Kosuke Nakashima

956 citations

25 papers · 620 indexed · h-index 12

Co-authors: Kevin B. Bacon Toshio Kokubo Takeshi Yura Noriyuki Yamamoto Michitaka Shichijo Takahiko Taniguchi Masako Satô Hiroichi Nagai
Topics: Phosphodiesterase function and regulation (9 papers)Cholinesterase and Neurodegenerative Diseases (7 papers)Receptor Mechanisms and Signaling (5 papers)
Cited by: Anesthesiology and Pain Medicine Immunology Developmental Neuroscience
Journals: PLoS ONE Neurology Journal of Medicinal Chemistry
Partner nations: Japan United States United Kingdom

In The Last Decade

Kosuke Nakashima

25 papers receiving 601 citations

Peers

Countries citing papers authored by Kosuke Nakashima

Since Specialization

Citations

This map shows the geographic impact of Kosuke Nakashima's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kosuke Nakashima with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kosuke Nakashima more than expected).

Fields of papers citing papers by Kosuke Nakashima

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kosuke Nakashima. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kosuke Nakashima. The network helps show where Kosuke Nakashima may publish in the future.

Co-authorship network of co-authors of Kosuke Nakashima

This figure shows the co-authorship network connecting the top 25 collaborators of Kosuke Nakashima. A scholar is included among the top collaborators of Kosuke Nakashima based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kosuke Nakashima. Kosuke Nakashima is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat 2025 ·Epilepsia ·(unknown),(unknown),Mahnaz Asgharnejad,(unknown),Kosuke Nakashima,Nicole A. Hawkins,H. Steve White	1
2	Neurological sedative indicators during general anesthesia with remimazolam 2022 ·Journal of Anesthesia ·Kazuhiro Shirozu,(unknown),(unknown),(unknown),Kosuke Nakashima,(unknown),Midoriko Higashi,Ken Yamaura	66
3	Design and synthesis of 6-methylpyridin-2-one derivatives as novel and potent GluN2A positive allosteric modulators for the treatment of cognitive impairment 2022 ·Bioorganic & Medicinal Chemistry ·(unknown),Takashi Yamashita,Toshihiro Imaeda,Hiroyuki Kakei,(unknown),Minoru Nakamura,Masaki Daini,(unknown),Kosuke Nakashima,(unknown),(unknown),Ezio Bettini,Annarosa Ugolini,Mauro Corsi,Tomoaki Hasui	2
4	Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity 2021 ·Bioorganic & Medicinal Chemistry ·(unknown),(unknown),Asato Kina,Masataka Murakami,Kazuaki Takami,(unknown),Masaki Seto,(unknown),Takashi Yamashita,Kosuke Nakashima,(unknown),Ezio Bettini,Annarosa Ugolini,Mauro Corsi,Tomoaki Hasui	6
5	Discovery of Novel HCN4 Blockers with Unique Blocking Kinetics and Binding Properties 2021 ·SLAS DISCOVERY ·Kosuke Nakashima,(unknown),Hideki Matsui	5
6	Clinical improvement in a patient with severe coronavirus disease 2019 after administration of hydroxychloroquine and continuous hemodiafiltlation with nafamostat mesylate 2020 ·Journal of Infection and Chemotherapy ·(unknown),Yuji Shono,Kentaro Tokuda,Kosuke Nakashima,Yuzo Yamamoto,Jun Maki,Yoji Nagasaki,Nobuyuki Shimono,Tomohiko Akahoshi,Tomoaki Taguchi	9
7	A Novel Inhibition Modality for Phosphodiesterase 2A 2020 ·SLAS DISCOVERY ·Kosuke Nakashima,Hideki Matsui	3
8	Transgenic mice overexpressing miR-137 in the brain show schizophrenia-associated behavioral deficits and transcriptome profiles 2019 ·PLoS ONE ·(unknown),Kazumasa Yokoyama,Shinya Tasaki,Junichi Kato,Kosuke Nakashima,Michiyasu Takeyama,Atsushi Nakatani,Motohisa Suzuki	18
9	A homozygous loss‐of‐function mutation in PDE2A associated to early‐onset hereditary chorea 2018 ·Movement Disorders ·Vincenzo Salpietro,Belén Pérez‐Dueñas,Kosuke Nakashima,Victoria San Antonio‐Arce,Andreea Manole,Stéphanie Efthymiou,Jana Vandrovcová,Conceição Bettencourt,Niccolò E. Mencacci,Christine Klein,Michy P. Kelly,Ceri H. Davies,Haruhide Kimura,Alfons Macaya,Henry Houlden	42
10	Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders 2017 ·Journal of Medicinal Chemistry ·Satoshi Mikami,Shinji Nakamura,(unknown),Izumi Nomura,Masanori Kawasaki,Shigekazu Sasaki,Hideyuki Oki,Hironori Kokubo,Isaac Hoffman,Hua Zou,Noriko Uchiyama,Kosuke Nakashima,(unknown),Haruka Imada,Noriko Suzuki,Hiroki Iwashita,Takahiko Taniguchi	26
11	Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket 2016 ·Bioorganic & Medicinal Chemistry ·Masato Yoshikawa,Takenori Hitaka,Tomoaki Hasui,Makoto Fushimi,Jun Kunitomo,Hironori Kokubo,Hideyuki Oki,Kosuke Nakashima,Takahiko Taniguchi	7
12	Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor 2015 ·Bioorganic & Medicinal Chemistry ·Masato Yoshikawa,Haruhi Kamisaki,Jun Kunitomo,Hideyuki Oki,Hironori Kokubo,(unknown),Tomomi Ikemoto,Kosuke Nakashima,(unknown),(unknown),Haruhide Kimura,Takahiko Taniguchi	21
13	Characterization of Binding and Inhibitory Properties of TAK-063, a Novel Phosphodiesterase 10A Inhibitor 2015 ·PLoS ONE ·(unknown),Kazunori Suzuki,(unknown),Maki Miyamoto,Kimio Tohyama,Kosuke Nakashima,Takahiko Taniguchi,Haruhide Kimura	21
14	Discovery of 1-[2-Fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor 2014 ·Journal of Medicinal Chemistry ·Jun Kunitomo,Masato Yoshikawa,Makoto Fushimi,Akira Kawada,(unknown),Hideyuki Oki,Hironori Kokubo,Mitsuyo Kondo,Kosuke Nakashima,(unknown),Kazunori Suzuki,Haruhide Kimura,Takahiko Taniguchi	56
15	Inhibition mechanism exploration of investigational drug TAK-441 as inhibitor against Vismodegib-resistant Smoothened mutant 2013 ·European Journal of Pharmacology ·Tsuyoshi Ishii,Yūji Shimizu,Kosuke Nakashima,Shigeru Kondo,Kazumasa Ogawa,Satoshi Sasaki,Hideki Matsui	35
16	A novel Syk kinase-selective inhibitor blocks antigen presentation of immune complexes in dendritic cells 2004 ·European Journal of Pharmacology ·Kosuke Nakashima,Toshio Kokubo,Michitaka Shichijo,(unknown),Takeshi Yura,Noriyuki Yamamoto	25
17	The Orally Available Spleen Tyrosine Kinase Inhibitor 2-[7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide Dihydrochloride (BAY 61-3606) Blocks Antigen-Induced Airway Inflammation in Rodents 2003 ·Journal of Pharmacology and Experimental Therapeutics ·Noriyuki Yamamoto,Keisuke Takeshita,Michitaka Shichijo,Toshio Kokubo,Masako Satô,Kosuke Nakashima,(unknown),Hiroichi Nagai,(unknown),Takeshi Yura,Kevin B. Bacon	154
18	CD40‐dependent and ‐independent activation of human tonsil B cells by CpG oligodeoxynucleotides 2003 ·European Journal of Immunology ·Florian Gantner,Patrice Hermann,Kosuke Nakashima,(unknown),Katsuya Sakai,Kevin B. Bacon	61
19	Efficient Induction of Peptide‐Specific Cytotoxic T Lymphocytes by LPS‐Activated Spleen Cells 2000 ·Microbiology and Immunology ·Kiyokazu Kakugawa,Keiko Udaka,Kosuke Nakashima,Kayo Inaba,Yoshitaka Oka,Haruo Sugiyama,Hirokazu Tamamura,Hideo Yamagishi	3
20	Sympathetic nerve activity in the skin in relation to vibration-induced white finger. 1992 ·Scandinavian Journal of Work Environment & Health ·Gen Ishida,(unknown),Kosuke Nakashima,Tomoaki Sato,Ken Takahashi	5

About Kosuke Nakashima

Kosuke Nakashima is a scholar working on Pharmacology, Cellular and Molecular Neuroscience and Developmental Neuroscience, having authored 25 papers that have together received 620 indexed citations. Recurring topics across this work include Phosphodiesterase function and regulation (9 papers), Cholinesterase and Neurodegenerative Diseases (7 papers) and Receptor Mechanisms and Signaling (5 papers). The work is most often cited by research in Anesthesiology and Pain Medicine (55 citations), Immunology (169 citations) and Developmental Neuroscience (22 citations). Kosuke Nakashima has collaborated with scholars based in Japan, United States and United Kingdom. Frequent co-authors include Kevin B. Bacon, Toshio Kokubo, Takeshi Yura, Noriyuki Yamamoto, Michitaka Shichijo, Takahiko Taniguchi, Masako Satô, Hiroichi Nagai, Keisuke Takeshita and Hideyuki Oki. Their work appears in journals such as PLoS ONE, Neurology and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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