Keith Brew

16.2k total citations · 5 hit papers
170 papers, 13.3k citations indexed

About

Keith Brew is a scholar working on Molecular Biology, Cancer Research and Genetics. According to data from OpenAlex, Keith Brew has authored 170 papers receiving a total of 13.3k indexed citations (citations by other indexed papers that have themselves been cited), including 99 papers in Molecular Biology, 44 papers in Cancer Research and 39 papers in Genetics. Recurrent topics in Keith Brew's work include Protease and Inhibitor Mechanisms (43 papers), Enzyme Structure and Function (32 papers) and Glycosylation and Glycoproteins Research (31 papers). Keith Brew is often cited by papers focused on Protease and Inhibitor Mechanisms (43 papers), Enzyme Structure and Function (32 papers) and Glycosylation and Glycoproteins Research (31 papers). Keith Brew collaborates with scholars based in United States, United Kingdom and Germany. Keith Brew's co-authors include Hideaki Nagase, Deendayal Dinakarpandian, Thomas Vanaman, Robert L. Hill, K. Ravi Acharya, Robert L. Hill, Sudhir K. Sinha, Janet T. Powell, Masahide Kashiwagi and Micky D. Tortorella and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Keith Brew

169 papers receiving 12.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Tissue inhibitors of metalloproteinases: evolution, structure and function

2000 1.6k citations Keith Brew, Deendayal Dinakarpandian et al. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology profile →
The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

2010 1.0k citations Keith Brew, Hideaki Nagase Biochimica et Biophysica Acta (BBA) - Molecular Cell Research profile →
Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1

1997 501 citations Hideaki Nagase, Keith Brew et al. profile →
A possible three-dimensional structure of bovine α-lactalbumin based on that of hen's egg-white lysozyme

1969 416 citations Keith Brew et al. Journal of Molecular Biology profile →
The role of alpha-lactalbumin and the A protein in lactose synthetase: a unique mechanism for the control of a biological reaction.

1968 373 citations Keith Brew et al. profile →

Peers

Countries citing papers authored by Keith Brew

Since Specialization

Citations

This map shows the geographic impact of Keith Brew's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Keith Brew with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Keith Brew more than expected).

Fields of papers citing papers by Keith Brew

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Keith Brew. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Keith Brew. The network helps show where Keith Brew may publish in the future.

Co-authorship network of co-authors of Keith Brew

This figure shows the co-authorship network connecting the top 25 collaborators of Keith Brew. A scholar is included among the top collaborators of Keith Brew based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Keith Brew. Keith Brew is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Thermodynamic Basis of Selectivity in the Interactions of Tissue Inhibitors of Metalloproteinases N-domains with Matrix Metalloproteinases-1, -3, and -14 2016 ·Journal of Biological Chemistry ·(unknown), Ying Wu, Keith Brew	5
2	The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity breakdown → 2010 ·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·Keith Brew, Hideaki Nagase	1036
3	A New Role for TIMP-1 in Modulating Neurite Outgrowth and Morphology of Cortical Neurons 2009 ·PLoS ONE ·(unknown), Évelyne Tremblay, Oualid Sbai, Lotfi Ferhat, Anne Bernard, Eliane Charrat, Yatma Gueye, Ngee Han Lim, Keith Brew, Jean‐Jacques Risso, Vincent Dive, (unknown), Santiago Rivera	52
4	Selective Modulation of Matrix Metalloproteinase 9 (MMP-9) Functions via Exosite Inhibition 2008 ·Journal of Biological Chemistry ·Janelle L. Lauer‐Fields, (unknown), Shunzi Li, Robert P. Hammer, Keith Brew, Gregg B. Fields	73
5	Tissue Inhibitor of Metalloproteinases-1 Promotes Liver Metastasis by Induction of Hepatocyte Growth Factor Signaling 2007 ·Cancer Research ·Charlotte Kopitz, Michael Gerg, Obul Reddy Bandapalli, (unknown), Caroline J. Pennington, (unknown), (unknown), (unknown), Dalibor Antolovic, Keith Brew, Hideaki Nagase, Manfred Stangl, Claus W. Hann von Weyhern, Björn L.D.M. Brücher, Karsten Brand, Lisa M. Coussens, Dylan R. Edwards, Achim Krüger	128
6	Constraining specificity in the N‐domain of tissue inhibitor of metalloproteinases‐1; gelatinase‐selective inhibitors 2007 ·Protein Science ·(unknown), Shuo Wei, Harinath Bahudhanapati, Smitha Kota, K. Ravi Acharya, Keith Brew	56
7	Conformational Changes Induced by Binding UDP-2F-galactose to α-1,3 Galactosyltransferase- Implications for Catalysis 2007 ·Journal of Molecular Biology ·Haryati Jamaluddin, Percy Tumbale, Stephen G. Withers, K. Ravi Acharya, Keith Brew	43
8	Energetics of Binding the Mammalian High Mobility Group Protein HMGA2 to poly(dA-dT)2 and poly(dA)-poly(dT) 2005 ·Journal of Molecular Biology ·Tengjiao Cui, Shuo Wei, Keith Brew, Fenfei Leng	32
9	Presence of tear lipocalin and other major proteins in lacrimal fluid of rabbits 2004 ·Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology ·Ana Maria Azzarolo, Keith Brew, Smitha Kota, (unknown), Jonathan Schwartz, Claudia Zylberberg	33
10	Increased Backbone Mobility in β-Barrel Enhances Entropy Gain Driving Binding of N-TIMP-1 to MMP-3 2003 ·Journal of Molecular Biology ·Sengodagounder Arumugam, Guanghua Gao, (unknown), Valentyna Semenchenko, Keith Brew, Steven R. Van Doren	68
11	Specificity and Mechanism of Metal Ion Activation in UDP-galactose:β-Galactoside-α-1,3-galactosyltransferase 2001 ·Journal of Biological Chemistry ·Yingnan Zhang, Peng George Wang, Keith Brew	45
12	TIMP-3 Binds to Sulfated Glycosaminoglycans of the Extracellular Matrix 2000 ·Journal of Biological Chemistry ·Wei‐Hsuan Yu, (unknown), Qi Meng, Keith Brew, J. Frederick Woessner	276
13	Tissue inhibitors of metalloproteinases: evolution, structure and function breakdown → 2000 ·Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology ·Keith Brew, Deendayal Dinakarpandian, Hideaki Nagase	1564
14	Primary structure of the major isomorph of the crustacean hyperglycemic hormone (CHH-I) from the sinus gland of the Mexican crayfish Procambarus bouvieri (Ortmann): Interspecies comparison 1993 ·Peptides ·Alberto Huberman, Manuel B. Aguilar, Keith Brew, Jeffrey Shabanowitz, Donald F. Hunt	60
15	Mapping of the calpain proteolysis products of the junctional foot protein of the skeletal muscle triad junction 1992 ·The Journal of Membrane Biology ·(unknown), (unknown), (unknown), Keith Brew, (unknown)	44
16	Characterization of 58-kilodalton human neutrophil collagenase: comparison with human fibroblast collagenase 1990 ·Biochemistry ·Satish Mallya, Kasim A. Mookhtiar, Yi Gao, Keith Brew, Marianna Dioszegi, Henning Birkedal‐Hansen, Harold E. Van Wart	79
17	Calcium regulates folding and disulfide-bond formation in α-lactalbumin 1989 ·Biochemical and Biophysical Research Communications ·(unknown), Keith Brew	47
18	Cloning and mapping of a testis-specific gene with sequence similarity to a sperm-coating glycoprotein gene 1989 ·Genomics ·Masanori Kasahara, Jutta Gutknecht, Keith Brew, Nigel K. Spurr, Peter N. Goodfellow	142
19	Sequence of a full-length cDNA for rat lung .beta.-galactoside-binding protein: primary and secondary structure of the lectin 1988 ·Biochemistry ·Linda Biadasz Clerch, Philip L. Whitney, Michael A. Hass, Keith Brew, Todd Miller, Rudolf Werner, Donald Massaro	124
20	Isolation of a calcium‐sensitive, 35,000‐dalton microfilament‐ and liposome‐binding protein from ascites tumor cell microvilli: Identification as monomeric calpactin 1987 ·Journal of Cellular Biochemistry ·(unknown), Keith Brew, Kermit L. Carraway, Coralie A. Carothers Carraway	10

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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