Morgan S. Gadd

2.4k citations

14 papers · 1.8k indexed · 1 hit paper · h-index 11

Co-authors: Alessio Ciulli Xavier Lucas Andrea Testa Kwok-Ho Chan Wenzhang Chen Michael Zengerle Douglas J. Lamont Carles Galdeano
Topics: Ubiquitin and proteasome pathways (8 papers)Protein Degradation and Inhibitors (6 papers)Peptidase Inhibition and Analysis (2 papers)
Cited by: Hematology Oncology Molecular Biology
Journals: Journal of the American Chemical Society Journal of Biological Chemistry Nature Communications
Partner nations: United Kingdom Australia Canada

In The Last Decade

Morgan S. Gadd

14 papers receiving 1.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Structural basis of PROTAC cooperative recognition for selective protein degradation

2017 826 citations Morgan S. Gadd, Andrea Testa et al. Nature Chemical Biology profile →

Peers

Countries citing papers authored by Morgan S. Gadd

Since Specialization

Citations

This map shows the geographic impact of Morgan S. Gadd's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Morgan S. Gadd with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Morgan S. Gadd more than expected).

Fields of papers citing papers by Morgan S. Gadd

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Morgan S. Gadd. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Morgan S. Gadd. The network helps show where Morgan S. Gadd may publish in the future.

Co-authorship network of co-authors of Morgan S. Gadd

This figure shows the co-authorship network connecting the top 25 collaborators of Morgan S. Gadd. A scholar is included among the top collaborators of Morgan S. Gadd based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Morgan S. Gadd. Morgan S. Gadd is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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14 of 14 papers shown

#	Work	Indexed citations
1	Selective Wee1 degradation by PROTAC degraders recruiting VHL and CRBN E3 ubiquitin ligases 2022 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),(unknown),(unknown),Morgan S. Gadd	22
2	3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation 2018 ·Journal of the American Chemical Society ·Andrea Testa,Xavier Lucas,(unknown),Kwok-Ho Chan,Jane E. Wright,(unknown),Morgan S. Gadd,William T. A. Harrison,Eun Jung Ko,Daniel A. Fletcher,Alessio Ciulli	114
3	Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex 2017 ·Structure ·Teresa A.F. Cardote,Morgan S. Gadd,Alessio Ciulli	110
4	Structural basis of PROTAC cooperative recognition for selective protein degradationbreakdown → 2017 ·Nature Chemical Biology ·Morgan S. Gadd,Andrea Testa,Xavier Lucas,Kwok-Ho Chan,Wenzhang Chen,Douglas J. Lamont,Michael Zengerle,Alessio Ciulli	826
5	Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298) 2017 ·Journal of Medicinal Chemistry ·Pedro Soares,Morgan S. Gadd,Julianty Frost,Carles Galdeano,Lucy C.J. Ellis,Ola Epemolu,Sónia Rocha,Kevin D. Read,Alessio Ciulli	123
6	Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition 2016 ·Nature Communications ·Julianty Frost,Carles Galdeano,Pedro Soares,Morgan S. Gadd,Katarzyna M. Grzes,Lucy C.J. Ellis,Ola Epemolu,Satoko Shimamura,Marcus Bantscheff,Paola Grandi,Kevin D. Read,Doreen A. Cantrell,Sónia Rocha,Alessio Ciulli	178
7	Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases 2015 ·PLoS ONE ·Morgan S. Gadd,Emil Bulatov,Alessio Ciulli	16
8	Biochemical and biophysical characterisation of haloalkane dehalogenases DmrA and DmrB in Mycobacterium strain JS60 and their role in growth on haloalkanes 2015 ·Molecular Microbiology ·Herman K.H. Fung,Morgan S. Gadd,(unknown),(unknown),J.M. Guss,Nicholas V. Coleman,Jacqueline M. Matthews	19
9	Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities 2014 ·Journal of Medicinal Chemistry ·Carles Galdeano,Morgan S. Gadd,Pedro Soares,Salvatore Scaffidi,Inge Van Molle,(unknown),Sarah H. Hewitt,David M. Dias,Alessio Ciulli	306
10	A Structural Basis for the Regulation of the LIM-Homeodomain Protein Islet 1 (Isl1) by Intra- and Intermolecular Interactions 2013 ·Journal of Biological Chemistry ·Morgan S. Gadd,David A. Jacques,(unknown),Vanessa J. Craig,Ann H. Kwan,J.M. Guss,Jacqueline M. Matthews	18
11	Crystallization and diffraction of an Isl1–Ldb1 complex 2012 ·Acta Crystallographica Section F Structural Biology and Crystallization Communications ·Morgan S. Gadd,David A. Jacques,J.M. Guss,Jacqueline M. Matthews	1
12	Solution Structure of the LIM-Homeodomain Transcription Factor Complex Lhx3/Ldb1 and the Effects of a Pituitary Mutation on Key Lhx3 Interactions 2012 ·PLoS ONE ·Mugdha Bhati,Christopher Lee,Morgan S. Gadd,Cy M. Jeffries,Ann H. Kwan,Andrew E. Whitten,Jill Trewhella,Joel P. Mackay,Jacqueline M. Matthews	7
13	Structural Basis for Partial Redundancy in a Class of Transcription Factors, the LIM Homeodomain Proteins, in Neural Cell Type Specification 2011 ·Journal of Biological Chemistry ·Morgan S. Gadd,Mugdha Bhati,Cy M. Jeffries,David B. Langley,Jill Trewhella,J.M. Guss,Jacqueline M. Matthews	32
14	Crystallization and diffraction of an Lhx4–Isl2 complex 2009 ·Acta Crystallographica Section F Structural Biology and Crystallization Communications ·Morgan S. Gadd,David B. Langley,J.M. Guss,Jacqueline M. Matthews	5

About Morgan S. Gadd

Morgan S. Gadd is a scholar working on Molecular Biology, Cancer Research and Oncology, having authored 14 papers that have together received 1.8k indexed citations. Recurring topics across this work include Ubiquitin and proteasome pathways (8 papers), Protein Degradation and Inhibitors (6 papers) and Peptidase Inhibition and Analysis (2 papers). The work is most often cited by research in Hematology (412 citations), Oncology (686 citations) and Molecular Biology (1.7k citations). Morgan S. Gadd has collaborated with scholars based in United Kingdom, Australia and Canada. Frequent co-authors include Alessio Ciulli, Xavier Lucas, Andrea Testa, Kwok-Ho Chan, Wenzhang Chen, Michael Zengerle, Douglas J. Lamont, Carles Galdeano, Pedro Soares and Teresa A.F. Cardote. Their work appears in journals such as Journal of the American Chemical Society, Journal of Biological Chemistry and Nature Communications.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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