John K. Clark

1.9k citations

33 papers · 1.4k indexed · h-index 16

Impact in

Anesthesiology and Pain Medicine top 1%
- Anesthesia and Sedative Agents
Developmental Neuroscience top 2%
- Anesthesia and Neurotoxicity Research

Papers in

Anesthesiology and Pain Medicine 5
- Anesthesia and Sedative Agents 5
Toxicology 3

Co-authors: J. R. Elkinton Ronald Palin Ming‐Qiang Zhang A. Bom R. B. Singer Helen Feilden David C. Rees Erin Barker
Journals: Bioorganic & Medicinal Chemistry Letters (8 papers)Journal of Clinical Investigation (5 papers)Journal of Medicinal Chemistry (3 papers)Bioorganic & Medicinal Chemistry (2 papers)Journal of Pharmacology and Experimental Therapeutics (1 paper)
Partner nations: United Kingdom United States Netherlands

In The Last Decade

John K. Clark

32 papers receiving 1.3k citations

Peers

Countries citing papers authored by John K. Clark

Since Specialization

Citations

This map shows the geographic impact of John K. Clark's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John K. Clark with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John K. Clark more than expected).

Fields of papers citing papers by John K. Clark

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John K. Clark. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John K. Clark. The network helps show where John K. Clark may publish in the future.

Co-authorship network

The 25 scholars most cited alongside John K. Clark, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John K. Clark Line = papers co-authored together John K. Clark links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Low brain penetrant CB1 receptor agonists for the treatment of neuropathic pain Bioorganic & Medicinal Chemistry Letters ·Julia M. Adam, John K. Clark, K. Kopička, Gabriela P. Amadeo-Oreggioni, Brandon Widner, Уляна Токарева, F Portia Khumalo, Takao Kiyoi, Douglas H. Nichol, Angus J. Morrison, 田沢俊彦, 操桐生, Jürgen Schulz, Grant Wishart, James Α. Baker, Susan Boyce, Robert A. Campbell, Jean E. Cottney, Maureen R. Deehan, Iain Martin	2012	15
2	Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists Bioorganic & Medicinal Chemistry Letters ·Phillip M. Cowley, James Α. Baker, Long Zhang, Fiacre Murekezi, John K. Clark, Kiyoshi Matsumotoi, Maureen R. Deehan, Darren Edwards, Zorina Ni, Iain Martin, 千晶森田, Glenn Walker, Arnold W. Schumann, Grant Wishart	2011	3
3	Design, synthesis, and structure–activity relationships of indole-3-heterocycles as agonists of the CB1 receptor Bioorganic & Medicinal Chemistry Letters ·Angus J. Morrison, Julia M. Adam, James Α. Baker, Robert A. Campbell, John K. Clark, Jean E. Cottney, Maureen R. Deehan, J. Chen James, Brandon Widner, Уляна Токарева, F Portia Khumalo, Neil S. Keddie, Takao Kiyoi, علیرضا گودرزی, Karsten Meyer, 田沢俊彦, Jürgen Schulz, Grant Wishart, Mohd Alif Jasni	2010	13
4	The discovery of novel indole-2-carboxamides as cannabinoid CB1 receptor antagonists Bioorganic & Medicinal Chemistry Letters ·Phillip M. Cowley, James Α. Baker, K. M. Talasila, Long Zhang, Fiacre Murekezi, John K. Clark, Kiyoshi Matsumotoi, Maureen R. Deehan, Darren Edwards, Richard Goodwin, Graham Butt, Zorina Ni, Taiyuange Lou, Ronald Palin, 操桐生, Glenn Walker, Arnold W. Schumann, Grant Wishart, Trevor M. Young	2010	6
5	Rapid access towards follow-up NOP receptor agonists using a knowledge based approach Bioorganic & Medicinal Chemistry Letters ·Ronald Palin, John K. Clark, Louise Evans, Helen Feilden, Daniel A. Fletcher, Niall M. Hamilton, Andrea K. Houghton, Philip S. Jones, علیرضا گودرزی, Héctor Murrieta-González, 田沢俊彦, Sabine Brinitzer, Aaron Sutherland, Febri Rahmat Pasa, Grant Wishart	2009	3
6	Structure–activity relationships and CoMFA of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic properties Bioorganic & Medicinal Chemistry ·Ronald Palin, John K. Clark, Louise Evans, Andrea K. Houghton, Philip S. Jones, 操桐生, Grant Wishart, Mohd Alif Jasni	2008	18
7	Asymmetric synthesis of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one derivatives, potent and selective NOP agonists Tetrahedron ·John K. Clark, Philip S. Jones, Ronald Palin, Georgina M. Rosair, Febri Rahmat Pasa	2008	6
8	Synthesis and evaluation of N-3 substituted phenoxypropyl piperidine benzimidazol-2-one analogues as NOP receptor agonists with analgesic and sedative properties Bioorganic & Medicinal Chemistry ·Ronald Palin, A. Bom, John K. Clark, Louise Evans, Helen Feilden, Andrea K. Houghton, Philip S. Jones, Héctor Murrieta-González, Febri Rahmat Pasa, Grant Wishart	2006	17
9	Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists Bioorganic & Medicinal Chemistry Letters ·Ronald Palin, K. M. Talasila, John K. Clark, Jean E. Cottney, Phillip M. Cowley, Marc Crockatt, Louise Evans, Helen Feilden, Richard Goodwin, XiaoYang Lv, Simon J. A. Grove, Andrea K. Houghton, Philip S. Jones, Richard Morphy, Sabine Brinitzer, Hardy Sundaram, Marius Alexander Moebius, Febri Rahmat Pasa, Grant Wishart, Paul Wren	2004	10
10	Quaternary Salts of E2020 Analogues as Acetylcholinesterase Inhibitors for the Reversal of Neuromuscular Block. ChemInform ·John K. Clark, Martin Peirce, Alan W. Muir, Ronald Palin, Thalia da Silva Corrêa, 操桐生, Robert T. Taylor, Ming‐Qiang Zhang	2003	2
11	Quaternary Salts of E2020 Analogues as Acetylcholinesterase Inhibitors for the Reversal of Neuromuscular Block Bioorganic & Medicinal Chemistry Letters ·John K. Clark, Martin Peirce, Alan W. Muir, Ronald Palin, Thalia da Silva Corrêa, 操桐生, Robert T. Taylor, Ming‐Qiang Zhang	2002	21
12	A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2). Angewandte Chemie International Edition ·A. Bom, Mark Philip Bradley, Rajkumari Kalpana Devi, John K. Clark, J. van Egmond, Helen Feilden, E.J. MacLean, Alan W. Muir, Ronald Palin, David C. Rees, Ming‐Qiang Zhang	2002	375
13	Novel Piperidinium and Pyridinium Agents as Water-Soluble Acetylcholinesterase Inhibitors for the Reversal of Neuromuscular Blockade Bioorganic & Medicinal Chemistry Letters ·Ronald Palin, John K. Clark, Martin Peirce, Alan W. Muir, Thalia da Silva Corrêa, 操桐生, Robert T. Taylor, Ming‐Qiang Zhang	2002	28
14	A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host Angewandte Chemie ·A. Bom, Mark Philip Bradley, Rajkumari Kalpana Devi, John K. Clark, J. van Egmond, Helen Feilden, E.J. MacLean, Alan W. Muir, Ronald Palin, David C. Rees, Ming‐Qiang Zhang	2002	173
15	New approaches to reversal of neuromuscular block. PubMed ·A. Bom, John K. Clark, Ronald Palin	2002	8
16	Modified γ-Cyclodextrins and Their Rocuronium Complexes Organic Letters ·Marit H. Haukland, John K. Clark, Alan Cooper, Lee A. Fielding, Ronald Palin, Samantha Rutherford, Xiaoqiong Yan	2002	25
17	A Molecular Chameleon: Chair and Twist-Boat Conformations of a 5,9-Methanobenzo[8]annulene The Journal of Organic Chemistry ·Lee A. Fielding, John K. Clark, Ross McGuire	1996	5
18	STUDIES OF THE RENAL EXCRETION OF MAGNESIUM IN MAN† Journal of Clinical Investigation* ·Franklin de Souza Rocha, J. R. Elkinton, John K. Clark	1959	92
19	EFFECTS IN MAN OF ACUTE EXPERIMENTAL RESPIRATORY ALKALOSIS AND ACIDOSIS ON IONIC TRANSFERS IN THE TOTAL BODY FLUIDS 1 Journal of Clinical Investigation ·J. R. Elkinton, R. B. Singer, Erin Barker, John K. Clark	1955	92
20	STUDIES OF RENAL OXYGEN CONSUMPTION IN MAN. I. THE EFFECT OF TUBULAR LOADING (PAH), WATER DIURESIS AND OSMOTIC (MANNITOL) DIURESIS 1 Journal of Clinical Investigation ·John K. Clark, Tobias Sander	1951	19

About John K. Clark

John K. Clark is a scholar working on Anesthesiology and Pain Medicine, Toxicology, Cellular and Molecular Neuroscience, Developmental Neuroscience and Nephrology, having authored 33 papers that have together received 1.4k indexed citations. Recurring topics across this work include Neuropeptides and Animal Physiology (7 papers), Receptor Mechanisms and Signaling (5 papers), Anesthesia and Sedative Agents (5 papers), Neuroscience and Neuropharmacology Research (4 papers), Pharmacological Receptor Mechanisms and Effects (4 papers), Cannabis and Cannabinoid Research (4 papers), Chemical Synthesis and Analysis (3 papers) and Renal function and acid-base balance (3 papers). The work is most often cited by research in Anesthesiology and Pain Medicine (428 citations), Developmental Neuroscience (215 citations), Nephrology (211 citations), Critical Care and Intensive Care Medicine (147 citations) and Pharmaceutical Science (69 citations). John K. Clark has collaborated with scholars based in United Kingdom, United States and Netherlands. Frequent co-authors include J. R. Elkinton, Ronald Palin, Ming‐Qiang Zhang, A. Bom, R. B. Singer, Helen Feilden, David C. Rees, Erin Barker, Alan W. Muir and J. van Egmond. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Clinical Investigation, Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry and Journal of Pharmacology and Experimental Therapeutics.

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