Denise A. Chan

6.3k total citations · 1 hit paper
47 papers, 5.1k citations indexed

About

Denise A. Chan is a scholar working on Cancer Research, Molecular Biology and Genetics. According to data from OpenAlex, Denise A. Chan has authored 47 papers receiving a total of 5.1k indexed citations (citations by other indexed papers that have themselves been cited), including 37 papers in Cancer Research, 30 papers in Molecular Biology and 9 papers in Genetics. Recurrent topics in Denise A. Chan's work include Cancer, Hypoxia, and Metabolism (36 papers), High Altitude and Hypoxia (8 papers) and Mitochondrial Function and Pathology (6 papers). Denise A. Chan is often cited by papers focused on Cancer, Hypoxia, and Metabolism (36 papers), High Altitude and Hypoxia (8 papers) and Mitochondrial Function and Pathology (6 papers). Denise A. Chan collaborates with scholars based in United States, New Zealand and Canada. Denise A. Chan's co-authors include Amato J. Giaccia, Patrick D. Sutphin, Sandra Turcotte, Michael P. Hay, William A. Denny, Adam J. Krieg, Jen‐Tsan Chi, Nicholas Denko, Darren E. Richard and Damien Gerald and has published in prestigious journals such as Cell, Journal of Biological Chemistry and Circulation.

In The Last Decade

Denise A. Chan

47 papers receiving 5.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

2013 471 citations Luika Timmerman, Thomas Holton et al. Cancer Cell profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Denise A. Chan United States	29	3.2k	2.8k	759	488	446	47	5.1k
Kyle D. Mansfield United States	23	3.7k 1.1×	2.6k 0.9×	628 0.8×	541 1.1×	302 0.7×	32	5.6k
Irina Tchernyshyov United States	10	3.6k 1.1×	3.4k 1.2×	499 0.7×	380 0.8×	309 0.7×	10	5.2k
Gin-Wen Chang United Kingdom	13	3.8k 1.2×	3.8k 1.4×	692 0.9×	744 1.5×	768 1.7×	18	5.7k
Christina Warnecke Germany	33	2.1k 0.7×	2.3k 0.8×	369 0.5×	603 1.2×	499 1.1×	44	4.4k
Ioanna Papandreou United States	23	2.7k 0.9×	2.2k 0.8×	378 0.5×	375 0.8×	327 0.7×	37	4.5k
Peppi Koivunen Finland	37	3.8k 1.2×	3.4k 1.2×	458 0.6×	849 1.7×	354 0.8×	101	6.3k
Natalya N. Pavlova United States	16	4.8k 1.5×	3.6k 1.3×	1.0k 1.3×	252 0.5×	603 1.4×	32	6.8k
Holger Hebestreit United Kingdom	14	3.4k 1.1×	3.4k 1.2×	488 0.6×	850 1.7×	489 1.1×	17	5.7k
Guo‐Hua Fong United States	32	4.0k 1.3×	1.9k 0.7×	876 1.2×	479 1.0×	622 1.4×	55	5.9k
Haifeng Yang United States	18	4.1k 1.3×	4.4k 1.6×	650 0.9×	1.0k 2.1×	597 1.3×	38	6.2k

Countries citing papers authored by Denise A. Chan

Since Specialization

Citations

This map shows the geographic impact of Denise A. Chan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Denise A. Chan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Denise A. Chan more than expected).

Fields of papers citing papers by Denise A. Chan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Denise A. Chan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Denise A. Chan. The network helps show where Denise A. Chan may publish in the future.

Co-authorship network of co-authors of Denise A. Chan

This figure shows the co-authorship network connecting the top 25 collaborators of Denise A. Chan. A scholar is included among the top collaborators of Denise A. Chan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Denise A. Chan. Denise A. Chan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Padró, Mercè, Raymond J. Louie, Brian V. Lananna, et al.. (2017). Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells. BMC Cancer. 17(1). 203–203. 18 indexed citations

Ko, Sae Hee, Allison Nauta, Shane D. Morrison, et al.. (2017). PHD-2 Suppression in Mesenchymal Stromal Cells Enhances Wound Healing. Plastic & Reconstructive Surgery. 141(1). 55e–67e. 15 indexed citations

Morrison, Shane D., Michael S. Hu, Shuli Li, et al.. (2014). Epidermal or Dermal Specific Knockout of PHD-2 Enhances Wound Healing and Minimizes Ischemic Injury. PLoS ONE. 9(4). e93373–e93373. 27 indexed citations

Timmerman, Luika, Thomas Holton, Mariia Yuneva, et al.. (2013). Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target. Cancer Cell. 24(4). 450–465. 471 indexed citations breakdown →

Chan, Denise A., Patrick D. Sutphin, Phuong Nguyen, et al.. (2011). Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality. Science Translational Medicine. 3(94). 94ra70–94ra70. 456 indexed citations

Bonnet, Muriel, Jack U. Flanagan, Denise A. Chan, et al.. (2011). SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells. Bioorganic & Medicinal Chemistry. 19(11). 3347–3356. 19 indexed citations

Krieg, Adam J., Erinn B. Rankin, Denise A. Chan, et al.. (2009). Regulation of the Histone Demethylase JMJD1A by Hypoxia-Inducible Factor 1α Enhances Hypoxic Gene Expression and Tumor Growth. Molecular and Cellular Biology. 30(1). 344–353. 278 indexed citations

Chan, Denise A., Tiara L.A. Kawahara, Patrick D. Sutphin, et al.. (2009). Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment. Cancer Cell. 15(6). 527–538. 181 indexed citations

Robitaille, Geneviève, et al.. (2008). (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a Matrix Metalloprotease Inhibitor, Is a Novel and Potent Activator of Hypoxia-Inducible Factors. Molecular Pharmacology. 74(1). 282–288. 8 indexed citations

10.

Turcotte, Sandra, Patrick D. Sutphin, Denise A. Chan, et al.. (2007). A novel molecule targeting VHL-deficient renal cell carcinoma that induces autophagic cell death. Molecular Cancer Therapeutics. 6. 2 indexed citations

11.

Chan, Denise A., et al.. (2007). Hypoxia-inducible Factor-1α Stabilization in Nonhypoxic Conditions: Role of Oxidation and Intracellular Ascorbate Depletion. Molecular Biology of the Cell. 19(1). 86–94. 148 indexed citations

12.

Glassford, Alexander J., Patrick Yue, Ahmad Y. Sheikh, et al.. (2007). HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes. American Journal of Physiology-Endocrinology and Metabolism. 293(6). E1590–E1596. 87 indexed citations

13.

Chan, Denise A., Adam J. Krieg, Sandra Turcotte, & Amato J. Giaccia. (2007). HIF Gene Expression in Cancer Therapy. Methods in enzymology on CD-ROM/Methods in enzymology. 435. 323–345. 22 indexed citations

14.

Sutphin, Patrick D., Amato J. Giaccia, & Denise A. Chan. (2007). Energy Regulation: HIF MXIes It Up with the C-MYC Powerhouse. Developmental Cell. 12(6). 845–846. 15 indexed citations

15.

Baek, Jin Hyen, Patrick C. Mahon, Jane C Oh, et al.. (2005). OS-9 Interacts with Hypoxia-Inducible Factor 1α and Prolyl Hydroxylases to Promote Oxygen-Dependent Degradation of HIF-1α. Molecular Cell. 17(4). 503–512. 187 indexed citations

16.

Sutphin, Patrick D., Denise A. Chan, & Amato J. Giaccia. (2004). Dead Cells Don’t Form Tumors: HIF-Dependent Cytotoxins. Cell Cycle. 3(2). 155–158. 12 indexed citations

17.

Gerald, Damien, Edurne Berra, Yves‐Michel Frapart, et al.. (2004). JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress. Cell. 118(6). 781–794. 471 indexed citations

18.

Bemis, Lynne, Denise A. Chan, Carla V. Finkielstein, et al.. (2004). Distinct aerobic and hypoxic mechanisms of HIF-α regulation by CSN5. Genes & Development. 18(7). 739–744. 60 indexed citations

19.

Faivre, Sandrine, et al.. (2003). DNA strand breaks and apoptosis induced by oxaliplatin in cancer cells. Biochemical Pharmacology. 66(2). 225–237. 168 indexed citations

20.

Chan, Denise A., Patrick D. Sutphin, Nicholas Denko, & Amato J. Giaccia. (2002). Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1α. Journal of Biological Chemistry. 277(42). 40112–40117. 214 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact