Francis P. Lach

3.9k citations

28 papers · 2.4k indexed · h-index 19

Cancer Research top 5%
- Carcinogens and Genotoxicity Assessment 2
Molecular Biology top 5%
- DNA Repair Mechanisms 26
- CRISPR and Genetic Engineering 8
- Genomics and Chromatin Dynamics 3
- Mitochondrial Function and Pathology 2
- Epigenetics and DNA Methylation 2
Genetics top 5%
- BRCA gene mutations in cancer 5
Oncology top 5%
Cell Biology top 5%
Plant Science
- Chromosomal and Genetic Variations 3

Co-authors: Agata Smogorzewska Arleen D. Auerbach Yonghwan Kim Helmut Hanenberg Rohini Desetty Kornelia Neveling Marcel Freund Melanie Wurm
Cited by: Cancer Research Molecular Biology Genetics
Journals: Journal of Clinical Investigation (1 paper)Nature Communications (1 paper)Nature Genetics (2 papers)
Partner nations: United States Germany United Kingdom

In The Last Decade

Francis P. Lach

28 papers receiving 2.4k citations

Peers

Countries citing papers authored by Francis P. Lach

Since Specialization

Citations

This map shows the geographic impact of Francis P. Lach's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Francis P. Lach with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Francis P. Lach more than expected).

Fields of papers citing papers by Francis P. Lach

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Francis P. Lach. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Francis P. Lach. The network helps show where Francis P. Lach may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Francis P. Lach, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Francis P. Lach Line = papers co-authored together Francis P. Lach links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	FANCA c.3624C>T (p.Ser1208=) is a hypomorphic splice variant associated with delayed onset of Fanconi anemia Blood Advances ·Ramanagouda Ramanagoudr‐Bhojappa,Rebecca Tryon,Francis P. Lach,Frank X. Donovan,Rochelle R. Maxwell,Allana Rosenberg,Margaret L. MacMillan,John E. Wagner,Arleen D. Auerbach,Agata Smogorzewska,Settara C. Chandrasekharappa	2024	2
2	RTF2 controls replication repriming and ribonucleotide excision at the replisome Nature Communications ·Brooke A. Conti,Penelope D. Ruiz,Cayla Broton,Nicolas J. Blobel,Molly C. Kottemann,Sunandini Sridhar,Francis P. Lach,Tom Wiley,Nanda Kumar Sasi,Thomas Carroll,Agata Smogorzewska	2024	2
3	The structure-specific endonuclease complex SLX4–XPF regulates Tus–Ter-induced homologous recombination Nature Structural & Molecular Biology ·Rajula Elango,Arvind Panday,Francis P. Lach,Nicholas A. Willis,Kaitlin Nicholson,Erin E. Duffey,Agata Smogorzewska,Ralph Scully	2022	14
4	Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia Cancer Discovery ·Zhaolin Yang,Xiaoli Wu,Yiliang Wei,Sofya A. Polyanskaya,Shruti V. Iyer,Moonjung Jung,Francis P. Lach,Emmalee R. Adelman,Olaf Klingbeil,Joseph P. Milazzo,Melissa Kramer,Osama E. Demerdash,Kenneth Chang,Sara Goodwin,Emily Hodges,W. Richard McCombie,María E. Figueroa,Agata Smogorzewska,Christopher R. Vakoc	2021	20
5	Association of clinical severity with FANCB variant type in Fanconi anemia Blood ·Moonjung Jung,Ramanagouda Ramanagoudr‐Bhojappa,Sylvie van Twest,Rasim Özgür Rosti,Vincent J. Murphy,Winnie Tan,Frank X. Donovan,Francis P. Lach,Danielle C. Kimble,Caroline S. Jiang,Roger A. Vaughan,Parinda A. Mehta,Filomena Pierri,Carlo Dufour,Arleen D. Auerbach,Andrew J. Deans,Agata Smogorzewska,Settara C. Chandrasekharappa	2020	25
6	Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links Genes & Development ·Kimberly A. Rickman,Raymond J. Noonan,Francis P. Lach,Sunandini Sridhar,Anderson T. Wang,Avinash Abhyankar,Athena L. Huang,Michael C. Kelly,Arleen D. Auerbach,Agata Smogorzewska	2020	50
7	Esophageal cancer as initial presentation of Fanconi anemia in patients with a hypomorphic FANCA variant Molecular Case Studies ·Francis P. Lach,Sonia Singh,Kimberly A. Rickman,Penelope D. Ruiz,Raymond J. Noonan,Kenneth B. Hymes,Mark D. DeLacure,Jennifer A. Kennedy,Settara C. Chandrasekharappa,Agata Smogorzewska	2020	11
8	Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity Molecular Cell ·Molly C. Kottemann,Brooke A. Conti,Francis P. Lach,Agata Smogorzewska	2017	39
9	A comprehensive approach to identification of pathogenic FANCA variants in Fanconi anemia patients and their families Human Mutation ·Danielle C. Kimble,Francis P. Lach,Siobhán Q. Gregg,Frank X. Donovan,Elizabeth K. Flynn,Aparna A. Kamat,Alice Young,Meghana Vemulapalli,James W. Thomas,James C. Mullikin,Arleen D. Auerbach,Agata Smogorzewska,Settara C. Chandrasekharappa	2017	28
10	Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia Cell Reports ·Kimberly A. Rickman,Francis P. Lach,Avinash Abhyankar,Frank X. Donovan,Erica Sanborn,Jennifer A. Kennedy,Carrie Sougnez,Stacey Gabriel,Olivier Elemento,Settara C. Chandrasekharappa,Detlev Schindler,Arleen D. Auerbach,Agata Smogorzewska	2015	111
11	Massively parallel sequencing, aCGH, and RNA-Seq technologies provide a comprehensive molecular diagnosis of Fanconi anemia Blood ·Settara C. Chandrasekharappa,Francis P. Lach,Danielle C. Kimble,Aparna A. Kamat,Jamie K. Teer,Frank X. Donovan,Elizabeth K. Flynn,Shurjo K. Sen,Supawat Thongthip,Erica Sanborn,Agata Smogorzewska,Arleen D. Auerbach,Elaine A. Ostrander	2013	62
12	Human GEN1 and the SLX4-Associated Nucleases MUS81 and SLX1 Are Essential for the Resolution of Replication-Induced Holliday Junctions Cell Reports ·Elizabeth Garner,Yonghwan Kim,Francis P. Lach,Molly C. Kottemann,Agata Smogorzewska	2013	113
13	Assessment of SLX4 Mutations in Hereditary Breast Cancers PLoS ONE ·Sohela Shah,Yonghwan Kim,Irina Ostrovnaya,Rajmohan Murali,Kasmintan A. Schrader,Francis P. Lach,Kara Sarrel,Rohini Rau‐Murthy,Nichole Hansen,Liyng Zhang,Tomas Kirchhoff,Zsofia K. Stadler,Mark E. Robson,Joseph Vijai,Kenneth Offit,Agata Smogorzewska	2013	34
14	Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency Journal of Clinical Investigation ·Laure Gineau,Céline Cognet,Nihan Kara,Francis P. Lach,Jean Dunne,Uma Veturi,Capucine Pïcard,Céline Trouillet,Céline Eidenschenk,Saïd Aoufouchi,Alexandre Alcaïs,Owen Smith,Frédéric Geissmann,Conleth Feighery,Laurent Abel,Agata Smogorzewska,Bruce Stillman,Éric Vivier,Jean‐Laurent Casanova,Emmanuelle Jouanguy	2012	195
15	Mutations of the SLX4 gene in Fanconi anemia Nature Genetics ·Yonghwan Kim,Francis P. Lach,Rohini Desetty,Helmut Hanenberg,Arleen D. Auerbach,Agata Smogorzewska	2011	259
16	A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair Molecular Cell ·Agata Smogorzewska,Rohini Desetty,T. Saito,Michael R. Schlabach,Francis P. Lach,Mathew E. Sowa,Allan Clark,Thomas A. Kunkel,J. Wade Harper,Mónica P. Colaiácovo,Stephen J. Elledge	2010	267
17	Identification and characterization of mutations in FANCL gene: A second case of Fanconi anemia belonging to FA-L complementation group Human Mutation ·Abdullah Mahmood Ali,Michelle Kirby,Michael Jansen,Francis P. Lach,Jennifer Schulte,Thiyam Ramsing Singh,Sat Dev Batish,Arleen D. Auerbach,David A. Williams,Amom Ruhikanta Meetei	2009	18
18	Biallelic mutations in PALB2 cause Fanconi anemia and predispose to childhood cancer Cancer Research ·Sarah Reid,Detlev Schindler,Helmut Hanenberg,Marc Tischkowitz,Sandra Hanks,Karen Barker,Patrick Kelly,Sheila Seal,Sat Dev Batish,Francis P. Lach,Reinhard Kalb,Kornelia Neveling,Christopher G. Mathew,Arleen D. Auerbach,Nazneen Rahman	2007	1
19	FANCI is a second monoubiquitinated member of the Fanconi anemia pathway Nature Structural & Molecular Biology ·Ashley E Sims,Elizabeth Spiteri,Robert J. Sims,Adriana Arita,Francis P. Lach,Thomas Landers,Melanie Wurm,Marcel Freund,Kornelia Neveling,Helmut Hanenberg,Arleen D. Auerbach,Tony T. Huang	2007	223
20	Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer Nature Genetics ·Sarah Reid,Detlev Schindler,Helmut Hanenberg,Karen Barker,Sandra Hanks,Reinhard Kalb,Kornelia Neveling,Patrick Kelly,Sheila Seal,Marcel Freund,Melanie Wurm,Sat Dev Batish,Francis P. Lach,Sevgi Yetgin,Heidemarie Neitzel,Hany Ariffin,Marc Tischkowitz,Christopher G. Mathew,Arleen D. Auerbach,Nazneen Rahman	2006	453

About Francis P. Lach

Francis P. Lach is a scholar working on Molecular Biology, Genetics and Otorhinolaryngology, having authored 28 papers that have together received 2.4k indexed citations. Recurring topics across this work include DNA Repair Mechanisms (26 papers), CRISPR and Genetic Engineering (8 papers), BRCA gene mutations in cancer (5 papers), Chromosomal and Genetic Variations (3 papers), Genomics and Chromatin Dynamics (3 papers), Mitochondrial Function and Pathology (2 papers), Carcinogens and Genotoxicity Assessment (2 papers) and Epigenetics and DNA Methylation (2 papers). The work is most often cited by research in Cancer Research (474 citations), Molecular Biology (2.1k citations) and Genetics (619 citations). Francis P. Lach has collaborated with scholars based in United States, Germany and United Kingdom. Frequent co-authors include Agata Smogorzewska, Arleen D. Auerbach, Yonghwan Kim, Helmut Hanenberg, Rohini Desetty, Kornelia Neveling, Marcel Freund, Melanie Wurm, Erica Sanborn and Molly C. Kottemann. Their work appears in journals such as Journal of Clinical Investigation, Nature Communications and Nature Genetics.

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