Christoph Schächtele

5.1k citations

77 papers · 4.3k indexed · 1 hit paper · h-index 32

Toxicology top 1%
- Bioactive Compounds and Antitumor Agents 6
Molecular Biology top 5%
- Cancer therapeutics and mechanisms 10
- Protein Kinase Regulation and GTPase Signaling 8
- Angiogenesis and VEGF in Cancer 6
Organic Chemistry top 2%
- Quinazolinone synthesis and applications 10
Pharmacology top 2%
- Microbial Natural Products and Biosynthesis 5
Cell Biology top 5%
Oncology
- HER2/EGFR in Cancer Research 11
Computational Theory and Mathematics
- Computational Drug Discovery Methods 6

Co-authors: Dieter Marmé Georg Martiny‐Baron Peter M. Blumberg Harald Mischak Marcelo G. Kazanietz Georg Kochs Hubert Hug Frank Totzke
Cited by: Toxicology Molecular Biology Organic Chemistry
Journals: Journal of Medicinal Chemistry (11 papers)Bioorganic & Medicinal Chemistry Letters (10 papers)Biochemical and Biophysical Research Communications (7 papers)
Partner nations: Germany United States France

In The Last Decade

Christoph Schächtele

77 papers receiving 4.2k citations

Hit Papers

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Peers

Countries citing papers authored by Christoph Schächtele

Since Specialization

Citations

This map shows the geographic impact of Christoph Schächtele's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christoph Schächtele with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christoph Schächtele more than expected).

Fields of papers citing papers by Christoph Schächtele

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christoph Schächtele. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christoph Schächtele. The network helps show where Christoph Schächtele may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Christoph Schächtele, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Christoph Schächtele Line = papers co-authored together Christoph Schächtele links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2 Bioorganic & Medicinal Chemistry Letters ·Ruben G.G. Leenders,Gobien Rp,Pedro Henrique Vieira,M. van Sande,Domilin Shyni,Vioalle Hefferan,Yusuf Ganisher ugli Samidinov,Daniel S. Müller,Jan E. Ehlert,Daniel Feger,久美子髙梨,Michael H.G. Kubbutat,Christoph Schächtele,Danny C. Lenstra,Jasmin Mecinović,Gerhard Müller	2019	3
2	Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors Bioorganic & Medicinal Chemistry Letters ·Wen Chen,Thomas Krüger,Abdulkarim Najjar,Frank Totzke,Christoph Schächtele,Wolfgang Sippl,Christoph A. Ritter,Andreas Hilgeroth	2017	18
3	Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors European Journal of Pharmaceutics and Biopharmaceutics ·Rondinelli Mendes-Dias,Abd El-Naser Badawy El-Sayed,Lutz Preu,Frank Totzke,Christoph Schächtele,Michael H.G. Kubbutat,Conrad Kunick	2017	2
4	Discovery of 4-anilino α-carbolines as novel Brk inhibitors Bioorganic & Medicinal Chemistry Letters ·Ветшева Мария Сергеевна,Gaoli Yan,امیرحسین خرمی روز,Maria Emília Oliveira de Queiroga,Christoph Schächtele,Frank Totzke,Wolfgang Sippl,Andreas Hilgeroth	2014	21
5	Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors European Journal of Medicinal Chemistry ·Maria Letícia de Castro Barbosa,Lı́dia Moreira Lima,Roberta Tesch,Carlos Maurício R. Sant’Anna,Frank Totzke,Michael H.G. Kubbutat,Christoph Schächtele,Stefan Laufer,Eliezer J. Barreiro	2013	126
6	Identification of Inhibitors of the Tyrosine Kinase c‐Met by Structure‐Based Virtual Screening Molecular Informatics ·Thomas Lemcke,Tim B. B. Skuldboel,Matthias Rarey,Frank Totzke,Christoph Schächtele,Michael H.G. Kubbutat,Conrad Kunick	2011	1
7	Dual IGF-1R/SRC inhibitors based on a N′-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure European Journal of Medicinal Chemistry ·Stefanie Schmidt,Lutz Preu,Thomas Lemcke,Frank Totzke,Christoph Schächtele,Michael H.G. Kubbutat,Conrad Kunick	2011	15
8	Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors Bioorganic & Medicinal Chemistry Letters ·Gaoli Yan,Mrunali H. Damania,Wolfgang Sippl,Christoph Schächtele,Frank Totzke,Andreas Hilgeroth	2010	7
9	Design, Synthesis, and Biological Evaluation of Novel 3-Aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as Vascular Endothelial Growth Factor Receptor (VEGF-R) Inhibitors Journal of Medicinal Chemistry ·Christian Peifer,E. Le Coarer,Cho Jiyoung,Zeng Xianjing,Frank Totzke,Christoph Schächtele,Regina Heidenreich,Martin Röcken,Dieter Schollmeyer,Stefan Laufer	2008	80
10	Meriolins, a New Class of Cell Death–Inducing Kinase Inhibitors with Enhanced Selectivity for Cyclin-Dependent Kinases Cancer Research ·Karima Bettayeb,Òscar M. Tirado,Séverine Marionneau‐Lambot,Yoan Ferandin,Olivier Lozach,Jonathan C. Morris,Silvia Mateo‐Lozano,Peter Drueckes,Christoph Schächtele,Michael H.G. Kubbutat,François Mouton‐Liger,Bernard Marquet,Benoı̂t Joseph,Aude Echalier,Jane Endicott,Vicente Notario,Laurent Meijer	2007	95
11	1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: A new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines European Journal of Medicinal Chemistry ·Golnaz Boraei-nezhad‬,Peter G. Jones,Frank Totzke,Christoph Schächtele,Michael H.G. Kubbutat,Conrad Kunick	2007	10
12	Structure‐Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone ChemBioChem ·Conrad Kunick,Anvar Musayev,Rick Gussio,Daniel Zaharevitz,Gabriela Fernanda Serrano-Ortega,Frank Totzke,Christoph Schächtele,Michael H.G. Kubbutat,Laurent Meijer,Thomas Lemcke	2005	34
13	Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes Bioorganic & Medicinal Chemistry Letters ·B. VOIGT,Laurent Meijer,Olivier Lozach,Christoph Schächtele,Frank Totzke,Andreas Hilgeroth	2004	39
14	Lack of an effect of novel inhibitors with high specificity for protein kinase C on the action of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate on mouse skin in vivo Carcinogenesis ·Michael Gschwendt,Gerhard Fürstenberger,Rahul D. Modi,Walter Kittstein,Wan-Nurisma Ayu Wan-Ismail,Claus Rudolph,Heidi Barth,Sruthymol Dinesan,Dieter Marmé,Christoph Schächtele,Friedrich Marks	1995	23
15	Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin a in phagocytes is not mediated by direct inhibition of protein kinase C Biochemical Pharmacology ·Katharina Wenzel‐Seifert,Christoph Schächtele,Richard Hummel,Tantiara Fiesta Sinaga,Roland Seifert	1994	7
16	Novel indolocarbazole protein kinase C inhibitors prevent reactivation of HIV-1 in latently infected cells Antiviral Research ·Raveena Ramadhani,Josef Schneider,Claus Rudolph,Dieter Marmé,Christoph Schächtele	1993	14
17	Characterization of multiple forms of phosphoinositide-specific phospholipase C from bovine aorta Cellular Signalling ·M. Späth,Rüdiger Woscholski,Christoph Schächtele	1991	10
18	Sites phosphorylated in bovine cardiac troponin T and I European Journal of Biochemistry ·Kristine M. Swiderek,Kornélia Jaquet,Helmut E. Meyer,Christoph Schächtele,Franz Hofmann,Ludwig M.G. Heilmeyer	1990	50
19	Effect of Ca2+ entry blockers on myosin light-chain kinase and protein kinase C European Journal of Pharmacology ·Christoph Schächtele,Bernd Wagner,Claus Rudolph	1989	14
20	Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine Biochemical and Biophysical Research Communications ·Christoph Schächtele,Roland Seifert,Hartmut Oßwald	1988	95

About Christoph Schächtele

Christoph Schächtele is a scholar working on Toxicology, Organic Chemistry and Oncology, having authored 77 papers that have together received 4.3k indexed citations. Recurring topics across this work include HER2/EGFR in Cancer Research (11 papers), Cancer therapeutics and mechanisms (10 papers), Quinazolinone synthesis and applications (10 papers), Protein Kinase Regulation and GTPase Signaling (8 papers), Bioactive Compounds and Antitumor Agents (6 papers), Angiogenesis and VEGF in Cancer (6 papers), Computational Drug Discovery Methods (6 papers) and Microbial Natural Products and Biosynthesis (5 papers). The work is most often cited by research in Toxicology (139 citations), Molecular Biology (2.4k citations) and Organic Chemistry (984 citations). Christoph Schächtele has collaborated with scholars based in Germany, United States and France. Frequent co-authors include Dieter Marmé, Georg Martiny‐Baron, Peter M. Blumberg, Harald Mischak, Marcelo G. Kazanietz, Georg Kochs, Hubert Hug, Frank Totzke, Roland Seifert and Michael H.G. Kubbutat. Their work appears in journals such as Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Biochemical and Biophysical Research Communications, European Journal of Medicinal Chemistry and MedChemComm.

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