David R. Harder

16.8k total citations · 2 hit papers
210 papers, 13.9k citations indexed

About

David R. Harder is a scholar working on Physiology, Biochemistry and Molecular Biology. According to data from OpenAlex, David R. Harder has authored 210 papers receiving a total of 13.9k indexed citations (citations by other indexed papers that have themselves been cited), including 89 papers in Physiology, 89 papers in Biochemistry and 50 papers in Molecular Biology. Recurrent topics in David R. Harder's work include Eicosanoids and Hypertension Pharmacology (89 papers), Nitric Oxide and Endothelin Effects (76 papers) and Hormonal Regulation and Hypertension (24 papers). David R. Harder is often cited by papers focused on Eicosanoids and Hypertension Pharmacology (89 papers), Nitric Oxide and Endothelin Effects (76 papers) and Hormonal Regulation and Hypertension (24 papers). David R. Harder collaborates with scholars based in United States, Japan and Germany. David R. Harder's co-authors include Debebe Gebremedhin, William B. Campbell, Richard J. Roman, John R. Falck, R. J. Roman, Phillip F. Pratt, Raymond C. Koehler, Jayashree Narayanan, Andrew R. Lange and Rudi Busse and has published in prestigious journals such as Nature, Journal of Biological Chemistry and Journal of Clinical Investigation.

In The Last Decade

David R. Harder

208 papers receiving 13.6k citations

Hit Papers

Identification of Epoxyeicosatrienoic Acids as Endotheliu... 1996 2026 2006 2016 1996 1999 250 500 750 1000
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Identification of Epoxyeicosatrienoic Acids as Endothelium-Derived Hyperpolarizing Factors
    1996 1.1k citations Debebe Gebremedhin, Phillip F. Pratt et al. profile →
  2. Cytochrome P450 2C is an EDHF synthase in coronary arteries
    1999 785 citations Beate Fißlthaler, Rüdiger Popp et al. Nature profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
David R. Harder United States 69 6.6k 5.5k 3.6k 3.5k 2.4k 210 13.9k
Richard J. Roman United States 55 4.9k 0.7× 2.7k 0.5× 2.9k 0.8× 1.6k 0.5× 1.4k 0.6× 130 8.3k
Debebe Gebremedhin United States 34 2.9k 0.4× 2.4k 0.4× 1.7k 0.5× 1.3k 0.4× 921 0.4× 62 5.5k
Beate Fißlthaler Germany 49 3.2k 0.5× 4.2k 0.8× 2.1k 0.6× 4.0k 1.1× 2.1k 0.9× 82 10.8k
Nabil J. Alkayed United States 50 2.4k 0.4× 1.2k 0.2× 2.1k 0.6× 1.8k 0.5× 493 0.2× 162 7.8k
Michel Félétou France 53 3.2k 0.5× 6.2k 1.1× 1.7k 0.5× 2.9k 0.8× 3.3k 1.4× 134 10.8k
Richard J. Roman United States 49 1.5k 0.2× 1.6k 0.3× 2.1k 0.6× 2.0k 0.6× 1.9k 0.8× 229 7.6k
Kafait U. Malik United States 44 1.6k 0.2× 1.7k 0.3× 1.2k 0.3× 2.6k 0.7× 1.5k 0.6× 226 6.4k
M. A. Cotter United Kingdom 46 695 0.1× 4.1k 0.8× 1.4k 0.4× 1.2k 0.3× 801 0.3× 137 7.3k
David W. Busija United States 55 913 0.1× 2.8k 0.5× 442 0.1× 2.8k 0.8× 1.0k 0.4× 264 9.0k
A.H. Weston United Kingdom 52 1.8k 0.3× 4.7k 0.9× 938 0.3× 4.3k 1.2× 3.2k 1.3× 136 9.2k

Countries citing papers authored by David R. Harder

Since Specialization
Citations

This map shows the geographic impact of David R. Harder's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David R. Harder with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David R. Harder more than expected).

Fields of papers citing papers by David R. Harder

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David R. Harder. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David R. Harder. The network helps show where David R. Harder may publish in the future.

Co-authorship network of co-authors of David R. Harder

This figure shows the co-authorship network connecting the top 25 collaborators of David R. Harder. A scholar is included among the top collaborators of David R. Harder based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David R. Harder. David R. Harder is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Gong, Xianghui, Michael P. Endsley, Kevin R. Rarick, et al.. (2019). Interaction of tumor cells and astrocytes promotes breast cancer brain metastases through TGF-β2/ANGPTL4 axes. npj Precision Oncology. 3(1). 24–24. 65 indexed citations
2.
3.
Zhang, Yue, Gina Hong, Kin Sing Stephen Lee, et al.. (2016). Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen‐glucose deprivation. Journal of Neurochemistry. 140(5). 814–825. 24 indexed citations
4.
Gebremedhin, Debebe, et al.. (2016). Expression of CYP 4A ω-hydroxylase and formation of 20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain astrocytes. Prostaglandins & Other Lipid Mediators. 124. 16–26. 20 indexed citations
5.
Khan, Abdul H., Amit Sharma, Kevin R. Rarick, et al.. (2015). Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats. PLoS ONE. 10(12). e0145335–e0145335. 1 indexed citations
6.
7.
Sarkar, Pallabi, Jayashree Narayanan, & David R. Harder. (2011). Differential effect of amyloid beta on the cytochrome P450 epoxygenase activity in rat brain. Neuroscience. 194. 241–249. 36 indexed citations
8.
Dunn, Kathryn, Marija Renić, Averia K. Flasch, et al.. (2008). Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. American Journal of Physiology-Heart and Circulatory Physiology. 295(6). H2455–H2465. 112 indexed citations
9.
Liu, Xiaoguang, Chunyuan Li, John R. Falck, et al.. (2008). Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex. American Journal of Physiology-Heart and Circulatory Physiology. 295(2). H619–H631. 65 indexed citations
10.
Terashvili, Maia, Leon F. Tseng, Hsiang-En Wu, et al.. (2008). Antinociception Produced by 14,15-Epoxyeicosatrienoic Acid Is Mediated by the Activation of β-Endorphin and Met-Enkephalin in the Rat Ventrolateral Periaqueductal Gray. Journal of Pharmacology and Experimental Therapeutics. 326(2). 614–622. 77 indexed citations
11.
Terashvili, Maia, Phillip F. Pratt, Debebe Gebremedhin, Jayashree Narayanan, & David R. Harder. (2006). Reactive Oxygen Species Cerebral Autoregulation in Health and Disease. Pediatric Clinics of North America. 53(5). 1029–1037. 21 indexed citations
12.
Yamaura, Ken, Debebe Gebremedhin, Jayashree Narayanan, et al.. (2006). Contribution of epoxyeicosatrienoic acids to the hypoxia-induced activation of Ca2+-activated K+ channel current in cultured rat hippocampal astrocytes. Neuroscience. 143(3). 703–716. 37 indexed citations
13.
Koehler, Raymond C., Debebe Gebremedhin, & David R. Harder. (2005). Role of astrocytes in cerebrovascular regulation. Journal of Applied Physiology. 100(1). 307–317. 218 indexed citations
14.
Medhora, Meetha, Jayashree Narayanan, David R. Harder, & Kristopher G. Maier. (2001). Identifying Endothelium-Derived Hyperpolarizing Factor: Recent Approaches to Assay the Role of Epoxyeicosatrienoic Acids. The Japanese Journal of Pharmacology. 86(4). 369–375. 22 indexed citations
15.
Fißlthaler, Beate, Rüdiger Popp, Ladislau Kiss, et al.. (1999). Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature. 401(6752). 493–497. 785 indexed citations breakdown →
16.
Alonso‐Galicia, Magdalena, John R. Falck, David R. Harder, & R. J. Roman. (1997). Structural determinants of the renal vascular response to 20-hydroxyeicosatetraenoic acid (20-HETE). The FASEB Journal. 11(3). 1 indexed citations
17.
Lange, Andrew R., Debebe Gebremedhin, Jayashree Narayanan, & David R. Harder. (1997). 20-Hydroxyeicosatetraenoic Acid-induced Vasoconstriction and Inhibition of Potassium Current in Cerebral Vascular Smooth Muscle Is Dependent on Activation of Protein Kinase C. Journal of Biological Chemistry. 272(43). 27345–27352. 152 indexed citations
18.
Gebremedhin, Debebe, Yunn‐Hwa Ma, John D. Imig, David R. Harder, & Richard J. Roman. (1993). Role of Cytochrome P-450 in Elevating Renal Vascular Tone in Spontaneously Hypertensive Rats. Journal of Vascular Research. 30(1). 53–60. 47 indexed citations
19.
Rubanyi, Gabor M., Ana D. Freay, Katalin Kauser, Anthony Johns, & David R. Harder. (1990). Mechanoreception by the Endothelium: Mediators and Mechanisms of Pressure- and Flow-Induced Vascular Responses. Journal of Vascular Research. 27(2-5). 246–257. 124 indexed citations
20.
Abel, Peter W., David R. Harder, & Kent Hermsmeyer. (1980). Membrane mechanisms of adrenergic constriction and dilation in cat cerebral arteries. 22(3). 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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