Diane E. Handy

11.5k total citations · 4 hit papers
89 papers, 8.5k citations indexed

About

Diane E. Handy is a scholar working on Molecular Biology, Physiology and Nutrition and Dietetics. According to data from OpenAlex, Diane E. Handy has authored 89 papers receiving a total of 8.5k indexed citations (citations by other indexed papers that have themselves been cited), including 40 papers in Molecular Biology, 26 papers in Physiology and 20 papers in Nutrition and Dietetics. Recurrent topics in Diane E. Handy's work include Nitric Oxide and Endothelin Effects (17 papers), Selenium in Biological Systems (14 papers) and Folate and B Vitamins Research (14 papers). Diane E. Handy is often cited by papers focused on Nitric Oxide and Endothelin Effects (17 papers), Selenium in Biological Systems (14 papers) and Folate and B Vitamins Research (14 papers). Diane E. Handy collaborates with scholars based in United States, China and Germany. Diane E. Handy's co-authors include Joseph Loscalzo, Edith Lubos, Rita Castro, Rui‐Sheng Wang, Jane A. Leopold, Wusheng Xiao, Haralambos Gavras, Conrado Johns, Filomena G. Ottaviano and Yingyi Zhang and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Circulation.

In The Last Decade

Diane E. Handy

88 papers receiving 8.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

2010 959 citations Edith Lubos, Joseph Loscalzo et al. Antioxidants and Redox Signaling profile →
Epigenetic Modifications

2011 770 citations Diane E. Handy, Rita Castro et al. Circulation profile →
NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism

2017 684 citations Diane E. Handy, Joseph Loscalzo et al. Antioxidants and Redox Signaling profile →
The role of glutathione peroxidase-1 in health and disease

2022 161 citations Diane E. Handy, Joseph Loscalzo Free Radical Biology and Medicine profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Diane E. Handy United States	47	3.9k	1.3k	1.2k	759	757	89	8.5k
Ginger L. Milne United States	58	2.9k 0.7×	1.5k 1.1×	1.3k 1.1×	749 1.0×	784 1.0×	258	10.1k
Mark F. McCarty United States	43	2.4k 0.6×	1.8k 1.4×	1.1k 0.9×	435 0.6×	683 0.9×	335	8.1k
Ying Liu China	51	2.6k 0.7×	1.8k 1.4×	1.2k 1.0×	397 0.5×	1.1k 1.4×	283	9.4k
Luc Rochette France	51	3.3k 0.9×	2.0k 1.5×	790 0.6×	2.2k 2.9×	1.0k 1.4×	338	10.2k
Catherine Vergely France	42	2.3k 0.6×	1.5k 1.1×	520 0.4×	1.3k 1.8×	603 0.8×	179	7.0k
Tak Yee Aw United States	48	4.4k 1.1×	1.4k 1.1×	1.1k 0.9×	254 0.3×	785 1.0×	138	10.5k
Ken‐ichi Miyamoto Japan	57	4.6k 1.2×	1.5k 1.1×	2.2k 1.8×	261 0.3×	976 1.3×	351	13.9k
Bernhard Hennig United States	63	3.5k 0.9×	1.6k 1.2×	2.4k 2.0×	465 0.6×	914 1.2×	244	11.5k
Neven Žarković Croatia	51	3.4k 0.9×	1.2k 0.9×	939 0.8×	281 0.4×	640 0.8×	235	9.3k
Juan Sastre Spain	59	3.7k 1.0×	2.3k 1.7×	1.1k 0.9×	315 0.4×	1.4k 1.9×	147	11.5k

Countries citing papers authored by Diane E. Handy

Since Specialization

Citations

This map shows the geographic impact of Diane E. Handy's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Diane E. Handy with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Diane E. Handy more than expected).

Fields of papers citing papers by Diane E. Handy

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Diane E. Handy. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Diane E. Handy. The network helps show where Diane E. Handy may publish in the future.

Co-authorship network of co-authors of Diane E. Handy

This figure shows the co-authorship network connecting the top 25 collaborators of Diane E. Handy. A scholar is included among the top collaborators of Diane E. Handy based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Diane E. Handy. Diane E. Handy is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Mirzakhani, Hooman, Diane E. Handy, Zheng Lü, et al.. (2023). Integration of circulating microRNAs and transcriptome signatures identifies early‐pregnancy biomarkers of preeclampsia. Clinical and Translational Medicine. 13(11). e1446–e1446. 4 indexed citations

Handy, Diane E. & Joseph Loscalzo. (2022). The role of glutathione peroxidase-1 in health and disease. Free Radical Biology and Medicine. 188. 146–161. 161 indexed citations breakdown →

An, Xingxing, Ashley N. Ogawa-Wong, Raffaele Ambrosio, et al.. (2020). A Type 2 Deiodinase-Dependent Increase in Vegfa Mediates Myoblast-Endothelial Cell Crosstalk During Skeletal Muscle Regeneration. Thyroid. 31(1). 115–127. 16 indexed citations

Handy, Diane E. & Joseph Loscalzo. (2016). Responses to reductive stress in the cardiovascular system. Free Radical Biology and Medicine. 109. 114–124. 118 indexed citations

Barroso, Madalena, Henk J. Blom, Isabel Tavares de Almeida, et al.. (2015). S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1862(1). 82–92. 65 indexed citations

Loscalzo, Joseph & Diane E. Handy. (2014). Epigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease (2013 Grover Conference Series). Pulmonary Circulation. 4(2). 169–174. 130 indexed citations

Maron, Bradley A., Yingyi Zhang, Kevin P. White, et al.. (2012). Aldosterone Inactivates the Endothelin-B Receptor via a Cysteinyl Thiol Redox Switch to Decrease Pulmonary Endothelial Nitric Oxide Levels and Modulate Pulmonary Arterial Hypertension. Circulation. 126(8). 963–974. 149 indexed citations

Mahoney, Christopher E., Diane E. Handy, Kevin P. White, et al.. (2012). Bone Morphogenetic Protein‐2 Decreases MicroRNA‐30b and MicroRNA‐30c to Promote Vascular Smooth Muscle Cell Calcification. Journal of the American Heart Association. 1(6). e003905–e003905. 115 indexed citations

Zhang, Zhaoyun, Zhihong Yang, Bo Zhu, et al.. (2012). Increasing Glucose 6-Phosphate Dehydrogenase Activity Restores Redox Balance in Vascular Endothelial Cells Exposed to High Glucose. PLoS ONE. 7(11). e49128–e49128. 45 indexed citations

10.

Malinouski, Mikalai, Sebastian Kehr, Lydia Finney, et al.. (2011). High-Resolution Imaging of Selenium in Kidneys: A Localized Selenium Pool Associated with Glutathione Peroxidase 3. Antioxidants and Redox Signaling. 16(3). 185–192. 36 indexed citations

11.

Lubos, Edith, Joseph Loscalzo, & Diane E. Handy. (2010). Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities. Antioxidants and Redox Signaling. 15(7). 1957–1997. 959 indexed citations breakdown →

12.

Ottaviano, Filomena G., Shiow‐Shih Tang, Diane E. Handy, & Joseph Loscalzo. (2009). Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells. Molecular and Cellular Biochemistry. 327(1-2). 111–126. 51 indexed citations

13.

Schnabel, Renate B., Edith Lubos, Claudia‐Martina Messow, et al.. (2008). Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease. American Heart Journal. 156(6). 1201.e1–1201.e11. 80 indexed citations

14.

Matsui, Reiko, Shanqin Xu, Jane A. Leopold, et al.. (2006). Glucose-6-Phosphate Dehydrogenase Deficiency Decreases Vascular Superoxide and Atherosclerotic Lesions in Apolipoprotein E ^−/− Mice. Arteriosclerosis Thrombosis and Vascular Biology. 26(4). 910–916. 64 indexed citations

15.

Handy, Diane E., Yufeng Zhang, & Joseph Loscalzo. (2005). Homocysteine Down-regulates Cellular Glutathione Peroxidase (GPx1) by Decreasing Translation. Journal of Biological Chemistry. 280(16). 15518–15525. 116 indexed citations

16.

Bierl, Charlene, Barbara Voetsch, Richard C. Jin, Diane E. Handy, & Joseph Loscalzo. (2004). Determinants of Human Plasma Glutathione Peroxidase (GPx-3) Expression. Journal of Biological Chemistry. 279(26). 26839–26845. 121 indexed citations

17.

Chotani, Maqsood A., Srabani Mitra, Baogen Y. Su, et al.. (2004). Regulation of α₂-adrenoceptors in human vascular smooth muscle cells. American Journal of Physiology-Heart and Circulatory Physiology. 286(1). H59–H67. 76 indexed citations

18.

Handy, Diane E. & Joseph Loscalzo. (2003). Homocysteine and atherothrombosis: Diagnosis and treatment. Current Atherosclerosis Reports. 5(4). 276–283. 20 indexed citations

19.

DeStefano, Anita L., Haralambos Gavras, Diane E. Handy, et al.. (1998). Autosomal Dominant Orthostatic Hypotensive Disorder Maps to Chromosome 18q. The American Journal of Human Genetics. 63(5). 1425–1430. 40 indexed citations

20.

Handy, Diane E., James McCluskey, Andrew M. Lew, John E. Coligan, & David H. Margulies. (1988). Signals controlling alternative splicing of major histocompatibility complex H-2 class I pre-mRNA. Immunogenetics. 28(2). 81–90. 14 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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