Koen Brusselmans

9.4k total citations · 4 hit papers
24 papers, 6.8k citations indexed

About

Koen Brusselmans is a scholar working on Cancer Research, Molecular Biology and Surgery. According to data from OpenAlex, Koen Brusselmans has authored 24 papers receiving a total of 6.8k indexed citations (citations by other indexed papers that have themselves been cited), including 18 papers in Cancer Research, 12 papers in Molecular Biology and 5 papers in Surgery. Recurrent topics in Koen Brusselmans's work include Cancer, Hypoxia, and Metabolism (12 papers), Cancer, Lipids, and Metabolism (11 papers) and Lipid metabolism and biosynthesis (4 papers). Koen Brusselmans is often cited by papers focused on Cancer, Hypoxia, and Metabolism (12 papers), Cancer, Lipids, and Metabolism (11 papers) and Lipid metabolism and biosynthesis (4 papers). Koen Brusselmans collaborates with scholars based in Belgium, France and United States. Koen Brusselmans's co-authors include Johannes V. Swinnen, Guido Verhoeven, Peter Carmeliet, Mieke Dewerchin, Lieve Moons, Patrick H. Maxwell, Ellen De Schrijver, Yuval Dor, Désiré Collen and Eli Keshet and has published in prestigious journals such as Nature, Journal of Biological Chemistry and Journal of Clinical Investigation.

In The Last Decade

Koen Brusselmans

24 papers receiving 6.7k citations

Hit Papers

Role of HIF-1α in hypoxia-mediated apoptosis, cell prolif... 1998 2026 2007 2016 1998 2002 2010 1999 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    1998 2.1k citations Peter Carmeliet, Yuval Dor et al. Nature profile →
  2. Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
    2002 590 citations Veerle Compernolle, Koen Brusselmans et al. Nature Medicine profile →
  3. De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
    2010 572 citations Evelien Rysman, Koen Brusselmans et al. Cancer Research profile →
  4. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
    1999 529 citations Peter Carmeliet, Yin‐Shan Ng et al. Nature Medicine profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Koen Brusselmans Belgium 21 4.2k 4.0k 1.0k 840 772 24 6.8k
Sarah‐Maria Fendt Belgium 45 5.4k 1.3× 3.9k 1.0× 774 0.7× 1.4k 1.7× 402 0.5× 95 8.8k
Georgia Hatzivassiliou United States 23 6.0k 1.4× 4.0k 1.0× 425 0.4× 1.1k 1.3× 599 0.8× 34 8.6k
Ruth Lupu United States 54 6.2k 1.5× 4.3k 1.1× 686 0.7× 2.8k 3.3× 622 0.8× 143 9.7k
Anne Le United States 34 4.0k 0.9× 3.5k 0.9× 552 0.5× 1.0k 1.2× 369 0.5× 94 6.0k
Brandon Faubert United States 23 4.3k 1.0× 2.9k 0.7× 475 0.5× 1.3k 1.5× 586 0.8× 33 7.2k
George Poulogiannis United Kingdom 28 3.8k 0.9× 2.1k 0.5× 465 0.4× 1.0k 1.2× 397 0.5× 46 5.8k
Ja Seung Koo South Korea 43 2.7k 0.6× 2.8k 0.7× 807 0.8× 2.4k 2.8× 565 0.7× 231 6.3k
Lucas B. Sullivan United States 20 4.4k 1.0× 3.2k 0.8× 388 0.4× 665 0.8× 427 0.6× 36 6.0k
Jinliang Xing China 46 4.0k 1.0× 2.3k 0.6× 771 0.7× 1.0k 1.2× 443 0.6× 160 6.3k
Elisabetta Mueller United States 31 6.1k 1.4× 2.4k 0.6× 426 0.4× 1.3k 1.5× 671 0.9× 51 8.5k

Countries citing papers authored by Koen Brusselmans

Since Specialization
Citations

This map shows the geographic impact of Koen Brusselmans's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Koen Brusselmans with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Koen Brusselmans more than expected).

Fields of papers citing papers by Koen Brusselmans

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Koen Brusselmans. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Koen Brusselmans. The network helps show where Koen Brusselmans may publish in the future.

Co-authorship network of co-authors of Koen Brusselmans

This figure shows the co-authorship network connecting the top 25 collaborators of Koen Brusselmans. A scholar is included among the top collaborators of Koen Brusselmans based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Koen Brusselmans. Koen Brusselmans is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
2.
Rysman, Evelien, Koen Brusselmans, Katryn Scheys, et al.. (2010). De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation. Cancer Research. 70(20). 8117–8126. 572 indexed citations breakdown →
3.
Rysman, Evelien, Koen Brusselmans, Griet Van Imschoot, et al.. (2010). Aberrant Activation of Fatty Acid Synthesis Suppresses Primary Cilium Formation and Distorts Tissue Development. Cancer Research. 70(22). 9453–9462. 32 indexed citations
4.
Brusselmans, Koen, Leen Timmermans, Tine Van de Sande, et al.. (2007). Squalene Synthase, a Determinant of Raft-associated Cholesterol and Modulator of Cancer Cell Proliferation. Journal of Biological Chemistry. 282(26). 18777–18785. 90 indexed citations
5.
Swinnen, Johannes V., Koen Brusselmans, & Guido Verhoeven. (2006). Increased lipogenesis in cancer cells: new players, novel targets. Current Opinion in Clinical Nutrition & Metabolic Care. 9(4). 358–365. 496 indexed citations
6.
Beckers, Annelies, Sophie Organe, Leen Timmermans, et al.. (2006). Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside. Molecular Cancer Therapeutics. 5(9). 2211–2217. 50 indexed citations
7.
Swinnen, Johan, Annelies Beckers, Koen Brusselmans, Leen Timmermans, & Guido Verhoeven. (2005). Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype: synergism between AICA riboside and methotrexate. 1 indexed citations
8.
Acker, Till, Antonio Díez‐Juan, Julián Aragonés, et al.. (2005). Genetic evidence for a tumor suppressor role of HIF-2α. Cancer Cell. 8(2). 131–141. 153 indexed citations
9.
Brusselmans, Koen, Ellen De Schrijver, Guido Verhoeven, & Johannes V. Swinnen. (2005). RNA Interference–Mediated Silencing of the Acetyl-CoA-Carboxylase-α Gene Induces Growth Inhibition and Apoptosis of Prostate Cancer Cells. Cancer Research. 65(15). 6719–6725. 233 indexed citations
10.
Brusselmans, Koen, Françoise Bono, Désiré Collen, et al.. (2004). A Novel Role for Vascular Endothelial Growth Factor as an Autocrine Survival Factor for Embryonic Stem Cells during Hypoxia. Journal of Biological Chemistry. 280(5). 3493–3499. 82 indexed citations
11.
Brusselmans, Koen, Ruth Vrolix, Guido Verhoeven, & Johannes V. Swinnen. (2004). Induction of Cancer Cell Apoptosis by Flavonoids Is Associated with Their Ability to Inhibit Fatty Acid Synthase Activity. Journal of Biological Chemistry. 280(7). 5636–5645. 378 indexed citations
12.
Swinnen, Johannes V., Hannelore V. Heemers, Tine Van de Sande, et al.. (2004). Androgens, lipogenesis and prostate cancer. The Journal of Steroid Biochemistry and Molecular Biology. 92(4). 273–279. 137 indexed citations
13.
Brusselmans, Koen, Veerle Compernolle, Marc Tjwa, et al.. (2003). Heterozygous deficiency of hypoxia-inducible factor–2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. Journal of Clinical Investigation. 111(10). 1519–1527. 256 indexed citations
14.
Brusselmans, Koen, Ellen De Schrijver, Walter Heyns, Guido Verhoeven, & Johannes V. Swinnen. (2003). Epigallocatechin‐3‐gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells. International Journal of Cancer. 106(6). 856–862. 157 indexed citations
15.
Schrijver, Ellen De, Koen Brusselmans, Walter Heyns, Guido Verhoeven, & Johannes V. Swinnen. (2003). RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells.. PubMed. 63(13). 3799–804. 220 indexed citations
16.
Compernolle, Veerle, Koen Brusselmans, Till Acker, et al.. (2002). Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nature Medicine. 8(7). 702–710. 590 indexed citations breakdown →
17.
Luttun, Aernout, Koen Brusselmans, Hideharu Fukao, et al.. (2002). Loss of placental growth factor protects mice against vascular permeability in pathological conditions. Biochemical and Biophysical Research Communications. 295(2). 428–434. 68 indexed citations
18.
Brusselmans, Koen, Françoise Bono, Patrick H. Maxwell, et al.. (2001). Hypoxia-inducible Factor-2α (HIF-2α) Is Involved in the Apoptotic Response to Hypoglycemia but Not to Hypoxia. Journal of Biological Chemistry. 276(42). 39192–39196. 97 indexed citations
19.
Carmeliet, Peter, Yin‐Shan Ng, Dieter Nuyens, et al.. (1999). Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nature Medicine. 5(5). 495–502. 529 indexed citations breakdown →
20.
Carmeliet, Peter, Yuval Dor, Jean-Marc Herbert, et al.. (1998). Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 394(6692). 485–490. 2119 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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