John A. Secrist

6.6k citations

169 papers · 5.5k indexed · 1 hit paper · h-index 38

Impact in

Physiology top 0.5%
- Adenosine and Purinergic Signaling
Infectious Diseases top 1%
- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology

Papers in

Physiology 17
- Adenosine and Purinergic Signaling 15
Infectious Diseases 53
- HIV/AIDS drug development and treatment 48

Co-authors: Nelson J. Leonard John A. Montgomery Jorge R. Barrio William B. Parker Gregorio Weber Kamal N. Tiwari James M. Riordan Sue C. Shaddix
Journals: Nucleosides Nucleotides & Nucleic Acids (25 papers)Journal of Medicinal Chemistry (20 papers)The Journal of Organic Chemistry (13 papers)Biochemistry (7 papers)Biochemical Pharmacology (5 papers)
Partner nations: United States Egypt Canada

In The Last Decade

John A. Secrist

167 papers receiving 5.1k citations

Hit Papers

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Fluorescent modification of adenosine-containing coenzymes. Biological activities and spectroscopic properties 1972 · 459 citations

Peers

Countries citing papers authored by John A. Secrist

Since Specialization

Citations

This map shows the geographic impact of John A. Secrist's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John A. Secrist with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John A. Secrist more than expected).

Fields of papers citing papers by John A. Secrist

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John A. Secrist. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John A. Secrist. The network helps show where John A. Secrist may publish in the future.

Co-authorship network

The 25 scholars most cited alongside John A. Secrist, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John A. Secrist Line = papers co-authored together John A. Secrist links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases Bioorganic Chemistry ·Abdalla E. A. Hassan, Reham A. I. Abou‐Elkhair, William B. Parker, Paula W. Allan, John A. Secrist	2015	7
2	Preclinical Antitumor Activity of Thiarabine in Human Leukemia and Lymphoma Xenograft Models Nucleosides Nucleotides & Nucleic Acids ·William R. Waud, Raymond Frommeyer, John A. Secrist	2012	1
3	Isolation and Characterization of a Murine P388 Leukemia Line Resistant to Thiarabine Nucleosides Nucleotides & Nucleic Acids ·William R. Waud, William B. Parker, Raymond Frommeyer, John A. Secrist	2012	2
4	The Alabama Drug Discovery Alliance: A Collaborative Partnership to Facilitate Academic Drug Discovery Pharmaceutical Research ·Maaike Everts, Wilson B. Knight, David Harris, John A. Secrist, Richard J. Whitley	2011	4
5	Novel substituted pyrimidines as HCV replication (replicase) inhibitors Bioorganic & Medicinal Chemistry Letters ·Cecil D. Kwong, Jeremy L. Clark, Anita T. Fowler, Feng Geng, Hollis S. Kezar, Abhijit Roychowdhury, Robert C. Reynolds, Joseph A. Maddry, Subramaniam Ananthan, John A. Secrist, Neng‐Yang Shih, John J. Piwinski, Cheng Li, Boris Feld, Hsueh‐Cheng Huang, Xiao Tong, F. George Njoroge, Ashok Arasappan	2011	4
6	Alteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicity Mutation research. Fundamental and molecular mechanisms of mutagenesis ·Jessica J. O’Konek, Brendon Ladd, Maria Julia Andrade Loureiro, Sashimatsung, Paul D. Boucher, P. Puygrenier, John A. Secrist, Donna S. Shewach	2009	2
7	Nucleosides as anticancer agents: from concept to the clinic Nucleic Acids Symposium Series ·John A. Secrist	2005	11
8	Designer Gene Therapy Using an Escherichia coli Purine Nucleoside Phosphorylase/Prodrug System Chemistry & Biology ·Eric M. Bennett, Ruchi Anand, Paula W. Allan, Abdalla E. A. Hassan, Jeong S. Hong, Dana N. Levasseur, David T. McPherson, William B. Parker, John A. Secrist, Eric J. Sorscher, Tim M. Townes, William R. Waud, S.E. Ealick	2003	42
9	Phosphorylation of 4′-thio-β-d-Arabinofuranosylcytosine and Its Analogs by Human Deoxycytidine Kinase Journal of Pharmacology and Experimental Therapeutics ·S. Chotchaisthit, Sue C. Shaddix, Kamal N. Tiwari, John A. Secrist, William B. Parker	2003	15
10	The novel nucleoside transport system exhibited by NB4 cells, csg, transports deoxyguanosine analogues, including ara-G Biochemical Pharmacology ·Maria Julia Andrade Loureiro, Varsha Gandhi, John A. Secrist, Kelly A. Meckling	2003	1
11	Antitumor activity of 2-fluoro-2′-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase Cancer Gene Therapy ·William B. Parker, Paula W. Allan, Abdalla E. A. Hassan, John A. Secrist, Eric J. Sorscher, William R. Waud	2002	62
12	SYNTHESIS AND BIOLOGICAL ACTIVITY OF 4′-THIO-L-XYLOFURANOSYL NUCLEOSIDES Nucleosides Nucleotides & Nucleic Acids ·Kamal N. Tiwari, Luis Maffei Sartini-Paulillo, John A. Montgomery, John A. Secrist	2001	7
13	Gene Therapy of Cancer: Activation of Nucleoside Prodrugs withE. coliPurine Nucleoside Phosphorylase Nucleosides and Nucleotides ·John A. Secrist, William B. Parker, Paula W. Allan, L. Lee Bennett, William R. Waud, Rajdeep Sharma, Anita T. Fowler, John A. Montgomery, S.E. Ealick, Alan Wells, G. Yancey Gillespie, Vijayakrishna K. Gadi, Eric J. Sorscher	1999	35
14	Synthesis and Biological Activity of 5-Azacytosine Nucleosides Derived from 4-Thio-2-Deoxy-L-threo-Pentofuranose and 4-Thio-2-Deoxy-D-erythro-Pentofuranose Nucleosides and Nucleotides ·Loredana Cappellacci, Kamal N. Tiwari, John A. Montgomery, John A. Secrist	1999	2
15	Polyamine Pools in HIV-Infected Cells Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology ·E. Lucile White, Lucy M. Rose, Paula W. Allan, Robert W. Buckheit, William M. Shannon, John A. Secrist	1998	4
16	The Synthesis and Biological Activity of Certain 4′-Thionucleosides Nucleosides and Nucleotides ·John A. Secrist, William B. Parker, K.P. Tiwari, Luis Maffei Sartini-Paulillo, Sue C. Shaddix, 耿之助上條, Leonard L. Bennett, John A. Montgomery	1995	19
17	Search for New Purine- and Ribose-Modified Adenosine Analogs as Selective Agonists and Antagonists at Adenosine Receptors Journal of Medicinal Chemistry ·Suhaib M. Siddiqi, Kenneth A. Jacobson, John L. Esker, Mark E. Olah, Xiao-duo Ji, Neli Melman, Kamal N. Tiwari, John A. Secrist, Stewart W. Schneller	1995	73
18	Metabolism and metabolic actions of 4′-thiothymidine in L1210 cells Biochemical Pharmacology ·William B. Parker, Sue C. Shaddix, Lucy M. Rose, Kamal N. Tiwari, Ahmed S. Al Askar, John A. Secrist, L. Lee Bennett	1995	13
19	Purification of human S-adenosylmethionine decarboxylase expressed in Escherichia coli and use of this protein to investigate the mechanism of inhibition by the irreversible inhibitors, 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine and 5'-{[(Z)-4-amino-2-butenyl]methylamino}-5'-deoxyadenosine Biochemistry ·Lisa M. Shantz, Bruce A. Stanley, John A. Secrist, Anthony E. Pegg	1992	29
20	Interactions of fluorescent analogs of adenine nucleotides with pyruvate kinase FEBS Letters ·Jorge R. Barrio, John A. Secrist, Yueh‐hsiu Chien, 甸子芩, James L. Robinson, Nelson J. Leonard	1973	29

About John A. Secrist

John A. Secrist is a scholar working on Physiology, Infectious Diseases, Virology, Biochemistry and Organic Chemistry, having authored 169 papers that have together received 5.5k indexed citations. Recurring topics across this work include Biochemical and Molecular Research (74 papers), HIV/AIDS drug development and treatment (48 papers), Cytomegalovirus and herpesvirus research (22 papers), Synthesis and Characterization of Heterocyclic Compounds (21 papers), Polyamine Metabolism and Applications (20 papers), Carbohydrate Chemistry and Synthesis (18 papers), DNA and Nucleic Acid Chemistry (15 papers) and Adenosine and Purinergic Signaling (15 papers). The work is most often cited by research in Physiology (527 citations), Infectious Diseases (1.4k citations), Organic Chemistry (1.7k citations), Virology (265 citations) and Molecular Biology (3.4k citations). John A. Secrist has collaborated with scholars based in United States, Egypt and Canada. Frequent co-authors include Nelson J. Leonard, John A. Montgomery, Jorge R. Barrio, William B. Parker, Jorge R. Barrio, Gregorio Weber, Kamal N. Tiwari, James M. Riordan, Sue C. Shaddix and E. Lucile White. Their work appears in journals such as Nucleosides Nucleotides & Nucleic Acids, Journal of Medicinal Chemistry, The Journal of Organic Chemistry, Biochemistry and Biochemical Pharmacology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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