phenol derivative compounds The Journal of Steroid Biochemistry and Molecular Biology ·M.C. Abad, Hossein B. Askari, John O’Neill, Alexandra L. Klinger, Cynthia Milligan, Frank Lewandowski, Barry A. Springer, John Spurlino, Dionisios Rentzeperis	2007	49
13	Inhibition of Matrix Metalloproteinases by Hydroxamates Containing Heteroatom-Based Modifications of the P1' Group Journal of Medicinal Chemistry ·Madhusudhan Gowravaram, Jeffrey S. Johnson, Daniel Delecki, Ewell R. Cook, Bruce E. Tomczuk, Arup K. Ghose, Alan M. Mathiowetz, John Spurlino, Byron Rubin, Douglas L. Smith, Tricia A. Pulvino, Robert C. Wahl	1995	48
14	Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives Bioorganic & Medicinal Chemistry Letters ·Michael J. Costanzo, Stephen C. Yabut, Han‐Cheng Zhang, Kimberley B. White, Lawrence de Garavilla, Yuanping Wang, Lisa Minor, Brett A. Tounge, Alexander N. Barnakov, Frank Lewandowski, Cynthia Milligan, John Spurlino, William M. Abraham, Victoria Boswell‐Smith, Clive Page, Bruce E. Maryanoff	2008	44
15	Atomic interactions in protein-carbohydrate complexes Journal of Molecular Biology ·John Spurlino, Lynn E. Rodseth, Florante A. Quiocho	1992	43
16	Rational design and synthesis of aminopiperazinones as β-secretase (BACE) inhibitors Bioorganic & Medicinal Chemistry Letters ·Gary Tresadern, Francisca Delgado, Óscar Delgado, Harrie J. M. Gijsen, Gregor J. Macdonald, Dieder Moechars, Frederik Rombouts, Richard Alexander, John Spurlino, Michiel Van Gool, Juan A. Vega, Andrés A. Trabanco	2011	36
17	2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors Bioorganic & Medicinal Chemistry Letters ·Lily Lee, K. D. Kreutter, Wenxi Pan, Carl Crysler, John Spurlino, Mark R. Player, Bruce E. Tomczuk, Tianbao Lu	2007	35
18	Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors Bioorganic & Medicinal Chemistry Letters ·Lei Qiao, Christian A. Baumann, Carl Crysler, Nisha Ninan, M.C. Abad, John Spurlino, Renée L. DesJarlais, Jukka Kervinen, Mike P. Neeper, Shariff Bayoumy, Robyn Williams, Ingrid C. Deckman, Malini Dasgupta, Rolanda L. Reed, Norman Huebert, Bruce E. Tomczuk, K.J.M. Moriarty	2005	34
19	Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors Bioorganic & Medicinal Chemistry Letters ·Richard Söll, Tianobao Lu, Bruce E. Tomczuk, Carl R. Illig, Cynthia L. Fedde, Stephen Eisennagel, Roger Bone, (unknown), John Spurlino, F. Raymond Salemme	2000	33
20	Discovery and Clinical Evaluation of 1-{N-[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif Journal of Medicinal Chemistry ·Tianbao Lu, Thomas Markotan, Shelley K. Ballentine, Edward C. Giardino, John Spurlino, Kathryn Brown, Bruce E. Maryanoff, Bruce E. Tomczuk, Bruce P. Damiano, Umesh Shukla, David W. End, Patricia Andrade-Gordon, Roger Bone, Mark R. Player	2010	28

About John Spurlino

John Spurlino is a scholar working on Molecular Biology, Organic Chemistry, Oncology, Immunology and Genetics, having authored 42 papers that have together received 2.8k indexed citations. Recurring topics across this work include Peptidase Inhibition and Analysis (9 papers), Chemical Synthesis and Analysis (8 papers), Coagulation, Bradykinin, Polyphosphates, and Angioedema (6 papers), Enzyme Structure and Function (6 papers), Protease and Inhibitor Mechanisms (6 papers), Computational Drug Discovery Methods (5 papers), Blood Coagulation and Thrombosis Mechanisms (5 papers) and Click Chemistry and Applications (4 papers). The work is most often cited by research in Molecular Biology (1.6k citations), Cancer Research (303 citations), Oncology (514 citations), Biochemistry (136 citations) and Biotechnology (152 citations). John Spurlino has collaborated with scholars based in United States, United Kingdom and Belgium. Frequent co-authors include Florante A. Quiocho, Lynn E. Rodseth, Andrew Sharff, Roger Bone, Robert C. Wahl, Douglas L. Smith, Tracey M. Banks, Bruce E. Tomczuk, F. Raymond Salemme and Richard Söll. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Journal of Biological Chemistry, Structure and Journal of Molecular Biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

John Spurlino

Impact in

Papers in i

In The Last Decade

John Spurlino

Peers

Countries citing papers authored by John Spurlino

Fields of papers citing papers by John Spurlino

All Works

About John Spurlino

Explore authors with similar magnitude of impact

Papers in