Makoto Makishima

22.6k total citations · 6 hit papers
258 papers, 16.6k citations indexed

About

Makoto Makishima is a scholar working on Molecular Biology, Pathology and Forensic Medicine and Surgery. According to data from OpenAlex, Makoto Makishima has authored 258 papers receiving a total of 16.6k indexed citations (citations by other indexed papers that have themselves been cited), including 129 papers in Molecular Biology, 55 papers in Pathology and Forensic Medicine and 51 papers in Surgery. Recurrent topics in Makoto Makishima's work include Vitamin D Research Studies (53 papers), Peroxisome Proliferator-Activated Receptors (45 papers) and Estrogen and related hormone effects (44 papers). Makoto Makishima is often cited by papers focused on Vitamin D Research Studies (53 papers), Peroxisome Proliferator-Activated Receptors (45 papers) and Estrogen and related hormone effects (44 papers). Makoto Makishima collaborates with scholars based in Japan, United States and India. Makoto Makishima's co-authors include David J. Mangelsdorf, Iichiro Shimomura, Morihiro Matsuda, Masanori Iwaki, Yukio Yamada, Michio Shimabukuro, Osamu Nakayama, Shigetada Furukawa, Takuya Fujita and Joyce J. Repa and has published in prestigious journals such as Science, Cell and Journal of Biological Chemistry.

In The Last Decade

Makoto Makishima

251 papers receiving 16.2k citations

Hit Papers

Increased oxidative stress in obesity and its impact on m... 1999 2026 2008 2017 2004 1999 2000 2002 2003 1000 2.0k 3.0k 4.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Increased oxidative stress in obesity and its impact on metabolic syndrome
    2004 4.3k citations Makoto Makishima et al. profile →
  2. Identification of a Nuclear Receptor for Bile Acids
    1999 2.2k citations Makoto Makishima et al. profile →
  3. Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
    2000 1.2k citations Makoto Makishima et al. profile →
  4. Vitamin D Receptor As an Intestinal Bile Acid Sensor
    2002 918 citations Makoto Makishima et al. profile →
  5. Induction of Adiponectin, a Fat-Derived Antidiabetic and Antiatherogenic Factor, by Nuclear Receptors
    2003 641 citations Makoto Makishima et al. profile →
  6. Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor
    2001 624 citations Makoto Makishima et al. Journal of Biological Chemistry profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Makoto Makishima Japan 45 5.7k 4.9k 4.0k 3.9k 3.2k 258 16.6k
Stefano Fiorucci Italy 73 5.7k 1.0× 6.0k 1.2× 5.0k 1.2× 4.1k 1.0× 2.8k 0.9× 355 20.0k
Antonio Moschetta Italy 56 5.4k 0.9× 4.9k 1.0× 5.0k 1.2× 3.9k 1.0× 1.8k 0.6× 202 13.8k
John Y.L. Chiang United States 68 6.3k 1.1× 7.8k 1.6× 6.1k 1.5× 4.7k 1.2× 2.1k 0.7× 164 16.3k
Christopher Liddle Australia 57 4.5k 0.8× 3.0k 0.6× 1.8k 0.5× 4.5k 1.1× 2.2k 0.7× 156 14.4k
Hisataka Moriwaki Japan 62 5.3k 0.9× 3.1k 0.6× 2.7k 0.7× 4.4k 1.1× 2.0k 0.6× 511 16.6k
Vay Liang W. Go United States 65 3.0k 0.5× 3.3k 0.7× 4.8k 1.2× 2.3k 0.6× 2.2k 0.7× 270 16.2k
Folkert Kuipers Netherlands 80 8.7k 1.5× 9.6k 2.0× 9.5k 2.4× 5.6k 1.4× 4.1k 1.3× 461 23.8k
Dieter Lütjohann Germany 81 8.7k 1.5× 3.8k 0.8× 11.7k 2.9× 2.0k 0.5× 5.1k 1.6× 386 22.0k
Kristopher W. Krausz United States 64 6.8k 1.2× 3.3k 0.7× 1.6k 0.4× 2.9k 0.7× 1.9k 0.6× 201 13.6k
Kristina Schoonjans Switzerland 89 16.6k 2.9× 8.6k 1.7× 7.6k 1.9× 6.9k 1.8× 8.2k 2.6× 203 32.8k

Countries citing papers authored by Makoto Makishima

Since Specialization
Citations

This map shows the geographic impact of Makoto Makishima's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Makoto Makishima with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Makoto Makishima more than expected).

Fields of papers citing papers by Makoto Makishima

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Makoto Makishima. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Makoto Makishima. The network helps show where Makoto Makishima may publish in the future.

Co-authorship network of co-authors of Makoto Makishima

This figure shows the co-authorship network connecting the top 25 collaborators of Makoto Makishima. A scholar is included among the top collaborators of Makoto Makishima based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Makoto Makishima. Makoto Makishima is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Endo‐Umeda, Kaori & Makoto Makishima. (2025). Exploring the Roles of Liver X Receptors in Lipid Metabolism and Immunity in Atherosclerosis. Biomolecules. 15(4). 579–579. 2 indexed citations
2.
3.
Ishizawa, Michiyasu, Masashi Takano, Atsushi Kittaka, Tarô Matsumoto, & Makoto Makishima. (2024). 2α-Substituted Vitamin D Derivatives Effectively Enhance the Osteoblast Differentiation of Dedifferentiated Fat Cells. Biomolecules. 14(6). 706–706. 1 indexed citations
4.
Ishizawa, Michiyasu, et al.. (2023). Vitamin D Receptor Mediates Attenuating Effect of Lithocholic Acid on Dextran Sulfate Sodium Induced Colitis in Mice. International Journal of Molecular Sciences. 24(4). 3517–3517. 19 indexed citations
5.
Takada, Ichiro, Shinya Hidano, Sayuri Takahashi, et al.. (2022). Transcriptional coregulator Ess2 controls survival of post-thymic CD4+ T cells through the Myc and IL-7 signaling pathways. Journal of Biological Chemistry. 298(9). 102342–102342. 10 indexed citations
6.
Li, Xiaoyan, Lijia Guo, Fuyuki Sato, et al.. (2022). Dec2 negatively regulates bone resorption in periodontitis. Journal of Periodontal Research. 57(5). 1056–1069. 1 indexed citations
7.
Nakashima, Hiroyuki, Kaori Endo‐Umeda, Masahiro Nakashima, et al.. (2021). Contrasting functional responses of resident Kupffer cells and recruited liver macrophages to irradiation and liver X receptor stimulation. PLoS ONE. 16(7). e0254886–e0254886. 7 indexed citations
8.
Sato, Fuyuki, et al.. (2021). The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation. International Journal of Molecular Sciences. 22(19). 10349–10349. 10 indexed citations
9.
Li, Xiaoyan, Fuyuki Sato, Tong Ho Kang, et al.. (2020). Dec1 deficiency protects the heart from fibrosis, inflammation, and myocardial cell apoptosis in a mouse model of cardiac hypertrophy. Biochemical and Biophysical Research Communications. 532(4). 513–519. 17 indexed citations
10.
Uno, Shigeyuki, Torahiko Tanaka, Makoto Fujimaki, et al.. (2019). Application of a Waveguide-Mode Sensor to Blood Testing for Hepatitis B Virus, Hepatitis C Virus, Human Immunodeficiency Virus and Treponema pallidum Infection. Sensors. 19(7). 1729–1729. 1 indexed citations
11.
Chuma, Masayuki, Makoto Makishima, Toru Imai, et al.. (2019). Relationship between hemoglobin levels and vancomycin clearance in patients with sepsis. European Journal of Clinical Pharmacology. 75(7). 929–937. 7 indexed citations
12.
Nishiyama, Yuko, Shuichi Mori, Makoto Makishima, et al.. (2018). Novel Nonsteroidal Progesterone Receptor (PR) Antagonists with a Phenanthridinone Skeleton. ACS Medicinal Chemistry Letters. 9(7). 641–645. 19 indexed citations
13.
Ishizawa, Michiyasu, Daisuke Akagi, & Makoto Makishima. (2018). Lithocholic Acid Is a Vitamin D Receptor Ligand That Acts Preferentially in the Ileum. International Journal of Molecular Sciences. 19(7). 1975–1975. 53 indexed citations
14.
Nishiyama, Yuko, Shinya Fujii, Makoto Makishima, Yuichi Hashimoto, & Minoru Ishikawa. (2018). Efficient Lead Finding, Activity Enhancement and Preliminary Selectivity Control of Nuclear Receptor Ligands Bearing a Phenanthridinone Skeleton. International Journal of Molecular Sciences. 19(7). 2090–2090. 3 indexed citations
15.
Nakagawa, Masaru, Shigeyuki Uno, Noriyoshi Iriyama, et al.. (2018). Combined treatment with benzo[a]pyrene and 1α,25-dihydroxyvitamin D3 induces expression of plasminogen activator inhibitor 1 in monocyte/macrophage-derived cells. Toxicology and Applied Pharmacology. 345. 48–56. 2 indexed citations
16.
Tamura, Mayuko, Michiyasu Ishizawa, Tsuyoshi Isojima, et al.. (2017). Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia. Scientific Reports. 7(1). 5102–5102. 14 indexed citations
17.
Makishima, Makoto, et al.. (2015). Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice. Biochemical and Biophysical Research Communications. 469(3). 477–482. 20 indexed citations
18.
Endo‐Umeda, Kaori, Shigeyuki Uno, Ko Fujimori, et al.. (2012). Differential Expression and Function of Alternative Splicing Variants of Human Liver X Receptor α. Molecular Pharmacology. 81(6). 800–810. 25 indexed citations
19.
Nishida, Shigeru, et al.. (2009). Modulation of Bile Acid Metabolism by 1α-Hydroxyvitamin D3 Administration in Mice. Drug Metabolism and Disposition. 37(10). 2037–2044. 43 indexed citations
20.
Makishima, Makoto. (2005). Nuclear Receptors as Targets for Drug Development: Regulation of Cholesterol and Bile Acid Metabolism by Nuclear Receptors. Journal of Pharmacological Sciences. 97(2). 177–183. 113 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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