John Orlowski

12.6k total citations · 3 hit papers
116 papers, 10.4k citations indexed

About

John Orlowski is a scholar working on Molecular Biology, Surgery and Cellular and Molecular Neuroscience. According to data from OpenAlex, John Orlowski has authored 116 papers receiving a total of 10.4k indexed citations (citations by other indexed papers that have themselves been cited), including 98 papers in Molecular Biology, 33 papers in Surgery and 24 papers in Cellular and Molecular Neuroscience. Recurrent topics in John Orlowski's work include Ion Transport and Channel Regulation (60 papers), Ion channel regulation and function (49 papers) and Pancreatic function and diabetes (31 papers). John Orlowski is often cited by papers focused on Ion Transport and Channel Regulation (60 papers), Ion channel regulation and function (49 papers) and Pancreatic function and diabetes (31 papers). John Orlowski collaborates with scholars based in Canada, United States and Japan. John Orlowski's co-authors include Sergio Grinstein, Joseph R. Casey, Jerry B. Lingrel, Gary E. Shull, Ramani A. Kandasamy, Masayuki Numata, Frank H. Yu, Elöd Z. Szabó, Elmer M. Price and Marcia M. Shull and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Nucleic Acids Research and Journal of Biological Chemistry.

In The Last Decade

John Orlowski

115 papers receiving 10.3k citations

Hit Papers

Sensors and regulators of intracellular pH 1992 2026 2003 2014 2009 1992 2004 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Sensors and regulators of intracellular pH
    2009 1.8k citations Sergio Grinstein, John Orlowski et al. profile →
  2. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins.
    1992 517 citations John Orlowski, Gary E. Shull et al. Journal of Biological Chemistry profile →
  3. Diversity of the mammalian sodium/proton exchanger SLC9 gene family
    2004 517 citations John Orlowski, Sergio Grinstein Pflügers Archiv - European Journal of Physiology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
John Orlowski Canada 52 7.6k 1.7k 1.3k 1.1k 944 116 10.4k
Jerry B. Lingrel United States 73 13.5k 1.8× 1.4k 0.8× 1.5k 1.2× 1.3k 1.2× 1.5k 1.5× 254 17.4k
Hisashi Hidaka Japan 56 7.4k 1.0× 1.1k 0.6× 2.2k 1.8× 1.5k 1.3× 1.6k 1.7× 272 12.8k
Jonathan Lytton Canada 43 7.5k 1.0× 812 0.5× 2.2k 1.8× 1.2k 1.1× 1000 1.1× 91 10.5k
Masafumi Tsujimoto Japan 59 6.8k 0.9× 802 0.5× 769 0.6× 1.0k 0.9× 689 0.7× 191 11.0k
Daniela Rotin Canada 61 10.0k 1.3× 829 0.5× 1.2k 0.9× 2.1k 1.9× 689 0.7× 125 13.0k
John T. Penniston United States 57 7.0k 0.9× 935 0.6× 1.6k 1.2× 1.5k 1.3× 1.3k 1.3× 169 9.6k
Stephen A. Baldwin United Kingdom 68 7.7k 1.0× 1.9k 1.1× 856 0.7× 920 0.8× 1.7k 1.8× 237 15.2k
William J. Dreyer United States 44 6.5k 0.9× 795 0.5× 1.8k 1.4× 1.2k 1.0× 647 0.7× 111 11.1k
Gary E. Shull United States 78 13.4k 1.8× 2.6k 1.5× 2.3k 1.8× 1.5k 1.3× 1.7k 1.8× 213 17.6k
Tetsuo Noda Japan 80 15.6k 2.1× 2.6k 1.6× 2.1k 1.7× 2.7k 2.4× 1.8k 2.0× 260 24.3k

Countries citing papers authored by John Orlowski

Since Specialization
Citations

This map shows the geographic impact of John Orlowski's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Orlowski with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Orlowski more than expected).

Fields of papers citing papers by John Orlowski

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Orlowski. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Orlowski. The network helps show where John Orlowski may publish in the future.

Co-authorship network of co-authors of John Orlowski

This figure shows the co-authorship network connecting the top 25 collaborators of John Orlowski. A scholar is included among the top collaborators of John Orlowski based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John Orlowski. John Orlowski is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Bokhari, Rakan, Jean Ouellet, John Orlowski, et al.. (2025). Pain experience of children with Christianson syndrome. Pain. 166(7). 1610–1621.
2.
Freeman, Spencer A., Sergio Grinstein, & John Orlowski. (2022). Determinants, maintenance, and function of organellar pH. Physiological Reviews. 103(1). 515–606. 58 indexed citations
3.
Dong, Yanli, Alina Ilie, Yiwei Gao, et al.. (2022). Structural basis of autoinhibition of the human NHE3-CHP1 complex. Science Advances. 8(21). eabn3925–eabn3925. 13 indexed citations
4.
Gruber, Reut, et al.. (2021). Sleep and daytime behavior in individuals with Christianson Syndrome. Sleep Medicine. 89. 55–59. 3 indexed citations
5.
Dong, Yanli, Yiwei Gao, Alina Ilie, et al.. (2021). Structure and mechanism of the human NHE1-CHP1 complex. Nature Communications. 12(1). 3474–3474. 60 indexed citations
6.
Ilie, Alina, et al.. (2020). Assorted dysfunctions of endosomal alkali cation/proton exchanger SLC9A6 variants linked to Christianson syndrome. Journal of Biological Chemistry. 295(20). 7075–7095. 10 indexed citations
7.
Boudreau, C., et al.. (2019). Paxillin S273 Phosphorylation Regulates Adhesion Dynamics and Cell Migration through a Common Protein Complex with PAK1 and βPIX. Scientific Reports. 9(1). 11430–11430. 21 indexed citations
8.
Ilie, Alina, Jonathan P. Reid, Annie Boucher, et al.. (2016). A Christianson syndrome-linked deletion mutation (∆287ES288) in SLC9A6 disrupts recycling endosomal function and elicits neurodegeneration and cell death. Molecular Neurodegeneration. 11(1). 63–63. 22 indexed citations
9.
Alexander, R. Todd, Valentin Jaumouillé, Tony Yeung, et al.. (2011). Membrane surface charge dictates the structure and function of the epithelial Na+/H+ exchanger. The EMBO Journal. 30(4). 679–691. 51 indexed citations
10.
Zaun, Hans C., Alvin Shrier, & John Orlowski. (2008). Calcineurin B Homologous Protein 3 Promotes the Biosynthetic Maturation, Cell Surface Stability, and Optimal Transport of the Na+/H+ Exchanger NHE1 Isoform. Journal of Biological Chemistry. 283(18). 12456–12467. 49 indexed citations
11.
Orlowski, John & Sergio Grinstein. (2004). Diversity of the mammalian sodium/proton exchanger SLC9 gene family. Pflügers Archiv - European Journal of Physiology. 447(5). 549–565. 517 indexed citations breakdown →
12.
Hayashi, Hisayoshi, et al.. (2002). A Slow pH-dependent Conformational Transition Underlies a Novel Mode of Activation of the Epithelial Na+/H+ Exchanger-3 Isoform. Journal of Biological Chemistry. 277(13). 11090–11096. 31 indexed citations
13.
Szászi, Katalin, Kazuyoshi Kurashima, Kozo Kaibuchi, Sergio Grinstein, & John Orlowski. (2001). Role of the Cytoskeleton in Mediating cAMP-dependent Protein Kinase Inhibition of the Epithelial Na+/H+ Exchanger NHE3. Journal of Biological Chemistry. 276(44). 40761–40768. 43 indexed citations
14.
Voyno-Yasenetskaya, T., et al.. (1996). Gα12 Differentially Regulates Na+-H+ Exchanger Isoforms. Journal of Biological Chemistry. 271(37). 22604–22610. 69 indexed citations
15.
Cabado, Ana G., Frank H. Yu, András Kapùs, et al.. (1996). Distinct Structural Domains Confer cAMP Sensitivity and ATP Dependence to the Na+/H+ Exchanger NHE3 Isoform. Journal of Biological Chemistry. 271(7). 3590–3599. 66 indexed citations
16.
Singh, Gurinder & John Orlowski. (1996). Transient Expression of Na + /H + Exchanger Isoform NHE-2 in LLC-PK 1 Cells: Inhibition of Endogenous NHE-3 and Regulation by Hypertonicity. The Journal of Membrane Biology. 151(3). 261–268. 11 indexed citations
17.
Claßen, M., et al.. (1995). Intent to treat metronidazole resistant H. pylori infection to 100% of cure. Therapy with quadruple therapy and its modification. Gastroenterology. 108(4). A216–A216. 4 indexed citations
18.
Demaurex, Nicolas, John Orlowski, Guy F. Brisseau, Michael Woodside, & Sergio Grinstein. (1995). The mammalian Na+/H+ antiporters NHE-1, NHE-2, and NHE-3 are electroneutral and voltage independent, but can couple to an H+ conductance.. The Journal of General Physiology. 106(1). 85–111. 52 indexed citations
19.
20.
Lingrel, Jerry B., John Orlowski, Marcia M. Shull, & Elmer M. Price. (1990). Molecular Genetics of Na,K-ATPase. Progress in nucleic acid research and molecular biology. 38. 37–89. 352 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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