Gerald S. Shadel

24.3k citations

127 papers · 16.7k indexed · 12 hit papers · h-index 64

Impact in

Aging top 0.1%
- Genetics, Aging, and Longevity in Model Organisms
Clinical Biochemistry top 0.1%
- Metabolism and Genetic Disorders

Papers in

Aging 12
Clinical Biochemistry 17
- Metabolism and Genetic Disorders 17

Co-authors: A. Phillip West David A. Clayton Tamás L. Horváth Sankar Ghosh Nicholas D. Bonawitz Nuno Raimundo Yong Pan Akiko Iwasaki
Journals: Journal of Biological Chemistry (9 papers)Cell Metabolism (7 papers)Proceedings of the National Academy of Sciences (7 papers)Molecular and Cellular Biology (6 papers)Cell (4 papers)
Partner nations: United States China Germany

In The Last Decade

Gerald S. Shadel

124 papers receiving 16.5k citations

Hit Papers

12 papers align trajectories log scale

Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal 2024 · 56 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2024 Nature Cell Biology
2024 Cell
2023 Science
2023 Annual Review of Biochemistry
2022 Immunity
2017 Nature reviews. Immunology
2015 Nature
2015 Cell
2014 Cell
2011 Nature reviews. Immunology
2011 Nature
1997 Annual Review of Biochemistry

Peers

Countries citing papers authored by Gerald S. Shadel

Since Specialization

Citations

This map shows the geographic impact of Gerald S. Shadel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gerald S. Shadel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gerald S. Shadel more than expected).

Fields of papers citing papers by Gerald S. Shadel

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gerald S. Shadel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gerald S. Shadel. The network helps show where Gerald S. Shadel may publish in the future.

Co-authors

The 25 scholars most cited alongside Gerald S. Shadel, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Gerald S. Shadel Line = papers co-authored together Gerald S. Shadel links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity Cell ·Matthew B. Maxwell, Marianne S. Hom, Jawoon Yi, Shitian Li, Samuel A. Rivera, Jingting Yu, Mannix J. Burns, Helen M. McRae, Braden T. Stevenson, Katherine Coakley, Josephine Ho, Kameneff Bojorquez Gastelum, Joshua C. Bell, Alexander C. Jones, Ramez N. Eskander, Emily C. Dykhuizen, Gerald S. Shadel, Susan M. Kaech, Diana C. Hargreaves Hit paper breakdown →	2024	48
2	Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal Nature Cell Biology ·Laura Newman, Sammy Weiser Novak, Gladys R. Rojas, Nimesha Tadepalle, Cara R. Schiavon, Danielle A. Grotjahn, Christina G. Towers, Marie‐Ève Tremblay, Matthew P. Donnelly, Sagnika Ghosh, Michaela Medina, Sienna Rocha, Ricardo Rodriguez-Enriquez, Joshua A. Chevez, Ian Lemersal, Uri Manor, Gerald S. Shadel Hit paper breakdown →	2024	56
3	Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1 Science ·Nazma Malik, Bibiana I. Ferreira, Pablo E. Hollstein, Stephanie D. Curtis, Elijah Trefts, Sammy Weiser Novak, Jingting Yu, Rebecca C. Gilson, Kristina Hellberg, Linjing Fang, Arlo Sheridan, Nasun Hah, Gerald S. Shadel, Uri Manor, Reuben J. Shaw Hit paper breakdown →	2023	126
4	Paradoxical aortic stiffening and subsequent cardiac dysfunction in Hutchinson–Gilford progeria syndrome Journal of The Royal Society Interface ·Sae‐Il Murtada, Yuki I. Kawamura, Alexander W. Caulk, H. Ahmadzadeh, Nicole Mikush, Kristin M. Zimmerman Savill, Dillon Kavanagh, Dar Weiss, Marcos Latorre, Zhen W. Zhuang, Gerald S. Shadel, Demetrios T. Braddock, Jay D. Humphrey	2020	18
5	Mitochondrial DNA stress signalling protects the nuclear genome Nature Metabolism ·Zheng Wu, Sebastian Oeck, A. Phillip West, Kailash Chandra Mangalhara, Alva G. Sainz, Laura Newman, Xiao‐Ou Zhang, Lizhen Wu, Qin Yan, Marcus Bosenberg, Yanfeng Liu, Parker L. Sulkowski, Victoria Tripple, Susan M. Kaech, Peter M. Glazer, Gerald S. Shadel	2019	104
6	Acquired Resistance to HER2-Targeted Therapies Creates Vulnerability to ATP Synthase Inhibition Cancer Research ·Molly Gale, Yao Li, Jian Cao, Zongzhi Liu, Marissa A. Holmbeck, Meiling Zhang, Sabine M. Lang, Lizhen Wu, Mariana DoCarmo, Swati Gupta, Keisuke Aoshima, Michael P. DiGiovanna, David F. Stern, David L. Rimm, Gerald S. Shadel, Xiang Chen, Qin Yan	2019	36
7	Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity Science Signaling ·Yichong Zhang, Ji‐Hoon Lee, Tanya T. Paull, Sarah Gehrke, Angelo D’Alessandro, Qianhui Dou, Vadim N. Gladyshev, Elizabeth A. Schroeder, Samantha K. Steyl, Brooke E. Christian, Gerald S. Shadel	2018	77
8	Mitochondrial DNA stress primes the antiviral innate immune response Nature ·A. Phillip West, William Khoury-Hanold, Matthew Staron, Michal Caspi Tal, Cristiana M. Pineda, Sabine M. Lang, Megan Bestwick, Brett A. Duguay, Nuno Raimundo, Donna A. MacDuff, Susan M. Kaech, James R. Smiley, Robert E. Means, Akiko Iwasaki, Gerald S. Shadel Hit paper breakdown →	2015	1351
9	Isolation of Mitochondria from Cells and Tissues Cold Spring Harbor Protocols ·David A. Clayton, Gerald S. Shadel	2014	50
10	Purification of Mitochondria by Sucrose Step Density Gradient Centrifugation Cold Spring Harbor Protocols ·David A. Clayton, Gerald S. Shadel	2014	42
11	Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA Cell ·Anthony Rongvaux, Ruaidhrí Jackson, Christian C. D. Harman, Tuo Li, A. Phillip West, Marcel R. de Zoete, Youtong Wu, Brian Yordy, Saquib A. Lakhani, Chia-Yi Kuan, Tadatsugu Taniguchi, Gerald S. Shadel, Zhijian J. Chen, Akiko Iwasaki, Richard A. Flavell Hit paper breakdown →	2014	646
12	Mitochondrial Respiratory Thresholds Regulate Yeast Chronological Life Span and its Extension by Caloric Restriction Cell Metabolism ·Alejandro Ocampo, Jingjing Liu, Elizabeth A. Schroeder, Gerald S. Shadel, Antoni Barrientos	2012	139
13	Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness Cell ·Nuno Raimundo, Lei Song, Timothy E. Shutt, Sharen E. McKay, Justin Cotney, Min‐Xin Guan, Thomas Gilliland, David Hohuan, Joseph Santos‐Sacchi, Gerald S. Shadel	2012	157
14	Transcriptional activation by mitochondrial transcription factor A involves preferential distortion of promoter DNA Nucleic Acids Research ·Christopher S. Malarkey, Megan Bestwick, Jane E. Kuhlwilm, Gerald S. Shadel, Mair E. A. Churchill	2011	56
15	Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling Proceedings of the National Academy of Sciences ·Michal Caspi Tal, Miwa Sasai, Heung Kyu Lee, Brian Yordy, Gerald S. Shadel, Akiko Iwasaki	2009	483
16	Checkpoint kinase phosphorylation in response to endogenous oxidative DNA damage in repair-deficient stationary-phase Saccharomyces cerevisiae Mechanisms of Ageing and Development ·Vaibhav Pawar, Jingjing Liu, Nila Patel, Nimrat Kaur, Paul W. Doetsch, Gerald S. Shadel, Hong Zhang, Wolfram Siede	2009	14
17	Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis Biochimica et Biophysica Acta (BBA) - Bioenergetics ·Maria A. Lebedeva, Jana S. Eaton, Gerald S. Shadel	2009	146
18	Multiple Interactions Involving the Amino-terminal Domain of Yeast mtRNA Polymerase Determine the Efficiency of Mitochondrial Protein Synthesis Journal of Biological Chemistry ·Matthew S. Rodeheffer, Gerald S. Shadel	2003	58
19	Human Mitochondrial Transcription Factor B1 Interacts with the C-Terminal Activation Region of h-mtTFA and Stimulates Transcription Independently of Its RNA Methyltransferase Activity Molecular and Cellular Biology ·Vicki McCulloch, Gerald S. Shadel	2003	105
20	A Saccharomyces cerevisiae Mitochondrial Transcription Factor, sc-mtTFB, Shares Features with Sigma Factors but Is Functionally Distinct Molecular and Cellular Biology ·Gerald S. Shadel, David A. Clayton	1995	52

About Gerald S. Shadel

Gerald S. Shadel is a scholar working on Aging, Clinical Biochemistry, Molecular Biology, Immunology and Cancer Research, having authored 127 papers that have together received 16.7k indexed citations. Recurring topics across this work include Mitochondrial Function and Pathology (72 papers), RNA modifications and cancer (22 papers), ATP Synthase and ATPases Research (19 papers), RNA Research and Splicing (17 papers), Metabolism and Genetic Disorders (17 papers), interferon and immune responses (17 papers), RNA and protein synthesis mechanisms (17 papers) and DNA Repair Mechanisms (15 papers). The work is most often cited by research in Aging (1.2k citations), Clinical Biochemistry (1.4k citations), Immunology (3.9k citations), Molecular Biology (12.0k citations) and Cancer Research (1.4k citations). Gerald S. Shadel has collaborated with scholars based in United States, China and Germany. Frequent co-authors include A. Phillip West, David A. Clayton, Tamás L. Horváth, Sankar Ghosh, Nicholas D. Bonawitz, Nuno Raimundo, Yong Pan, Akiko Iwasaki, Thomas Baldwin and Michal Caspi Tal. Their work appears in journals such as Journal of Biological Chemistry, Cell Metabolism, Proceedings of the National Academy of Sciences, Molecular and Cellular Biology and Cell.

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