Kazuhiko Koike

56.4k total citations · 10 hit papers
1.0k papers, 36.4k citations indexed

About

Kazuhiko Koike is a scholar working on Surgery, Pulmonary and Respiratory Medicine and Epidemiology. According to data from OpenAlex, Kazuhiko Koike has authored 1.0k papers receiving a total of 36.4k indexed citations (citations by other indexed papers that have themselves been cited), including 441 papers in Surgery, 341 papers in Pulmonary and Respiratory Medicine and 325 papers in Epidemiology. Recurrent topics in Kazuhiko Koike's work include Liver Disease Diagnosis and Treatment (209 papers), Pancreatic and Hepatic Oncology Research (162 papers) and Gallbladder and Bile Duct Disorders (157 papers). Kazuhiko Koike is often cited by papers focused on Liver Disease Diagnosis and Treatment (209 papers), Pancreatic and Hepatic Oncology Research (162 papers) and Gallbladder and Bile Duct Disorders (157 papers). Kazuhiko Koike collaborates with scholars based in Japan, United States and China. Kazuhiko Koike's co-authors include Kyoji Moriya, Hiroyuki Isayama, Yousuke Nakai, Josep M. Llovet, Augusto Villanueva, Riccardo Lencioni, Richard S. Finn, Eli Pikarsky, Robin Kate Kelley and Jessica Zucman‐Rossi and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

In The Last Decade

Kazuhiko Koike

997 papers receiving 35.8k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Hepatocellular carcinoma

2021 4.1k citations Josep M. Llovet, Robin Kate Kelley et al. Nature Reviews Disease Primers profile →
Correction: Corrigendum: MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma

2012 1.2k citations Motoyuki Otsuka, Masao Akanuma et al. profile →
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice

1998 982 citations Kyoji Moriya, Hiroshi Yotsuyanagi et al. profile →
Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance

2004 601 citations Takeya Tsutsumi, Kyoji Moriya et al. profile →
Radiofrequency Ablation for Hepatocellular Carcinoma: 10-Year Outcome and Prognostic Factors

2011 547 citations Ryosuke Tateishi, Kenichiro Enooku et al. profile →
Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma

2015 544 citations Hayato Nakagawa, Yotaro Kudo et al. profile →
ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

2014 396 citations Hayato Nakagawa, Atsushi Umemura et al. profile →
Japan Gastroenterological Endoscopy Society guidelines for colorectal endoscopic submucosal dissection/endoscopic mucosal resection

2019 252 citations Kazuhiko Koike et al. Digestive Endoscopy profile →
Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020

2021 179 citations Motoyuki Otsuka, Kazuhiko Koike et al. Journal of Gastroenterology profile →
Evidence-based clinical practice guidelines for peptic ulcer disease 2020

2021 149 citations Tomoari Kamada, Kiichi Satoh et al. Journal of Gastroenterology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Kazuhiko Koike Japan	80	11.4k	10.3k	10.2k	8.7k	8.5k	1.0k	36.4k
Kazuaki Chayama Japan	99	15.7k 1.4×	14.9k 1.4×	10.7k 1.0×	9.8k 1.1×	7.4k 0.9×	1.4k	45.3k
Yoshihiko Maehara Japan	92	6.2k 0.5×	8.7k 0.8×	14.4k 1.4×	12.2k 1.4×	13.5k 1.6×	1.7k	42.9k
Masao Omata Japan	112	17.7k 1.6×	19.5k 1.9×	13.6k 1.3×	9.3k 1.1×	8.9k 1.1×	1.1k	50.7k
Peter Schirmacher Germany	86	9.2k 0.8×	10.6k 1.0×	6.8k 0.7×	6.7k 0.8×	11.6k 1.4×	681	36.7k
Nicholas F. LaRusso United States	97	7.4k 0.6×	10.8k 1.0×	12.2k 1.2×	6.1k 0.7×	5.2k 0.6×	404	28.1k
Peter R. Galle Germany	102	16.1k 1.4×	19.4k 1.9×	11.0k 1.1×	7.4k 0.8×	13.4k 1.6×	1.2k	55.7k
Masatoshi Kudo Japan	103	17.6k 1.5×	30.9k 3.0×	11.0k 1.1×	8.6k 1.0×	13.1k 1.5×	1.4k	48.7k
Masatoshi Makuuchi Japan	97	13.2k 1.2×	28.1k 2.7×	25.3k 2.5×	9.6k 1.1×	11.8k 1.4×	782	48.1k
Yuman Fong United States	120	9.7k 0.9×	20.1k 1.9×	25.0k 2.4×	15.9k 1.8×	27.9k 3.3×	859	56.6k
Yoshio Yamaoka Japan	91	5.7k 0.5×	8.8k 0.9×	23.5k 2.3×	5.0k 0.6×	3.5k 0.4×	814	35.9k

Countries citing papers authored by Kazuhiko Koike

Since Specialization

Citations

This map shows the geographic impact of Kazuhiko Koike's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kazuhiko Koike with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kazuhiko Koike more than expected).

Fields of papers citing papers by Kazuhiko Koike

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kazuhiko Koike. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kazuhiko Koike. The network helps show where Kazuhiko Koike may publish in the future.

Co-authorship network of co-authors of Kazuhiko Koike

This figure shows the co-authorship network connecting the top 25 collaborators of Kazuhiko Koike. A scholar is included among the top collaborators of Kazuhiko Koike based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kazuhiko Koike. Kazuhiko Koike is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Nishikawa, Takako, Natsuko Ohtomo, Yukiko Inoue, et al.. (2025). Insulin-like Growth Factor-I Reduces Collagen Production by Hepatic Stellate Cells Through Stimulation of Collagen Degradation System via mTOR-Dependent Signaling Pathway. Biomedicines. 13(3). 566–566. 1 indexed citations

Takahashi, Atsushi, Hiromasa Ohira, Kazumichi Abe, et al.. (2024). Autoimmune Hepatitis with Metabolic Dysfunction-associated Fatty Liver Disease. Internal Medicine. 64(3). 337–342. 1 indexed citations

Sato, Masaya, Masaya Sato, Takashi Tanaka, et al.. (2021). Development of novel deep multimodal representation learning‐based model for the differentiation of liver tumors on B‐mode ultrasound images. Journal of Gastroenterology and Hepatology. 37(4). 678–684. 18 indexed citations

Llovet, Josep M., Robin Kate Kelley, Augusto Villanueva, et al.. (2021). Hepatocellular carcinoma. Nature Reviews Disease Primers. 7(1). 6–6. 4089 indexed citations breakdown →

Kamada, Tomoari, Kiichi Satoh, Toshiyuki Itoh, et al.. (2021). Evidence-based clinical practice guidelines for peptic ulcer disease 2020. Journal of Gastroenterology. 56(4). 303–322. 149 indexed citations breakdown →

Okushin, Kazuya, Takeya Tsutsumi, Kazuhiko Ikeuchi, et al.. (2020). Heterozygous knockout of Bile salt export pump ameliorates liver steatosis in mice fed a high-fat diet. PLoS ONE. 15(8). e0234750–e0234750. 13 indexed citations

Ishigaki, Kazunaga, Yousuke Nakai, Hiroki Oyama, et al.. (2020). Endoscopic Ultrasound-Guided Tissue Acquisition by 22-Gauge Franseen and Standard Needles for Solid Pancreatic Lesions. Gut and Liver. 14(6). 817–825. 20 indexed citations

Tatsuno, Kenji, Yutaka Midorikawa, Tadatoshi Takayama, et al.. (2019). Impact of AAV2 and Hepatitis B Virus Integration Into Genome on Development of Hepatocellular Carcinoma in Patients with Prior Hepatitis B Virus Infection. Clinical Cancer Research. 25(20). 6217–6227. 26 indexed citations

Ono, Satoshi, Tetsuo Ushiku, Yotaro Kudo, et al.. (2018). Transparency‐enhancing technology allows three‐dimensional assessment of gastrointestinal mucosa: A porcine model. Pathology International. 68(2). 102–108. 20 indexed citations

10.

Niikura, Ryota, Yoku Hayakawa, Yoshihiro Hirata, et al.. (2018). Distinct Chemopreventive Effects of Aspirin in Diffuse and Intestinal-Type Gastric Cancer. Cancer Prevention Research. 11(5). 279–286. 12 indexed citations

11.

Kishikawa, Takahiro, Motoyuki Otsuka, Tatsunori Suzuki, et al.. (2018). Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models of Pancreatic Cancer. Molecular Cancer Research. 16(8). 1255–1262. 11 indexed citations

12.

Nakagawa, Hayato, Yohko Hikiba, Yoshihiro Hirata, et al.. (2014). Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis. Proceedings of the National Academy of Sciences. 111(3). 1090–1095. 95 indexed citations

13.

Miyabayashi, Koji, Hideaki Ijichi, Dai Mohri, et al.. (2013). Erlotinib Prolongs Survival in Pancreatic Cancer by Blocking Gemcitabine-Induced MAPK Signals. Cancer Research. 73(7). 2221–2234. 40 indexed citations

14.

Ono, Satoshi, Mitsuhiro Fujishiro, Shinya Kodashima, et al.. (2012). Evaluation of safety of endoscopic biopsy without cessation of antithrombotic agents in Japan. Journal of Gastroenterology. 47(7). 770–774. 37 indexed citations

15.

Niimi, Keiko, Osamu Goto, Mitsuhiro Fujishiro, et al.. (2012). Endoscopic mucosal resection with a ligation device or endoscopic submucosal dissection for rectal carcinoid tumors: An analysis of 24 consecutive cases. Digestive Endoscopy. 24(6). 443–447. 47 indexed citations

16.

Nakagawa, Hayato, Akihiro Isogawa, Ryosuke Tateishi, et al.. (2011). Serum gamma-glutamyltransferase level is associated with serum superoxide dismutase activity and metabolic syndrome in a Japanese population. Journal of Gastroenterology. 47(2). 187–194. 14 indexed citations

17.

Misawa, Yoshiki, Ryoichi Saito, Kyoji Moriya, et al.. (2007). Application of loop-mediated isothermal amplification technique to rapid and direct detection of methicillin-resistant Staphylococcus aureus (MRSA) in blood cultures. Journal of Infection and Chemotherapy. 13(3). 134–140. 91 indexed citations

18.

Koike, Kazuhiko, et al.. (2005). A Novel Type of Kleptoplastidy in (Dinophyceae): Presence of Haptophyte-type Plastid in. Protist. 156(2). 225–237. 53 indexed citations

19.

Koike, Kazuhiko. (2005). Molecular Basis of Hepatitis C Virus–Associated Hepatocarcinogenesis: Lessons From Animal Model Studies. Clinical Gastroenterology and Hepatology. 3(10 Suppl 2). S132–S135. 70 indexed citations

20.

Koike, Kazuhiko, Kyoji Moriya, Kohei Ishibashi, et al.. (1995). Expression of hepatitis C virus envelope proteins in transgenic mice. Journal of General Virology. 76(12). 3031–3038. 74 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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