Emanuele Perola

3.6k citations

33 papers · 2.2k indexed · h-index 22

Computational Theory and Mathematics top 0.5%
- Computational Drug Discovery Methods 9
Pharmacology top 2%
- Cholinesterase and Neurodegenerative Diseases 6
Molecular Biology top 5%
- Protein Structure and Dynamics 5
- Cancer therapeutics and mechanisms 4
- RNA and protein synthesis mechanisms 4
Infectious Diseases top 5%
- Tuberculosis Research and Epidemiology 3
Virology top 5%
Organic Chemistry
- Chemical synthesis and alkaloids 5
- Click Chemistry and Applications 3

Co-authors: Paul S. Charifson W. Patrick Walters Doriano Lamba Yuan‐Ping Pang Luciano Cellai Cecilia Bartolucci Kun Xu Franklyn G. Prendergast
Cited by: Computational Theory and Mathematics Pharmacology Molecular Biology
Journals: Angewandte Chemie International Edition (1 paper)The EMBO Journal (1 paper)Biochemistry (1 paper)
Partner nations: United States Italy Germany

In The Last Decade

Emanuele Perola

33 papers receiving 2.1k citations

Peers

Countries citing papers authored by Emanuele Perola

Since Specialization

Citations

This map shows the geographic impact of Emanuele Perola's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Emanuele Perola with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Emanuele Perola more than expected).

Fields of papers citing papers by Emanuele Perola

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Emanuele Perola. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Emanuele Perola. The network helps show where Emanuele Perola may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Emanuele Perola, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Emanuele Perola Line = papers co-authored together Emanuele Perola links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	BLU-808, a Potent and Selective Small Molecule Inhibitor of Wild-type c-KIT for Mast Cell Disorders Journal of Allergy and Clinical Immunology ·Alexandra Grassian,Andrew M. Haidle,Sophia AuDuong,James Α. Baker,Guangyan Du,Megan Hatlen,Melissa Hiki,Wei Hu,Kevin Keane,Thiwanka Samarakoon Mudiyanselage,Emanuele Perola,Christine Pien,Priyanka Sawant,Doug Wilson,Rob Meissner,Jason D. Brubaker,Scott Ribich,J.H Kim	2024	4
2	2-N-Arylthiazole inhibitors of Mycobacterium tuberculosis Bioorganic & Medicinal Chemistry Letters ·Michael P. Clark,Tiansheng Wang,Emanuele Perola,David D. Deininger,Harmon Zuccola,Steven M. Jones,Hong Gao,Brian C. VanderVen,David G. Russell,Carolyn Shoen,Michael H. Cynamon,John A. Thomson,Christopher P. Locher	2017	9
3	Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment PLoS Pathogens ·Brian C. VanderVen,Ruth J. Fahey,Wonsik Lee,Yan‐Cheng Liu,Robert B. Abramovitch,Christine Memmott,Adam M. Crowe,Lindsay D. Eltis,Emanuele Perola,David D. Deininger,Tiansheng Wang,Christopher P. Locher,David G. Russell	2015	203
4	Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors Bioorganic & Medicinal Chemistry Letters ·Michael J. Boyd,Upul K. Bandarage,Hamilton B. Bennett,Randal R. Byrn,Ioana Davies,Wenxin Gu,Marc Jacobs,Mark W. Ledeboer,Brian Ledford,Joshua R. Leeman,Emanuele Perola,Tiansheng Wang,Youssef L. Bennani,Michael P. Clark,Paul S. Charifson	2015	26
5	Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit Antimicrobial Agents and Chemotherapy ·Randal A. Byrn,Steven J.M. Jones,Hamilton B. Bennett,Chris Bral,Michael P. Clark,Marc Jacobs,Ann D. Kwong,Mark W. Ledeboer,Joshua R. Leeman,Colleen F. McNeil,Mark A. Murcko,Azin Nezami,Emanuele Perola,René Rijnbrand,Kumkum Saxena,Alice Tsai,Yi Zhou,Paul S. Charifson	2014	149
6	Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy Bioorganic & Medicinal Chemistry Letters ·Emanuele Perola,Dean Stamos,Anne‐Laure Grillot,Steven Ronkin,Tiansheng Wang,Arnaud LeTiran,Qing Tang,David D. Deininger,Yusheng Liao,Shi‐Kai Tian,Joseph E. Drumm,David P. Nicolau,Pamela R. Tessier,Nagraj Mani,Trudy H. Grossman,Paul S. Charifson	2014	8
7	Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: Aminoalkoxypyrimidine carboxamides Bioorganic & Medicinal Chemistry Letters ·Wenxin Gu,Tiansheng Wang,François Maltais,Brian Ledford,Joseph M. Kennedy,Yunyi Wei,Christian H. Gross,Jonathan D. Parsons,Leonard Duncan,S J Ryan Arends,Cameron Stuver Moody,Emanuele Perola,Jeremy Green,Paul S. Charifson	2012	12
8	Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-Amino-pyrido[2,3-d]pyrimidin-5(8H)-ones Bioorganic & Medicinal Chemistry Letters ·Tiansheng Wang,Leonard Duncan,Wenxin Gu,Hardwin O’Dowd,Yunyi Wei,Emanuele Perola,Jonathan D. Parsons,Christian H. Gross,Cameron Stuver Moody,S J Ryan Arends,Paul S. Charifson	2012	13
9	An Analysis of the Binding Efficiencies of Drugs and Their Leads in Successful Drug Discovery Programs Journal of Medicinal Chemistry ·Emanuele Perola	2010	139
10	Novel thiol-based TACE inhibitors: Rational design, synthesis, and SAR of thiol-containing aryl sulfonamides Bioorganic & Medicinal Chemistry Letters ·B. Govinda Rao,Upul K. Bandarage,Tiansheng Wang,Jon H. Come,Emanuele Perola,Yunyi Wei,Shi‐Kai Tian,Jeffrey O. Saunders	2007	26
11	A detailed comparison of current docking and scoring methods on systems of pharmaceutical relevance Proteins Structure Function and Bioinformatics ·Emanuele Perola,W. Patrick Walters,Paul S. Charifson	2004	363
12	EUDOC: a computer program for identification of drug interaction sites in macromolecules and drug leads from chemical databases Journal of Computational Chemistry ·Yuan‐Ping Pang,Emanuele Perola,Kun Xu,Franklyn G. Prendergast	2001	74
13	Discovery of a new inhibitor lead of adenovirus proteinase: steps toward selective, irreversible inhibitors of cysteine proteinases FEBS Letters ·Yuan‐Ping Pang,Kun Xu,Thomas M. Kollmeyer,Emanuele Perola,William J. McGrath,Dave T. Green,Walter F. Mangel	2001	27
14	Three-dimensional structure of a complex of galanthamine (Nivalin�) with acetylcholinesterase fromTorpedo californica: Implications for the design of new anti-Alzheimer drugs Proteins Structure Function and Bioinformatics ·Cecilia Bartolucci,Emanuele Perola,Christian Pilger,Gregor Fels,Doriano Lamba	2000	124
15	NMR structure of the chimeric hybrid duplex r(gcaguggc)⋅r(gcca)d(CTGC) comprising the tRNA-DNA junction formed during initiation of HIV-1 reverse transcription Journal of Biomolecular NMR ·Thomas Szyperski,Matthias Götte,Martin Billeter,Emanuele Perola,Luciano Cellai,H. Heumann,Kurt Wüthrich	1999	36
16	Fractions of Chemically Oversulphated Galactosaminoglycan Sulphates Inhibit Three Enveloped Viruses: Human Immunodeficiency Virus Type 1, Herpes Simplex Virus Type 1 and Human Cytomegalovirus Antiviral chemistry & chemotherapy ·Antonino Di,Emanuele Perola,Barbara Bartolini,Maria Marzano,Lino Liverani,Giuseppe Mascellani,A. Benedetto,Luciano Cellai	1999	12
17	Synthesis and activity studies of N-[ω-N′-(adamant-1′-yl)aminoalkyl]-2-(4′-dimethylaminophenyl)acetamides: In the search of selective inhibitors for the different molecular forms of acetylcholinesterase Bioorganic & Medicinal Chemistry Letters ·Emanuele Perola,Luciano Cellai,Mario Brufani	1998	1
18	Long chain analogs of physostigmine as potential drugs for Alzheimer's disease: new insights into the mechanism of action in the inhibition of acetylcholinesterase Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology ·Emanuele Perola,Luciano Cellai,Doriano Lamba,Luigi Filocamo,Mario Brufani	1997	52
19	Inhibition of human leukocyte elastase by chemically and naturally oversulfated galactosaminoglycans Carbohydrate Research ·Cecilia Bartolucci,Luciano Cellai,Maria Adelaide Iannelli,Doriano Lamba,Lino Liverani,Giuseppe Mascellani,Emanuele Perola	1995	22
20	HIV-1 reverse transcriptase-associated RNase H cleaves RNA/RNA in arrested complexes: implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA. The EMBO Journal ·Matthias Götte,S. Fackler,Thomas Hermann,Emanuele Perola,Luciano Cellai,H. Groß,S F Le Grice,Hermann Heumann	1995	81

About Emanuele Perola

Emanuele Perola is a scholar working on Toxicology, Computational Theory and Mathematics and Virology, having authored 33 papers that have together received 2.2k indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (9 papers), Cholinesterase and Neurodegenerative Diseases (6 papers), Protein Structure and Dynamics (5 papers), Chemical synthesis and alkaloids (5 papers), Cancer therapeutics and mechanisms (4 papers), RNA and protein synthesis mechanisms (4 papers), Click Chemistry and Applications (3 papers) and Tuberculosis Research and Epidemiology (3 papers). The work is most often cited by research in Computational Theory and Mathematics (993 citations), Pharmacology (418 citations) and Molecular Biology (1.3k citations). Emanuele Perola has collaborated with scholars based in United States, Italy and Germany. Frequent co-authors include Paul S. Charifson, W. Patrick Walters, Doriano Lamba, Yuan‐Ping Pang, Luciano Cellai, Cecilia Bartolucci, Kun Xu, Franklyn G. Prendergast, Tiansheng Wang and Mario Brufani. Their work appears in journals such as Angewandte Chemie International Edition, The EMBO Journal and Biochemistry.

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