Charles L. Brooks

59.4k total citations · 12 hit papers
427 papers, 40.5k citations indexed

About

Charles L. Brooks is a scholar working on Molecular Biology, Materials Chemistry and Atomic and Molecular Physics, and Optics. According to data from OpenAlex, Charles L. Brooks has authored 427 papers receiving a total of 40.5k indexed citations (citations by other indexed papers that have themselves been cited), including 339 papers in Molecular Biology, 130 papers in Materials Chemistry and 86 papers in Atomic and Molecular Physics, and Optics. Recurrent topics in Charles L. Brooks's work include Protein Structure and Dynamics (241 papers), Enzyme Structure and Function (110 papers) and RNA and protein synthesis mechanisms (80 papers). Charles L. Brooks is often cited by papers focused on Protein Structure and Dynamics (241 papers), Enzyme Structure and Function (110 papers) and RNA and protein synthesis mechanisms (80 papers). Charles L. Brooks collaborates with scholars based in United States, Germany and China. Charles L. Brooks's co-authors include Michael Feig, Alexander D. MacKerell, Martin Karplus, Wonpil Im, D.J. Price, Florence Tama, John Karanicolas, Michael S. Lee, Sandeep Patel and Douglas J. Tobias and has published in prestigious journals such as Nature, Science and Chemical Reviews.

In The Last Decade

Charles L. Brooks

420 papers receiving 39.9k citations

Hit Papers

Extending the treatment of backbone energetic... 1984 2026 1998 2012 2004 2015 2003 1989 2004 500 1000 1.5k 2.0k 2.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Extending the treatment of backbone energetics in protein force fields: Limitations of gas‐phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations
    2004 2.9k citations Charles L. Brooks et al. Journal of Computational Chemistry profile →
  2. CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field
    2015 2.8k citations Charles L. Brooks et al. profile →
  3. Detailed analysis of grid‐based molecular docking: A case study of CDOCKER—A CHARMm‐based MD docking algorithm
    2003 1.3k citations Charles L. Brooks et al. Journal of Computational Chemistry profile →
  4. Computer simulation of liquids
    1989 1.2k citations Charles L. Brooks profile →
  5. A modified TIP3P water potential for simulation with Ewald summation
    2004 1.2k citations D.J. Price, Charles L. Brooks profile →
  6. Improved Treatment of the Protein Backbone in Empirical Force Fields
    2003 828 citations Charles L. Brooks et al. Journal of the American Chemical Society profile →
  7. MMTSB Tool Set: enhanced sampling and multiscale modeling methods for applications in structural biology
    2004 761 citations Charles L. Brooks et al. profile →
  8. Proteins: A Theoretical Perspective of Dynamics, Structure and Thermodynamics
    1990 602 citations Charles L. Brooks et al. profile →
  9. Generalized born model with a simple smoothing function
    2003 544 citations Charles L. Brooks et al. Journal of Computational Chemistry profile →
  10. Stochastic boundary conditions for molecular dynamics simulations of ST2 water
    1984 472 citations Charles L. Brooks et al. profile →
  11. CHARMM-GUI ligand reader and modeler for CHARMM force field generation of small molecules
    2017 413 citations Charles L. Brooks et al. Journal of Computational Chemistry profile →
  12. Theoretical study of blocked glycine and alanine peptide analogs
    1991 314 citations Charles L. Brooks et al. Journal of the American Chemical Society profile →

Peers

Charles L. Brooks
Bernard R. Brooks United States
Piotr Cieplak United States
Vijay S. Pande United States
Alan E. Mark Australia
Jeffry D. Madura United States
Jeremy C. Smith United States
Darrin M. York United States
Ken A. Dill United States
Kenneth M. Merz United States
Lee G. Pedersen United States
Bernard R. Brooks United States
Charles L. Brooks
Citations per year, relative to Charles L. Brooks Charles L. Brooks (= 1×) peers Bernard R. Brooks

Countries citing papers authored by Charles L. Brooks

Since Specialization
Citations

This map shows the geographic impact of Charles L. Brooks's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Charles L. Brooks with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Charles L. Brooks more than expected).

Fields of papers citing papers by Charles L. Brooks

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Charles L. Brooks. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Charles L. Brooks. The network helps show where Charles L. Brooks may publish in the future.

Co-authorship network of co-authors of Charles L. Brooks

This figure shows the co-authorship network connecting the top 25 collaborators of Charles L. Brooks. A scholar is included among the top collaborators of Charles L. Brooks based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Charles L. Brooks. Charles L. Brooks is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Hayes, Ryan L., et al.. (2025). Multiple Molecule λ-Dynamics: Probing Drug Resistance with Concurrent Protein and Ligand Perturbations. The Journal of Physical Chemistry Letters. 16(25). 6273–6278.
2.
Brooks, Charles L., et al.. (2024). Guiding discovery of protein sequence-structure-function modeling. Bioinformatics. 40(1). 2 indexed citations
3.
Hayes, Ryan L., et al.. (2024). Selection pressures on evolution of ribonuclease H explored with rigorous free–energy–based design. Proceedings of the National Academy of Sciences. 121(3). e2312029121–e2312029121. 5 indexed citations
4.
Wu, Yujin, Jesse W. Wotring, Sahil Arora, et al.. (2023). TMPRSS2 Inhibitor Discovery Facilitated through an In Silico and Biochemical Screening Platform. ACS Medicinal Chemistry Letters. 14(6). 860–866. 10 indexed citations
5.
Artikis, Efrosini, Aron Broom, Brian Fuglestad, et al.. (2022). A fine balance of hydrophobic-electrostatic communication pathways in a pH-switching protein. Proceedings of the National Academy of Sciences. 119(26). e2119686119–e2119686119. 5 indexed citations
6.
Wan, Qun, B. Bennett, Troy Wymore, et al.. (2021). Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid–Base Catalysis. ACS Catalysis. 11(9). 5873–5884. 9 indexed citations
7.
Dockrey, Summer A. Baker, April L. Lukowski, Troy Wymore, et al.. (2019). Structural Basis for Selectivity in Flavin-Dependent Monooxygenase-Catalyzed Oxidative Dearomatization. ACS Catalysis. 9(4). 3633–3640. 33 indexed citations
8.
Mustoe, Anthony M., et al.. (2015). Noncanonical Secondary Structure Stabilizes Mitochondrial tRNA Ser(UCN) by Reducing the Entropic Cost of Tertiary Folding. Journal of the American Chemical Society. 137(10). 3592–3599. 15 indexed citations
9.
Panahi, Afra & Charles L. Brooks. (2015). Membrane Environment Modulates the pKa Values of Transmembrane Helices. The Journal of Physical Chemistry.
10.
Law, Sean M., Jessica K. Gagnon, Anna K. Mapp, & Charles L. Brooks. (2014). Prepaying the entropic cost for allosteric regulation in KIX. Proceedings of the National Academy of Sciences. 111(33). 12067–12072. 50 indexed citations
11.
Mustoe, Anthony M., Charles L. Brooks, & Hashim M. Al‐Hashimi. (2014). Hierarchy of RNA Functional Dynamics. Annual Review of Biochemistry. 83(1). 441–466. 140 indexed citations
12.
Foit, Linda, Jenny George, Bin W. Zhang, Charles L. Brooks, & James C.A. Bardwell. (2013). Chaperone activation by unfolding. Proceedings of the National Academy of Sciences. 110(14). E1254–62. 60 indexed citations
13.
Eichhorn, Catherine D., Jun Feng, Krishna C. Suddala, et al.. (2011). Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch. Nucleic Acids Research. 40(3). 1345–1355. 50 indexed citations
14.
Khandogin, Jana & Charles L. Brooks. (2007). Linking folding with aggregation in Alzheimer's β-amyloid peptides. Proceedings of the National Academy of Sciences. 104(43). 16880–16885. 141 indexed citations
15.
Price, D.J. & Charles L. Brooks. (2005). Detailed considerations for a balanced and broadly applicable force field: A study of substituted benzenes modeled with OPLS‐AA. Journal of Computational Chemistry. 26(14). 1529–1541. 26 indexed citations
16.
Taufer, Michela, Michael F. Crowley, D.J. Price, Andrew A. Chien, & Charles L. Brooks. (2005). Study of a highly accurate and fast protein–ligand docking method based on molecular dynamics: Research Articles. Concurrency and Computation Practice and Experience. 17(14). 1627–1641. 11 indexed citations
17.
Tama, Florence, et al.. (2005). The 13Å Structure of a Chaperonin GroEL–Protein Substrate Complex by Cryo-electron Microscopy. Journal of Molecular Biology. 348(1). 219–230. 61 indexed citations
18.
Natrajan, Anand, Michael F. Crowley, Nancy Wilkins‐Diehr, et al.. (2004). Studying protein folding on the Grid: experiences using CHARMM on NPACI resources under Legion: Research Articles. Concurrency and Computation Practice and Experience. 16(4). 385–397. 1 indexed citations
19.
Thorpe, Ian F. & Charles L. Brooks. (2003). Barriers to Hydride Transfer in Wild Type and Mutant Dihydrofolate Reductase from E. c oli. The Journal of Physical Chemistry B. 107(50). 14042–14051. 54 indexed citations
20.
Sneddon, Scott, Douglas J. Tobias, & Charles L. Brooks. (1989). Thermodynamics of amide hydrogen bond formation in polar and apolar solvents. Journal of Molecular Biology. 209(4). 817–820. 78 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Rankless by CCL
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