Holger Heyn

21.4k total citations · 5 hit papers
80 papers, 6.2k citations indexed

About

Holger Heyn is a scholar working on Molecular Biology, Genetics and Cancer Research. According to data from OpenAlex, Holger Heyn has authored 80 papers receiving a total of 6.2k indexed citations (citations by other indexed papers that have themselves been cited), including 65 papers in Molecular Biology, 20 papers in Genetics and 15 papers in Cancer Research. Recurrent topics in Holger Heyn's work include Epigenetics and DNA Methylation (31 papers), RNA modifications and cancer (20 papers) and Single-cell and spatial transcriptomics (17 papers). Holger Heyn is often cited by papers focused on Epigenetics and DNA Methylation (31 papers), RNA modifications and cancer (20 papers) and Single-cell and spatial transcriptomics (17 papers). Holger Heyn collaborates with scholars based in Spain, United States and Germany. Holger Heyn's co-authors include Manel Esteller, Sebastián Morán, Juan Sandoval, Marta Gut, Elisabetta Mereu, Sergi Sayols, Miguel Ángel Pujana, Marina Bibikova, Jordi Serra-Musach and Paula Nieto and has published in prestigious journals such as Nature, Cell and Nucleic Acids Research.

In The Last Decade

Holger Heyn

77 papers receiving 6.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome

2011 732 citations Holger Heyn, Sebastián Morán et al. profile →
DNA methylation profiling in the clinic: applications and challenges

2012 561 citations Holger Heyn, Manel Esteller profile →
SPOTlight: seeded NMF regression to deconvolute spatial transcriptomics spots with single-cell transcriptomes

2021 379 citations Marc Elosua-Bayés, Paula Nieto et al. Nucleic Acids Research profile →
The emerging landscape of spatial profiling technologies

2022 201 citations Holger Heyn et al. profile →
Spatiotemporal omics for biology and medicine

2024 59 citations Holger Heyn et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Holger Heyn Spain	43	4.9k	1.3k	1.1k	704	681	80	6.2k
Gerda Egger Austria	30	5.5k 1.1×	1.7k 1.3×	832 0.8×	650 0.9×	445 0.7×	66	6.8k
Yun Huang United States	45	6.4k 1.3×	816 0.6×	950 0.9×	540 0.8×	710 1.0×	152	8.4k
Agustín F. Fernández Spain	44	5.6k 1.2×	2.3k 1.8×	817 0.8×	890 1.3×	629 0.9×	117	7.4k
Lu Wen China	43	5.8k 1.2×	1.9k 1.5×	850 0.8×	855 1.2×	751 1.1×	193	8.1k
Hao Zhu United States	37	4.4k 0.9×	1.6k 1.2×	628 0.6×	471 0.7×	575 0.8×	116	6.2k
Johnathan R. Whetstine United States	34	8.7k 1.8×	1.1k 0.9×	1.3k 1.2×	805 1.1×	442 0.6×	51	9.9k
Bernard Thienpont Belgium	32	3.6k 0.7×	1.2k 0.9×	1.1k 1.1×	972 1.4×	728 1.1×	81	5.4k
Sjaak Philipsen Netherlands	45	6.1k 1.2×	813 0.6×	1.2k 1.1×	716 1.0×	933 1.4×	122	8.2k
Abdel Elkahloun United States	42	4.3k 0.9×	1.5k 1.2×	1.3k 1.2×	1.1k 1.6×	543 0.8×	114	7.1k
Bo Wen China	36	5.7k 1.2×	1.2k 1.0×	2.0k 1.9×	324 0.5×	351 0.5×	95	7.4k

Countries citing papers authored by Holger Heyn

Since Specialization

Citations

This map shows the geographic impact of Holger Heyn's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Holger Heyn with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Holger Heyn more than expected).

Fields of papers citing papers by Holger Heyn

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Holger Heyn. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Holger Heyn. The network helps show where Holger Heyn may publish in the future.

Co-authorship network of co-authors of Holger Heyn

This figure shows the co-authorship network connecting the top 25 collaborators of Holger Heyn. A scholar is included among the top collaborators of Holger Heyn based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Holger Heyn. Holger Heyn is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Estévez‐Gómez, Nuria, et al.. (2025). Differential performance of strategies for single-cell whole-genome amplification. Cell Reports Methods. 5(4). 101025–101025. 1 indexed citations

Mereu, Elisabetta, Neus Prats, Mònica Aguilera, et al.. (2023). Targeting lymphoid-derived IL-17 signaling to delay skin aging. Nature Aging. 3(6). 688–704. 43 indexed citations

Guillén, Yolanda, Teresa Lobo‐Jarne, María Maqueda, et al.. (2023). β‐Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T‐cell acute lymphoblastic leukemia. EMBO Molecular Medicine. 15(2). e16554–e16554. 9 indexed citations

Narayanan, Ashwin, Inmaculada Hernández, Juan C. Nieto, et al.. (2023). Tumor heterogeneity and tumor-microglia interactions in primary and recurrent IDH1-mutant gliomas. Cell Reports Medicine. 4(11). 101249–101249. 18 indexed citations

Cozzuto, Luca, Patricia Lorden, Norio Hamada, et al.. (2022). Controlled X‐chromosome dynamics defines meiotic potential of female mouse in vitro germ cells. The EMBO Journal. 41(12). e109457–e109457. 14 indexed citations

Cuartero, Sergi, Adrià Cañellas‐Socias, Sarah Wells, et al.. (2022). Cohesin couples transcriptional bursting probabilities of inducible enhancers and promoters. Nature Communications. 13(1). 4342–4342. 20 indexed citations

Fernández‐Rodríguez, Juana, Yvonne Richaud‐Patín, Ernest Terribas, et al.. (2022). Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromas. Cell Reports. 38(7). 110385–110385. 24 indexed citations

Elosua-Bayés, Marc, Paula Nieto, Elisabetta Mereu, Marta Gut, & Holger Heyn. (2021). SPOTlight: seeded NMF regression to deconvolute spatial transcriptomics spots with single-cell transcriptomes. Nucleic Acids Research. 49(9). e50–e50. 379 indexed citations breakdown →

Llonch, Sílvia, Montserrat Barragán, Paula Nieto, et al.. (2021). Single human oocyte transcriptome analysis reveals distinct maturation stage‐dependent pathways impacted by age. Aging Cell. 20(5). e13360–e13360. 67 indexed citations

10.

Pascual, Gloria, Diana Domínguez, Felipe Beckedorff, et al.. (2021). Dietary palmitic acid promotes a prometastatic memory via Schwann cells. Nature. 599(7885). 485–490. 186 indexed citations

11.

Vizán, Pedro, Arantxa Gutiérrez, Martin Lange, et al.. (2020). The Polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation. Science Advances. 6(32). 23 indexed citations

12.

Francesconi, Mirko, Bruno Di Stefano, Clara Berenguer, et al.. (2019). Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming. eLife. 8. 41 indexed citations

13.

Vara, Covadonga, Andreu Paytuví-Gallart, Yasmina Cuartero, et al.. (2019). Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis. Cell Reports. 28(2). 352–367.e9. 108 indexed citations

14.

Barriga, Francisco M., Miyeko Mana, María Méndez-Lago, et al.. (2017). Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells. Cell stem cell. 20(6). 801–816.e7. 132 indexed citations

15.

Martín-Trujillo, Álex, Enrique Vidal, Ana Monteagudo, et al.. (2017). Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors. Nature Communications. 8(1). 467–467. 27 indexed citations

16.

Guillaumet-Adkins, Amy & Holger Heyn. (2017). Single-Cell Genomics Unravels Brain Cell-Type Complexity. Advances in experimental medicine and biology. 978. 393–407. 6 indexed citations

17.

Reinhold, William C., Sudhir Varma, Margot Sunshine, et al.. (2016). The NCI-60 Methylome and Its Integration into CellMiner. Cancer Research. 77(3). 601–612. 44 indexed citations

18.

Sánchez‐Mut, José V., Holger Heyn, Enrique Vidal, et al.. (2016). Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns. Translational Psychiatry. 6(1). e718–e718. 119 indexed citations

19.

Heyn, Holger, Sabine Schreek, Ulrich Lehmann, et al.. (2009). Abstract #2538: Identification of microRNAs miR-203 and miR-335 forming a network of regulation in breast cancer development. Cancer Research. 69. 2538–2538. 2 indexed citations

20.

Yang, Sheng, Holger Heyn, Yu‐Zhong Zhang, E.E. Büllesbach, & Christian Schwabe. (1993). The Expression of Human Relaxin in Yeast. Archives of Biochemistry and Biophysics. 300(2). 734–737. 6 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact