Kanji Higashio

16.1k total citations · 7 hit papers
84 papers, 13.3k citations indexed

About

Kanji Higashio is a scholar working on Molecular Biology, Oncology and Hepatology. According to data from OpenAlex, Kanji Higashio has authored 84 papers receiving a total of 13.3k indexed citations (citations by other indexed papers that have themselves been cited), including 48 papers in Molecular Biology, 38 papers in Oncology and 25 papers in Hepatology. Recurrent topics in Kanji Higashio's work include Bone Metabolism and Diseases (35 papers), Bone health and treatments (32 papers) and Liver physiology and pathology (25 papers). Kanji Higashio is often cited by papers focused on Bone Metabolism and Diseases (35 papers), Bone health and treatments (32 papers) and Liver physiology and pathology (25 papers). Kanji Higashio collaborates with scholars based in Japan, Australia and United States. Kanji Higashio's co-authors include Hisataka Yasuda, Tomonori Morinaga, Toshio Suda, Nobuyuki Shima, N. Nakagawa, Masaaki Goto, Kyoji Yamaguchi, Kazuki Yano, Nobuyuki Udagawa and Masahiko Kinosaki and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and The Journal of Experimental Medicine.

In The Last Decade

Kanji Higashio

84 papers receiving 13.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

1998 3.5k citations Hisataka Yasuda, Nobuyuki Shima et al. profile →
Tumor Necrosis Factor α Stimulates Osteoclast Differentiation by a Mechanism Independent of the Odf/Rankl–Rank Interaction

2000 1.1k citations Naoyuki Takahashi, Eijiro Jimi et al. profile →
Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesisin Vitro¹

1998 984 citations Hisataka Yasuda, Nobuyuki Shima et al. Endocrinology profile →
Severe Osteoporosis in Mice Lacking Osteoclastogenesis Inhibitory Factor/Osteoprotegerin

1998 634 citations Atsuko Mizuno, Akihiko Murakami et al. Biochemical and Biophysical Research Communications profile →
Isolation of a Novel Cytokine from Human Fibroblasts That Specifically Inhibits Osteoclastogenesis

1997 623 citations Toshio Suda, Masaaki Goto et al. Biochemical and Biophysical Research Communications profile →
Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 95: 3597-602

1998 597 citations Hisataka Yasuda, N. Nakagawa et al. profile →
RANK Is the Essential Signaling Receptor for Osteoclast Differentiation Factor in Osteoclastogenesis

1998 591 citations N. Nakagawa, Masahiko Kinosaki et al. Biochemical and Biophysical Research Communications profile →

Peers

Countries citing papers authored by Kanji Higashio

Since Specialization

Citations

This map shows the geographic impact of Kanji Higashio's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kanji Higashio with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kanji Higashio more than expected).

Fields of papers citing papers by Kanji Higashio

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kanji Higashio. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kanji Higashio. The network helps show where Kanji Higashio may publish in the future.

Co-authorship network of co-authors of Kanji Higashio

This figure shows the co-authorship network connecting the top 25 collaborators of Kanji Higashio. A scholar is included among the top collaborators of Kanji Higashio based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kanji Higashio. Kanji Higashio is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Parathyroid Hormone-induced Bone Resorption Does Not Occur in the Absence of Osteopontin 2001 ·Journal of Biological Chemistry ·(unknown), David T. Denhardt, (unknown), Teruhito Yamashita, Yukari Muguruma, Kunikazu Tsuji, Keith A. Hruska, Kanji Higashio, Shoji ENOMOTO, Akira Nifuji, Susan R. Rittling, Masaki Noda	104
2	Bone Morphogenetic Protein 2 Stimulates Osteoclast Differentiation and Survival Supported by Receptor Activator of Nuclear Factor-κB Ligand 2001 ·Endocrinology ·Kanami Itoh, Nobuyuki Udagawa, Takenobu Katagiri, Shun‐ichiro Iemura, Naoto Ueno, Hisataka Yasuda, Kanji Higashio, J Quinn, Matthew T. Gillespie, T. John Martin, (unknown), Naoyuki Takahashi	211
3	Synovial cells from a patient with rheumatoid arthritis produce osteoclastogenesis inhibitory factor/osteoprotegerin: reciprocal regulation of the production by inflammatory cytokines and basic fibroblast growth factor 2001 ·Journal of Bone and Mineral Metabolism ·Kazuki Yano, N. Nakagawa, Hisataka Yasuda, Toshio Suda, Kanji Higashio	24
4	Cloning and characterization of the gene encoding mouse osteoclast differentiation factor 1999 ·Gene ·(unknown), (unknown), (unknown), (unknown), Atsuko Mizuno, Hisataka Yasuda, Nobuyuki Shima, Akihiko Murakami, Masatsugu Ueda, Kanji Higashio	21
5	Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor 1999 ·Bone ·Nobuyuki Udagawa, N. Takahashi, Eijiro Jimi, Kentaro Matsuzaki, Taro Tsurukai, Kanami Itoh, N. Nakagawa, Hisataka Yasuda, Masaaki Goto, Toshio Suda, Kanji Higashio, Matthew T. Gillespie, T. John Martin	358
6	Effective Administration Route for the Deleted Form of Hepatocyte Growth Factor To Exert Its Pharmacological Effects 1999 ·Journal of Pharmaceutical Sciences ·(unknown), Nobuaki Fujise, (unknown), Hiroaki Masunaga, Kanji Higashio	15
7	Hypocalcemic Effect of Osteoclastogenesis Inhibitory Factor/Osteoprotegerin in the Thyroparathyroidectomized Rat 1998 ·Endocrinology ·Michiko Yamamoto, Takehiko Murakami, Miyuki Nishikawa, Toshio Suda, Shin-ichi Mochizuki, Kanji Higashio, Takuhiko Akatsu, Kazuo Motoyoshi, Naokazu Nagata	39
8	Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesisin Vitro¹ breakdown → 1998 ·Endocrinology ·Hisataka Yasuda, Nobuyuki Shima, N. Nakagawa, Shin-ichi Mochizuki, Kazuki Yano, Nobuaki Fujise, Yasushi Sato, Masaaki Goto, Kyoji Yamaguchi, (unknown), Takeshi Kanno, Akihiko Murakami, Toshio Suda, Tomonori Morinaga, Kanji Higashio	984
9	Natural hepatocyte growth factor (HGF) from human serum and a bound form of recombinant HGF with heparan sulfate are indistinguishable in their physicochemical properties 1998 ·International Journal of Biological Macromolecules ·Kazuki Yano, Toshio Suda, Masatsugu Ueda, Kanji Higashio	6
10	Preventive effects of the deleted form of hepatocyte growth factor against various liver injuries 1998 ·European Journal of Pharmacology ·Hiroaki Masunaga, Nobuaki Fujise, Akira Shiota, Hiromi Ogawa, Yasushi Sato, (unknown), Hiroshi Yasuda, Kanji Higashio	30
11	Transforming Growth Factor-β Stimulates the Production of Osteoprotegerin/Osteoclastogenesis Inhibitory Factor by Bone Marrow Stromal Cells 1998 ·Journal of Biological Chemistry ·Hiroyuki Takai, Masahiro Kanematsu, Kazuki Yano, Toshio Suda, Kanji Higashio, Kyoji Ikeda, Ken Watanabe, Yoshiji Yamada	241
12	Osteoclastogenesis inhibitory factor exhibits hypocalcemic effects in normal mice and in hypercalcemic nude mice carrying tumors associated with humoral hypercalcemia of malignancy 1998 ·Bone ·Takuhiko Akatsu, Takehiko Murakami, Kohei Ono, Masanobu Nishikawa, Toshio Suda, Shin-ichi Mochizuki, Nobuaki Fujise, Kanji Higashio, K Motoyoshi, Michiko Yamamoto, Noriko Nagata	64
13	Characterization of Structural Domains of Human Osteoclastogenesis Inhibitory Factor 1998 ·Journal of Biological Chemistry ·Kyoji Yamaguchi, Masahiko Kinosaki, Masaaki Goto, F Kobayashi, Toshio Suda, Tomonori Morinaga, Kanji Higashio	166
14	Structure of the mouse osteoclastogenesis inhibitory factor (OCIF) gene and its expression in embryogenesis 1998 ·Gene ·Atsuko Mizuno, Akihiko Murakami, N. Nakagawa, Hisataka Yasuda, Toshio Suda, Tomonori Morinaga, Kanji Higashio	35
15	Osteoclastogenesis Inhibitory Factor Suppresses Osteoclast Survival by Interfering in the Interaction of Stromal Cells with Osteoclast 1998 ·Biochemical and Biophysical Research Communications ·Takuhiko Akatsu, Takehiko Murakami, Miyuki Nishikawa, Katsuhiro Ono, Nariyoshi Shinomiya, Toshio Suda, Shin-ichi Mochizuki, Kyoji Yamaguchi, Masahiko Kinosaki, Kanji Higashio, Michiko Yamamoto, Kazuo Motoyoshi, (unknown)	106
16	Possible roles of arachidonic acid and its metabolites in induction of tissue plasminogen activator (t-PA) production in human fibroblast, IMR-90 cells by proteose peptone 1992 ·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·Akira Suzuki, (unknown), Kanji Higashio, T Kumasaka	2
17	A Human α-Fetoprotein Enhancer-Binding Protein, ATBF1, Contains Four Homeodomains and Seventeen Zinc Fingers 1991 ·Molecular and Cellular Biology ·Tomonori Morinaga, Hisataka Yasuda, Tomoko Hashimoto, Kanji Higashio, Taiki Tamaoki	16
18	Production of Tissue Plasminogen Activator(t-PA)by Human Embryonic Lung Diploid Fibroblast IMR-90 Cells Stimulated by Proteose Peptone. 1991 ·Nippon Nōgeikagaku Kaishi ·Akira Suzuki, Yasuharu Itagaki, (unknown), Kanji Higashio	3
19	ELISA for F-TCF (human hepatocyte growth factor/hHGF)/fibroblast-derived tumor cytotoxic factor antigen employing monoclonal antibodies and its application to patients with liver diseases 1991 ·Gastroenterologia Japonica ·Nobuyuki Shima, Kanji Higashio, (unknown), (unknown)	9
20	1977 ·Nippon Nōgeikagaku Kaishi ·Kanji Higashio, Yasuo Yoshioka, (unknown)	1

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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