Kiichi Hirota

15.4k total citations · 9 hit papers
189 papers, 12.1k citations indexed

About

Kiichi Hirota is a scholar working on Molecular Biology, Cancer Research and Genetics. According to data from OpenAlex, Kiichi Hirota has authored 189 papers receiving a total of 12.1k indexed citations (citations by other indexed papers that have themselves been cited), including 87 papers in Molecular Biology, 60 papers in Cancer Research and 21 papers in Genetics. Recurrent topics in Kiichi Hirota's work include Cancer, Hypoxia, and Metabolism (57 papers), Redox biology and oxidative stress (27 papers) and High Altitude and Hypoxia (18 papers). Kiichi Hirota is often cited by papers focused on Cancer, Hypoxia, and Metabolism (57 papers), Redox biology and oxidative stress (27 papers) and High Altitude and Hypoxia (18 papers). Kiichi Hirota collaborates with scholars based in Japan, United States and United Kingdom. Kiichi Hirota's co-authors include Gregg L. Semenza, Patrick C. Mahon, Junji Yodoi, Akira Nishiyama, Minoru Matsui, Junji Yodoi, Kenjiro Mori, Satoshi Iwata, Hajime Nakamura and Hiroshi Masutani and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Journal of Clinical Investigation.

In The Last Decade

Kiichi Hirota

183 papers receiving 11.9k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

2001 1.1k citations Kiichi Hirota, Gregg L. Semenza et al. profile →
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 696 citations Kiichi Hirota, Akira Nishiyama et al. profile →
Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells

2002 684 citations Kiichi Hirota, Gregg L. Semenza et al. profile →
Correction: Corrigendum: Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate toward tumour blood vessels

2013 621 citations Hiroshi Harada, Kiichi Hirota et al. profile →
Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression

1999 615 citations Akira Nishiyama, Kiichi Hirota et al. profile →
Cell Type–Specific Regulation of Angiogenic Growth Factor Gene Expression and Induction of Angiogenesis in Nonischemic Tissue by a Constitutively Active Form of Hypoxia-Inducible Factor 1

2003 512 citations Kiichi Hirota, Gregg L. Semenza et al. profile →
Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus

1999 502 citations Kiichi Hirota, Miyahiko Murata et al. profile →
Regulation of angiogenesis by hypoxia-inducible factor 1

2006 367 citations Kiichi Hirota, Gregg L. Semenza profile →
Full-length 16S rRNA gene amplicon analysis of human gut microbiota using MinION™ nanopore sequencing confers species-level resolution

2021 209 citations Yoshiyuki Matsuo, Katsura Mizushima et al. profile →

Peers

Countries citing papers authored by Kiichi Hirota

Since Specialization

Citations

This map shows the geographic impact of Kiichi Hirota's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kiichi Hirota with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kiichi Hirota more than expected).

Fields of papers citing papers by Kiichi Hirota

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kiichi Hirota. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kiichi Hirota. The network helps show where Kiichi Hirota may publish in the future.

Co-authorship network of co-authors of Kiichi Hirota

This figure shows the co-authorship network connecting the top 25 collaborators of Kiichi Hirota. A scholar is included among the top collaborators of Kiichi Hirota based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kiichi Hirota. Kiichi Hirota is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Identification of beneficial symbiont candidates in commensalism as potential oral gatekeepers 2025 ·Microbiology Spectrum ·(unknown), (unknown), Tamotsu Kato, Yoshiyuki Matsuo, (unknown), (unknown), (unknown), Koji Yamanegi, Kiichi Hirota, Hiroshi Ohno, Hideki Ogura, Satoshi Ishido, Kazuhito Noguchi, Hiromitsu Kishimoto	0
2	Dexmedetomidine suppresses glucose‐stimulated insulin secretion in pancreatic β‐cells 2024 ·FEBS Open Bio ·M. Kusunoki, Kiichi Hirota, (unknown), (unknown), Yoshiyuki Matsuo, Mikio Hayashi	0
3	Impact of neoadjuvant therapy on gut microbiome in patients with resectable/borderline resectable pancreatic ductal adenocarcinoma 2023 ·Pancreatology ·(unknown), Daisuke Hashimoto, Tsukasa Ikeura, Takashi Ito, (unknown), (unknown), Shinji Nakayama, So Yamaki, Tomohisa Yamamoto, Kosuke Fujimoto, Yoshiyuki Matsuo, Shohei Akagawa, Mitsuaki Ishida, Kiyoshi Yamaguchi, Seiya Imoto, Kiichi Hirota, Satoshi Uematsu, Sohei Satoi, Mitsugu Sekimoto, Makoto Naganuma	4
4	A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS5 2022 ·PNAS Nexus ·Motoki Watanabe, Shogen Boku, (unknown), (unknown), Mamiko Sukeno, Mitsuharu Masuda, Katsura Mizushima, (unknown), Yosuke Iizumi, Kiichi Hirota, Yuji Naito, Michihiro Mutoh, Tomoshi Kameda, Toshiyuki Sakai	1
5	Isolation and Characterization of Mammalian Otic Progenitor Cells that Can Differentiate into Both Sensory Epithelial and Neuronal Cell Lineages 2020 ·The Anatomical Record ·Ken Kojima, (unknown), Kei Tashiro, Kiichi Hirota, Takeshi Nishio, Miyahiko Murata, Nobuo Kato, Saburo Kawaguchi, Azel Zine, Juichi Ito, Thomas R. Van De Water	3
6	A proposal for a new temperature-corrected formula for the oxygen content of blood 2020 ·SHILAP Revista de lepidopterología ·Kiichi Hirota, Miyahiko Murata, Koh Shingu	0
7	Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner 2016 ·Scientific Reports ·Hiroki Daijo, Yuma Hoshino, Shinichi Kai, Kengo Suzuki, Kenichiro Nishi, Yoshiyuki Matsuo, Hiroshi Harada, Kiichi Hirota	58
8	VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway 2016 ·Tumor Biology ·Ryuji Yamaguchi, Hiroshi Harada, Kiichi Hirota	11
9	The volatile anesthetic isoflurane differentially suppresses the induction of erythropoietin synthesis elicited by acute anemia and systemic hypoxemia in mice in an hypoxia-inducible factor-2-dependent manner 2014 ·European Journal of Pharmacology ·Shinichi Kai, Tomoharu Tanaka, (unknown), Kengo Suzuki, Kiichi Hirota	7
10	Hydrogen Sulfide Inhibits Hypoxia- But Not Anoxia-Induced Hypoxia-Inducible Factor 1 Activation in a von Hippel-Lindau- and Mitochondria-Dependent Manner 2011 ·Antioxidants and Redox Signaling ·Shinichi Kai, Tomoharu Tanaka, Hiroki Daijo, Hiroshi Harada, Shun Kishimoto, Kengo Suzuki, Satoshi Takabuchi, Keizo Takenaga, Kazuhiko Fukuda, Kiichi Hirota	68
11	Effects of n-propyl gallate on neuronal survival after forebrain ischemia in rats 2011 ·Resuscitation ·(unknown), Masahiko Kawaguchi, Kiichi Hirota, Shinichi Kai, Noboru Konishi, Hitoshi Furuya	3
12	Anesthetic Management of Adult Ambulatory Surgery in Kyoto University Hospital 2010 ·THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA ·Masami Sato, Gotaro Shirakami, Kiichi Hirota, Kazuhiko Fukuda	0
13	Successful airway management with use of a laryngeal mask airway in a patient with CHARGE syndrome 2009 ·Journal of Anesthesia ·Yusuke Hara, Kiichi Hirota, Kazuhiko Fukuda	6
14	Hypoxia and Hypoxia-Inducible Factor-1 Expression Enhance Osteolytic Bone Metastases of Breast Cancer 2007 ·Cancer Research ·Toru Hiraga, Shinae Kizaka‐Kondoh, Kiichi Hirota, Masahiro Hiraoka, Toshiyuki Yoneda	193
15	Anoxic depolarization of rat hippocampal slices is prevented by thiopental but not by propofol or isoflurane 2005 ·British Journal of Anaesthesia ·(unknown), Kiichi Hirota, Steven Roth, Masako Yamazaki	12
16	Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases 2005 ·Biochemical and Biophysical Research Communications ·Kiichi Hirota, Gregg L. Semenza	189
17	Thioredoxin Superfamily and Thioredoxin‐Inducing Agents 2002 ·Annals of the New York Academy of Sciences ·Kiichi Hirota, Hajime Nakamura, Hiroshi Masutani, Junji Yodoi	127
18	Mouse glutaredoxin — cDNA cloning, high level expression in E. coli and its possible implication in redox regulation of the DNA binding activity in transcription factor PEBP2 1999 ·Free Radical Research ·Takayuki Nakamura, (unknown), Kiichi Hirota, Akira Nishiyama, Hajime Nakamura, Hiromi Wada, Junji Yodoi	25
19	High prevalence of cytotoxin positive Helicobacter pylori in patients unrelated to the presence of peptic ulcers in Japan 1997 ·Gut ·K. Ogura, Fumihiko Kanai, Shin Maeda, Hisako Yoshida, Mitsuo Ogura, Keng‐Hsin Lan, Kiichi Hirota, Takeshi Kawabe, Yasushi Shiratori, Masao Omata	37
20	Antihepatotoxic principles of Artemisia capillaris buds. 1984 ·PubMed ·Yoshinobu Kiso, Satoshi Ogasawara, Kiichi Hirota, Noriko Watanabe, Yoshiteru Oshima, Chohachi Konno, Hiroshi Hikino	43

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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