Heather R. Christofk

14.7k total citations · 5 hit papers
72 papers, 8.5k citations indexed

About

Heather R. Christofk is a scholar working on Molecular Biology, Cancer Research and Oncology. According to data from OpenAlex, Heather R. Christofk has authored 72 papers receiving a total of 8.5k indexed citations (citations by other indexed papers that have themselves been cited), including 47 papers in Molecular Biology, 34 papers in Cancer Research and 11 papers in Oncology. Recurrent topics in Heather R. Christofk's work include Cancer, Hypoxia, and Metabolism (28 papers), RNA modifications and cancer (8 papers) and Mitochondrial Function and Pathology (7 papers). Heather R. Christofk is often cited by papers focused on Cancer, Hypoxia, and Metabolism (28 papers), RNA modifications and cancer (8 papers) and Mitochondrial Function and Pathology (7 papers). Heather R. Christofk collaborates with scholars based in United States, United Kingdom and Japan. Heather R. Christofk's co-authors include Lewis C. Cantley, Matthew G. Vander Heiden, John M. Asara, Stuart L. Schreiber, Robert E. Gerszten, Marian H. Harris, Arvind Ramanathan, Ru Wei, Mark D. Fleming and Daniel Braas and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Heather R. Christofk

68 papers receiving 8.4k citations

Hit Papers

The M2 splice isoform of pyruvate kinase is important for... 2008 2026 2014 2020 2008 2008 2010 2016 2019 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    2008 2.2k citations Heather R. Christofk, Matthew G. Vander Heiden et al. Nature profile →
  2. Pyruvate kinase M2 is a phosphotyrosine-binding protein
    2008 817 citations Heather R. Christofk, Matthew G. Vander Heiden et al. Nature profile →
  3. Evidence for an alternative glycolytic pathway in rapidly proliferating cells
    2010 509 citations Matthew G. Vander Heiden, Jason W. Locasale et al. Europe PMC (PubMed Central) profile →
  4. Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
    2016 377 citations Abigail S. Krall, Daniel Braas et al. Nature Communications profile →
  5. Viral hijacking of cellular metabolism
    2019 350 citations Shivani K Thaker, James Ch’ng et al. BMC Biology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Heather R. Christofk United States 35 6.0k 4.0k 1.1k 702 673 72 8.5k
Elizaveta Freinkman United States 35 5.7k 0.9× 3.0k 0.7× 939 0.9× 645 0.9× 571 0.8× 40 8.1k
Georgia Hatzivassiliou United States 23 6.0k 1.0× 4.0k 1.0× 1.1k 1.0× 910 1.3× 845 1.3× 34 8.6k
Natalya N. Pavlova United States 16 4.8k 0.8× 3.6k 0.9× 1.0k 0.9× 462 0.7× 653 1.0× 32 6.8k
Nathalie M. Mazure France 39 5.5k 0.9× 4.1k 1.0× 1.0k 0.9× 1.6k 2.3× 552 0.8× 87 8.4k
Yun‐Sil Lee South Korea 44 5.6k 0.9× 2.8k 0.7× 989 0.9× 382 0.5× 924 1.4× 174 8.4k
David H. Hawke United States 48 7.4k 1.2× 2.7k 0.7× 1.7k 1.6× 620 0.9× 878 1.3× 134 9.9k
Hongchuan Jin China 53 7.6k 1.3× 4.8k 1.2× 1.4k 1.3× 1.0k 1.5× 693 1.0× 197 10.1k
Alex von Kriegsheim United Kingdom 38 5.8k 1.0× 4.0k 1.0× 1.3k 1.2× 699 1.0× 782 1.2× 120 9.2k
Sarah‐Maria Fendt Belgium 45 5.4k 0.9× 3.9k 1.0× 1.4k 1.3× 633 0.9× 1.7k 2.6× 95 8.8k
Karen Blyth United Kingdom 43 4.7k 0.8× 2.2k 0.5× 1.9k 1.7× 406 0.6× 939 1.4× 134 7.0k

Countries citing papers authored by Heather R. Christofk

Since Specialization
Citations

This map shows the geographic impact of Heather R. Christofk's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Heather R. Christofk with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Heather R. Christofk more than expected).

Fields of papers citing papers by Heather R. Christofk

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Heather R. Christofk. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Heather R. Christofk. The network helps show where Heather R. Christofk may publish in the future.

Co-authorship network of co-authors of Heather R. Christofk

This figure shows the co-authorship network connecting the top 25 collaborators of Heather R. Christofk. A scholar is included among the top collaborators of Heather R. Christofk based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Heather R. Christofk. Heather R. Christofk is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Galvan, C., et al.. (2024). Inhibition of Pyruvate Oxidation Diminishes Melanoma Progression. Journal of Investigative Dermatology. 145(5). 1237–1241.e2.
2.
Galvan, C., et al.. (2024). Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma. Science Advances. 10(38). eadn2806–eadn2806. 1 indexed citations
3.
Jacobson, Elsie, Hannah Sunshine, Blake R. Wilde, et al.. (2023). ZFP36-mediated mRNA decay regulates metabolism. Cell Reports. 42(5). 112411–112411. 17 indexed citations
4.
Wilde, Blake R., Daiki Ueno, Edward D. Esplin, et al.. (2023). FH Variant Pathogenicity Promotes Purine Salvage Pathway Dependence in Kidney Cancer. Cancer Discovery. 13(9). 2072–2089. 19 indexed citations
5.
Ch’ng, James, K. Mark Parnell, Nicolás M. Reinoso-Vizcaíno, et al.. (2021). Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas. Proceedings of the National Academy of Sciences. 118(25). 45 indexed citations
6.
Attar, Narsis, Chen Cheng, Maria Vogelauer, et al.. (2021). A pathogenic role for histone H3 copper reductase activity in a yeast model of Friedreich’s ataxia. Science Advances. 7(51). eabj9889–eabj9889. 13 indexed citations
7.
Mullen, Peter, Gustavo Garcia, Arunima Purkayastha, et al.. (2021). SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition. Nature Communications. 12(1). 1876–1876. 91 indexed citations
8.
Krall, Abigail S., Peter J. Mullen, Milica Momcilovic, et al.. (2021). Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth. Cell Metabolism. 33(5). 1013–1026.e6. 177 indexed citations
9.
Lu, Eric, Kathryn E. Hatchell, Sarah M. Nielsen, et al.. (2021). Fumarate hydratase variant prevalence and manifestations among individuals receiving germline testing. Cancer. 128(4). 675–684. 16 indexed citations
10.
Albrecht, Lauren V., Nydia Tejeda‐Muñoz, Daniele Di Biagio, et al.. (2020). GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery. Cell Reports. 32(4). 107973–107973. 51 indexed citations
11.
Thaker, Shivani K, James Ch’ng, & Heather R. Christofk. (2019). Viral hijacking of cellular metabolism. BMC Biology. 17(1). 59–59. 350 indexed citations breakdown →
12.
Momcilovic, Milica, Anthony E. Jones, Sean T. Bailey, et al.. (2019). In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 575(7782). 380–384. 152 indexed citations
13.
Jelínek, David, Aimee Flores, Mélanie Uebelhoer, et al.. (2018). Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue. Journal of Visualized Experiments. 11 indexed citations
14.
Lam, Larry, Liudmilla Rubbi, Roberto Ferrari, et al.. (2016). Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma. Genome Medicine. 8(1). 54–54. 10 indexed citations
15.
Krall, Abigail S. & Heather R. Christofk. (2013). A metabolic metamorphosis. Nature. 496(7443). 38–40. 11 indexed citations
16.
Braas, Daniel, Ethan Ahler, David A. Nathanson, et al.. (2012). Metabolomics Strategy Reveals Subpopulation of Liposarcomas Sensitive to Gemcitabine Treatment. Cancer Discovery. 2(12). 1109–1117. 27 indexed citations
17.
Heiden, Matthew G. Vander, Jason W. Locasale, Kenneth D. Swanson, et al.. (2010). Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells. Science. 329(5998). 1492–1499. 31 indexed citations
18.
Heiden, Matthew G. Vander, Jason W. Locasale, Kenneth D. Swanson, et al.. (2010). Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Europe PMC (PubMed Central). 509 indexed citations breakdown →
19.
Heiden, Matthew G. Vander, Heather R. Christofk, Eli Schuman, et al.. (2009). Identification of small molecule inhibitors of pyruvate kinase M2. Biochemical Pharmacology. 79(8). 1118–1124. 201 indexed citations
20.
Asara, John M., Heather R. Christofk, Lisa M. Freimark, & Lewis C. Cantley. (2008). A label‐free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen. PROTEOMICS. 8(5). 994–999. 167 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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