Stephen Safe

66.9k total citations · 8 hit papers
822 papers, 51.9k citations indexed

About

Stephen Safe is a scholar working on Health, Toxicology and Mutagenesis, Molecular Biology and Cancer Research. According to data from OpenAlex, Stephen Safe has authored 822 papers receiving a total of 51.9k indexed citations (citations by other indexed papers that have themselves been cited), including 322 papers in Health, Toxicology and Mutagenesis, 264 papers in Molecular Biology and 206 papers in Cancer Research. Recurrent topics in Stephen Safe's work include Toxic Organic Pollutants Impact (292 papers), Effects and risks of endocrine disrupting chemicals (193 papers) and Estrogen and related hormone effects (147 papers). Stephen Safe is often cited by papers focused on Toxic Organic Pollutants Impact (292 papers), Effects and risks of endocrine disrupting chemicals (193 papers) and Estrogen and related hormone effects (147 papers). Stephen Safe collaborates with scholars based in United States, Canada and South Korea. Stephen Safe's co-authors include Maen Abdelrahim, O. Hutzinger, Sudhakar Chintharlapalli, Kyounghyun Kim, George G. J. M. Kuiper, J. Christopher Corton, Un-Ho Jin, Robert C. Burghardt, Bart van der Burg and Bo Carlsson and has published in prestigious journals such as Nature, Science and Nucleic Acids Research.

In The Last Decade

Stephen Safe

814 papers receiving 50.0k citations

Hit Papers

Interaction of Estrogenic Chemicals and Phytoestrogens wi... 1984 2026 1998 2012 1998 2006 1990 1994 2012 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
    1998 3.6k citations Stephen Safe et al. profile →
  2. The 2005 World Health Organization Reevaluation of Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-Like Compounds
    2006 3.0k citations Stephen Safe et al. Toxicological Sciences profile →
  3. Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)
    1990 1.6k citations Stephen Safe profile →
  4. Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment
    1994 1.5k citations Stephen Safe profile →
  5. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer
    2012 680 citations Kyounghyun Kim, Stephen Safe et al. profile →
  6. Polychlorinated Biphenyls (PCBs) and Polybrominated Biphenyls (PBBs): Biochemistry, Toxicology, and Mechanism of Action
    1984 663 citations Stephen Safe, O. Hutzinger profile →
  7. Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans
    1986 618 citations Stephen Safe profile →
  8. High-resolution PCB analysis: synthesis and chromatographic properties of all 209 PCB congeners
    1984 525 citations Stephen Safe et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Stephen Safe United States 107 21.9k 16.8k 11.9k 9.0k 4.7k 822 51.9k
Bruce N. Ames United States 115 7.8k 0.4× 32.7k 1.9× 15.1k 1.3× 4.5k 0.5× 2.9k 0.6× 317 69.9k
Daniel W. Nebert United States 104 10.4k 0.5× 18.6k 1.1× 9.8k 0.8× 3.7k 0.4× 8.4k 1.8× 488 45.9k
Irwin Fridovich United States 116 12.3k 0.6× 33.8k 2.0× 2.2k 0.2× 2.7k 0.3× 3.2k 0.7× 420 88.8k
Takashi Sügimura Japan 113 3.6k 0.2× 24.4k 1.5× 13.6k 1.1× 4.2k 0.5× 10.7k 2.3× 1.2k 50.0k
Jan-Ακε Gustafsson Sweden 138 5.7k 0.3× 33.6k 2.0× 7.9k 0.7× 38.5k 4.3× 13.5k 2.9× 1.2k 85.2k
Helmut Sies Germany 132 4.3k 0.2× 30.1k 1.8× 3.2k 0.3× 1.8k 0.2× 2.9k 0.6× 657 81.4k
Frank J. Gonzalez United States 171 7.3k 0.3× 56.6k 3.4× 15.7k 1.3× 8.5k 0.9× 27.1k 5.7× 1.3k 119.2k
Dean P. Jones United States 109 5.5k 0.2× 26.9k 1.6× 2.8k 0.2× 1.6k 0.2× 2.6k 0.5× 742 54.8k
Curtis D. Klaassen United States 102 10.9k 0.5× 10.8k 0.6× 2.2k 0.2× 1.6k 0.2× 11.3k 2.4× 829 40.2k
John M.C. Gutteridge United Kingdom 90 5.9k 0.3× 18.4k 1.1× 1.8k 0.2× 1.2k 0.1× 2.0k 0.4× 232 60.6k

Countries citing papers authored by Stephen Safe

Since Specialization
Citations

This map shows the geographic impact of Stephen Safe's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Stephen Safe with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Stephen Safe more than expected).

Fields of papers citing papers by Stephen Safe

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Stephen Safe. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Stephen Safe. The network helps show where Stephen Safe may publish in the future.

Co-authorship network of co-authors of Stephen Safe

This figure shows the co-authorship network connecting the top 25 collaborators of Stephen Safe. A scholar is included among the top collaborators of Stephen Safe based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Stephen Safe. Stephen Safe is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Callaway, Evelyn, et al.. (2024). Aryl hydrocarbon receptor activity in intestinal epithelial cells in the formation of colonic tertiary lymphoid tissues. American Journal of Physiology-Gastrointestinal and Liver Physiology. 327(2). G154–G174. 1 indexed citations
2.
Allred, Kimberly F., et al.. (2024). Involvement of Intestinal Epithelium Aryl Hydrocarbon Receptor Expression and 3, 3′-Diindolylmethane in Colonic Tertiary Lymphoid Tissue Formation. International Journal of Molecular Sciences. 25(18). 10153–10153. 2 indexed citations
3.
Safe, Stephen, et al.. (2023). Selective aryl hydrocarbon receptor modulators can act as antidepressants in obese female mice. Journal of Affective Disorders. 333. 409–419. 3 indexed citations
4.
Yang, Yongjian, Daniel Osorio, Laurie A. Davidson, et al.. (2021). Single-cell RNA Sequencing Reveals How the Aryl Hydrocarbon Receptor Shapes Cellular Differentiation Potency in the Mouse Colon. Cancer Prevention Research. 15(1). 17–28. 9 indexed citations
5.
Karki, Keshav, et al.. (2020). A Bis-Indole–Derived NR4A1 Antagonist Induces PD-L1 Degradation and Enhances Antitumor Immunity. Cancer Research. 80(5). 1011–1023. 32 indexed citations
6.
Shrestha, Rupesh, et al.. (2020). The Histone Methyltransferase Gene G9A Is Regulated by Nuclear Receptor 4A1 in Alveolar Rhabdomyosarcoma Cells. Molecular Cancer Therapeutics. 20(3). 612–622. 14 indexed citations
7.
Hedrick, Erik, et al.. (2019). Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma. Molecular Cancer Research. 17(11). 2221–2232. 20 indexed citations
8.
Jin, Un-Ho, Hyejin Park, Xi Li, et al.. (2018). Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. Toxicological Sciences. 164(1). 205–217. 88 indexed citations
9.
Karki, Keshav, et al.. (2017). Piperlongumine Induces Reactive Oxygen Species (ROS)-Dependent Downregulation of Specificity Protein Transcription Factors. Cancer Prevention Research. 10(8). 467–477. 68 indexed citations
10.
Hoffmann, Aline Rodrigues, et al.. (2016). PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1. Cancer Research. 77(3). 732–741. 28 indexed citations
11.
Lee, Syng‐Ook, Un-Ho Jin, Jeong Han Kang, et al.. (2014). The Orphan Nuclear Receptor NR4A1 (Nur77) Regulates Oxidative and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells. Molecular Cancer Research. 12(4). 527–538. 90 indexed citations
12.
Bousquet, Marina, Guoqing Zhuang, Cong Meng, et al.. (2013). miR-150 Blocks MLL-AF9–Associated Leukemia through Oncogene Repression. Molecular Cancer Research. 11(8). 912–922. 30 indexed citations
13.
Sreevalsan, Sandeep & Stephen Safe. (2013). The Cannabinoid WIN 55,212-2 Decreases Specificity Protein Transcription Factors and the Oncogenic Cap Protein eIF4E in Colon Cancer Cells. Molecular Cancer Therapeutics. 12(11). 2483–2493. 28 indexed citations
14.
Zhang, Shu, Kyounghyun Kim, Catherine Pfent, et al.. (2011). Aryl Hydrocarbon Receptor Agonists Induce MicroRNA-335 Expression and Inhibit Lung Metastasis of Estrogen Receptor Negative Breast Cancer Cells. Molecular Cancer Therapeutics. 11(1). 108–118. 86 indexed citations
15.
Lee, Syng‐Ook, Maen Abdelrahim, Kyungsil Yoon, et al.. (2010). Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth. Cancer Research. 70(17). 6824–6836. 132 indexed citations
16.
Liu, Xinyi, Maen Abdelrahim, Ala Abudayyeh, Ping Lei, & Stephen Safe. (2009). The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression. Molecular Cancer Therapeutics. 8(5). 1207–1217. 24 indexed citations
17.
Lans, Martine C., et al.. (1993). Effects of hydroxy-dioxins on thyroid hormone binding to transthyretin and thyroid hormone type 1 deiodinase activity in vitro and in vivo.. Human & Experimental Toxicology. 12. 68–68. 2 indexed citations
18.
Pellizzari, Edo D., et al.. (1988). Drinking-Water Criteria Document for polychlorinated biphenyls (PCBs) (final), April 1988. OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information). 31(1). 250–259. 1 indexed citations
19.
Safe, Stephen & O. Hutzinger. (1988). Environmental toxin series: Cadmium. OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information). 11(5). 581–90. 3 indexed citations
20.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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