Guy W. Bemis

6.3k citations

24 papers · 3.7k indexed · 1 hit paper · h-index 21

Impact in

Computational Theory and Mathematics top 0.1%
- Computational Drug Discovery Methods
Molecular Biology top 5%
- Chemical Synthesis and Analysis
- Protein Structure and Dynamics

Papers in ⓘ

Computational Theory and Mathematics 8
- Computational Drug Discovery Methods 8
Organic Chemistry 13
- Synthesis and biological activity 7
- Click Chemistry and Applications 3

Co-authors: Mark A. Murcko (6 shared papers)Ajay (2 shared papers)Albert C. Pierce (3 shared papers)Keith P. Wilson (3 shared papers)Irwin D. Kuntz (2 shared papers)Michael Su (2 shared papers)Paul R. Caron (2 shared papers)S. Pazhanisamy (3 shared papers)
Journals: Journal of Medicinal Chemistry (6 papers)Bioorganic & Medicinal Chemistry Letters (5 papers)Proteins Structure Function and Bioinformatics (2 papers)Mini-Reviews in Medicinal Chemistry (1 paper)ACS Medicinal Chemistry Letters (1 paper)
Partner nations: United States India

In The Last Decade

Guy W. Bemis

24 papers receiving 3.5k citations

Hit Papers

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The Properties of Known Drugs. 1. Molecular Frameworks 1996 · 1.7k citations

Peers

Countries citing papers authored by Guy W. Bemis

Since Specialization

Citations

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Fields of papers citing papers by Guy W. Bemis

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Guy W. Bemis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Guy W. Bemis. The network helps show where Guy W. Bemis may publish in the future.

Co-authors

The 25 scholars most cited alongside Guy W. Bemis, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Guy W. Bemis Line = papers co-authored together Guy W. Bemis links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 24 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	The Properties of Known Drugs. 1. Molecular Frameworks Journal of Medicinal Chemistry ·Guy W. Bemis, Mark A. Murcko Hit paper breakdown →	1996	1681
2	Designing Libraries with CNS Activity Journal of Medicinal Chemistry ·Ajay, Guy W. Bemis, Mark A. Murcko	1999	251
3	The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase Chemistry & Biology ·Keith P. Wilson, Patricia G. McCaffrey, Kathy Hsiao, S. Pazhanisamy, Vincent Galullo, Guy W. Bemis, Matthew J. Fitzgibbon, Paul R. Caron, Mark A. Murcko, Michael Su	1997	239
4	Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases Proceedings of the National Academy of Sciences ·Sladjana Prišić, Selasi Dankwa, Daniel Schwartz, Michael F. Chou, Jason W. Locasale, Choong‐Min Kang, Guy W. Bemis, George M. Church, Hanno Steen, Robert N. Husson	2010	220
5	Properties of Known Drugs. 2. Side Chains Journal of Medicinal Chemistry ·Guy W. Bemis, Mark A. Murcko	1999	202
6	The SHAPES strategy: an NMR-based approach for lead generation in drug discovery Chemistry & Biology ·Jasna Fejzo, Christopher A. Lepre, Jeffrey W. Peng, Guy W. Bemis, Ajay, Mark A. Murcko, Jonathan M. Moore	1999	194
7	Kinase inhibitors and the case for CH…O hydrogen bonds in protein–ligand binding Proteins Structure Function and Bioinformatics ·Albert C. Pierce, Kathryn L. Sandretto, Guy W. Bemis	2002	184
8	BREED: Generating Novel Inhibitors through Hybridization of Known Ligands. Application to CDK2, P38, and HIV Protease Journal of Medicinal Chemistry ·Albert C. Pierce, Govinda Rao, Guy W. Bemis	2004	128
9	Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors Journal of Medicinal Chemistry ·Alex M. Aronov, Christopher Baker, Guy W. Bemis, Jingrong Cao, Guanjing Chen, Pamella J. Ford, Ursula A. Germann, Jeremy Green, Michael Hale, Marc Jacobs, James W. Janetka, François Maltais, Gabriel Martínez-Botella, Mark Namchuk, Judy Straub, Qing Tang, Xiaoling Xie	2007	98
10	Inhibitors ofp38 MAP Kinase: TherapeuticIntervention inCytokine-Mediated Diseases Current Medicinal Chemistry ·Francesco G. Salituro, Ursula A. Germann, Keith P. Wilson, Guy W. Bemis, Ted Fox, Michael Su	1999	71
11	Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro Biochemical Journal ·Fiona McPhee, Patricia Caldera, Guy W. Bemis, Antony F. McDonagh, Irwin D. Kuntz, Charles S. Craik	1996	58
12	A fast and efficient method for 2D and 3D molecular shape description Journal of Computer-Aided Molecular Design ·Guy W. Bemis, Irwin D. Kuntz	1992	56
13	Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase Bioorganic & Medicinal Chemistry Letters ·Ron Grey, Albert C. Pierce, Guy W. Bemis, Marc Jacobs, Cameron Stuver Moody, Rahul Jajoo, Narinder Mohal, Jeremy Green	2009	47
14	Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions ACS Medicinal Chemistry Letters ·Tiansheng Wang, Guy W. Bemis, Brian L. Hanzelka, Harmon Zuccola, Michael Wynn, Cameron Stuver Moody, Jeremy Green, Christopher P. Locher, Aixiang Liu, Hongwu Gao, Yuzhou Xu, Shaohui Wang, Jie Wang, Youssef L. Bennani, John A. Thomson, Ute Müh	2017	40
15	Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Jingrong Cao, Huai Gao, Guy W. Bemis, Francesco G. Salituro, Mark W. Ledeboer, Edmund Harrington, Susanne Wilke, Paul Taslimi, S. Pazhanisamy, Xiaoling Xie, Marc Jacobs, Jeremy Green	2009	36
16	CORES: An Automated Method for Generating Three-Dimensional Models of Protein/Ligand Complexes Journal of Medicinal Chemistry ·Brian Hare, W. Patrick Walters, Paul R. Caron, Guy W. Bemis	2004	36
17	Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK) Bioorganic & Medicinal Chemistry Letters ·Luc J. Farmer, Guy W. Bemis, Shawn Britt, John E. Cochran, Martin Connors, Edmund Harrington, Thomas Hoock, William Markland, Suganthini Nanthakumar, Paul Taslimi, Ernst ter Haar, Jian Wang, Darshana Zhaveri, Francesco G. Salituro	2008	25
18	Kinase Chemogenomics: Targeting the Human Kinome for Target Validation and Drug Discovery Mini-Reviews in Medicinal Chemistry ·Ernst ter Haar, W. Patrick Walters, S. Pazhanisamy, Parham Taslımı, A C Pierce, Guy W. Bemis, Francesco G. Salituro, Scott L. Harbeson	2004	24
19	Dramatic reversal of diastereoselectivity in an N-acyliminium ion cyclization leading to hexahydropyrrolo[2,1-a]isoquinolines. A case of competing steric interactions The Journal of Organic Chemistry ·Bruce E. Maryanoff, David F. McComsey, Harold R. Almond, Martin S. Mutter, Guy W. Bemis, Robert R. Whittle, R. A. Olofson	1986	24
20	4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: Potent and selective p70S6 kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Upul K. Bandarage, Brian Hare, Jonathan D. Parsons, Ly Pham, Craig Marhefka, Guy W. Bemis, Qing Tang, Cameron Stuver Moody, Steve Rodems, Sundeep Shah, Christopher Adams, Jose E. Guerrero Bravo, Emmanuelle Charonnet, Vladimir Savić, Jon H. Come, Jeremy Green	2009	21

About Guy W. Bemis

Guy W. Bemis is a scholar working on Computational Theory and Mathematics, Organic Chemistry, Molecular Biology, Physical and Theoretical Chemistry and Infectious Diseases, having authored 24 papers that have together received 3.7k indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (8 papers), Synthesis and biological activity (7 papers), Melanoma and MAPK Pathways (5 papers), Biochemical and Molecular Research (4 papers), Chemical Synthesis and Analysis (3 papers), Click Chemistry and Applications (3 papers), Enzyme Structure and Function (3 papers) and Molecular spectroscopy and chirality (2 papers). The work is most often cited by research in Computational Theory and Mathematics (1.9k citations), Molecular Biology (2.3k citations), Organic Chemistry (946 citations), Pharmacology (484 citations) and Spectroscopy (358 citations). Guy W. Bemis has collaborated with scholars based in United States and India. Frequent co-authors include Mark A. Murcko, Ajay, Albert C. Pierce, Keith P. Wilson, Irwin D. Kuntz, Michael Su, Paul R. Caron, S. Pazhanisamy, Jeffrey W. Peng and Jonathan M. Moore. Their work appears in journals such as Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Proteins Structure Function and Bioinformatics, Mini-Reviews in Medicinal Chemistry and ACS Medicinal Chemistry Letters.

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