James H. Hurley

36.8k total citations · 8 hit papers
232 papers, 22.1k citations indexed

About

James H. Hurley is a scholar working on Molecular Biology, Cell Biology and Epidemiology. According to data from OpenAlex, James H. Hurley has authored 232 papers receiving a total of 22.1k indexed citations (citations by other indexed papers that have themselves been cited), including 149 papers in Molecular Biology, 136 papers in Cell Biology and 53 papers in Epidemiology. Recurrent topics in James H. Hurley's work include Cellular transport and secretion (122 papers), Autophagy in Disease and Therapy (50 papers) and Calcium signaling and nucleotide metabolism (39 papers). James H. Hurley is often cited by papers focused on Cellular transport and secretion (122 papers), Autophagy in Disease and Therapy (50 papers) and Calcium signaling and nucleotide metabolism (39 papers). James H. Hurley collaborates with scholars based in United States, Germany and United Kingdom. James H. Hurley's co-authors include Juan S. Bonifacino, Thomas Wollert, Lindsey N. Young, Phyllis I. Hanson, Saurav Misra, Jennifer Lippincott‐Schwartz, Scott D. Emr, Sangho Lee, Young Jun Im and Xuefeng Ren and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

James H. Hurley

231 papers receiving 21.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

2010 632 citations James H. Hurley et al. Nature profile →
Membrane budding and scission by the ESCRT machinery: it's all in the neck

2010 588 citations James H. Hurley et al. profile →
Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

1995 565 citations James H. Hurley et al. profile →
Ubiquitin-binding domains

2006 515 citations James H. Hurley, Sangho Lee et al. Biochemical Journal profile →
Membrane scission by the ESCRT-III complex

2009 514 citations James H. Hurley et al. Nature profile →
Mechanisms of Autophagy Initiation

2017 506 citations James H. Hurley, Lindsey N. Young Annual Review of Biochemistry profile →
ESCRT s are everywhere

2015 485 citations James H. Hurley profile →
Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex

2023 104 citations James H. Hurley et al. Nature profile →

Peers

Countries citing papers authored by James H. Hurley

Since Specialization

Citations

This map shows the geographic impact of James H. Hurley's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James H. Hurley with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James H. Hurley more than expected).

Fields of papers citing papers by James H. Hurley

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James H. Hurley. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James H. Hurley. The network helps show where James H. Hurley may publish in the future.

Co-authorship network of co-authors of James H. Hurley

This figure shows the co-authorship network connecting the top 25 collaborators of James H. Hurley. A scholar is included among the top collaborators of James H. Hurley based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James H. Hurley. James H. Hurley is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	The human autophagy-initiating complexes ULK1C and PI3KC3-C1 2025 ·Journal of Biological Chemistry ·(unknown), James H. Hurley	3
2	In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment 2025 ·Proceedings of the National Academy of Sciences ·(unknown), (unknown), (unknown), (unknown), (unknown), Florian Wilfling, Samantha C. Lewis, James H. Hurley	3
3	Structural pathway for PI3-kinase regulation by VPS15 in autophagy 2025 ·Science ·(unknown), (unknown), Thanh Ngoc Nguyen, (unknown), Grace Khuu, Shanlin Rao, (unknown), (unknown), Anthony T. Iavarone, Xuefeng Ren, Michael Lazarou, Gerhard Hummer, James H. Hurley	9
4	Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery 2025 ·Nature Cell Biology ·Elias Adriaenssens, (unknown), (unknown), (unknown), Justyna Sawa‐Makarska, Thanh Ngoc Nguyen, Xuefeng Ren, Martina Schuschnig, Julia Romanov, Grace Khuu, Louise Uoselis, Michael Lazarou, Gerhard Hummer, James H. Hurley, Sascha Martens	2
5	A structural pathway for class III PI 3-kinase activation by the myristoylated GTP-binding pseudokinase VPS15 2024 ·Biophysical Journal ·(unknown), (unknown), Xuefeng Ren, Shanlin Rao, (unknown), Anthony T. Iavarone, (unknown), Gerhard Hummer, James H. Hurley	2
6	Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes 2024 ·Proceedings of the National Academy of Sciences ·(unknown), (unknown), (unknown), (unknown), Martin Kampmann, Ke Xu, James H. Hurley	38
7	Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore 2024 ·Science Advances ·Shanlin Rao, Marvin Skulsuppaisarn, (unknown), Xuefeng Ren, Michael Lazarou, James H. Hurley, Gerhard Hummer	18
8	In vitro reconstitution of calcium-dependent recruitment of the human ESCRT machinery in lysosomal membrane repair 2022 ·Proceedings of the National Academy of Sciences ·(unknown), Kevin P. Larsen, (unknown), (unknown), James H. Hurley	31
9	Clathrin-associated AP-1 controls termination of STING signalling 2022 ·Nature ·Ying Liu, Pengbiao Xu, (unknown), Chong Liu, (unknown), Xuefeng Ren, James H. Hurley, Andrea Ablasser	99
10	Structural basis for autophagy inhibition by the human Rubicon–Rab7 complex 2020 ·Proceedings of the National Academy of Sciences ·Hersh K. Bhargava, Keisuke Tabata, (unknown), Maho Hamasaki, Daniel P. Farrell, Ivan Anishchenko, Frank DiMaio, Young Jun Im, Tamotsu Yoshimori, James H. Hurley	23
11	Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein 2020 ·Proceedings of the National Academy of Sciences ·Thomas G. Flower, Cosmo Z. Buffalo, Richard M. Hooy, Marc Allaire, Xuefeng Ren, James H. Hurley	169
12	A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy 2020 ·The Journal of Cell Biology ·Dorotea Fracchiolla, Chunmei Chang, James H. Hurley, Sascha Martens	72
13	ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer 2020 ·The Journal of Cell Biology ·Xiaoshan Shi, Adam L. Yokom, Chunxin Wang, Lindsey N. Young, Richard J. Youle, James H. Hurley	64
14	Structural pathway for allosteric activation of the autophagic PI 3-kinase complex I 2019 ·Proceedings of the National Academy of Sciences ·Lindsey N. Young, Felix Goerdeler, James H. Hurley	39
15	ATP-dependent force generation and membrane scission by ESCRT-III and Vps4 2018 ·Science ·Johannes Schöneberg, (unknown), Shannon Yan, Maurizio Righini, Il‐Hyung Lee, Lars A. Carlson, Amir Houshang Bahrami, Daniel Goldman, Xuefeng Ren, Gerhard Hummer, Carlos Bustamante, James H. Hurley	126
16	Mechanisms of Autophagy Initiation breakdown → 2017 ·Annual Review of Biochemistry ·James H. Hurley, Lindsey N. Young	506
17	Scaffolding the cup-shaped double membrane in autophagy 2017 ·PLoS Computational Biology ·Amir Houshang Bahrami, Mary Grace Lin, Xuefeng Ren, James H. Hurley, Gerhard Hummer	31
18	HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons 2015 ·Science ·Qing-Tao Shen, Xuefeng Ren, Rui Zhang, Il‐Hyung Lee, James H. Hurley	37
19	In vitro reconstitution of the ordered assembly of the endosomal sorting complex required for transport at membrane-bound HIV-1 Gag clusters 2012 ·Proceedings of the National Academy of Sciences ·Lars A. Carlson, James H. Hurley	75
20	Ubiquitin-binding domains breakdown → 2006 ·Biochemical Journal ·James H. Hurley, Sangho Lee, Gali Prag	515

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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