Lien Spans

1.4k citations

29 papers · 967 indexed · h-index 16

Impact in

Cancer Research top 10%
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
Pulmonary and Respiratory Medicine top 5%
- Prostate Cancer Treatment and Research
- Sarcoma Diagnosis and Treatment

Papers in ⓘ

Pulmonary and Respiratory Medicine 18
- Prostate Cancer Treatment and Research 11
- Sarcoma Diagnosis and Treatment 4
Molecular Biology 14
- Cancer-related gene regulation 4
- Epigenetics and DNA Methylation 3

Co-authors: Frank Claessens (14 shared papers)Christine Helsen (12 shared papers)Liesbeth Clinckemalie (8 shared papers)Steven Joniau (8 shared papers)Michaël R. Laurent (3 shared papers)Thomas Van den Broeck (5 shared papers)Stefan Preković (5 shared papers)Vanessa Dubois (5 shared papers)
Journals: The FASEB Journal (2 papers)PLoS ONE (2 papers)Molecular Cancer Therapeutics (1 paper)Clinical Cancer Research (1 paper)Nature Reviews Urology (1 paper)
Partner nations: Belgium United States Netherlands

In The Last Decade

Lien Spans

28 papers receiving 957 citations

Peers

Countries citing papers authored by Lien Spans

Since Specialization

Citations

This map shows the geographic impact of Lien Spans's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lien Spans with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lien Spans more than expected).

Fields of papers citing papers by Lien Spans

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lien Spans. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lien Spans. The network helps show where Lien Spans may publish in the future.

Co-authors

The 25 scholars most cited alongside Lien Spans, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Lien Spans Line = papers co-authored together Lien Spans links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 29 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Structural basis for nuclear hormone receptor DNA binding Molecular and Cellular Endocrinology ·Christine Helsen, Stefanie Kerkhofs, Liesbeth Clinckemalie, Lien Spans, Michaël R. Laurent, Steven Boonen, Dirk Vanderschueren, Frank Claessens	2011	108
2	Emerging mechanisms of enzalutamide resistance in prostate cancer Nature Reviews Urology ·Frank Claessens, Christine Helsen, Stefan Preković, Thomas Van den Broeck, Lien Spans, Hendrik Van Poppel, Steven Joniau	2014	107
3	Androgen Regulation of the TMPRSS2 Gene and the Effect of a SNP in an Androgen Response Element Molecular Endocrinology ·Liesbeth Clinckemalie, Lien Spans, Vanessa Dubois, Michaël R. Laurent, Christine Helsen, Steven Joniau, Frank Claessens	2013	98
4	A satellite cell‐specific knockout of the androgen receptor reveals myostatin as a direct androgen target in skeletal muscle The FASEB Journal ·Vanessa Dubois, Michaël R. Laurent, Mieke Sinnesael, Nele Cielen, Christine Helsen, Liesbeth Clinckemalie, Lien Spans, Ghislaine Gayan‐Ramirez, Louise Deldicque, Peter Hespel, Geert Carmeliet, Dirk Vanderschueren, Frank Claessens	2014	96
5	Recurrent MALAT1–GLI1 oncogenic fusion and GLI1 up‐regulation define a subset of plexiform fibromyxoma The Journal of Pathology ·Lien Spans, Christopher D.�M. Fletcher, Cristina R. Antonescu, Alexandre Rouquette, Jean‐Michel Coindre, Raf Sciot, Maria Dêbiec‐Rychter	2016	90
6	The Effect of F877L and T878A Mutations on Androgen Receptor Response to Enzalutamide Molecular Cancer Therapeutics ·Stefan Preković, Martin E. van Royen, Arnout Voet, Bart Geverts, René Houtman, Diana Melchers, Kam Y. J. Zhang, Thomas Van den Broeck, Elien Smeets, Lien Spans, Adriaan B. Houtsmuller, Steven Joniau, Frank Claessens, Christine Helsen	2016	80
7	Combination Approach for Detecting Different Types of Alterations in Circulating Tumor DNA in Leiomyosarcoma Clinical Cancer Research ·Joanna Przybył, Jacob J. Chabon, Lien Spans, Kristen N. Ganjoo, Sujay Vennam, Aaron M. Newman, Erna Forgó, Sushama Varma, Shirley Zhu, Maria Dêbiec‐Rychter, Ash A. Alizadeh, Maximilian Diehn, Matt van de Rijn	2018	44
8	A 629RKLKK633 motif in the hinge region controls the androgen receptor at multiple levels Cellular and Molecular Life Sciences ·Tamzin Tanner, Sarah Denayer, Bart Geverts, Nora Van Tilborgh, Stefanie Kerkhofs, Christine Helsen, Lien Spans, Vanessa Dubois, Adriaan B. Houtsmuller, Frank Claessens, Annemie Haelens	2010	42
9	Dynamic Switching of Active Promoter and Enhancer Domains Regulates Tet1 and Tet2 Expression during Cell State Transitions between Pluripotency and Differentiation Molecular and Cellular Biology ·Abhishek Sohni, Michela Bartoccetti, Rita Khoueiry, Lien Spans, Joris Vande Velde, Linde De Troyer, Kirthi Pulakanti, Frank Claessens, Sridhar Rao, Kian Peng Koh	2015	41
10	The Role of Single Nucleotide Polymorphisms in Predicting Prostate Cancer Risk and Therapeutic Decision Making BioMed Research International ·Thomas Van den Broeck, Steven Joniau, Liesbeth Clinckemalie, Christine Helsen, Stefan Preković, Lien Spans, Lorenzo Tosco, Hendrik Van Poppel, Frank Claessens	2014	39
11	Comparative Genomic and Transcriptomic Analyses of LNCaP and C4-2B Prostate Cancer Cell Lines PLoS ONE ·Lien Spans, Christine Helsen, Liesbeth Clinckemalie, Thomas Van den Broeck, Stefan Preković, Steven Joniau, Evelyne Lerut, Frank Claessens	2014	33
12	Genomic and epigenomic analysis of high-risk prostate cancer reveals changes in hydroxymethylation and TET1 Oncotarget ·Lien Spans, Thomas Van den Broeck, Elien Smeets, Stefan Preković, Bernard Thienpont, Diether Lambrechts, R. Jeffrey Karnes, Nicholas Erho, Mohammed Alshalalfa, Elai Davicioni, Christine Helsen, Thomas Gevaert, Lorenzo Tosco, Karin Haustermans, Evelyne Lerut, Steven Joniau, Frank Claessens	2016	28
13	Comprehensive targeted next‐generation sequencing approach in the molecular diagnosis of gastrointestinal stromal tumor Genes Chromosomes and Cancer ·Isabelle Vanden Bempt, Sara Vander Borght, Raf Sciot, Lien Spans, Sofie Claerhout, Hilde Brems, Stefan Lehnert, Luc De Raedt, Sabine Fransis, Bart Neuville, Baki Topal, Patrick Schöffski, Eric Legius, Maria Dêbiec‐Rychter	2020	25
14	The Genomic Landscape of Prostate Cancer International Journal of Molecular Sciences ·Lien Spans, Liesbeth Clinckemalie, Christine Helsen, Dirk Vanderschueren, Steven Boonen, Evelyne Lerut, Steven Joniau, Frank Claessens	2013	22
15	A role for selective androgen response elements in the development of the epididymis and the androgen control of the 5 α reductase II gene The FASEB Journal ·Stefanie Kerkhofs, Vanessa Dubois, Karel De Gendt, Christine Helsen, Liesbeth Clinckemalie, Lien Spans, Frans Schuit, Steven Boonen, Dirk Vanderschueren, Philippa T. K. Saunders, Guido Verhoeven, Frank Claessens	2012	21
16	Variations in the exome of the LNCaP prostate cancer cell line The Prostate ·Lien Spans, Zeynep Kalender Atak, Filip Van Nieuwerburgh, Dieter Deforce, Evelyne Lerut, Stein Aerts, Frank Claessens	2011	16
17	Single-cell Atlas of Penile Cancer Reveals TP53 Mutations as a Driver of an Aggressive Phenotype, Irrespective of Human Papillomavirus Status, and Provides Clues for Treatment Personalization European Urology ·Laura Elst, Gino Philips, Kaat Vandermaesen, Ayse Bassez, Francesca Lodi, Manon Vreeburg, Oscar R. Brouwer, Rogier Schepers, Thomas Van Brussel, Sambit K. Mohanty, Anil V. Parwani, Lien Spans, Isabelle Vanden Bempt, Gerd Jacomen, Marcella Baldewijns, Diether Lambrechts, Maarten Albersen	2024	13
18	The transcription intermediary factor 1β coactivates the androgen receptor. PubMed ·Nora Van Tilborgh, Lien Spans, Christine Helsen, Liesbeth Clinckemalie, Vanessa Dubois, E. Lerut, Steven Boonen, Dirk Vanderschueren, Frank Claessens	2013	12
19	Comprehensive immunomolecular profiling of endometrial carcinoma: A tertiary retrospective study Gynecologic Oncology ·Jasper Victoor, Sara Vander Borght, Lien Spans, Stefan Lehnert, Hilde Brems, Annouschka Laenen, Ignace Vergote, Toon Van Gorp, Els Van Nieuwenhuysen, Sileny Han, Stefan Timmerman, Anne‐Sophie Van Rompuy, Isabelle Vanden Bempt	2021	10
20	Detection of Circulating Tumor DNA in Patients With Uterine Leiomyomas JCO Precision Oncology ·Joanna Przybył, Lien Spans, Deirdre Lum, Shirley Zhu, Sujay Vennam, Erna Forgó, Sushama Varma, Kristen N. Ganjoo, Trevor Hastie, Raffick A.R. Bowen, Maria Dêbiec‐Rychter, Matt van de Rijn	2019	10

About Lien Spans

Lien Spans is a scholar working on Pulmonary and Respiratory Medicine, Molecular Biology, Cancer Research, Genetics and Surgery, having authored 29 papers that have together received 967 indexed citations. Recurring topics across this work include Prostate Cancer Treatment and Research (11 papers), Cancer Genomics and Diagnostics (5 papers), Sarcoma Diagnosis and Treatment (4 papers), Cancer-related gene regulation (4 papers), Hormonal and reproductive studies (3 papers), Epigenetics and DNA Methylation (3 papers), Genital Health and Disease (3 papers) and Genetic factors in colorectal cancer (2 papers). The work is most often cited by research in Cancer Research (215 citations), Pulmonary and Respiratory Medicine (400 citations), Gastroenterology (46 citations), Endocrinology, Diabetes and Metabolism (129 citations) and Molecular Biology (489 citations). Lien Spans has collaborated with scholars based in Belgium, United States and Netherlands. Frequent co-authors include Frank Claessens, Christine Helsen, Liesbeth Clinckemalie, Steven Joniau, Michaël R. Laurent, Thomas Van den Broeck, Stefan Preković, Vanessa Dubois, Dirk Vanderschueren and Hendrik Van Poppel. Their work appears in journals such as The FASEB Journal, PLoS ONE, Molecular Cancer Therapeutics, Clinical Cancer Research and Nature Reviews Urology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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