Christoph Schächtele

5.1k citations

77 papers · 4.3k indexed · 1 hit paper · h-index 32

Co-authors: Dieter Marmé Georg Martiny‐Baron Peter M. Blumberg Harald Mischak Marcelo G. Kazanietz Georg Kochs Hubert Hug Frank Totzke
Topics: HER2/EGFR in Cancer Research (11 papers)Cancer therapeutics and mechanisms (10 papers)Quinazolinone synthesis and applications (10 papers)
Cited by: Toxicology Molecular Biology Organic Chemistry
Journals: Proceedings of the National Academy of Sciences Journal of Biological Chemistry Cancer Research
Partner nations: Germany United States France

In The Last Decade

Christoph Schächtele

77 papers receiving 4.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976

1993 1.5k citations Dieter Marmé, Christoph Schächtele et al. profile →

Peers

Countries citing papers authored by Christoph Schächtele

Since Specialization

Citations

This map shows the geographic impact of Christoph Schächtele's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christoph Schächtele with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christoph Schächtele more than expected).

Fields of papers citing papers by Christoph Schächtele

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christoph Schächtele. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christoph Schächtele. The network helps show where Christoph Schächtele may publish in the future.

Co-authorship network of co-authors of Christoph Schächtele

This figure shows the co-authorship network connecting the top 25 collaborators of Christoph Schächtele. A scholar is included among the top collaborators of Christoph Schächtele based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christoph Schächtele. Christoph Schächtele is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2 2019 ·Bioorganic & Medicinal Chemistry Letters ·Ruben G.G. Leenders,(unknown),(unknown),M. van Sande,(unknown),(unknown),(unknown),Daniel S. Müller,Jan E. Ehlert,Daniel Feger,(unknown),Michael H.G. Kubbutat,Christoph Schächtele,Danny C. Lenstra,Jasmin Mecinović,Gerhard Müller	3
2	Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors 2017 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),Thomas Krüger,Abdulkarim Najjar,Frank Totzke,Christoph Schächtele,Wolfgang Sippl,Christoph A. Ritter,Andreas Hilgeroth	18
3	Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors 2017 ·European Journal of Pharmaceutics and Biopharmaceutics ·(unknown),(unknown),Lutz Preu,Frank Totzke,Christoph Schächtele,Michael H.G. Kubbutat,Conrad Kunick	2
4	Discovery of 4-anilino α-carbolines as novel Brk inhibitors 2014 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),(unknown),(unknown),(unknown),Christoph Schächtele,Frank Totzke,Wolfgang Sippl,Andreas Hilgeroth	21
5	Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors 2013 ·European Journal of Medicinal Chemistry ·Maria Letícia de Castro Barbosa,Lı́dia Moreira Lima,Roberta Tesch,Carlos Maurício R. Sant’Anna,Frank Totzke,Michael H.G. Kubbutat,Christoph Schächtele,Stefan Laufer,Eliezer J. Barreiro	126
6	Identification of Inhibitors of the Tyrosine Kinase c‐Met by Structure‐Based Virtual Screening 2011 ·Molecular Informatics ·Thomas Lemcke,(unknown),Matthias Rarey,Frank Totzke,Christoph Schächtele,Michael H.G. Kubbutat,Conrad Kunick	1
7	Dual IGF-1R/SRC inhibitors based on a N′-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure 2011 ·European Journal of Medicinal Chemistry ·Stefanie Schmidt,Lutz Preu,Thomas Lemcke,Frank Totzke,Christoph Schächtele,Michael H.G. Kubbutat,Conrad Kunick	15
8	Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors 2010 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),(unknown),Wolfgang Sippl,Christoph Schächtele,Frank Totzke,Andreas Hilgeroth	7
9	Design, Synthesis, and Biological Evaluation of Novel 3-Aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as Vascular Endothelial Growth Factor Receptor (VEGF-R) Inhibitors 2008 ·Journal of Medicinal Chemistry ·Christian Peifer,(unknown),(unknown),(unknown),Frank Totzke,Christoph Schächtele,Regina Heidenreich,Martin Röcken,Dieter Schollmeyer,Stefan Laufer	80
10	Meriolins, a New Class of Cell Death–Inducing Kinase Inhibitors with Enhanced Selectivity for Cyclin-Dependent Kinases 2007 ·Cancer Research ·Karima Bettayeb,Òscar M. Tirado,Séverine Marionneau‐Lambot,Yoan Ferandin,Olivier Lozach,Jonathan C. Morris,Silvia Mateo‐Lozano,Peter Drueckes,Christoph Schächtele,Michael H.G. Kubbutat,François Mouton‐Liger,Bernard Marquet,Benoı̂t Joseph,Aude Echalier,Jane Endicott,Vicente Notario,Laurent Meijer	95
11	1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: A new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines 2007 ·European Journal of Medicinal Chemistry ·(unknown),Peter G. Jones,Frank Totzke,Christoph Schächtele,Michael H.G. Kubbutat,Conrad Kunick	10
12	Structure‐Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone 2005 ·ChemBioChem ·Conrad Kunick,(unknown),Rick Gussio,Daniel Zaharevitz,(unknown),Frank Totzke,Christoph Schächtele,Michael H.G. Kubbutat,Laurent Meijer,Thomas Lemcke	34
13	Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes 2004 ·Bioorganic & Medicinal Chemistry Letters ·B. VOIGT,Laurent Meijer,Olivier Lozach,Christoph Schächtele,Frank Totzke,Andreas Hilgeroth	39
14	Lack of an effect of novel inhibitors with high specificity for protein kinase C on the action of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate on mouse skin in vivo 1995 ·Carcinogenesis ·Michael Gschwendt,Gerhard Fürstenberger,(unknown),Walter Kittstein,(unknown),Claus Rudolph,Heidi Barth,(unknown),Dieter Marmé,Christoph Schächtele,Friedrich Marks	23
15	Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin a in phagocytes is not mediated by direct inhibition of protein kinase C 1994 ·Biochemical Pharmacology ·Katharina Wenzel‐Seifert,Christoph Schächtele,Richard Hummel,(unknown),Roland Seifert	7
16	Novel indolocarbazole protein kinase C inhibitors prevent reactivation of HIV-1 in latently infected cells 1993 ·Antiviral Research ·(unknown),Josef Schneider,Claus Rudolph,Dieter Marmé,Christoph Schächtele	14
17	Characterization of multiple forms of phosphoinositide-specific phospholipase C from bovine aorta 1991 ·Cellular Signalling ·M. Späth,Rüdiger Woscholski,Christoph Schächtele	10
18	Sites phosphorylated in bovine cardiac troponin T and I 1990 ·European Journal of Biochemistry ·Kristine M. Swiderek,Kornélia Jaquet,Helmut E. Meyer,Christoph Schächtele,Franz Hofmann,Ludwig M.G. Heilmeyer	50
19	Effect of Ca2+ entry blockers on myosin light-chain kinase and protein kinase C 1989 ·European Journal of Pharmacology ·Christoph Schächtele,Bernd Wagner,Claus Rudolph	14
20	Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine 1988 ·Biochemical and Biophysical Research Communications ·Christoph Schächtele,Roland Seifert,Hartmut Oßwald	95

About Christoph Schächtele

Christoph Schächtele is a scholar working on Toxicology, Organic Chemistry and Oncology, having authored 77 papers that have together received 4.3k indexed citations. Recurring topics across this work include HER2/EGFR in Cancer Research (11 papers), Cancer therapeutics and mechanisms (10 papers) and Quinazolinone synthesis and applications (10 papers). The work is most often cited by research in Toxicology (139 citations), Molecular Biology (2.4k citations) and Organic Chemistry (984 citations). Christoph Schächtele has collaborated with scholars based in Germany, United States and France. Frequent co-authors include Dieter Marmé, Georg Martiny‐Baron, Peter M. Blumberg, Harald Mischak, Marcelo G. Kazanietz, Georg Kochs, Hubert Hug, Frank Totzke, Roland Seifert and Michael H.G. Kubbutat. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Cancer Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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