Lingle Wang

12.4k total citations · 4 hit papers
59 papers, 7.6k citations indexed

About

Lingle Wang is a scholar working on Molecular Biology, Computational Theory and Mathematics and Materials Chemistry. According to data from OpenAlex, Lingle Wang has authored 59 papers receiving a total of 7.6k indexed citations (citations by other indexed papers that have themselves been cited), including 48 papers in Molecular Biology, 34 papers in Computational Theory and Mathematics and 15 papers in Materials Chemistry. Recurrent topics in Lingle Wang's work include Protein Structure and Dynamics (38 papers), Computational Drug Discovery Methods (34 papers) and RNA and protein synthesis mechanisms (10 papers). Lingle Wang is often cited by papers focused on Protein Structure and Dynamics (38 papers), Computational Drug Discovery Methods (34 papers) and RNA and protein synthesis mechanisms (10 papers). Lingle Wang collaborates with scholars based in United States, Germany and Belgium. Lingle Wang's co-authors include Richard A. Friesner, Robert Abel, B. J. Berne, Edward Harder, Markus K. Dahlgren, Chuanjie Wu, Wolfgang Damm, Chao Lü, Dmitry Lupyan and Jennifer L. Knight and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Nature Communications.

In The Last Decade

Lingle Wang

57 papers receiving 7.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

2015 2.4k citations Edward Harder, Wolfgang Damm et al. Journal of Chemical Theory and Computation profile →
OPLS4: Improving Force Field Accuracy on Challenging Regimes of Chemical Space

2021 1.1k citations Chao Lü, Chuanjie Wu et al. Journal of Chemical Theory and Computation profile →
OPLS3e: Extending Force Field Coverage for Drug-Like Small Molecules

2019 857 citations Katarina Roos, Chuanjie Wu et al. Journal of Chemical Theory and Computation profile →
Replica Exchange with Solute Scaling: A More Efficient Version of Replica Exchange with Solute Tempering (REST2)

2011 582 citations Lingle Wang, Richard A. Friesner et al. profile →

Peers

Countries citing papers authored by Lingle Wang

Since Specialization

Citations

This map shows the geographic impact of Lingle Wang's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lingle Wang with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lingle Wang more than expected).

Fields of papers citing papers by Lingle Wang

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lingle Wang. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lingle Wang. The network helps show where Lingle Wang may publish in the future.

Co-authorship network of co-authors of Lingle Wang

This figure shows the co-authorship network connecting the top 25 collaborators of Lingle Wang. A scholar is included among the top collaborators of Lingle Wang based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Lingle Wang. Lingle Wang is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Predicting Resistance to Small Molecule Kinase Inhibitors 2025 ·Journal of Chemical Information and Modeling ·(unknown), (unknown), Evan Paull, (unknown), Phani Ghanakota, (unknown), Jackson Chief Elk, Jared M. Sampson, Lingle Wang, Robert Abel, Steven K. Albanese	1
2	A Method for Treating Significant Conformational Changes in Alchemical Free Energy Simulations of Protein–Ligand Binding 2024 ·Journal of Chemical Theory and Computation ·(unknown), Alina P. Sergeeva, Edward Harder, Lingle Wang, Jared M. Sampson, Barry Honig, Richard A. Friesner	1
3	Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors 2023 ·Proceedings of the National Academy of Sciences ·(unknown), (unknown), Per Plenge, Lingle Wang, Christoffer Bundgaard, Benny Bang‐Andersen, Claus J. Løland, Lei Shi	8
4	Enhancing Hit Discovery in Virtual Screening through Absolute Protein–Ligand Binding Free-Energy Calculations 2023 ·Journal of Chemical Information and Modeling ·Wei Chen, (unknown), Steven V. Jerome, Mayako Michino, Eelke B. Lenselink, David J. Huggins, Alexandre Beautrait, Jérémie Vendôme, Robert Abel, Richard A. Friesner, Lingle Wang	69
5	Is the Functional Response of a Receptor Determined by the Thermodynamics of Ligand Binding? 2023 ·Journal of Chemical Theory and Computation ·Martin Vögele, Bin W. Zhang, Jonas Kaindl, Lingle Wang	11
6	The maximal and current accuracy of rigorous protein-ligand binding free energy calculations 2023 ·Communications Chemistry ·Gregory A. Ross, Chao Lü, Guido Scarabelli, Steven K. Albanese, Evelyne M. Houang, Robert Abel, Edward Harder, Lingle Wang	64
7	Reliable and Accurate Prediction of Single-Residue p K _a Values through Free Energy Perturbation Calculations 2022 ·Journal of Chemical Theory and Computation ·(unknown), Wei Chen, Anthony Clark, Chao Lü, Edward Harder, Lingle Wang, Richard A. Friesner, Edward B. Miller	13
8	Evaluation of Free Energy Calculations for the Prioritization of Macrocycle Synthesis 2020 ·Journal of Chemical Information and Modeling ·Janet L. Paulsen, Haoyu S. Yu, Dan Sindhikara, Lingle Wang, T.C. Appleby, Armando G. Villaseñor, Uli Schmitz, Devleena Shivakumar	14
9	Enhancing Water Sampling in Free Energy Calculations with Grand Canonical Monte Carlo 2020 ·Journal of Chemical Theory and Computation ·Gregory A. Ross, (unknown), Yuqing Deng, Chao Lü, Edward Harder, Robert Abel, Lingle Wang	67
10	Advancing Free-Energy Calculations of Metalloenzymes in Drug Discovery via Implementation of LFMM Potentials 2020 ·Journal of Chemical Theory and Computation ·(unknown), Delaram Ghoreishi, (unknown), Wolfgang Damm, Edward Harder, Robert Abel, Lingle Wang, Haoyu S. Yu	8
11	Is Structure-Based Drug Design Ready for Selectivity Optimization? 2020 ·Journal of Chemical Information and Modeling ·Steven K. Albanese, John D. Chodera, Andrea Volkamer, (unknown), Robert Abel, Lingle Wang	28
12	Improving the Accuracy of Protein Thermostability Predictions for Single Point Mutations 2020 ·Biophysical Journal ·Jianxin Duan, Dmitry Lupyan, Lingle Wang	46
13	OPLS3e: Extending Force Field Coverage for Drug-Like Small Molecules breakdown → 2019 ·Journal of Chemical Theory and Computation ·Katarina Roos, Chuanjie Wu, Wolfgang Damm, (unknown), James Stevenson, Chao Lü, Markus K. Dahlgren, Sayan Mondal, Wei Chen, Lingle Wang, Robert Abel, Richard A. Friesner, Edward Harder	857
14	Toward Atomistic Modeling of Irreversible Covalent Inhibitor Binding Kinetics 2019 ·Journal of Chemical Information and Modeling ·Haoyu S. Yu, Cen Gao, Dmitry Lupyan, Yujie Wu, Takayuki Kimura, Chuanjie Wu, Leif D. Jacobson, Edward Harder, Robert Abel, Lingle Wang	29
15	Relative Binding Affinity Prediction of Charge-Changing Sequence Mutations with FEP in Protein–Protein Interfaces 2019 ·Journal of Molecular Biology ·Anthony Clark, Christopher Negron, Kevin Hauser, Mengzhen Sun, Lingle Wang, Robert Abel, Richard A. Friesner	68
16	Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations 2018 ·Communications Biology ·Kevin Hauser, Christopher Negron, Steven K. Albanese, Soumya S. Ray, Thomas Steinbrecher, Robert Abel, John D. Chodera, Lingle Wang	64
17	A Critical Review of Validation, Blind Testing, and Real- World Use of Alchemical Protein-Ligand Binding Free Energy Calculations 2017 ·Current Topics in Medicinal Chemistry ·Robert Abel, Lingle Wang, David L. Mobley, Richard A. Friesner	72
18	Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors 2017 ·Journal of Medicinal Chemistry ·Bernd Kuhn, Michal Tichý, Lingle Wang, Shaughnessy Robinson, Rainer E. Martin, A. Kuglstatter, Jörg Benz, Maude Giroud, Tanja Schirmeister, Robert Abel, François Diederich, Jérôme Hert	101
19	Predicting the Effect of Amino Acid Single-Point Mutations on Protein Stability—Large-Scale Validation of MD-Based Relative Free Energy Calculations 2016 ·Journal of Molecular Biology ·Thomas Steinbrecher, (unknown), Lingle Wang, Robert Abel, Christopher Negron, David A. Pearlman, Eric Feyfant, Jianxin Duan, Woody Sherman	84
20	Hydrophobic interactions in model enclosures from small to large length scales: non-additivity in explicit and implicit solvent models 2010 ·Faraday Discussions ·Lingle Wang, Richard A. Friesner, B. J. Berne	30

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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