Hongxu Xian

1.8k total citations · 2 hit papers
14 papers, 1.3k citations indexed

About

Hongxu Xian is a scholar working on Molecular Biology, Immunology and Epidemiology. According to data from OpenAlex, Hongxu Xian has authored 14 papers receiving a total of 1.3k indexed citations (citations by other indexed papers that have themselves been cited), including 10 papers in Molecular Biology, 7 papers in Immunology and 5 papers in Epidemiology. Recurrent topics in Hongxu Xian's work include Autophagy in Disease and Therapy (5 papers), Mitochondrial Function and Pathology (5 papers) and Inflammasome and immune disorders (5 papers). Hongxu Xian is often cited by papers focused on Autophagy in Disease and Therapy (5 papers), Mitochondrial Function and Pathology (5 papers) and Inflammasome and immune disorders (5 papers). Hongxu Xian collaborates with scholars based in United States, Singapore and Sweden. Hongxu Xian's co-authors include Yih‐Cherng Liou, Michael Karin, Elsa Sánchez‐López, Lin Xiao, Gerald S. Shadel, Kosuke Watari, Hal M. Hoffman, Janset Onyuru, Harini Sampath and Wei Ying and has published in prestigious journals such as Journal of Biological Chemistry, Nature Communications and Immunity.

In The Last Decade

Hongxu Xian

14 papers receiving 1.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

2022 453 citations Hongxu Xian, Kosuke Watari et al. Immunity profile →
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

2021 281 citations Hongxu Xian, Yuan Liu et al. Immunity profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Hongxu Xian United States	9	922	353	339	125	86	14	1.3k
Xudong Liao United States	16	761 0.8×	350 1.0×	250 0.7×	218 1.7×	295 3.4×	27	1.7k
Keman Xu United States	20	664 0.7×	562 1.6×	149 0.4×	113 0.9×	161 1.9×	46	1.4k
Eleanna Kaffe United States	21	924 1.0×	208 0.6×	294 0.9×	131 1.0×	118 1.4×	32	1.6k
Bijay Pattnaik India	15	716 0.8×	151 0.4×	193 0.6×	219 1.8×	243 2.8×	35	1.3k
Patrick Lowe United States	17	610 0.7×	349 1.0×	645 1.9×	129 1.0×	206 2.4×	27	1.6k
Mohammed Kouadir China	13	1.0k 1.1×	413 1.2×	154 0.5×	153 1.2×	41 0.5×	24	1.4k
Sudhakar Veeranki United States	21	644 0.7×	305 0.9×	122 0.4×	236 1.9×	79 0.9×	34	1.2k
Ramón Cueto United States	17	570 0.6×	332 0.9×	140 0.4×	124 1.0×	82 1.0×	23	1.1k
Christelle Kamga United States	7	585 0.6×	183 0.5×	233 0.7×	136 1.1×	54 0.6×	8	1.1k
Chaojun Yan China	11	834 0.9×	117 0.3×	357 1.1×	133 1.1×	153 1.8×	18	1.1k

Countries citing papers authored by Hongxu Xian

Since Specialization

Citations

This map shows the geographic impact of Hongxu Xian's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hongxu Xian with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hongxu Xian more than expected).

Fields of papers citing papers by Hongxu Xian

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hongxu Xian. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hongxu Xian. The network helps show where Hongxu Xian may publish in the future.

Co-authorship network of co-authors of Hongxu Xian

This figure shows the co-authorship network connecting the top 25 collaborators of Hongxu Xian. A scholar is included among the top collaborators of Hongxu Xian based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hongxu Xian. Hongxu Xian is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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14 of 14 papers shown

Xian, Hongxu, Kosuke Watari, Masafumi Ohira, et al.. (2025). Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation. Nature Immunology. 26(7). 1168–1181. 3 indexed citations

Yang, Qiaoyun, Hongxu Xian, Minghao Wang, et al.. (2025). Death‐Associated Protein 3 Triggers Intrinsic Apoptosis via Miro1 Upon Inducing Intracellular Calcium Changes. MedComm. 6(5). e70214–e70214. 1 indexed citations

Nilsson, A., Hongxu Xian, Shabnam Shalapour, Jörg Cammenga, & Michael Karin. (2023). IRF1 regulates self-renewal and stress responsiveness to support hematopoietic stem cell maintenance. Science Advances. 9(43). eadg5391–eadg5391. 10 indexed citations

Nilsson, A., Hongxu Xian, Shabnam Shalapour, Jörg Cammenga, & Michael Karin. (2023). 3166 – IRF1 REGULATES SELF-RENEWAL AND STRESS-RESPONSIVENESS TO SUPPORT HEMATOPOIETIC STEM CELL MAINTENANCE. Experimental Hematology. 124. S132–S132. 1 indexed citations

Xian, Hongxu & Michael Karin. (2023). Oxidized mitochondrial DNA: a protective signal gone awry. Trends in Immunology. 44(3). 188–200. 52 indexed citations

Xian, Hongxu, Kosuke Watari, Elsa Sánchez‐López, Gerald S. Shadel, & Michael Karin. (2022). FEN1-Generated Oxidized DNA Fragments Escape Mitochondria via mPTP- and VDAC-Dependent Channels to License NLRP3 Inflammasome and STING Activation. SSRN Electronic Journal. 2 indexed citations

Xian, Hongxu, Kosuke Watari, Elsa Sánchez‐López, et al.. (2022). Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 55(8). 1370–1385.e8. 453 indexed citations breakdown →

Xian, Hongxu, Yuan Liu, A. Nilsson, et al.. (2021). Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity. 54(7). 1463–1477.e11. 281 indexed citations breakdown →

Xian, Hongxu, A. Nilsson, Timothy R. Crother, et al.. (2020). Short Term Metformin Intervention Inhibits IL-6 and IL-1β Secretion and Prevents Acute Respiratory Distress Syndrome-Implications for COVID-19. SSRN Electronic Journal. 1 indexed citations

10.

Xian, Hongxu & Yih‐Cherng Liou. (2020). Functions of outer mitochondrial membrane proteins: mediating the crosstalk between mitochondrial dynamics and mitophagy. Cell Death and Differentiation. 28(3). 827–842. 104 indexed citations

11.

Xian, Hongxu, Qiaoyun Yang, Lin Xiao, Han‐Ming Shen, & Yih‐Cherng Liou. (2019). STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism. Nature Communications. 10(1). 2059–2059. 104 indexed citations

12.

Xian, Hongxu & Yih‐Cherng Liou. (2019). Loss of MIEF1/MiD51 confers susceptibility to BAX-mediated cell death and PINK1-PRKN-dependent mitophagy. Autophagy. 15(12). 2107–2125. 54 indexed citations

13.

Xiao, Bin, et al.. (2017). Reactive oxygen species trigger Parkin/PINK1 pathway–dependent mitophagy by inducing mitochondrial recruitment of Parkin. Journal of Biological Chemistry. 292(40). 16697–16708. 186 indexed citations

14.

Xiao, Lin, Hongxu Xian, Bin Xiao, et al.. (2015). Death-associated Protein 3 Regulates Mitochondrial-encoded Protein Synthesis and Mitochondrial Dynamics. Journal of Biological Chemistry. 290(41). 24961–24974. 36 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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