Keizo Takenaga

6.0k citations

139 papers · 4.8k indexed · 1 hit paper · h-index 37

Molecular Biology top 2%
Cancer Research top 1%
Oncology top 5%
Immunology top 5%
Genetics top 5%

Co-authors: Nobuko Koshikawa Jun‐Ichi Hayashi Miho Akimoto Yoshio Honma Kazuto Nakada Kaori Ishikawa Hirotake Imanishi Yohko Nakamura
Topics: Cancer, Hypoxia, and Metabolism (26 papers)S100 Proteins and Annexins (20 papers)Mitochondrial Function and Pathology (18 papers)
Cited by: Cancer Research Molecular Biology Immunology and Allergy
Journals: Science Proceedings of the National Academy of Sciences Journal of Biological Chemistry
Partner nations: Japan United States Denmark

In The Last Decade

Keizo Takenaga

136 papers receiving 4.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

2008 1.2k citations Kaori Ishikawa, Keizo Takenaga et al. Science profile →

Peers

Countries citing papers authored by Keizo Takenaga

Since Specialization

Citations

This map shows the geographic impact of Keizo Takenaga's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Keizo Takenaga with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Keizo Takenaga more than expected).

Fields of papers citing papers by Keizo Takenaga

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Keizo Takenaga. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Keizo Takenaga. The network helps show where Keizo Takenaga may publish in the future.

Co-authorship network of co-authors of Keizo Takenaga

This figure shows the co-authorship network connecting the top 25 collaborators of Keizo Takenaga. A scholar is included among the top collaborators of Keizo Takenaga based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Keizo Takenaga. Keizo Takenaga is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	ATR Inhibition Synergizes With Alkylating PI Polyamide Targeting MYCN by Suppressing DNA Repair in MYCN‐Amplified Neuroblastoma 2025 ·Cancer Science ·(unknown),Hiroyuki Yoda,(unknown),(unknown),Keizo Takenaga,(unknown),Nobuko Koshikawa,Atsushi Takatori	0
2	Downregulation of sST2 , a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells 2025 ·FEBS Open Bio ·Miho Akimoto,Nobuko Koshikawa,Takao Morinaga,Mimi Tamamori‐Adachi,Atsushi Takatori,Keizo Takenaga	0
3	Anticancer Effect of the Triphenylphosphonium‐Conjugated Quinolone Antibiotics Targeting Mitochondrial DNA Replication 2025 ·Cancer Science ·(unknown),(unknown),(unknown),Nobuko Koshikawa,Rie Igarashi,Atsushi Takatori,Keizo Takenaga	0
4	Poly (ADP-ribose) polymerase inhibitor sensitized DNA damage caused by an alkylating pyrrole-imidazole polyamide targeting MYCN in neuroblastoma cells 2024 ·Biochemical and Biophysical Research Communications ·(unknown),Hiroyuki Yoda,(unknown),(unknown),Keizo Takenaga,(unknown),Nobuko Koshikawa,Atsushi Takatori	2
5	Hypoxia induces downregulation of the tumor-suppressive sST2 in colorectal cancer cells via the HIF–nuclear IL-33–GATA3 pathway 2023 ·Proceedings of the National Academy of Sciences ·Miho Akimoto,Takao Susa,Noriyuki Okudaira,Nobuko Koshikawa,Harumi Hisaki,Masayoshi Iizuka,Hiroko Okinaga,Keizo Takenaga,Tomoki Okazaki,Mimi Tamamori‐Adachi	7
6	A linear five-ring pyrrole-imidazole polyamide-triphenylphosphonium conjugate targeting a mitochondrial DNA mutation efficiently induces apoptosis of HeLa cybrid cells carrying the mutation 2021 ·Biochemical and Biophysical Research Communications ·Nobuko Koshikawa,(unknown),(unknown),(unknown),Kohei Tsuji,Takayoshi Watanabe,Jason Lin,(unknown),Keizo Takenaga,Hiroki Nagase	7
7	The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells 2016 ·BMC Anesthesiology ·(unknown),Masahiro Tanaka,Chisato Sumi,(unknown),M. Kusunoki,Kenichiro Nishi,Yoshiyuki Matsuo,Keizo Takenaga,Koh Shingu,Kiichi Hirota	33
8	Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells 2012 ·Clinical & Experimental Metastasis ·(unknown),Miho Akimoto,(unknown),Tsuneo Tanaka,Yoshitsugu Tajima,Yoshio Honma,Keizo Takenaga	69
9	Hydrogen Sulfide Inhibits Hypoxia- But Not Anoxia-Induced Hypoxia-Inducible Factor 1 Activation in a von Hippel-Lindau- and Mitochondria-Dependent Manner 2011 ·Antioxidants and Redox Signaling ·Shinichi Kai,Tomoharu Tanaka,Hiroki Daijo,Hiroshi Harada,Shun Kishimoto,Kengo Suzuki,Satoshi Takabuchi,Keizo Takenaga,Kazuhiko Fukuda,Kiichi Hirota	68
10	The innate immune system in host mice targets cells with allogenic mitochondrial DNA 2010 ·The Journal of Experimental Medicine ·Kaori Ishikawa,Noriko Toyama‐Sorimachi,Kazuto Nakada,(unknown),Hirotake Imanishi,(unknown),Shigemi Sasawatari,Mamoru Niikura,Keizo Takenaga,Hiromichi Yonekawa,Jun‐Ichi Hayashi	37
11	Generation of trans‐mitochondrial mito‐mice by the introduction of a pathogenic G13997A mtDNA from highly metastatic lung carcinoma cells 2010 ·FEBS Letters ·Mutsumi Yokota,Hiroshi Shitara,Osamu Hashizume,Kaori Ishikawa,Kazuto Nakada,Rie Ishii,Choji Taya,Keizo Takenaga,Hiromichi Yonekawa,Jun‐Ichi Hayashi	33
12	ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasisbreakdown → 2008 ·Science ·Kaori Ishikawa,Keizo Takenaga,Miho Akimoto,Nobuko Koshikawa,Aya Yamaguchi,Hirotake Imanishi,Kazuto Nakada,Yoshio Honma,Jun‐Ichi Hayashi	1158
13	Modified expression of Mts1/S100A4 protein in C6 glioma cells or surrounding astrocytes affects migration of tumor cells in vitro and in vivo 2007 ·Neurobiology of Disease ·Keizo Takenaga,(unknown),Marina Zelenina,Miki Ohira,Toshihiko Iuchi,(unknown),Mats Sjöquist,Elena N. Kozlova	20
14	Role of intracellular S100A4 for migration of rat astrocytes 2005 ·Glia ·Keizo Takenaga,Elena N. Kozlova	37
15	Expression of Escherichia coli uracil phosphoribosyltransferase gene in murine colon carcinoma cells augments the antitumoral effect of 5-fluorouracil and induces protective immunity 2000 ·Cancer Gene Therapy ·Kiyoko Kawamura,(unknown),Hirofumi Hamada,Keizo Takenaga,Shigeru Sakiyama,(unknown)	18
16	Transduction of murine colon carcinoma cells with interleukin-15 gene induces antitumor effects in immunocompetent and immunocompromised hosts 2000 ·Cancer Gene Therapy ·(unknown),Yu Yoshida,(unknown),Tomoko Maeda,Keizo Takenaga,Teruo Kouzu,Takehide Asano,Takenori Ochiai,(unknown),Masatoshi Tagawa	17
17	Extracellular Role of S100A4 Calcium-Binding Protein in the Periodontal Ligament 1999 ·Biochemical and Biophysical Research Communications ·Wagner R. Duarte,Tadahiro Iimura,Keizo Takenaga,Keiichi Ohya,Isao Ishikawa,Shohei Kasugai	57
18	Loss of tumorigenicity of human pancreatic carcinoma cells engineered to produce interleukin-2 or interleukin-4 in nude mice: a potentiality for cancer gene therapy 1998 ·Cancer Letters ·Masaki Kimura,(unknown),Keizo Takenaga,Fukuo Kondo,Taketo Yamaguchi,Hiromitsu Saisho,Akira Nakagawara,S Sakiyama	12
19	Structural differences between heparan sulphates of proteoglycan involved in the formation of basement membranes in vivo by Lewis-lung-carcinoma-derived cloned cells with different metastatic potentials 1992 ·Biochemical Journal ·Hayao Nakanishi,Kayoko Oguri,Keiichi Yoshida,Naoki Itano,Keizo Takenaga,Takashi Kazama,Aichi Yoshida,Minoru Okayama	32
20	Enhanced metastatic potential of cloned low-metastatic Lewis lung carcinoma cells treated in vitro with dimethyl sulfoxide. 1984 ·PubMed ·Keizo Takenaga	42

About Keizo Takenaga

Keizo Takenaga is a scholar working on Cancer Research, Biotechnology and Molecular Biology, having authored 139 papers that have together received 4.8k indexed citations. Recurring topics across this work include Cancer, Hypoxia, and Metabolism (26 papers), S100 Proteins and Annexins (20 papers) and Mitochondrial Function and Pathology (18 papers). The work is most often cited by research in Cancer Research (1.5k citations), Molecular Biology (3.4k citations) and Immunology and Allergy (209 citations). Keizo Takenaga has collaborated with scholars based in Japan, United States and Denmark. Frequent co-authors include Nobuko Koshikawa, Jun‐Ichi Hayashi, Miho Akimoto, Yoshio Honma, Kazuto Nakada, Kaori Ishikawa, Hirotake Imanishi, Yohko Nakamura, Shigeru Sakiyama and Aya Yamaguchi. Their work appears in journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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