Christopher A. Lepre

3.1k total citations · 1 hit paper
28 papers, 2.4k citations indexed

About

Christopher A. Lepre is a scholar working on Molecular Biology, Computational Theory and Mathematics and Oncology. According to data from OpenAlex, Christopher A. Lepre has authored 28 papers receiving a total of 2.4k indexed citations (citations by other indexed papers that have themselves been cited), including 23 papers in Molecular Biology, 9 papers in Computational Theory and Mathematics and 6 papers in Oncology. Recurrent topics in Christopher A. Lepre's work include Computational Drug Discovery Methods (9 papers), Protein Structure and Dynamics (6 papers) and Signaling Pathways in Disease (6 papers). Christopher A. Lepre is often cited by papers focused on Computational Drug Discovery Methods (9 papers), Protein Structure and Dynamics (6 papers) and Signaling Pathways in Disease (6 papers). Christopher A. Lepre collaborates with scholars based in United States. Christopher A. Lepre's co-authors include Jonathan M. Moore, Stephen J. Lippard, Daniel P. Bancroft, Jeffrey W. Peng, Mark A. Murcko, Jasna Fejzo, John A. Thomson, Stephen P. Chambers, Ernst ter Haar and Norzehan Abdul-Manan and has published in prestigious journals such as Cell, Chemical Reviews and Journal of the American Chemical Society.

In The Last Decade

Christopher A. Lepre

28 papers receiving 2.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide

1996 554 citations Kurt Morgenstern, Chao Lin et al. Cell profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Christopher A. Lepre United States	21	1.5k	536	430	376	332	28	2.4k
Vincent Madison United States	40	3.2k 2.1×	489 0.9×	163 0.4×	1.0k 2.7×	331 1.0×	97	4.7k
Gaetano Barbato Italy	23	1.6k 1.1×	181 0.3×	233 0.5×	122 0.3×	65 0.2×	53	2.4k
Paul Reichert United States	19	857 0.6×	335 0.6×	264 0.6×	172 0.5×	74 0.2×	46	2.1k
Wieslaw M. Kazmierski United States	25	2.8k 1.8×	302 0.6×	111 0.3×	1.2k 3.2×	152 0.5×	73	3.8k
Peter S. Dragovich United States	27	1.0k 0.7×	568 1.1×	221 0.5×	876 2.3×	216 0.7×	77	2.8k
Zhulun Wang United States	27	1.3k 0.9×	230 0.4×	98 0.2×	408 1.1×	148 0.4×	55	2.6k
Jason R. Schnell United Kingdom	22	2.4k 1.6×	180 0.3×	35 0.1×	191 0.5×	187 0.6×	36	3.3k
Chong‐Hwan Chang United States	28	1.8k 1.1×	147 0.3×	43 0.1×	769 2.0×	324 1.0×	51	3.0k
Yuk Y. Sham United States	31	2.2k 1.4×	293 0.5×	31 0.1×	625 1.7×	182 0.5×	85	3.2k
Tyuji Hoshino Japan	26	1.3k 0.8×	166 0.3×	38 0.1×	232 0.6×	181 0.5×	154	2.3k

Countries citing papers authored by Christopher A. Lepre

Since Specialization

Citations

This map shows the geographic impact of Christopher A. Lepre's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christopher A. Lepre with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christopher A. Lepre more than expected).

Fields of papers citing papers by Christopher A. Lepre

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christopher A. Lepre. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christopher A. Lepre. The network helps show where Christopher A. Lepre may publish in the future.

Co-authorship network of co-authors of Christopher A. Lepre

This figure shows the co-authorship network connecting the top 25 collaborators of Christopher A. Lepre. A scholar is included among the top collaborators of Christopher A. Lepre based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christopher A. Lepre. Christopher A. Lepre is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Lepre, Christopher A.. (2011). Practical Aspects of NMR-Based Fragment Screening. Methods in enzymology on CD-ROM/Methods in enzymology. 493. 219–239. 48 indexed citations

Haar, Ernst ter, Christopher M. Koth, Norzehan Abdul-Manan, et al.. (2010). Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism. Structure. 18(9). 1083–1093. 155 indexed citations

Haar, Ernst ter, et al.. (2007). Crystal Structure of the P38α-MAPKAP Kinase 2 Heterodimer. Journal of Biological Chemistry. 282(13). 9733–9739. 90 indexed citations

Lepre, Christopher A.. (2007). Fragment-based drug discovery using the SHAPES method. Expert Opinion on Drug Discovery. 2(12). 1555–1566. 11 indexed citations

Lepre, Christopher A., Jonathan M. Moore, & Jeffrey W. Peng. (2004). Theory and Applications of NMR-Based Screening in Pharmaceutical Research. Chemical Reviews. 104(8). 3641–3676. 245 indexed citations

Fejzo, Jasna, Christopher A. Lepre, & Xiaoling Xie. (2003). Application of NMR Screening in Drug Discovery. Current Topics in Medicinal Chemistry. 3(1). 81–97. 38 indexed citations

Peng, Jeffrey W., Christopher A. Lepre, Jasna Fejzo, Norzehan Abdul-Manan, & Jonathan M. Moore. (2002). Nuclear Magnetic Resonance-Based Approaches for Lead Generation in Drug Discovery. Methods in enzymology on CD-ROM/Methods in enzymology. 338. 202–230. 55 indexed citations

Lepre, Christopher A., Jeffrey W. Peng, Jasna Fejzo, et al.. (2002). Applications of SHAPES Screening in Drug Discovery. Combinatorial Chemistry & High Throughput Screening. 5(8). 583–590. 37 indexed citations

Lepre, Christopher A.. (2001). Library design for NMR-based screening. Drug Discovery Today. 6(3). 133–140. 45 indexed citations

10.

Fejzo, Jasna, Christopher A. Lepre, Jeffrey W. Peng, et al.. (1999). The SHAPES strategy: an NMR-based approach for lead generation in drug discovery. Chemistry & Biology. 6(10). 755–769. 194 indexed citations

11.

Lepre, Christopher A. & Jonathan M. Moore. (1998). Microdrop screening: A rapid method to optimize solvent conditions for NMR spectroscopy of proteins. Journal of Biomolecular NMR. 12(4). 493–499. 52 indexed citations

12.

Morgenstern, Kurt, Chao Lin, Ted Fox, et al.. (1996). Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide. Cell. 87(2). 343–355. 554 indexed citations breakdown →

13.

Fejzo, Jasna, Christopher A. Lepre, Jeffrey W. Peng, et al.. (1996). Dynamic NMR studies of ligand‐receptor interactions: Design and analysis of a rapidly exchanging complex of FKBP‐12/FK506 with a 24 kDa calcineurin fragment. Protein Science. 5(9). 1917–1921. 8 indexed citations

14.

Lepre, Christopher A., et al.. (1994). Solution Structure of FK506 Bound to the R42K, H87V Double Mutant of FKBP-12. Biochemistry. 33(46). 13571–13580. 10 indexed citations

15.

Cheng, Jya‐Wei, Christopher A. Lepre, & Jonathan M. Moore. (1994). 15N NMR Relaxation Studies of the FK506 Binding Protein: Dynamic Effects of Ligand Binding and Implications for Calcineurin Recognition. Biochemistry. 33(14). 4093–4100. 59 indexed citations

16.

Lepre, Christopher A., et al.. (1993). Nitrogen-15 NMR relaxation studies of the FK506 binding protein: Backbone dynamics of the uncomplexed receptor. Biochemistry. 32(35). 9000–9010. 48 indexed citations

17.

Lepre, Christopher A., John A. Thomson, & Jonathan M. Moore. (1992). Solution structure of FK506 bound to FKBP‐12. FEBS Letters. 302(1). 89–96. 32 indexed citations

18.

Moore, Jonathan M., Christopher A. Lepre, Garry P. Gippert, et al.. (1991). High-resolution solution structure of reduced French bean plastocyanin and comparison with the crystal structure of poplar plastocyanin. Journal of Molecular Biology. 221(2). 533–555. 91 indexed citations

19.

Lepre, Christopher A., Laurent Chassot, Catherine E. Costello, & S.J. Lippard. (1990). Synthesis and characterization of trans-diamminedichloroplatinum(II) adducts of d(CCTCGAGTCTCC).cntdot.d(GGAGACTCGAGG). Biochemistry. 29(3). 811–823. 57 indexed citations

20.

Lepre, Christopher A., Kenneth G. Strothkamp, & Stephen J. Lippard. (1987). Synthesis and proton NMR spectroscopic characterization of trans-[Pt(NH3)2[d(ApGpGpCpCpT)-N7-A(1),N7-G(3)]]. Biochemistry. 26(18). 5651–5657. 29 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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