David R. Brigstock

18.7k citations

112 papers · 6.8k indexed · 1 hit paper · h-index 46

Co-authors: Runping Gao Ruju Chen Alyssa Charrier Sherri Kemper Li Chen Amy W. Rachfal Kenneth D. Brown Gail E. Besner
Topics: Connective Tissue Growth Factor Research (58 papers)Fibroblast Growth Factor Research (18 papers)Liver physiology and pathology (16 papers)
Cited by: Hepatology Molecular Biology Cancer Research
Journals: Journal of Biological Chemistry Gastroenterology PLoS ONE
Partner nations: United States China Canada

In The Last Decade

David R. Brigstock

111 papers receiving 6.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The Connective Tissue Growth Factor/Cysteine- Rich 61/Nephroblastoma Overexpressed (CCN) Family*

1999 513 citations David R. Brigstock profile →

Peers

Countries citing papers authored by David R. Brigstock

Since Specialization

Citations

This map shows the geographic impact of David R. Brigstock's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David R. Brigstock with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David R. Brigstock more than expected).

Fields of papers citing papers by David R. Brigstock

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David R. Brigstock. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David R. Brigstock. The network helps show where David R. Brigstock may publish in the future.

Co-authorship network of co-authors of David R. Brigstock

This figure shows the co-authorship network connecting the top 25 collaborators of David R. Brigstock. A scholar is included among the top collaborators of David R. Brigstock based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David R. Brigstock. David R. Brigstock is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Interleukin-6 participates in human pancreatic stellate cell activation and collagen I production via TGF-β1/Smad pathway 2021 ·Cytokine ·(unknown),Hongyan Li,Li Sun,David R. Brigstock,Runping Gao	27
2	Cellular or Exosomal microRNAs Associated with CCN Gene Expression in Liver Fibrosis 2016 ·Methods in molecular biology ·Li Chen,David R. Brigstock	6
3	An immortalized rat pancreatic stellate cell line RP-2 as a new cell model for evaluating pancreatic fibrosis, inflammation and immunity 2015 ·Hepatobiliary & pancreatic diseases international ·Rongli Piao,(unknown),David R. Brigstock,Runping Gao	11
4	Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice 2012 ·Laboratory Investigation ·Guangcun Huang,Gail E. Besner,David R. Brigstock	32
5	Integrin expression and function in the response of primary culture hepatic stellate cells to connective tissue growth factor (CCN2) 2010 ·Journal of Cellular and Molecular Medicine ·Guangcun Huang,David R. Brigstock	28
6	Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis 2010 ·Laboratory Investigation ·Alyssa Charrier,David R. Brigstock	39
7	Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function 2009 ·World Journal of Gastroenterology ·Runping Gao,David R. Brigstock	13
8	High expression of connective tissue growth factor in pre‐B acute lymphoblastic leukaemia 2007 ·British Journal of Haematology ·(unknown),Alex H. Beesley,Martin J. Firth,Joseph R. Freitas,Jette Ford,David R. Brigstock,Nicholas de Klerk,Ursula R. Kees	27
9	Important Roles for Macrophage Colony-stimulating Factor, CC Chemokine Ligand 2, and Mononuclear Phagocytes in the Pathogenesis of Pulmonary Fibrosis 2007 ·American Journal of Respiratory and Critical Care Medicine ·Christopher P. Baran,Judy M. Opalek,(unknown),Christie A. Newland,James M. O’Brien,Melissa Hunter,Benjamin Bringardner,Martha M. Monick,David R. Brigstock,Paul C. Stromberg,Gary W. Hunninghake,Clay B. Marsh	153
10	TNF-α, but not IFN-γ, regulates CCN2 (CTGF), collagen type I, and proliferation in mesangial cells: possible roles in the progression of renal fibrosis 2007 ·American Journal of Physiology-Renal Physiology ·Laurinda A. Cooker,Darryl R. Peterson,(unknown),(unknown),(unknown),Feridoon Najmabadi,David R. Brigstock,Bruce L. Riser	48
11	Intrinsic biological activity of the thrombospondin structural homology repeat in connective tissue growth factor 2006 ·Journal of Endocrinology ·Zhen-yue Tong,David R. Brigstock	29
12	Expression of connective tissue growth factor (CCN2) in desmoplastic small round cell tumour 2004 ·Journal of Clinical Pathology ·Amy W. Rachfal,Mark Luquette,David R. Brigstock	19
13	Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61) 2002 ·Angiogenesis ·David R. Brigstock	263
14	Site-directed Mutagenesis of Heparin-binding EGF-like Growth Factor (HB-EGF): Analysis of O -glycosylation Sites and Properties 2001 ·Growth Factors ·(unknown),David R. Brigstock,Gail E. Besner	6
15	Immunohistochemical Localization of Connective Tissue Growth Factor (CTGF) in the Mouse Embryo between Days 7.5 and 14.5 of Gestation 1999 ·Growth Factors ·Gulnar A. Surveyor,David R. Brigstock	61
16	Induction of Anchorage Independent Growth by Heparin-binding EGF-like Growth Factor (HB-EGF) 1999 ·Growth Factors ·Paul A. Harding,(unknown),(unknown),Matthew T. Miller,David R. Brigstock,Gail E. Besner	18
17	Localization of Connective Tissue Growth Factor during the Period of Embryo Implantation in the Mouse1 1998 ·Biology of Reproduction ·Gulnar A. Surveyor,Amy K. Wilson,David R. Brigstock	67
18	Interaction of Heparin-Binding EGF-Like Growth Factor (HB-EGF) with the Epidermal Growth Factor Receptor: Modulation by Heparin, Heparinase, or Synthetic Heparin-Binding HB-EGF Fragments 1992 ·Growth Factors ·Gail E. Besner,(unknown),(unknown),(unknown),(unknown),David R. Brigstock	57
19	Polypeptide growth factors in uterine tissues and secretions 1989 ·Reproduction ·David R. Brigstock,R. B. Heap,Kenneth D. Brown	90
20	Stimulation of polyphosphoinositide hydrolysis in Swiss 3T3 cells by recombinant fibroblast growth factors 1989 ·FEBS Letters ·Kenneth D. Brown,(unknown),David R. Brigstock	33

About David R. Brigstock

David R. Brigstock is a scholar working on Hepatology, Molecular Biology and Pathology and Forensic Medicine, having authored 112 papers that have together received 6.8k indexed citations. Recurring topics across this work include Connective Tissue Growth Factor Research (58 papers), Fibroblast Growth Factor Research (18 papers) and Liver physiology and pathology (16 papers). The work is most often cited by research in Hepatology (661 citations), Molecular Biology (4.6k citations) and Cancer Research (869 citations). David R. Brigstock has collaborated with scholars based in United States, China and Canada. Frequent co-authors include Runping Gao, Ruju Chen, Alyssa Charrier, Sherri Kemper, Li Chen, Amy W. Rachfal, Kenneth D. Brown, Gail E. Besner, Gulnar A. Surveyor and Paul A. Harding. Their work appears in journals such as Journal of Biological Chemistry, Gastroenterology and PLoS ONE.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact