Michael W. Lark

14.4k citations

111 papers · 11.2k indexed · 3 hit papers · h-index 55

Impact in

Immunology and Allergy top 0.2%
- Cell Adhesion Molecules Research
Rheumatology top 0.1%
- Osteoarthritis Treatment and Mechanisms

Papers in

Immunology and Allergy 31
- Cell Adhesion Molecules Research 31
Rheumatology 47
- Osteoarthritis Treatment and Mechanisms 43

Co-authors: Zorina S. Galis Galina K. Sukhova Peter Libby Jonathan D. Violin Stefan Lohmander Lori A. Hoerrner David G. Soergel Alan J. Grodzinsky
Journals: Osteoarthritis and Cartilage (12 papers)Journal of Biological Chemistry (8 papers)Journal of Pharmacology and Experimental Therapeutics (6 papers)Journal of Orthopaedic Research® (6 papers)Journal of Bone and Mineral Research (5 papers)
Partner nations: United States Sweden United Kingdom

In The Last Decade

Michael W. Lark

111 papers receiving 10.8k citations

Hit Papers

align trajectories log scale

A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine 2013 · 502 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2013 Journal of Pharmacology and Experimental Therapeutics
1994 Journal of Clinical Investigation
1994 Circulation Research

Peers

Countries citing papers authored by Michael W. Lark

Since Specialization

Citations

This map shows the geographic impact of Michael W. Lark's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael W. Lark with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael W. Lark more than expected).

Fields of papers citing papers by Michael W. Lark

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael W. Lark. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael W. Lark. The network helps show where Michael W. Lark may publish in the future.

Co-authors

The 25 scholars most cited alongside Michael W. Lark, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Michael W. Lark Line = papers co-authored together Michael W. Lark links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers Pain ·David G. Soergel, Ruth Ann Subach, Nancy Burnham, Michael W. Lark, Ian E. James, Brian M. Sadler, Franck Skobieranda, Jonathan D. Violin, Lynn R. Webster	2014	220
2	Biased ligands at G-protein-coupled receptors: promise and progress Trends in Pharmacological Sciences ·Jonathan D. Violin, Aimee L. Crombie, David G. Soergel, Michael W. Lark	2014	290
3	TRVO27, A BETA-ARRESTIN BIASED LIGAND AT THE ANGIOTENSIN 2 TYPE 1 RECEPTOR, PRODUCES RAPID, REVERSIBLE CHANGES IN HEMODYNAMICS IN PATIENTS WITH STABLE SYSTOLIC HEART FAILURE Journal of the American College of Cardiology ·David G. Soergel, Ruth Ann Subach, Ian E. James, Conrad L. Cowan, Maxine Gowen, Michael W. Lark	2013	12
4	First Clinical Experience with TRV027: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers The Journal of Clinical Pharmacology ·David G. Soergel, Ruth Ann Subach, Conrad L. Cowan, Jonathan D. Violin, Michael W. Lark	2013	68
5	Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13 Arthritis Research & Therapy ·David Long, Simon Blake, Руженков Виктор Александрович, Michael W. Lark, Richard F. Loeser	2008	70
6	Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury Arthritis & Rheumatism ·Michael A. DiMicco, Parth Patwari, Patrick N. Siparsky, Sanjay Kumar, Michael A. Pratta, Michael W. Lark, Young‐Jo Kim, Alan J. Grodzinsky	2004	83
7	Biosynthetic response and mechanical properties of articular cartilage after injurious compression Journal of Orthopaedic Research® ·Bodo Kurz, Moonsoo M. Jin, Parth Patwari, Debbie M. Cheng, Michael W. Lark, Alan J. Grodzinsky	2001	173
8	FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis Osteoarthritis and Cartilage ·Ian E. James, Sanjay Kumar, Michael R. Barnes, Catherine J. Gress, Jerome Halle, Robert A. Dodds, J.R. Connor, Zhengke Gao, David A. Campbell, Stanislav Žatecký, 田民正, Simon Blake, Maxine Gowen, Michael W. Lark	2000	55
9	Differential expression of Egr-1 in osteoarthritic compared to normal adult human articular cartilage Osteoarthritis and Cartilage ·Alan Rumsey, J.R. Connor, Robert A. Dodds, Ian E. James, Sanjay Kumar, Edward J. Keller, Michael W. Lark, Maxine Gowen, Mark Nuttall	2000	32
10	SB 203580 Inhibits p38 Mitogen-Activated Protein Kinase, Nitric Oxide Production, and Inducible Nitric Oxide Synthase in Bovine Cartilage-Derived Chondrocytes The Journal of Immunology ·Alison M. Badger, Michael N. Cook, Michael W. Lark, Asharanisa Lubis, Barbara A. Swift, Allen H. Nelson, Frank C. Barone, Sanjay Kumar	1998	134
11	Transport of tissue inhibitor of metalloproteinases‐1 through cartilage: Contributions of fluid flow and electrical migration Journal of Orthopaedic Research® ·Joachim Marquardt, Michael W. Lark, Stephen B. Trippel, Alan J. Grodzinsky	1998	30
12	Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. Journal of Clinical Investigation ·Michael W. Lark, E K Bayne, Hee Chan Kang, Coral Harper, Lori A. Hoerrner, Nancy I. Hutchinson, Irwin Singer, Susan Donatelli, Jeffrey R. Weidner, H R Williams, Richard A. Mumford, Stefan Lohmander	1997	387
13	Cell-mediated Catabolism of Aggrecan Journal of Biological Chemistry ·Michael W. Lark, Kauther Al Sadeq, Jeffrey R. Weidner, 卢文静, James H. Kimura, Hollis R. Williams, Richard A. Mumford, Carl R. Flannery, Steven S. Carlson, Mineo Iwata, John D. Sandy	1995	169
14	A LONGITUDINAL STUDY OF CARTILAGE MATRIX METABOLISM IN PATIENTS WITH CRUCIATE LIGAMENT RUPTURE—SYNOVIAL FLUID CONCENTRATIONS OF AGGRECAN FRAGMENTS, STROMELYSIN-1 AND TISSUE INHIBITOR OF METALLOPROTEINASE-1 Lara D. Veeken ·Leif Dahlberg, Thomas Fridén, Harald Roos, Michael W. Lark, Stefan Lohmander	1994	65
15	Effects of Matrix Metalloproteinases on Cartilage Biophysical Properties in Vitro and in Vivo^a Annals of the New York Academy of Sciences ·Lawrence J. Bonassar, Ayush Verma, E. Frank, Jessi Ellen Souza Maldonado, Vernon L. Moore, Michael W. Lark, Charles G. Caldwell, Judith C. Fenninger, Alan J. Grodzinsky	1994	2
16	Comparison of the Proteoglycanolytic Activities of Human Leukocyte Elastase and Human Cathepsin G in Vitro and in Vivo Connective Tissue Research ·Joseph McDonnell, Noris Joany Martínez Castillo, Wilson B. Knight, Michael W. Lark, Barbara Green, Martin Poe, Vernon L. Moore	1993	28
17	Production, Purification and Characterization of Canine Prostromelysin Matrix ·刘彦君, Nancy I. Hutchinson, Lori A. Walakovits, Susan Donatelli, Karen L. MacNaul, Coral Harper, Patricia M. Cameron, Vernon L. Moore, Michael W. Lark	1992	7
18	Production and Purification of Prostromelysin and Procollagenase from IL-1 Beta-Stimulated Human Gingival Fibroblasts Connective Tissue Research ·Michael W. Lark, Lori A. Walakovits, Bernard East, Melkamu Abte Afele, Patricia M. Cameron, Yulifila Indra Kaseala	1990	24
19	Arterial chondroitin sulfate proteoglycan: localization with a monoclonal antibody. Journal of Histochemistry & Cytochemistry ·Michael W. Lark, Tet-Kin Yeo, H Mar, Stephanie Lara, Ingegerd Hellström, K E Hellström, Thomas N. Wight	1988	43
20	Selective solubilization of hyaluronic acid from fibroblast substratum adhesion sites. Journal of Biological Chemistry ·Michael W. Lark, Lloyd A. Culp	1982	20

About Michael W. Lark

Michael W. Lark is a scholar working on Immunology and Allergy, Rheumatology, Cancer Research, Cell Biology and Microbiology, having authored 111 papers that have together received 11.2k indexed citations. Recurring topics across this work include Osteoarthritis Treatment and Mechanisms (43 papers), Protease and Inhibitor Mechanisms (34 papers), Cell Adhesion Molecules Research (31 papers), Proteoglycans and glycosaminoglycans research (18 papers), Knee injuries and reconstruction techniques (15 papers), Receptor Mechanisms and Signaling (15 papers), Bone Metabolism and Diseases (10 papers) and Bone health and treatments (9 papers). The work is most often cited by research in Immunology and Allergy (1.7k citations), Rheumatology (3.5k citations), Cancer Research (3.2k citations), Equine (166 citations) and Hematology (1.0k citations). Michael W. Lark has collaborated with scholars based in United States, Sweden and United Kingdom. Frequent co-authors include Zorina S. Galis, Galina K. Sukhova, Peter Libby, Jonathan D. Violin, Stefan Lohmander, Lori A. Hoerrner, David G. Soergel, Alan J. Grodzinsky, Maxine Gowen and Peter Libby. Their work appears in journals such as Osteoarthritis and Cartilage, Journal of Biological Chemistry, Journal of Pharmacology and Experimental Therapeutics, Journal of Orthopaedic Research® and Journal of Bone and Mineral Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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