Mark A. Kay

49.7k total citations · 14 hit papers
296 papers, 33.4k citations indexed

About

Mark A. Kay is a scholar working on Molecular Biology, Genetics and Infectious Diseases. According to data from OpenAlex, Mark A. Kay has authored 296 papers receiving a total of 33.4k indexed citations (citations by other indexed papers that have themselves been cited), including 229 papers in Molecular Biology, 194 papers in Genetics and 35 papers in Infectious Diseases. Recurrent topics in Mark A. Kay's work include Virus-based gene therapy research (185 papers), RNA Interference and Gene Delivery (103 papers) and CRISPR and Genetic Engineering (103 papers). Mark A. Kay is often cited by papers focused on Virus-based gene therapy research (185 papers), RNA Interference and Gene Delivery (103 papers) and CRISPR and Genetic Engineering (103 papers). Mark A. Kay collaborates with scholars based in United States, Germany and Japan. Mark A. Kay's co-authors include Anja Ehrhardt, Dirk Grimm, Theresa A. Storm, Leonard Meuse, Clare E. Thomas, Hiroyuki Nakai, Stephen R. Yant, Luigi Naldini, André Lieber and Joseph C. Glorioso and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Mark A. Kay

291 papers receiving 32.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Progress and problems with the use of viral vectors for gene therapy

2003 2.0k citations Anja Ehrhardt, Mark A. Kay et al. profile →
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

2006 1.3k citations Dirk Grimm, Theresa A. Storm et al. profile →
Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

2001 997 citations Mark A. Kay et al. profile →
RNA interference in adult mice

2002 849 citations Leonard Meuse, Mark A. Kay et al. profile →
Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector

2000 782 citations Mark A. Kay, Valder R. Arruda et al. profile →
Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice

2007 598 citations Mark A. Kay, Milton J. Finegold et al. profile →
AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B

2003 578 citations Mark A. Kay, Katherine A. High et al. profile →
Human tRNA-derived small RNAs in the global regulation of RNA silencing

2010 574 citations Dirk Haussecker, Yong Huang et al. RNA profile →
In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses

2008 537 citations Dirk Grimm, Joyce Lee et al. Journal of Virology profile →
A nonviral minicircle vector for deriving human iPS cells

2010 537 citations Mark A. Kay, Joseph C. Wu et al. Nature Methods profile →
State-of-the-art gene-based therapies: the road ahead

2011 520 citations Mark A. Kay profile →
Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors

1997 504 citations Carol H. Miao, G. Patijn et al. profile →
A transfer-RNA-derived small RNA regulates ribosome biogenesis

2017 405 citations Jianpeng Xu, Kirk Chu et al. profile →
Evaluating the state of the science for adeno-associated virus integration: An integrated perspective

2022 128 citations Mark A. Kay, Eugenio Montini et al. Molecular Therapy profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Mark A. Kay United States	98	25.5k	17.3k	4.4k	3.1k	2.8k	296	33.4k
Luigi Naldini Italy	99	29.0k 1.1×	17.4k 1.0×	9.1k 2.1×	3.8k 1.2×	2.6k 0.9×	309	43.6k
Richard C. Mulligan United States	85	23.1k 0.9×	11.9k 0.7×	8.6k 2.0×	3.2k 1.0×	1.5k 0.5×	202	41.2k
Frank L. Graham Canada	69	17.7k 0.7×	14.3k 0.8×	6.4k 1.5×	1.2k 0.4×	3.2k 1.2×	184	28.6k
David T. Curiel United States	86	17.8k 0.7×	17.4k 1.0×	11.0k 2.5×	1.4k 0.4×	2.7k 1.0×	595	28.6k
Beverly L. Davidson United States	89	19.2k 0.8×	8.4k 0.5×	1.5k 0.3×	3.3k 1.0×	1.3k 0.5×	334	28.1k
Jeffrey D. Esko United States	87	19.4k 0.8×	3.5k 0.2×	1.7k 0.4×	2.4k 0.8×	1.3k 0.5×	318	31.7k
Guangping Gao United States	77	16.6k 0.6×	14.5k 0.8×	3.5k 0.8×	880 0.3×	3.2k 1.2×	355	24.7k
Johan H. van Es Netherlands	72	23.1k 0.9×	8.0k 0.5×	17.7k 4.1×	4.6k 1.5×	631 0.2×	131	41.4k
Moshé Yaniv France	90	18.6k 0.7×	6.6k 0.4×	4.2k 1.0×	2.2k 0.7×	363 0.1×	296	26.7k
Mauro Giacca Italy	80	13.7k 0.5×	2.6k 0.1×	2.0k 0.4×	2.3k 0.7×	2.5k 0.9×	410	22.7k

Countries citing papers authored by Mark A. Kay

Since Specialization

Citations

This map shows the geographic impact of Mark A. Kay's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Mark A. Kay with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Mark A. Kay more than expected).

Fields of papers citing papers by Mark A. Kay

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Mark A. Kay. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Mark A. Kay. The network helps show where Mark A. Kay may publish in the future.

Co-authorship network of co-authors of Mark A. Kay

This figure shows the co-authorship network connecting the top 25 collaborators of Mark A. Kay. A scholar is included among the top collaborators of Mark A. Kay based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Mark A. Kay. Mark A. Kay is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Hermans, Cédric, Carmen Unzu, Mark A. Kay, et al.. (2025). Operationalising a Haemophilia Gene Editing Lexicon for Practical Use. Haemophilia. 31(2). 207–213.

Vogel, Paul, Inga Jarmoskaite, Jonathan M. Geisinger, et al.. (2025). Stereo-random oligonucleotides enable efficient recruitment of ADAR in vitro and in vivo. Nature Communications. 16(1). 8849–8849.

Hermans, Cédric, Leonard A. Valentino, Courtney D. Thornburg, et al.. (2024). A novel gene editing lexicon strategy for the haemophilia community: Research plan for development and preliminary results. Haemophilia. 30(6). 1272–1280. 2 indexed citations

Alencastro, Gustavo de, Katja Pekrun, Paul N. Valdmanis, et al.. (2020). Tracking Adeno-Associated Virus Capsid Evolution by High-Throughput Sequencing. Human Gene Therapy. 31(9-10). 553–564. 18 indexed citations

Su, Yichi, Joel R. Walker, Yun‐Hee Park, et al.. (2020). Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals. Nature Methods. 17(8). 852–860. 128 indexed citations

Zaleta-Rivera, Kathia, Alexandra Dainis, Alexandre J. S. Ribeiro, et al.. (2019). Allele-Specific Silencing Ameliorates Restrictive Cardiomyopathy Attributable to a Human Myosin Regulatory Light Chain Mutation. Circulation. 140(9). 765–778. 34 indexed citations

Lu, Jiamiao, James A. Williams, Jeremy Luke, et al.. (2016). A 5′ Noncoding Exon Containing Engineered Intron Enhances Transgene Expression from Recombinant AAV Vectors in vivo. Human Gene Therapy. 28(1). 125–134. 20 indexed citations

Nichols, Timothy C., et al.. (2015). Translational Data from Adeno-Associated Virus-Mediated Gene Therapy of Hemophilia B in Dogs. PubMed. 26(1). 5–14. 27 indexed citations

Nichols, Timothy C., et al.. (2014). Translational Data from AAV-Mediated Gene Therapy of Hemophilia B in Dogs. 776275620–776275620. 4 indexed citations

10.

Wang, Yongming, Ping Liang, Feng Lan, et al.. (2014). Genome Editing of Isogenic Human Induced Pluripotent Stem Cells Recapitulates Long QT Phenotype for Drug Testing. Journal of the American College of Cardiology. 64(5). 451–459. 121 indexed citations

11.

Haussecker, Dirk, Yong Huang, Ashley Lau, et al.. (2010). Human tRNA-derived small RNAs in the global regulation of RNA silencing. RNA. 16(4). 673–695. 574 indexed citations breakdown →

12.

Jäger, L., et al.. (2009). A rapid protocol for construction and production of high-capacity adenoviral vectors. Nature Protocols. 4(4). 547–564. 59 indexed citations

13.

Grimm, Dirk, Joyce Lee, Tushar Desai, et al.. (2008). In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses. Journal of Virology. 82(12). 5887–5911. 537 indexed citations breakdown →

14.

Tward, Aaron D., Kirk D. Jones, Stephen R. Yant, et al.. (2007). Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proceedings of the National Academy of Sciences. 104(37). 14771–14776. 164 indexed citations

15.

Nakai, Hiroyuki, Xiaolin Wu, Sally Fuess, et al.. (2005). Large-Scale Molecular Characterization of Adeno-Associated Virus Vector Integration in Mouse Liver. Journal of Virology. 79(6). 3606–3614. 140 indexed citations

16.

Miao, Carol H., Kazuo Ohashi, G. Patijn, et al.. (2000). Inclusion of the Hepatic Locus Control Region, an Intron, and Untranslated Region Increases and Stabilizes Hepatic Factor IX Gene Expression in Vivo but Not in Vitro. Molecular Therapy. 1(6). 522–532. 204 indexed citations

17.

Vilain, Éric, Martine Le Merrer, C Lecointre, et al.. (1999). IMAGe, a New Clinical Association of Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, and Genital Anomalies. The Journal of Clinical Endocrinology & Metabolism. 84(12). 4335–4340. 78 indexed citations

18.

Murry, Charles E., et al.. (1996). Muscle differentiation during repair of myocardial necrosis in rats via gene transfer with MyoD.. Journal of Clinical Investigation. 98(10). 2209–2217. 107 indexed citations

19.

Lieber, André, Marie-Jeanne T.F.D. Vrancken Peeters, Allen M. Gown, James D. Perkins, & Mark A. Kay. (1995). A Modified Urokinase Plasminogen Activator Induces Liver Regeneration Without Bleeding. Human Gene Therapy. 6(8). 1029–1037. 42 indexed citations

20.

Kay, Mark A., Qiutang Li, Ta-Jen Liu, et al.. (1992). Hepatic Gene Therapy: Persistent Expression of Human α1-Antitrypsin in Mice after Direct Gene Delivery In Vivo. Human Gene Therapy. 3(6). 641–647. 155 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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