Larry W. Hertel

4.7k citations

32 papers · 3.9k indexed · 2 hit papers · h-index 22

Oncology top 1%
Molecular Biology top 5%
Pulmonary and Respiratory Medicine top 5%
Cancer Research top 5%
Organic Chemistry top 5%

Co-authors: Gerald B. Grindey William Plunkett Sherri Chubb Volker Heinemann Julian S. Kroin Peng Huang Donna S. Shewach G B Boder
Topics: HIV/AIDS drug development and treatment (9 papers)DNA Repair Mechanisms (7 papers)Biochemical and Molecular Research (7 papers)
Cited by: Oncology Cancer Research Genetics
Journals: Journal of the American Chemical Society Nucleic Acids Research International Journal of Radiation Oncology*Biology*Physics
Partner nations: United States Netherlands

In The Last Decade

Larry W. Hertel

32 papers receiving 3.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Action of 2',2'-difluorodeoxycytidine on DNA synthesis.

1991 754 citations Sherri Chubb, Larry W. Hertel et al. PubMed profile →
Evaluation of the antitumor activity of gemcitabine (2',2'-difluoro-2'-deoxycytidine).

1990 601 citations Larry W. Hertel, G B Boder et al. PubMed profile →

Peers

Countries citing papers authored by Larry W. Hertel

Since Specialization

Citations

This map shows the geographic impact of Larry W. Hertel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Larry W. Hertel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Larry W. Hertel more than expected).

Fields of papers citing papers by Larry W. Hertel

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Larry W. Hertel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Larry W. Hertel. The network helps show where Larry W. Hertel may publish in the future.

Co-authorship network of co-authors of Larry W. Hertel

This figure shows the co-authorship network connecting the top 25 collaborators of Larry W. Hertel. A scholar is included among the top collaborators of Larry W. Hertel based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Larry W. Hertel. Larry W. Hertel is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3 2003 ·Bioorganic & Medicinal Chemistry Letters ·Kumiko Takeuchi,Todd J. Kohn,(unknown),Vincent P. Rocco,(unknown),(unknown),Larry W. Hertel,David L. Nelson,David B. Wainscott,(unknown),Janice Shaw,Penny G. Threlkeld,David T. Wong	18
2	Advances Toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 2 2003 ·Bioorganic & Medicinal Chemistry Letters ·Kumiko Takeuchi,Todd J. Kohn,(unknown),Vincent P. Rocco,(unknown),Daniel J. Koch,(unknown),Larry W. Hertel,David L. Nelson,David B. Wainscott,(unknown),Janice Shaw,Penny G. Threlkeld,David T. Wong	20
3	Comparison of the Mechanism of Cytotoxicity of 2-Chloro-9-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)adenine, 2-Chloro-9-(2-deoxy-2-fluoro-β-d-ribofuranosyl)adenine, and 2-Chloro-9-(2-deoxy-2,2-difluoro-β-d-ribofuranosyl)adenine in CEM Cells 1999 ·Molecular Pharmacology ·William B. Parker,Sue C. Shaddix,Lucy M. Rose,Donna S. Shewach,Larry W. Hertel,John A. Secrist,John A. Montgomery,L. Lee Bennett	35
4	Radiosensitization of pancreatic cancer cells by 2′,2′-difluoro-2′-deoxycytidine 1996 ·International Journal of Radiation OncologyBiologyPhysics ·Theodore S. Lawrence,Emily Yun‐Chia Chang,Tina M. Hahn,Larry W. Hertel,Donna S. Shewach	255
5	Ab initio quantum mechanical and X-ray crystallographic studies of gemcitabine and 2′-deoxy cytosine 1996 ·Computers & Chemistry ·Frederick H. Hausheer,Noel D. Jones,P. Seetharamulu,U. Chandra Singh,Jack B. Deeter,Larry W. Hertel,Julian S. Kroin	7
6	Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft models 1996 ·Investigational New Drugs ·Ronald L. Merriman,Larry W. Hertel,Richard M. Schultz,Peter J. Houghton,Janet A. Houghton,Pamela Rutherford,Lee R. Tanzer,G B Boder,Gerald B. Grindey	71
7	Excision of 2',2'-difluorodeoxycytidine (gemcitabine) monophosphate residues from DNA. 1996 ·PubMed ·Varsha Gandhi,(unknown),Feng Chen,Larry W. Hertel,William Plunkett	60
8	Cytotoxicity, metabolism, and mechanisms of action of 2',2'-difluorodeoxyguanosine in Chinese hamster ovary cells. 1995 ·PubMed ·Varsha Gandhi,Shin Mineishi,Ping Huang,(unknown),Yang Yu,F. Chen,Billie Nowak,Sherri Chubb,Larry W. Hertel,William Plunkett	31
9	Evaluation of new anticancer agents against the MIA PaCa-2 and PANC-1 human pancreatic carcinoma xenografts. 1993 ·PubMed ·Richard M. Schultz,Ronald L. Merriman,John E. Toth,Johannes Zimmermann,Larry W. Hertel,Sherri L. Andis,(unknown),Pamela Rutherford,Lee R. Tanzer,Gerald B. Grindey	57
10	Nucleotide specificity of human deoxycytidine kinase. 1992 ·Molecular Pharmacology ·Donna S. Shewach,Kara Reynolds,Larry W. Hertel	99
11	Synthesis and restriction enzyme analysis of oligodeoxyribonucleotides containing the anti-cancer drug 2', 2'-difluoro-2'-deoxycytidine 1992 ·Nucleic Acids Research ·Frank C. Richardson,Katherine K. Richardson,Julian S. Kroin,Larry W. Hertel	16
12	Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate: a mechanism of self-potentiation. 1992 ·PubMed ·Volker Heinemann,(unknown),Sherri Chubb,Arindam Sen,Larry W. Hertel,Gerald B. Grindey,William Plunkett	276
13	Cytotoxicity and Antitumor Activity of 2′,2′-Difluorodeoxycytidine (Gemcitabine) 1990 ·Cancer Investigation ·Gerald B. Grindey,Larry W. Hertel,William Plunkett	29
14	Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine. 1990 ·Molecular Pharmacology ·Volker Heinemann,(unknown),Sherri Chubb,A. Sen,Larry W. Hertel,Gerald B. Grindey,William Plunkett	342
15	Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine. 1988 ·PubMed ·Volker Heinemann,Larry W. Hertel,Gerald B. Grindey,William Plunkett	432
16	Synthesis of 2-deoxy-2,2-difluoro-D-ribose and 2-deoxy-2,2'-difluoro-D-ribofuranosyl nucleosides 1988 ·The Journal of Organic Chemistry ·Larry W. Hertel,Julian S. Kroin,Jerry W. Misner,J. M. Tustin	316
17	Electronic control of stereoselectivity. 10. Aryl substituent effects on electrophilic stereoselection in 11-isopropylidenedibenzonorbornadienes. Direct competition of dissimilarly functionalized benzo groups 1981 ·The Journal of Organic Chemistry ·Leo A. Paquette,(unknown),Larry W. Hertel	7
18	Electronic control of stereoselectivity. 8. The stereochemical course of electrophilic additions to aryl-substituted 9-isopropylidenebenzonorbornenes 1981 ·Journal of the American Chemical Society ·Leo A. Paquette,Larry W. Hertel,Rolf Gleiter,M. C. BOEHM,Mark A. Beno,Gary G. Christoph	41
19	Electronic control of stereoselectivity. 1. Singlet oxygen and related electrophilic additions to aryl-substituted 7-isopropylidenebenzonorbornenes 1978 ·Journal of the American Chemical Society ·Leo A. Paquette,Larry W. Hertel,Rolf Gleiter,M. C. BOEHM	32
20	Characterization of the aglycones of the toxic principle of the sea cucumber Holothuria atra 1977 ·Toxicon ·Thomas J. Delia,Larry W. Hertel,(unknown)	6

About Larry W. Hertel

Larry W. Hertel is a scholar working on Infectious Diseases, Genetics and Molecular Biology, having authored 32 papers that have together received 3.9k indexed citations. Recurring topics across this work include HIV/AIDS drug development and treatment (9 papers), DNA Repair Mechanisms (7 papers) and Biochemical and Molecular Research (7 papers). The work is most often cited by research in Oncology (2.0k citations), Cancer Research (625 citations) and Genetics (366 citations). Larry W. Hertel has collaborated with scholars based in United States and Netherlands. Frequent co-authors include Gerald B. Grindey, William Plunkett, Sherri Chubb, Volker Heinemann, Julian S. Kroin, Peng Huang, Donna S. Shewach, G B Boder, Tina M. Hahn and Theodore S. Lawrence. Their work appears in journals such as Journal of the American Chemical Society, Nucleic Acids Research and International Journal of Radiation Oncology*Biology*Physics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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