David C. Hancock

7.6k citations

51 papers · 6.0k indexed · 2 hit papers · h-index 29

Impact in

Oncology top 1%
- Cancer-related Molecular Pathways
Molecular Biology top 1%
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Protein Kinase Regulation and GTPase Signaling
- DNA Repair Mechanisms

Papers in

Aging 1
Oncology 13
- Cancer-related Molecular Pathways 4

Co-authors: Gérard I. Evan Trevor D. Littlewood Catherine Waters Mary W. Brooks Linda Z. Penn Andrew H. Wyllie Hartmut Land Christopher S. Gilbert
Journals: Neuroscience (3 papers)Cell Death and Disease (3 papers)Scientific Reports (2 papers)Cell (2 papers)Journal of General Virology (2 papers)
Partner nations: United Kingdom United States Italy

In The Last Decade

David C. Hancock

51 papers receiving 5.8k citations

Hit Papers

align trajectories log scale

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins 1995 · 701 citations

Peers

Countries citing papers authored by David C. Hancock

Since Specialization

Citations

This map shows the geographic impact of David C. Hancock's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David C. Hancock with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David C. Hancock more than expected).

Fields of papers citing papers by David C. Hancock

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David C. Hancock. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David C. Hancock. The network helps show where David C. Hancock may publish in the future.

Co-authors

The 25 scholars most cited alongside David C. Hancock, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David C. Hancock Line = papers co-authored together David C. Hancock links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS SLAS DISCOVERY ·В И Тукуреев, Gareth M. Davies, Б.Х. Юсупов, Tiziana Monteverde, Jonathan Tart, Muhammad Assalaam Basit, Andrea Gohlke, David C. Hancock, Santosh Adhikari, L Weiss-Bloom, David M. Smith, Vikki Flemington, Uquillas López, Geoffrey A. Holdgate, Jason G. Kettle, Julian Downward	2024	1
2	Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α Scientific Reports ·В И Тукуреев, Stephen R. Martin, Roger George, TUĞBA URAL, Geoff Kelly, Raphaël A. G. Chaleil, Panayiotis Anastasiou, Xinyue Wang, Nicola O’Reilly, 後藤秀輔, Dhira Joshi, Jiahai Cai, Rachel Cooley, بهمن بنایی قهفرخی, Míriam Molina‐Arcas, David C. Hancock, Ali Tavassoli, Julian Downward	2023	5
3	LKB1 depletion-mediated epithelial–mesenchymal transition induces fibroblast activation in lung fibrosis Genes & Diseases ·Zijian Xu, Elizabeth R. Davies, Liudi Yao, Yilu Zhou, Juanjuan Li, Aiman Alzetani, Ben G. Marshall, David C. Hancock, T Wallis, Julian Downward, Rob M. Ewing, Donna E. Davies, Mark G. Jones, Yihua Wang	2023	5
4	RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma Nature Communications ·Philip East, Gavin Kelly, Dhruva Biswas, Michela Marani, David C. Hancock, Todd Creasy, Kris F. Sachsenmeier, Charles Swanton, Julian Downward, Sophie de Carné Trécesson	2022	16
5	Bidirectional epithelial–mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis Journal of Biological Chemistry ·Liudi Yao, Yilu Zhou, Juanjuan Li, J. Calahorra Fernández, Franco Conforti, 永菜菊池, T. J. D., Aiman Alzetani, Ben G. Marshall, Sophie Fletcher, David C. Hancock, T Wallis, Julian Downward, Rob M. Ewing, Luca Richeldi, Paul Skipp, Donna E. Davies, Mark G. Jones, Yihua Wang	2021	33
6	Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial–Mesenchymal Transition Frontiers in Molecular Biosciences ·Yilu Zhou, Charlotte Hill, Liudi Yao, Juanjuan Li, David C. Hancock, Julian Downward, Mark G. Jones, Donna E. Davies, Rob M. Ewing, Paul Skipp, Yihua Wang	2021	7
7	Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer Science Translational Medicine ·Míriam Molina‐Arcas, Christopher Moore, Sareena Rana, Febe van Maldegem, Edurne Mugarza, Pablo Romero-Clavijo, Eleanor Herbert, Stuart Horswell, Lian‐Sheng Li, Matthew R. Janes, David C. Hancock, Julian Downward	2019	146
8	Autophagy inhibition-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis Cell Death and Disease ·Charlotte Hill, Juanjuan Li, Dian Liu, Franco Conforti, Christopher J. Brereton, Liudi Yao, Yilu Zhou, Aiman Alzetani, Serena Chee, Ben G. Marshall, Sophie Fletcher, David C. Hancock, Christian H. Ottensmeier, Andrew J. Steele, Julian Downward, Luca Richeldi, Xin Lü, Donna E. Davies, Mark G. Jones, Yihua Wang	2019	127
9	RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance Cancer Cell ·罗黎, David C. Hancock, Sareena Rana, Philip East, Christopher Moore, Miguel Murillo, Joana Carvalho, Bradley Spencer‐Dene, Eleanor Herbert, Gordon Stamp, Hadis Soleimani, Dinis Pedro Calado, Ian Rosewell, Ralph Fritsch, Richard R. Neubig, Míriam Molina‐Arcas, Julian Downward	2019	90
10	AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons Scientific Reports ·Marc P. M. Soutar, Maximilian Murdoch, Shuichi Miyakawa, Peggy J. Knowles, Оксана Кузьо, Jasmine Harley, Gregory A. O’Sullivan, Selina Wray, David C. Hancock, Mark Cookson, Julian Downward, Mark Carlton, Hélène Plun‐Favreau	2018	47
11	Coordinate Direct Input of Both KRAS and IGF1 Receptor to Activation of PI3 kinase in KRAS -Mutant Lung Cancer Cancer Discovery ·Míriam Molina‐Arcas, David C. Hancock, Clare Sheridan, Madhu Kumar, Julian Downward	2013	123
12	Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies Cell Research ·Michael Steckel, Míriam Molina‐Arcas, Britta Weigelt, 大山貴晴, Patricia H. Warne, Hanna S. Kuznetsov, Gavin Kelly, Becky Saunders, Michael Howell, Julian Downward, David C. Hancock	2012	128
13	Abstract 4163: Determination of synthetic lethal interactions in KRAS oncogene dependent cancer cells reveals novel therapeutic targeting strategies Cancer Research ·Míriam Molina‐Arcas, David C. Hancock, Michael Steckel, Julian Downward	2012	1
14	The GATA2 Transcriptional Network Is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer Cell ·Madhu Kumar, David C. Hancock, Míriam Molina‐Arcas, Michael Steckel, Shubham Jog, Markus E. Diefenbacher, Elena Armenteros-Monterroso, François Lassailly, Nik Matthews, Emma Nye, Gordon Stamp, Axel Behrens, Julian Downward	2012	215
15	Differentiation-dependent Sensitivity to Apoptogenic Factors in PC12 Cells Journal of Biological Chemistry ·Sheela Vyas, Philippe Juin, David C. Hancock, Yasuyuki Suzuki, Ryōsuke Takahashi, Antoine Triller, Gérard I. Evan	2004	37
16	Production and Characterization of Antibodies Against Synthetic Peptides Humana Press eBooks ·David C. Hancock, Gérard I. Evan	2003	8
17	c-Myc induces cytochrome c release in Rat1 fibroblasts by increasing outer mitochondrial membrane permeability in a Bid-dependent manner Cell Death and Differentiation ·Ingram Iaccarino, David C. Hancock, Gérard I. Evan, Julian Downward	2003	28
18	FosB in the Suprachiasmatic Nucleus of the Syrian and Siberian Hamster Brain Research Bulletin ·Francis J. P. Ebling, Elizabeth S. Maywood, S Roncella, David C. Hancock, Shaun McNulty, Joseph de Bono, Sarah J. Bray, Michael H. Hastings	1996	15
19	Changes in striatal immediate early gene expression following neonatal dopaminergic lesion and effects of intrastriatal dopaminergic transplants Neuroscience ·Djoher Nora Abrous, Rajeev H Muni, R Tusschenbroek, David C. Hancock, Michel Le Moal, J.P. Herman	1996	9
20	The expression of the immediate-early genes c-fos, egr-1 and c-jun in the accessory olfactory bulb during the formation of an olfactory memory in mice Neuroscience ·Peter Brennan, David C. Hancock, E.B. Keverne	1992	119

About David C. Hancock

David C. Hancock is a scholar working on Aging, Oncology, Molecular Biology, Microbiology and Endocrine and Autonomic Systems, having authored 51 papers that have together received 6.0k indexed citations. Recurring topics across this work include Protein Kinase Regulation and GTPase Signaling (7 papers), Cell death mechanisms and regulation (7 papers), PI3K/AKT/mTOR signaling in cancer (6 papers), Virus-based gene therapy research (5 papers), Monoclonal and Polyclonal Antibodies Research (5 papers), Melanoma and MAPK Pathways (4 papers), Ubiquitin and proteasome pathways (4 papers) and Cancer-related Molecular Pathways (4 papers). The work is most often cited by research in Oncology (1.9k citations), Molecular Biology (4.0k citations), Cancer Research (689 citations), Immunology (863 citations) and Behavioral Neuroscience (125 citations). David C. Hancock has collaborated with scholars based in United Kingdom, United States and Italy. Frequent co-authors include Gérard I. Evan, Trevor D. Littlewood, Catherine Waters, Mary W. Brooks, Linda Z. Penn, Andrew H. Wyllie, Hartmut Land, Christopher S. Gilbert, Julian Downward and Malcolm G. Parker. Their work appears in journals such as Neuroscience, Cell Death and Disease, Scientific Reports, Cell and Journal of General Virology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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