Kristian Helin

50.6k total citations · 16 hit papers
275 papers, 37.0k citations indexed

About

Kristian Helin is a scholar working on Molecular Biology, Oncology and Genetics. According to data from OpenAlex, Kristian Helin has authored 275 papers receiving a total of 37.0k indexed citations (citations by other indexed papers that have themselves been cited), including 228 papers in Molecular Biology, 86 papers in Oncology and 42 papers in Genetics. Recurrent topics in Kristian Helin's work include Epigenetics and DNA Methylation (137 papers), Cancer-related Molecular Pathways (69 papers) and Cancer-related gene regulation (62 papers). Kristian Helin is often cited by papers focused on Epigenetics and DNA Methylation (137 papers), Cancer-related Molecular Pathways (69 papers) and Cancer-related gene regulation (62 papers). Kristian Helin collaborates with scholars based in Denmark, Italy and United States. Kristian Helin's co-authors include Diego Pasini, Adrian P. Bracken, Karl Agger, Paul A. Cloos, Klaus Hansen, Jesper Frank Christensen, Eros Lazzerini Denchi, Juri Rappsilber, Ali Fattaey and Jens Vilstrup Johansen and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Kristian Helin

272 papers receiving 36.6k citations

Hit Papers

UTX and JMJD3 are histone... 1992 2026 2003 2014 2007 2006 2011 2016 2004 250 500 750 1000
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
    2007 1.0k citations Karl Agger, Paul A. Cloos et al. profile →
  2. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
    2006 1.0k citations Diego Pasini, Kristian Helin et al. profile →
  3. TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
    2011 786 citations Jesper Frank Christensen, Marianne Terndrup Pedersen et al. profile →
  4. Role of TET enzymes in DNA methylation, development, and cancer
    2016 772 citations K. Rasmussen, Kristian Helin profile →
  5. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
    2004 703 citations Diego Pasini, Eros Lazzerini Denchi et al. The EMBO Journal profile →
  6. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
    2007 689 citations Daniela Kleine‐Kohlbrecher, Diego Pasini et al. profile →
  7. Molecular mechanisms and potential functions of histone demethylases
    2012 672 citations Susanne M. Kooistra, Kristian Helin profile →
  8. Transcriptional regulation by Polycomb group proteins
    2013 656 citations Kristian Helin et al. Nature Structural & Molecular Biology profile →
  9. E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis
    2001 621 citations Emanuela Grassilli, Elena Prosperini et al. profile →
  10. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F
    1992 577 citations Kristian Helin et al. profile →
  11. The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
    2006 568 citations Paul A. Cloos, Karl Agger et al. profile →
  12. A model for transmission of the H3K27me3 epigenetic mark
    2008 567 citations Diego Pasini, Juri Rappsilber et al. profile →
  13. The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation
    2007 542 citations Diego Pasini, Kristian Helin et al. Molecular and Cellular Biology profile →
  14. Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease
    2008 521 citations Paul A. Cloos, Karl Agger et al. profile →
  15. Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation
    2019 398 citations Anne Laugesen, Jonas W. Højfeldt et al. Molecular Cell profile →
  16. H3K4me3 regulates RNA polymerase II promoter-proximal pause-release
    2023 186 citations Kristian Helin et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Kristian Helin Denmark 103 31.3k 9.1k 4.8k 4.6k 2.3k 275 37.0k
Alan D. D’Andrea United States 98 25.3k 0.8× 11.2k 1.2× 6.7k 1.4× 5.1k 1.1× 3.2k 1.4× 313 32.7k
Thomas Ried United States 84 17.7k 0.6× 7.3k 0.8× 6.2k 1.3× 6.2k 1.3× 2.0k 0.9× 378 27.8k
Robert N. Eisenman United States 82 25.2k 0.8× 5.8k 0.6× 2.9k 0.6× 5.1k 1.1× 2.8k 1.2× 204 30.7k
Ramon Parsons United States 66 23.4k 0.7× 12.9k 1.4× 6.9k 1.4× 2.7k 0.6× 2.4k 1.0× 157 33.2k
Thomas M. Roberts United States 84 19.6k 0.6× 7.6k 0.8× 2.6k 0.5× 3.4k 0.7× 3.4k 1.5× 309 28.9k
Hartmut Beug Austria 82 16.1k 0.5× 7.4k 0.8× 3.4k 0.7× 4.2k 0.9× 3.4k 1.5× 254 25.3k
Martine F. Roussel United States 83 19.4k 0.6× 12.4k 1.4× 3.3k 0.7× 2.6k 0.6× 4.0k 1.7× 242 27.9k
Johannes L. Bos Netherlands 92 25.6k 0.8× 11.1k 1.2× 5.2k 1.1× 3.5k 0.7× 3.1k 1.3× 246 39.6k
Woodring E. Wright United States 99 28.4k 0.9× 4.9k 0.5× 2.4k 0.5× 4.1k 0.9× 2.9k 1.2× 294 43.5k
Jane E. Visvader Australia 70 14.6k 0.5× 13.2k 1.5× 5.9k 1.2× 2.8k 0.6× 2.6k 1.1× 182 25.0k

Countries citing papers authored by Kristian Helin

Since Specialization
Citations

This map shows the geographic impact of Kristian Helin's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kristian Helin with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kristian Helin more than expected).

Fields of papers citing papers by Kristian Helin

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kristian Helin. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kristian Helin. The network helps show where Kristian Helin may publish in the future.

Co-authorship network of co-authors of Kristian Helin

This figure shows the co-authorship network connecting the top 25 collaborators of Kristian Helin. A scholar is included among the top collaborators of Kristian Helin based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kristian Helin. Kristian Helin is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Damhofer, Helene, Tülin Tatar, Benjamin Southgate, et al.. (2024). TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers. Cell Death and Disease. 15(4). 273–273. 6 indexed citations
2.
Hansen, Stine L., Hjalte List Larsen, Jordi Guiu, et al.. (2023). An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate. Science Advances. 9(28). eadg4055–eadg4055. 35 indexed citations
3.
Rosikiewicz, Wojciech, Yurii Sedkov, Baranda S. Hansen, et al.. (2021). PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands. Life Science Alliance. 5(1). e202101228–e202101228. 17 indexed citations
4.
Weis-Banke, Stine Emilie, Mads Lerdrup, Daniela Kleine‐Kohlbrecher, et al.. (2020). Mutant FOXL2C134W Hijacks SMAD4 and SMAD2/3 to Drive Adult Granulosa Cell Tumors. Cancer Research. 80(17). 3466–3479. 37 indexed citations
5.
Rasmussen, K., Ivan Berest, Koutarou Nishimura, et al.. (2019). TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells. Genome Research. 29(4). 564–575. 64 indexed citations
6.
Højfeldt, Jonas W., Anne Laugesen, Berthe M. Willumsen, et al.. (2018). Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2. Nature Structural & Molecular Biology. 25(3). 225–232. 157 indexed citations
7.
Paroni, Gabriela, Marco Bolis, Adriana Zanetti, et al.. (2018). HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive cases. Oncogene. 38(15). 2675–2689. 21 indexed citations
8.
Cloos, Paul A., et al.. (2018). The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation. Cancer Research. 78(15). 4114–4125. 50 indexed citations
9.
Oo, James A., Kristian Helin, Gerd Geißlinger, et al.. (2018). The histone demethylase Jarid1b mediates angiotensin II‐induced endothelial dysfunction by controlling the 3′UTR of soluble epoxide hydrolase. Acta Physiologica. 225(1). e13168–e13168. 7 indexed citations
10.
Grassilli, Emanuela, Fabrizio Pisano, Maria Grazia Cerrito, et al.. (2016). A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation. Oncogene. 35(33). 4368–4378. 52 indexed citations
11.
Pedersen, Marianne Terndrup, Susanne M. Kooistra, Aliaksandra Radzisheuskaya, et al.. (2016). Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self‐renewal and early development. The EMBO Journal. 35(14). 1550–1564. 84 indexed citations
12.
Malatesta, Martina, Cornelia Steinhauer, Faizaan Mohammad, et al.. (2013). Histone Acetyltransferase PCAF Is Required for Hedgehog–Gli-Dependent Transcription and Cancer Cell Proliferation. Cancer Research. 73(20). 6323–6333. 95 indexed citations
13.
Grassilli, Emanuela, Elena Federzoni, Leonarda Ianzano, et al.. (2013). Inhibition of GSK3B Bypass Drug Resistance of p53-Null Colon Carcinomas by Enabling Necroptosis in Response to Chemotherapy. Clinical Cancer Research. 19(14). 3820–3831. 78 indexed citations
14.
Hudlebusch, Heidi Rye, Eric Santoni‐Rugiu, Ronald Simon, et al.. (2011). The Histone Methyltransferase and Putative Oncoprotein MMSET Is Overexpressed in a Large Variety of Human Tumors. Clinical Cancer Research. 17(9). 2919–2933. 111 indexed citations
15.
Hudlebusch, Heidi Rye, Julie Skotte, Eric Santoni‐Rugiu, et al.. (2011). MMSET Is Highly Expressed and Associated with Aggressiveness in Neuroblastoma. Cancer Research. 71(12). 4226–4235. 50 indexed citations
16.
Kleine‐Kohlbrecher, Daniela, Jesper Frank Christensen, Julien Vandamme, et al.. (2010). A Functional Link between the Histone Demethylase PHF8 and the Transcription Factor ZNF711 in X-Linked Mental Retardation. Molecular Cell. 38(2). 165–178. 172 indexed citations
17.
Cirò, Marco, Elena Prosperini, Micaela Quarto, et al.. (2009). ATAD2 Is a Novel Cofactor for MYC, Overexpressed and Amplified in Aggressive Tumors. Cancer Research. 69(21). 8491–8498. 185 indexed citations
18.
Denchi, Eros Lazzerini, Claire Attwooll, Diego Pasini, & Kristian Helin. (2005). Deregulated E2F Activity Induces Hyperplasia and Senescence-Like Features in the Mouse Pituitary Gland. Molecular and Cellular Biology. 25(7). 2660–2672. 153 indexed citations
19.
Attwooll, Claire, Eros Lazzerini Denchi, & Kristian Helin. (2004). The E2F family: specific functions and overlapping interests. The EMBO Journal. 23(24). 4709–4716. 448 indexed citations
20.
Fiore, Pier Paolo Di, Kristian Helin, Matthias H. Kraus, et al.. (1992). A single amino acid substitution is sufficient to modify the mitogenic properties of the epidermal growth factor receptor to resemble that of gp185erbB-2.. The EMBO Journal. 11(11). 3927–3933. 24 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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