Kwok-Ho Chan

3.4k total citations · 3 hit papers
17 papers, 2.5k citations indexed

About

Kwok-Ho Chan is a scholar working on Molecular Biology, Hematology and Oncology. According to data from OpenAlex, Kwok-Ho Chan has authored 17 papers receiving a total of 2.5k indexed citations (citations by other indexed papers that have themselves been cited), including 15 papers in Molecular Biology, 7 papers in Hematology and 5 papers in Oncology. Recurrent topics in Kwok-Ho Chan's work include Protein Degradation and Inhibitors (13 papers), Ubiquitin and proteasome pathways (12 papers) and Multiple Myeloma Research and Treatments (7 papers). Kwok-Ho Chan is often cited by papers focused on Protein Degradation and Inhibitors (13 papers), Ubiquitin and proteasome pathways (12 papers) and Multiple Myeloma Research and Treatments (7 papers). Kwok-Ho Chan collaborates with scholars based in United Kingdom, United States and Hong Kong. Kwok-Ho Chan's co-authors include Alessio Ciulli, Michael Zengerle, Andrea Testa, Xavier Lucas, Morgan S. Gadd, Wenzhang Chen, Douglas J. Lamont, Chiara Maniaci, Scott J. Hughes and Kam‐Bo Wong and has published in prestigious journals such as Nature, Science and Journal of the American Chemical Society.

In The Last Decade

Kwok-Ho Chan

16 papers receiving 2.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Structural basis of PROTAC cooperative recognition for selective protein degradation

2017 826 citations Morgan S. Gadd, Andrea Testa et al. Nature Chemical Biology profile →
Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

2015 760 citations Michael Zengerle, Kwok-Ho Chan et al. ACS Chemical Biology profile →
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

2021 168 citations Satomi Imaide, Kristin M. Riching et al. Nature Chemical Biology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Kwok-Ho Chan United Kingdom	14	2.4k	920	723	122	55	17	2.5k
Wenzhang Chen China	11	1.1k 0.5×	441 0.5×	298 0.4×	62 0.5×	22 0.4×	19	1.2k
Momar Toure United States	14	2.0k 0.8×	889 1.0×	658 0.9×	178 1.5×	48 0.9×	18	2.2k
Yanke Liang United States	16	1.3k 0.6×	646 0.7×	222 0.3×	181 1.5×	24 0.4×	23	1.7k
Morgan S. Gadd United Kingdom	11	1.7k 0.7×	686 0.7×	412 0.6×	66 0.5×	33 0.6×	14	1.8k
Philipp M. Cromm Germany	14	1.6k 0.7×	467 0.5×	248 0.3×	355 2.9×	90 1.6×	19	1.7k
Brian E. Cathers United States	17	2.2k 0.9×	619 0.7×	904 1.3×	121 1.0×	33 0.6×	31	2.6k
Scott J. Hughes United Kingdom	14	1.5k 0.6×	645 0.7×	416 0.6×	73 0.6×	29 0.5×	19	1.6k
Taavi K. Neklesa United States	18	2.0k 0.8×	784 0.9×	380 0.5×	141 1.2×	65 1.2×	25	2.2k
Eunhwa Ko United States	14	1.3k 0.6×	461 0.5×	334 0.5×	290 2.4×	44 0.8×	20	1.5k
Blake E. Smith United States	4	1.5k 0.6×	684 0.7×	423 0.6×	53 0.4×	37 0.7×	8	1.6k

Countries citing papers authored by Kwok-Ho Chan

Since Specialization

Citations

This map shows the geographic impact of Kwok-Ho Chan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kwok-Ho Chan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kwok-Ho Chan more than expected).

Fields of papers citing papers by Kwok-Ho Chan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kwok-Ho Chan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kwok-Ho Chan. The network helps show where Kwok-Ho Chan may publish in the future.

Co-authorship network of co-authors of Kwok-Ho Chan

This figure shows the co-authorship network connecting the top 25 collaborators of Kwok-Ho Chan. A scholar is included among the top collaborators of Kwok-Ho Chan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kwok-Ho Chan. Kwok-Ho Chan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

17 of 17 papers shown

Jurewicz, Anthony J., Kwok-Ho Chan, Markus A. Queisser, et al.. (2026). Identification of an allosteric site on the E3 ligase adapter cereblon. Nature. 651(8105). 482–490.

Röth, Sascha, Nur Mehpare Kocatürk, Thomas Macartney, et al.. (2023). Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3. Cell chemical biology. 30(10). 1261–1276.e7. 15 indexed citations

Röth, Sascha, Thomas Macartney, Kwok-Ho Chan, et al.. (2022). Screening of E3 Ligases Uncovers KLHDC2 as an Efficient Proximity-Induced Degrader of K-RAS, STK33, β-catenin and FoxP3. SSRN Electronic Journal. 1 indexed citations

Bond, Adam G., Conner Craigon, Kwok-Ho Chan, et al.. (2021). Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins. Journal of Medicinal Chemistry. 64(20). 15477–15502. 63 indexed citations

Imaide, Satomi, Kristin M. Riching, Nikolai Makukhin, et al.. (2021). Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity. Nature Chemical Biology. 17(11). 1157–1167. 168 indexed citations breakdown →

Röth, Sascha, Thomas Macartney, Agnieszka Konopacka, et al.. (2020). Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System. Cell chemical biology. 27(9). 1151–1163.e6. 47 indexed citations

Klein, Victoria G., Chad E. Townsend, Andrea Testa, et al.. (2020). Understanding and Improving the Membrane Permeability of VH032-Based PROTACs. ACS Medicinal Chemistry Letters. 11(9). 1732–1738. 90 indexed citations

Testa, Andrea, Xavier Lucas, Kwok-Ho Chan, et al.. (2018). 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation. Journal of the American Chemical Society. 140(29). 9299–9313. 114 indexed citations

Zengerle, Michael, Kwok-Ho Chan, Andrea Testa, et al.. (2018). Optimization of a “bump-and-hole” approach to allele-selective BET bromodomain inhibition. Chemical Science. 9(9). 2452–2468. 33 indexed citations

10.

Gadd, Morgan S., Andrea Testa, Xavier Lucas, et al.. (2017). Structural basis of PROTAC cooperative recognition for selective protein degradation. Nature Chemical Biology. 13(5). 514–521. 826 indexed citations breakdown →

11.

Chan, Kwok-Ho, Michael Zengerle, Andrea Testa, & Alessio Ciulli. (2017). Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. Journal of Medicinal Chemistry. 61(2). 504–513. 172 indexed citations

12.

Chan, Kwok-Ho, et al.. (2016). Chemical genetics approaches for selective intervention in epigenetics. Current Opinion in Chemical Biology. 33. 186–194. 19 indexed citations

13.

Zengerle, Michael, Kwok-Ho Chan, & Alessio Ciulli. (2015). Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chemical Biology. 10(8). 1770–1777. 760 indexed citations breakdown →

14.

Baud, Matthias G. J., Enrique Lin-Shiao, Teresa A.F. Cardote, et al.. (2014). A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes. Science. 346(6209). 638–641. 110 indexed citations

15.

Chan, Kwok-Ho, et al.. (2012). Structural Basis for GTP-Dependent Dimerization of Hydrogenase Maturation Factor HypB. PLoS ONE. 7(1). e30547–e30547. 24 indexed citations

16.

Chan, Kwok-Ho, et al.. (2012). Interaction between Hydrogenase Maturation Factors HypA and HypB Is Required for [NiFe]-Hydrogenase Maturation. PLoS ONE. 7(2). e32592–e32592. 27 indexed citations

17.

Chan, Kwok-Ho & Kam‐Bo Wong. (2011). Structure of an essential GTPase, YsxC, fromThermotoga maritima. Acta Crystallographica Section F Structural Biology and Crystallization Communications. 67(6). 640–646. 4 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact