Karl J. Okolotowicz

417 citations

20 papers · 337 indexed · h-index 13

Organic Chemistry
Pharmacology
- Cholinesterase and Neurodegenerative Diseases 3
Molecular Biology
- Receptor Mechanisms and Signaling 3
- Chemical Synthesis and Analysis 2
Toxicology
Oncology
Cardiology and Cardiovascular Medicine
- Cardiac electrophysiology and arrhythmias 4
Cancer Research
- NF-κB Signaling Pathways 3
Immunology
- interferon and immune responses 2
Computational Theory and Mathematics
- Computational Drug Discovery Methods 2
Cellular and Molecular Neuroscience
- Neuroscience and Neural Engineering 2

Co-authors: John R. Cashman Mark Mercola Jiongjia Cheng Mary A. Dwyer Mary MacDonald Daniel A. J. Ryan Marion Lanier Paul Bushway
Cited by: Organic Chemistry Pharmacology Molecular Biology
Partner nations: United States

In The Last Decade

Karl J. Okolotowicz

20 papers receiving 333 citations

Peers

Countries citing papers authored by Karl J. Okolotowicz

Since Specialization

Citations

This map shows the geographic impact of Karl J. Okolotowicz's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Karl J. Okolotowicz with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Karl J. Okolotowicz more than expected).

Fields of papers citing papers by Karl J. Okolotowicz

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Karl J. Okolotowicz. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Karl J. Okolotowicz. The network helps show where Karl J. Okolotowicz may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Karl J. Okolotowicz, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Karl J. Okolotowicz Line = papers co-authored together Karl J. Okolotowicz links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Human iPSC-derived cardiomyocytes and pyridyl-phenyl mexiletine analogs Mark T. Johnson,Jorge Gomez‐Galeno,Daniel A. J. Ryan,Karl J. Okolotowicz,Wesley L. McKeithan,Kevin J. Sampson,Robert S. Kass,Mark Mercola,John R. Cashman	2021	7
2	Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes John R. Cashman,Daniel A. J. Ryan,Wesley L. McKeithan,Karl J. Okolotowicz,Jorge Gomez‐Galeno,Mark Johnson,Kevin J. Sampson,Robert S. Kass,Arash Pezhouman,Hrayr S. Karagueuzian,Mark Mercola	2021	7
3	Human‐induced pluripotent stem cell‐derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs Jorge Gomez‐Galeno,Karl J. Okolotowicz,Mark Johnson,Wesley L. McKeithan,Mark Mercola,John R. Cashman	2021	2
4	Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity Wesley L. McKeithan,Dries Feyen,Arne A.N. Bruyneel,Karl J. Okolotowicz,Daniel A. J. Ryan,Kevin J. Sampson,F Potet,A. K. Savchenko,Jorge Gomez‐Galeno,Michelle M. Vu,Ricardo Serrano,Alfred L. George,Robert S. Kass,John R. Cashman,Mark Mercola	2020	35
5	A Novel Small Molecule Inhibits Tumor Growth and Synergizes Effects of Enzalutamide on Prostate Cancer Jiongjia Cheng,Stephanie Moore,Jorge Gomez‐Galeno,Donghoon Lee,Karl J. Okolotowicz,John R. Cashman	2019	13
6	Inhibition of invasive pancreatic cancer: restoring cell apoptosis by activating mitochondrial p53. Jiongjia Cheng,Karl J. Okolotowicz,Daniel A. J. Ryan,Evangeline Mose,Andrew M. Lowy,John R. Cashman	2019	13
7	A Novel Inhibitor Targets Both Wnt Signaling and ATM/p53 in Colorectal Cancer Jiongjia Cheng,Mary A. Dwyer,Karl J. Okolotowicz,Mark Mercola,John R. Cashman	2018	22
8	Novel tertiary sulfonamides as potent anti-cancer agents Karl J. Okolotowicz,Mary A. Dwyer,Daniel A. J. Ryan,Jiongjia Cheng,Emily A. Cashman,Stephanie Moore,Mark Mercola,John R. Cashman	2018	25
9	1,5-Disubstituted benzimidazoles that direct cardiomyocyte differentiation from mouse embryonic stem cells Karl J. Okolotowicz,Paul Bushway,Marion Lanier,Cynthia B. Gilley,Mark Mercola,John R. Cashman	2015	13
10	Stereoselective synthesis of mexiletine and structural analogs with chiral tert-butanesulfinamide Daniel A. J. Ryan,Karl J. Okolotowicz,Mark Mercola,John R. Cashman	2015	6
11	Preclinical Studies of Noncharged Oxime Reactivators for Organophosphate Exposure Karl J. Okolotowicz,Mary A. Dwyer,Emily Smith,John R. Cashman	2013	15
12	Substituted heteroaromatic compounds: effect on nicotine self-administration in rats John R. Cashman,Karl J. Okolotowicz,Matt A. Cerny,Robert A. Johnson,Aaron Janowsky,Marc R. Azar	2012	1
13	Synthesis and SAR of b-Annulated 1,4-Dihydropyridines Define Cardiomyogenic Compounds as Novel Inhibitors of TGFβ Signaling Dennis Schade,Marion Lanier,Erik Willems,Karl J. Okolotowicz,Paul Bushway,Christine Wahlquist,Cynthia B. Gilley,Mark Mercola,John R. Cashman	2012	59
14	Direct detection of the hydrolysis of nerve agent model compounds using a fluorescent probe Xueying Zheng,Karl J. Okolotowicz,Beilin Wang,Mary MacDonald,John R. Cashman,Jun Zhang	2010	15
15	Inhibition of Bfl-1 with N-aryl maleimides John R. Cashman,Mary MacDonald,Senait Ghirmai,Karl J. Okolotowicz,Eduard Sergienko,Brock Brown,Xochella Garcia,Dayong Zhai,Russell Dahl,John C. Reed	2010	23
16	Selective benzimidazole inhibitors of the antigen receptor-mediated NF-κB activation pathway Karl J. Okolotowicz,Ranxin Shi,Xueying Zheng,Mary MacDonald,John C. Reed,John R. Cashman	2010	11
17	Chemical Biology Strategy Reveals Pathway-Selective Inhibitor of NF-κB Activation Induced by Protein Kinase C Ranxin Shi,Daniel Ré,Eric Dudl,Michael Cuddy,Karl J. Okolotowicz,Russell Dahl,Ying Su,Andrew Hurder,Shinichi Kitada,Satyamaheshwar Peddibhotla,Gregory P. Roth,Layton H. Smith,Thomas J. Kipps,Nicholas D. P. Cosford,John R. Cashman,John C. Reed	2010	14
18	Inhibition of Protein Kinase C-Driven Nuclear Factor-κB Activation: Synthesis, Structure−Activity Relationship, and Pharmacological Profiling of Pathway Specific Benzimidazole Probe Molecules Satyamaheshwar Peddibhotla,Ranxin Shi,Pasha M. Khan,Layton H. Smith,Arianna Mangravita-Novo,Michael Vicchiarelli,Ying Su,Karl J. Okolotowicz,John R. Cashman,John C. Reed,Gregory P. Roth	2010	16
19	Chemical Synthesis of Two Series of Nerve Agent Model Compounds and Their Stereoselective Interaction with Human Acetylcholinesterase and Human Butyrylcholinesterase Nora H. Barakat,Xueying Zheng,Cynthia B. Gilley,Mary MacDonald,Karl J. Okolotowicz,John R. Cashman,Shubham Vyas,Jeremy M. Beck,Christopher M. Hadad,Jun Zhang	2009	39
20	Inactivation of Protein Farnesyltransferase by Active-Site-Targeted Dicarbonyl Compounds Karl J. Okolotowicz,Wei‐Jen Lee,Rosemarie F. Hartman,Ann Y. Kim,Steven R. Ottersberg,Dale Robinson,Scott R. Lefler,Seth D. Rose	2001	1

About Karl J. Okolotowicz

Karl J. Okolotowicz is a scholar working on Cancer Research, Molecular Biology and Pharmacology, having authored 20 papers that have together received 337 indexed citations. Recurring topics across this work include Cardiac electrophysiology and arrhythmias (4 papers), Cholinesterase and Neurodegenerative Diseases (3 papers), Receptor Mechanisms and Signaling (3 papers), NF-κB Signaling Pathways (3 papers), Chemical Synthesis and Analysis (2 papers), interferon and immune responses (2 papers), Computational Drug Discovery Methods (2 papers) and Neuroscience and Neural Engineering (2 papers). The work is most often cited by research in Organic Chemistry (102 citations), Pharmacology (46 citations) and Molecular Biology (164 citations). Karl J. Okolotowicz has collaborated with scholars based in United States. Frequent co-authors include John R. Cashman, Mark Mercola, Jiongjia Cheng, Mary A. Dwyer, Mary MacDonald, Daniel A. J. Ryan, Marion Lanier, Paul Bushway, Dennis Schade and Christine Wahlquist.

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