Florent Beaufils

2.7k total citations · 1 hit paper
37 papers, 2.1k citations indexed

About

Florent Beaufils is a scholar working on Molecular Biology, Organic Chemistry and Pathology and Forensic Medicine. According to data from OpenAlex, Florent Beaufils has authored 37 papers receiving a total of 2.1k indexed citations (citations by other indexed papers that have themselves been cited), including 24 papers in Molecular Biology, 21 papers in Organic Chemistry and 4 papers in Pathology and Forensic Medicine. Recurrent topics in Florent Beaufils's work include PI3K/AKT/mTOR signaling in cancer (13 papers), Radical Photochemical Reactions (6 papers) and Catalytic C–H Functionalization Methods (5 papers). Florent Beaufils is often cited by papers focused on PI3K/AKT/mTOR signaling in cancer (13 papers), Radical Photochemical Reactions (6 papers) and Catalytic C–H Functionalization Methods (5 papers). Florent Beaufils collaborates with scholars based in Switzerland, Germany and France. Florent Beaufils's co-authors include Alexandre Juillerat, Kai Johnsson, Christian Heinis, Maik Kindermann, Arnaud Gautier, Ivan R. Corrêa, Philippe Renaud, F. Dénès, Matthias P. Wymann and Denise Rageot and has published in prestigious journals such as Angewandte Chemie International Edition, Nature Communications and Cancer Research.

In The Last Decade

Florent Beaufils

36 papers receiving 2.1k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

An Engineered Protein Tag for Multiprotein Labeling in Living Cells

2008 833 citations Arnaud Gautier, Alexandre Juillerat et al. Chemistry & Biology profile →

Peers

Countries citing papers authored by Florent Beaufils

Since Specialization

Citations

This map shows the geographic impact of Florent Beaufils's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Florent Beaufils with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Florent Beaufils more than expected).

Fields of papers citing papers by Florent Beaufils

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Florent Beaufils. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Florent Beaufils. The network helps show where Florent Beaufils may publish in the future.

Co-authorship network of co-authors of Florent Beaufils

This figure shows the co-authorship network connecting the top 25 collaborators of Florent Beaufils. A scholar is included among the top collaborators of Florent Beaufils based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Florent Beaufils. Florent Beaufils is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Title	Journal	Authors	Indexed citations
1	Investigation of morpholine isosters for the development of a potent, selective and metabolically stable mTOR kinase inhibitor	European Journal of Medicinal Chemistry	Chiara Tarantelli, Florent Beaufils et al.	11
2	4-(Difluoromethyl)-5-(4-((3R,5S)-3,5-dimethylmorpholino)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders	Journal of Medicinal Chemistry	Chiara Borsari, Erhan Keleş et al.	18
3	A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor	Journal of Medicinal Chemistry	Chiara Borsari, Denise Rageot et al.	30
4	Brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD	Neuropharmacology	Doriano Fabbro, Denise Rageot et al.	14
5	Scalable, Economical, and Practical Synthesis of 4-(Difluoromethyl)pyridin-2-amine, a Key Intermediate for Lipid Kinase Inhibitors	Organic Process Research & Development	Denise Rageot, Florent Beaufils et al.	7
6	The Novel TORC1/2 Kinase Inhibitor PQR620 Has Anti-Tumor Activity in Lymphomas as a Single Agent and in Combination with Venetoclax	Cancers	Chiara Tarantelli, Eugenio Gaudio et al.	12
7	(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase	Journal of Medicinal Chemistry	Denise Rageot, Thomas Bohnacker et al.	49
8	The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy	Neuropharmacology	Claudia Brandt, Petra Hillmann et al.	63
9	Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention	Nature Communications	Thomas Bohnacker, A.E. Prota et al.	86
10	5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology	Journal of Medicinal Chemistry	Florent Beaufils, Vladimir Cmiljanović et al.	115
11	Ein zellpermeables und photospaltbares Reagens für die selektive intrazelluläre Protein‐Protein‐Dimerisierung	Angewandte Chemie	Mirjam Zimmermann, V. Hoffmann et al.	7
12	Cell‐Permeant and Photocleavable Chemical Inducer of Dimerization	Angewandte Chemie International Edition	Mirjam Zimmermann, V. Hoffmann et al.	53
13	Chemical Development of Intracellular Protein Heterodimerizers	Chemistry & Biology	Mirjam Zimmermann, Olivier Jacques et al.	49
14	Total Syntheses of Amphidinolides B1, B4, G1, H1 and Structure Revision of Amphidinolide H2	Chemistry - A European Journal	Alois Fürstner, Laure C. Bouchez et al.	94
15	An Engineered Protein Tag for Multiprotein Labeling in Living Cells breakdown →	Chemistry & Biology	Arnaud Gautier, Alexandre Juillerat et al.	833
16	Total Syntheses of Amphidinolide H and G	Angewandte Chemie International Edition	Alois Fürstner, Laure C. Bouchez et al.	98
17	Dimethyl Phosphite Mediated Hydrogen Atom Abstraction: A Tin‐Free Procedure for the Preparation of Cyclopentane Derivatives	Angewandte Chemie International Edition	Florent Beaufils, F. Dénès et al.	34
18	Dimethyl Phosphite Mediated Hydrogen Atom Abstraction: A Tin‐Free Procedure for the Preparation of Cyclopentane Derivatives	Angewandte Chemie	Florent Beaufils, F. Dénès et al.	8
19	Thiophenol-Mediated Hydrogen Atom Abstraction: An Efficient Tin-Free Procedure for the Preparation of Cyclopentane Derivatives	Organic Letters	Florent Beaufils, F. Dénès et al.	44
20	Diastereoselective Radical‐Mediated Hydrogen‐Atom Abstraction	Angewandte Chemie International Edition	Philippe Renaud, Florent Beaufils et al.	33

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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