Hakon Leffler

25.0k citations

279 papers · 19.0k indexed · 4 hit papers · h-index 78

Impact in

Immunology top 0.05%
- Galectins and Cancer Biology
- Toxin Mechanisms and Immunotoxins
Endocrinology top 0.2%
- Escherichia coli research studies

Papers in

Immunology 184
- Galectins and Cancer Biology 177
- Toxin Mechanisms and Immunotoxins 55
Endocrinology 22
- Escherichia coli research studies 22

Co-authors: Ulf J. Nilsson S H Barondes Michael A. Gitt D.N. Cooper Gunnar C. Hansson Samuel H. Barondes Michael E. Breimer James M. Rini
Journals: Journal of Biological Chemistry (36 papers)Journal of Medicinal Chemistry (13 papers)Glycobiology (9 papers)Biochemistry (9 papers)Infection and Immunity (8 papers)
Partner nations: Sweden United States France

In The Last Decade

Hakon Leffler

276 papers receiving 18.4k citations

Hit Papers

align trajectories log scale

Galectins at a glance 2018 · 464 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2018 Journal of Cell Science
2002 Glycoconjugate Journal
1994 Journal of Biological Chemistry
1980 FEMS Microbiology Letters

Peers

Countries citing papers authored by Hakon Leffler

Since Specialization

Citations

This map shows the geographic impact of Hakon Leffler's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hakon Leffler with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hakon Leffler more than expected).

Fields of papers citing papers by Hakon Leffler

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hakon Leffler. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hakon Leffler. The network helps show where Hakon Leffler may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Hakon Leffler, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Hakon Leffler Line = papers co-authored together Hakon Leffler links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction Communications Chemistry ·Aslihan Berra Bolat, Taffy Nivert, AK Akintokun, Tihomir Tomašič, 傅颖, Jurij Lah, GAYATHRI D, Anders Sundin, Hakon Leffler, Ulf J. Nilsson, Derek T. Logan, Marko Anderluh	2025	1
2	Effect of GB1107, a novel galectin-3 inhibitor on pro-fibrotic signalling in the liver European Journal of Pharmacology ·Alison C. MacKinnon, Duncan C. Humphries, A DALGLEISH, James A. Roper, Ian Holyer, Ricardo Desidério da Silva, Ross Mills, Ulf J. Nilsson, Hakon Leffler, Anders N. Pedersen, Hans Schambye, Fredrik R. Zetterberg, Robert J. Slack	2024	4
3	Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket ACS Medicinal Chemistry Letters ·S Kurauchi, Taffy Nivert, M. Håkansson, Richard Johnsson, Diandra Ushli de Lima, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Tihomir Tomašič, Ulf J. Nilsson	2024	2
4	Increased Galectin-9 Levels Correlate with Disease Activity in Patients with DMARD-Naïve Rheumatoid Arthritis and Modulate the Secretion of MCP-1 and IL-6 from Synovial Fibroblasts Cells ·香本頴利, Wan-Cheng LI, Akul Y. Mehta, Kristian Stengaard‐Pedersen, Pierre Busson, Peter Junker, Kim Hørslev‐Petersen, Merete Lund Hetland, Mikkel Østergaard, Malene Hvid, Hakon Leffler, Tue Wenzel Kragstrup, Richard D. Cummings, Bent Deleuran	2023	7
5	Design and synthesis of novel 3-triazolyl-1-thiogalactosides as galectin-1, -3 and -8 inhibitors RSC Advances ·S Kurauchi, Phillip B. Sparling, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Ulf J. Nilsson, Tihomir Tomašič	2022	6
6	Selective Galectin‐8N Ligands: The Design and Synthesis of Phthalazinone‐d‐Galactals ChemMedChem ·S Kurauchi, Anders Sundin, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Ulf J. Nilsson, Tihomir Tomašič	2021	6
7	Entropy–Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C SHILAP Revista de lepidopterología ·Jeong Hyo Bae, 相珍李, Majda Misini Ignjatović, 贾志洋, Octav Caldararu, Kristoffer Peterson, A. Arteche-Andrés, Ulrika Brath, Hakon Leffler, Esko Oksanen, Derek T. Logan, Ulf J. Nilsson, Ulf Ryde, Mikael Akke	2021	28
8	Selective Monovalent Galectin‐8 Ligands Based on 3‐Lactoylgalactoside ChemMedChem ·Kyung-Ju 문경주Mun, Gloria Paz Núñez, S Kurauchi, Tihomir Tomašič, Žiga Jakopin, Hakon Leffler, Ulf J. Nilsson, Daniel Ricklin, Janez Mravljak, Oliver Schwardt, Marko Anderluh	2021	7
9	Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain ACS Medicinal Chemistry Letters ·Taffy Nivert, Elsa Idolla Ginting, Kei SIBUYA, Anders Sundin, M. Håkansson, Xiaona Xu, Hakon Leffler, Tihomir Tomašič, Marko Anderluh, Žiga Jakopin, Ulf J. Nilsson	2021	10
10	An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade Cancer Research ·Lynda Vuong, 王金礼, Claire Rooney, Brian J. McHugh, Sarah Howie, Christopher D. Gregory, Stuart J. Forbes, Neil C. Henderson, Fredrik R. Zetterberg, Ulf J. Nilsson, Hakon Leffler, Paul Ford, Anders N. Pedersen, Lise Gravelle, Susan Tantawi, Hans Schambye, Tariq Sethi, Alison C. MacKinnon	2019	104
11	In Vivo Veritas: ¹⁸F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors Journal of Medicinal Chemistry ·Klas Bratteby, Della-Vos Ta, Pérez San José C, Kristoffer Peterson, Vladimir Shalgunov, Karin Grohmannova, Hakon Leffler, Fredrik R. Zetterberg, Tomas G. Olsson, Nic Gillings, Ulf J. Nilsson, Matthias M. Herth, Maria Erlandsson	2019	20
12	Human trophoblast requires galectin-3 for cell migration and invasion Scientific Reports ·Žanka Bojić‐Trbojević, Milica Jovanović Krivokuća, Aleksandra Vilotić, Nikola Kolundžić, Ivana Stefanoska, Fredrik R. Zetterberg, Ulf J. Nilsson, Hakon Leffler, Ljiljana Vićovac	2019	29
13	Interplay between Conformational Entropy and Solvation Entropy in Protein–Ligand Binding Journal of the American Chemical Society ·Rory Hart, Olof Stenström, Majda Misini Ignjatović, Octav Caldararu, Martin Olsson, Maja Kovačević, Hakon Leffler, Esko Oksanen, Derek T. Logan, Ulf J. Nilsson, Ulf Ryde, Mikael Akke	2019	102
14	Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity Journal of Medicinal Chemistry ·Kristoffer Peterson, 贾志洋, Olof Stenström, Priya Ranjan Prasad Verma, Gianluca Borgia, M. Håkansson, Barbro Kahl‐Knutsson, Fredrik R. Zetterberg, Hakon Leffler, Mikael Akke, Derek T. Logan, Ulf J. Nilsson	2017	84
15	Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C Acta Crystallographica Section D Structural Biology ·Maja Kovačević, K. Saraboji, Janina Sprenger, 贾志洋, 李富廷, Ulf J. Nilsson, Hakon Leffler, S. Zoë Fisher, Tobias E. Schrader, Andreas Ostermann, Leighton Coates, Matthew P. Blakeley, Esko Oksanen, Derek T. Logan	2016	15
16	Galectin‐3‐Binding Glycomimetics that Strongly Reduce Bleomycin‐Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition ChemBioChem ·Tamara Delaine, P.M. Collins, Alison C. MacKinnon, Gunjan Sharma, John Stegmayr, Vishal Kumar Rajput, Santanu Mandal, Ian Cumpstey, Valente, Bader A. Salameh, Barbro Kahl‐Knutsson, Hilde van Hattum, Monique van Scherpenzeel, Roland J. Pieters, Tariq Sethi, Hans Schambye, Stina Oredsson, Hakon Leffler, Helen Blanchard, Ulf J. Nilsson	2016	151
17	Galectin-3 Targeted Therapy with a Small Molecule Inhibitor Activates Apoptosis and Enhances Both Chemosensitivity and Radiosensitivity in Papillary Thyroid Cancer Molecular Cancer Research ·Chi‐Iou Lin, Edward E. Whang, David B. Donner, Xiaofeng Jiang, Brendan D. Price, Adelaide M. Carothers, Tamara Delaine, Hakon Leffler, Ulf J. Nilsson, Vânia Nosé, Francis D. Moore, Daniel T. Ruan	2009	55
18	The role of integrin glycosylation in galectin-8-mediated trabecular meshwork cell adhesion and spreading Glycobiology ·J.J.P.R. Horovitz, Zhiyi Cao, Hakon Leffler, Noorjahan Panjwani	2008	35
19	Phylogenetic Analysis of the Vertebrate Galectin Family Molecular Biology and Evolution ·Denis Houzelstein, Isabelle Gonçalves, Andrew J. Fadden, Sukhvinder Sidhu, Douglas N.W. Cooper, Kurt Drickamer, Hakon Leffler, Praveen Chompreda	2004	220
20	Galectin mediated tethering and neutrophil leukocyte arrest under laminar flow conditions. Blood ·Maria Hedlund, Per Bengtson, Peter Påhlsson, Hakon Leffler	2002	1

About Hakon Leffler

Hakon Leffler is a scholar working on Immunology, Endocrinology, Molecular Biology, Oncology and Immunology and Allergy, having authored 279 papers that have together received 19.0k indexed citations. Recurring topics across this work include Galectins and Cancer Biology (177 papers), Glycosylation and Glycoproteins Research (147 papers), Signaling Pathways in Disease (59 papers), Toxin Mechanisms and Immunotoxins (55 papers), Peptidase Inhibition and Analysis (49 papers), Carbohydrate Chemistry and Synthesis (27 papers), Escherichia coli research studies (22 papers) and Protein Tyrosine Phosphatases (15 papers). The work is most often cited by research in Immunology (12.0k citations), Endocrinology (1.4k citations), Molecular Biology (12.3k citations), Oncology (2.5k citations) and Immunology and Allergy (469 citations). Hakon Leffler has collaborated with scholars based in Sweden, United States and France. Frequent co-authors include Ulf J. Nilsson, S H Barondes, Michael A. Gitt, D.N. Cooper, Gunnar C. Hansson, Samuel H. Barondes, Michael E. Breimer, James M. Rini, Anna Karlsson and C Svanborg-Edén. Their work appears in journals such as Journal of Biological Chemistry, Journal of Medicinal Chemistry, Glycobiology, Biochemistry and Infection and Immunity.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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