Fernanda Ortis

5.8k citations

43 papers · 4.7k indexed · 2 hit papers · h-index 30

Impact in

Cell Biology top 0.5%
- Endoplasmic Reticulum Stress and Disease
Genetics top 0.5%
- Diabetes and associated disorders

Papers in ⓘ

Cell Biology 18
- Endoplasmic Reticulum Stress and Disease 17
Genetics 28
- Diabetes and associated disorders 27

Co-authors: Décio L. Eizirik (30 shared papers)Máikel L. Colli (7 shared papers)Alessandra K. Cardozo (14 shared papers)Miriam Cnop (9 shared papers)Daniel A. Cunha (9 shared papers)Laurence Ladrière (7 shared papers)Esteban N. Gurzov (10 shared papers)Piero Marchetti (8 shared papers)
Journals: Diabetes (4 papers)Diabetologia (4 papers)Journal of Biological Chemistry (3 papers)Journal of Molecular Endocrinology (3 papers)Molecular Endocrinology (2 papers)
Partner nations: Belgium Brazil United States

In The Last Decade

Fernanda Ortis

43 papers receiving 4.6k citations

Hit Papers

align trajectories log scale

The role of inflammation in insulitis and β-cell loss in type 1 diabetes 2009 · 799 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2009 Nature Reviews Endocrinology
2008 Journal of Cell Science

Peers

Countries citing papers authored by Fernanda Ortis

Since Specialization

Citations

This map shows the geographic impact of Fernanda Ortis's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Fernanda Ortis with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Fernanda Ortis more than expected).

Fields of papers citing papers by Fernanda Ortis

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Fernanda Ortis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Fernanda Ortis. The network helps show where Fernanda Ortis may publish in the future.

Co-authors

The 25 scholars most cited alongside Fernanda Ortis, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Fernanda Ortis Line = papers co-authored together Fernanda Ortis links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 43 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	The role of inflammation in insulitis and β-cell loss in type 1 diabetes Nature Reviews Endocrinology ·Décio L. Eizirik, Máikel L. Colli, Fernanda Ortis Hit paper breakdown →	2009	799
2	Initiation and execution of lipotoxic ER stress in pancreatic β-cells Journal of Cell Science ·Daniel A. Cunha, Paul Hekerman, Laurence Ladrière, Angie Bazarra-Castro, Fernanda Ortis, Marion C. Wakeham, Fabrice Moore, Joanne Rasschaert, Alessandra K. Cardozo, Elisa A. Bellomo, Lutgart Overbergh, Chantal Mathieu, R Lupi, Tsonwin Hai, André Herchuelz, Piero Marchetti, Guy A. Rutter, Décio L. Eizirik, Miriam Cnop Hit paper breakdown →	2008	501
3	Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca2+ ATPase 2b and Deplete Endoplasmic Reticulum Ca2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells Diabetes ·Alessandra K. Cardozo, Fernanda Ortis, Joachim Størling, Yingmei Feng, Joanne Rasschaert, Morten Tonnesen, Françoise Van Eylen, Thomas Mandrup‐Poulsen, André Herchuelz, Décio L. Eizirik	2005	443
4	The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines PLoS Genetics ·Décio L. Eizirik, Michael Sammeth, Thomas Bouckenooghe, Guy Bottu, Giorgia Sisino, Mariana Igoillo‐Esteve, Fernanda Ortis, Izortze Santín, Máikel L. Colli, Jenny Barthson, Luc Bouwens, Linda Hughes, Lorna Gregory, Gerton Lunter, Lorella Marselli, Piero Marchetti, Mark I. McCarthy, Miriam Cnop	2012	358
5	Selective Inhibition of Eukaryotic Translation Initiation Factor 2α Dephosphorylation Potentiates Fatty Acid-induced Endoplasmic Reticulum Stress and Causes Pancreatic β-Cell Dysfunction and Apoptosis Journal of Biological Chemistry ·Miriam Cnop, Laurence Ladrière, Paul Hekerman, Fernanda Ortis, Alessandra K. Cardozo, Zeynep Doğusan, Daisy Flamez, Michael Boyce, Junying Yuan, Décio L. Eizirik	2006	257
6	Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB Diabetes ·Daniel A. Cunha, Laurence Ladrière, Fernanda Ortis, Mariana Igoillo‐Esteve, Esteban N. Gurzov, R Lupi, Piero Marchetti, Décio L. Eizirik, Miriam Cnop	2009	191
7	Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes Diabetologia ·Mariana Igoillo‐Esteve, Lorella Marselli, Daniel A. Cunha, Laurence Ladrière, Fernanda Ortis, Francesco Grieco, Francesco Dotta, Gordon C. Weir, Piero Marchetti, Décio L. Eizirik, Miriam Cnop	2010	174
8	STAT1 Is a Master Regulator of Pancreatic β-Cell Apoptosis and Islet Inflammation Journal of Biological Chemistry ·Fabrice Moore, Najib Naamane, Máikel L. Colli, Thomas Bouckenooghe, Fernanda Ortis, Esteban N. Gurzov, Mariana Igoillo‐Esteve, Chantal Mathieu, Gianluca Bontempi, Thomas Thykjær, Torben F. Ørntoft, Décio L. Eizirik	2010	151
9	Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis Cell Death and Differentiation ·Esteban N. Gurzov, Fernanda Ortis, Daniel A. Cunha, Guillermo Gosset, Min Li, Alessandra K. Cardozo, Décio L. Eizirik	2009	138
10	Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells Diabetologia ·Fernanda Ortis, Pierre Pirot, Najib Naamane, Alexandra Y. Kreins, Joanne Rasschaert, Fabrice Moore, Emilie Théâtre, Catherine Verhaeghe, Nils E. Magnusson, Alain Chariot, Torben F. Ørntoft, Décio L. Eizirik	2008	133
11	Cytokines Interleukin-1β and Tumor Necrosis Factor-α Regulate Different Transcriptional and Alternative Splicing Networks in Primary β-Cells Diabetes ·Fernanda Ortis, Najib Naamane, Daisy Flamez, Laurence Ladrière, Fabrice Moore, Daniel A. Cunha, Máikel L. Colli, Thomas Thykjær, Kasper Thorsen, Torben F. Ørntoft, Décio L. Eizirik	2009	126
12	Cytokine-Induced Proapoptotic Gene Expression in Insulin-Producing Cells Is Related to Rapid, Sustained, and Nonoscillatory Nuclear Factor-κB Activation Molecular Endocrinology ·Fernanda Ortis, Alessandra K. Cardozo, Daisy Crispim, Joachim Størling, Thomas Mandrup‐Poulsen, Décio L. Eizirik	2006	116
13	Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis Diabetologia ·Florent Allagnat, Fotini Christulia, Fernanda Ortis, Pierre Pirot, S Lortz, Sigurd Lenzen, Décio L. Eizirik, Alessandra K. Cardozo	2010	108
14	p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic β-Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress Journal of Biological Chemistry ·Esteban N. Gurzov, Carla Maria Ramos Germano, Daniel A. Cunha, Fernanda Ortis, Jean‐Marie Vanderwinden, Piero Marchetti, Lin Zhang, Décio L. Eizirik	2010	102
15	Cell-permeable peptides induce dose- and length-dependent cytotoxic effects Biochimica et Biophysica Acta (BBA) - Biomembranes ·Alessandra K. Cardozo, Valérie Büchillier, Marc Mathieu, Jianhua Chen, Fernanda Ortis, Laurence Ladrière, Nathalie Allaman-Pillet, Olivier Poirot, Stephan Kellenberger, J. Beckmann, Décio L. Eizirik, Christophe Bonny, Fabienne Maurer	2007	96
16	Transcriptional Regulation of the Endoplasmic Reticulum Stress Gene Chop in Pancreatic Insulin-Producing Cells Diabetes ·Pierre Pirot, Fernanda Ortis, Miriam Cnop, Yanjun Ma, Linda M. Hendershot, Décio L. Eizirik, Alessandra K. Cardozo	2007	90
17	Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation Journal of Molecular Endocrinology ·Kira Meyerovich, Fernanda Ortis, Florent Allagnat, Alessandra K. Cardozo	2016	82
18	Loss of PPARγ in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue The Journal of Nutritional Biochemistry ·Amir J. Guri, Raquel Hontecillas, Gerardo Ferrer, Oriol Casagran, Umesh D. Wankhade, Alexis M Noble, Décio L. Eizirik, Fernanda Ortis, Miriam Cnop, Dongmin Liu, Hongwei Si, Josep Bassaganya‐Riera	2007	77
19	MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA Human Molecular Genetics ·Máikel L. Colli, Fabrice Moore, Esteban N. Gurzov, Fernanda Ortis, Décio L. Eizirik	2009	72
20	Lipotoxicity and β-Cell Failure in Type 2 Diabetes: Oxidative Stress Linked to NADPH Oxidase and ER Stress Cells ·Eloisa Aparecida Vilas‐Boas, Davidson Correa de Almeida, Letícia Prates Roma, Fernanda Ortis, Ângelo Rafael Carpinelli	2021	71

About Fernanda Ortis

Fernanda Ortis is a scholar working on Cell Biology, Genetics, Surgery, Immunology and Physiology, having authored 43 papers that have together received 4.7k indexed citations. Recurring topics across this work include Pancreatic function and diabetes (33 papers), Diabetes and associated disorders (27 papers), Endoplasmic Reticulum Stress and Disease (17 papers), Immune Cell Function and Interaction (8 papers), NF-κB Signaling Pathways (6 papers), Diabetes Management and Research (3 papers), Diet, Metabolism, and Disease (3 papers) and Metabolism, Diabetes, and Cancer (3 papers). The work is most often cited by research in Cell Biology (1.5k citations), Genetics (1.9k citations), Surgery (2.7k citations), Endocrinology, Diabetes and Metabolism (1.0k citations) and Physiology (166 citations). Fernanda Ortis has collaborated with scholars based in Belgium, Brazil and United States. Frequent co-authors include Décio L. Eizirik, Máikel L. Colli, Alessandra K. Cardozo, Miriam Cnop, Daniel A. Cunha, Laurence Ladrière, Esteban N. Gurzov, Piero Marchetti, Fabrice Moore and Joanne Rasschaert. Their work appears in journals such as Diabetes, Diabetologia, Journal of Biological Chemistry, Journal of Molecular Endocrinology and Molecular Endocrinology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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