Bruce N. Ames

90.0k total citations · 23 hit papers
317 papers, 69.9k citations indexed

About

Bruce N. Ames is a scholar working on Molecular Biology, Cancer Research and Nutrition and Dietetics. According to data from OpenAlex, Bruce N. Ames has authored 317 papers receiving a total of 69.9k indexed citations (citations by other indexed papers that have themselves been cited), including 158 papers in Molecular Biology, 71 papers in Cancer Research and 50 papers in Nutrition and Dietetics. Recurrent topics in Bruce N. Ames's work include Carcinogens and Genotoxicity Assessment (66 papers), Folate and B Vitamins Research (34 papers) and DNA Repair Mechanisms (26 papers). Bruce N. Ames is often cited by papers focused on Carcinogens and Genotoxicity Assessment (66 papers), Folate and B Vitamins Research (34 papers) and DNA Repair Mechanisms (26 papers). Bruce N. Ames collaborates with scholars based in United States, United Kingdom and Japan. Bruce N. Ames's co-authors include Dorothy M. Maron, Robert G. Martin, Edith F. Yamasaki, Kenneth B. Beckman, Joyce McCann, Donald T. Dubin, Mark K. Shigenaga, Joyce C. McCann, Yorihiro Yamamoto and Lois Swirsky Gold and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Bruce N. Ames

313 papers receiving 64.1k citations

Hit Papers

Revised methods for the Salmonella mutagenicity test 1960 2026 1982 2004 1983 1975 1961 1998 1987 2.0k 4.0k 6.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Revised methods for the Salmonella mutagenicity test
    1983 6.4k citations Dorothy M. Maron, Bruce N. Ames Mutation Research/Environmental Mutagenesis and Related Subjects profile →
  2. Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test
    1975 6.2k citations Bruce N. Ames et al. Mutation Research/Environmental Mutagenesis and Related Subjects profile →
  3. A Method for Determining the Sedimentation Behavior of Enzymes: Application to Protein Mixtures
    1961 5.2k citations Bruce N. Ames et al. profile →
  4. The Free Radical Theory of Aging Matures
    1998 3.0k citations Kenneth B. Beckman, Bruce N. Ames profile →
  5. Bilirubin Is an Antioxidant of Possible Physiological Importance
    1987 3.0k citations Bruce N. Ames et al. profile →
  6. Dietary Carcinogens and Anticarcinogens
    1983 2.5k citations Bruce N. Ames profile →
  7. The Role of Polyamines in the Neutralization of Bacteriophage Deoxyribonucleic Acid
    1960 2.5k citations Bruce N. Ames et al. profile →
  8. Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection
    1973 1.7k citations Bruce N. Ames et al. Proceedings of the National Academy of Sciences profile →
  9. Oxygen Radicals and Human Disease
    1987 1.6k citations Bruce N. Ames et al. profile →
  10. An Improved Bacterial Test System for the Detection and Classification of Mutagens and Carcinogens
    1973 1.2k citations Bruce N. Ames et al. Proceedings of the National Academy of Sciences profile →
  11. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
    1997 1.1k citations Carol M. Wehr, Bruce N. Ames et al. Proceedings of the National Academy of Sciences profile →
  12. Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium
    1985 859 citations Bruce N. Ames et al. profile →
  13. Oxidative Decay of DNA
    1997 781 citations Kenneth B. Beckman, Bruce N. Ames profile →
  14. Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay
    1983 755 citations Richard Cathcart, Bruce N. Ames et al. profile →
  15. Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation
    1990 720 citations Gisela Storz, Louis A. Tartaglia et al. profile →
  16. Too Many Rodent Carcinogens: Mitogenesis Increases Mutagenesis
    1990 612 citations Bruce N. Ames et al. profile →
  17. Endogenous Oxidative DNA Damage, Aging, and Cancer
    1989 610 citations Bruce N. Ames profile →
  18. γ-Tocopherol, the major form of vitamin E in the US diet, deserves more attention
    2001 601 citations Stephan Christen, Mark K. Shigenaga et al. American Journal of Clinical Nutrition profile →
  19. Endogenous mutagens and the causes of aging and cancer
    1991 587 citations Bruce N. Ames et al. Mutation research. Fundamental and molecular mechanisms of mutagenesis profile →
  20. DNA oxidation matters: The HPLC–electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine
    1998 570 citations Kenneth B. Beckman, Mark K. Shigenaga et al. Proceedings of the National Academy of Sciences profile →
  21. Naturally occurring carbonyl compounds are mutagens Salmonella tester strain TA104
    1985 443 citations Bruce N. Ames et al. profile →
  22. Identifying Environmental Chemicals Causing Mutations and Cancer
    1979 405 citations Bruce N. Ames profile →
  23. Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior
    2015 362 citations Bruce N. Ames et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Bruce N. Ames United States 115 32.7k 15.1k 7.8k 7.3k 7.2k 317 69.9k
Masayuki Yamamoto Japan 169 85.7k 2.6× 9.1k 0.6× 5.0k 0.6× 7.2k 1.0× 6.0k 0.8× 1.4k 119.9k
Helmut Sies Germany 132 30.1k 0.9× 3.2k 0.2× 4.3k 0.5× 5.9k 0.8× 13.5k 1.9× 657 81.4k
Bharat B. Aggarwal United States 166 48.7k 1.5× 14.7k 1.0× 959 0.1× 6.4k 0.9× 4.3k 0.6× 574 104.9k
Stephen S. Hecht United States 93 18.5k 0.6× 10.2k 0.7× 6.9k 0.9× 3.1k 0.4× 1.6k 0.2× 801 38.7k
Irwin Fridovich United States 116 33.8k 1.0× 2.2k 0.1× 12.3k 1.6× 17.1k 2.3× 11.0k 1.5× 420 88.8k
Frank J. Gonzalez United States 171 56.6k 1.7× 15.7k 1.0× 7.3k 0.9× 2.7k 0.4× 4.2k 0.6× 1.3k 119.2k
Takashi Sügimura Japan 113 24.4k 0.7× 13.6k 0.9× 3.6k 0.5× 3.6k 0.5× 1.4k 0.2× 1.2k 50.0k
Rüssel J. Reiter United States 166 24.7k 0.8× 3.1k 0.2× 3.7k 0.5× 15.9k 2.2× 4.3k 0.6× 1.5k 112.7k
Barry Halliwell United Kingdom 176 45.3k 1.4× 5.1k 0.3× 8.7k 1.1× 20.1k 2.8× 20.1k 2.8× 736 138.6k
John M.C. Gutteridge United Kingdom 90 18.4k 0.6× 1.8k 0.1× 5.9k 0.7× 9.1k 1.2× 10.4k 1.4× 232 60.6k

Countries citing papers authored by Bruce N. Ames

Since Specialization
Citations

This map shows the geographic impact of Bruce N. Ames's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bruce N. Ames with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bruce N. Ames more than expected).

Fields of papers citing papers by Bruce N. Ames

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bruce N. Ames. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bruce N. Ames. The network helps show where Bruce N. Ames may publish in the future.

Co-authorship network of co-authors of Bruce N. Ames

This figure shows the co-authorship network connecting the top 25 collaborators of Bruce N. Ames. A scholar is included among the top collaborators of Bruce N. Ames based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Bruce N. Ames. Bruce N. Ames is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Strong, Randy, David B. Allison, Bruce N. Ames, et al.. (2013). Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell. 13(2). 273–282. 310 indexed citations
2.
Morris, Claudia R., Jung H. Suh, Ward Hagar, et al.. (2007). Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease. Blood. 111(1). 402–410. 144 indexed citations
3.
Ames, Bruce N.. (2006). Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proceedings of the National Academy of Sciences. 103(47). 17589–17594. 268 indexed citations
4.
Villanueva, Jesus A., Robert E. Chapin, Alan J. Conley, et al.. (2006). Chronic Ethanol Perturbs Testicular Folate Metabolism and Dietary Folate Deficiency Reduces Sex Hormone Levels in the Yucatan Micropig1. Biology of Reproduction. 76(3). 455–465. 18 indexed citations
5.
Jacob, Robert A., Charles B. Stephensen, Jeffrey B. Blumberg, et al.. (2003). Moderate Antioxidant Supplementation Has No Effect on Biomarkers of Oxidant Damage in Healthy Men with Low Fruit and Vegetable Intakes. Journal of Nutrition. 133(3). 740–743. 70 indexed citations
6.
Girault, Isabelle, Alexander E. Karu, Mary Helen Barcellos‐Hoff, et al.. (2001). Immunodetection of 3-nitrotyrosine in the liver of zymosan-treated rats with a new monoclonal antibody: comparison to analysis by HPLC. Free Radical Biology and Medicine. 31(11). 1375–1387. 22 indexed citations
7.
Lykkesfeldt, Jens, et al.. (2000). Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes. American Journal of Clinical Nutrition. 71(2). 530–536. 188 indexed citations
8.
Beckman, Kenneth B. & Bruce N. Ames. (1999). Endogenous oxidative damage of mtDNA. Mutation research. Fundamental and molecular mechanisms of mutagenesis. 424(1-2). 51–58. 163 indexed citations
9.
Hagen, Tory M., Carol M. Wehr, & Bruce N. Ames. (1998). Mitochondrial Decay in Aging: Reversal through Supplementation of Acetyl‐l‐Carnitine and N‐tert‐Butyl‐α‐phenyl‐nitronea. Annals of the New York Academy of Sciences. 854(1). 214–223. 78 indexed citations
10.
Ames, Bruce N.. (1998). Micronutrients prevent cancer and delay aging. Toxicology Letters. 102-103. 5–18. 269 indexed citations
11.
Beckman, Kenneth B. & Bruce N. Ames. (1997). Oxidants, Antioxidants, and Aging. Cold Spring Harbor Monograph Archive. 34. 201–246. 31 indexed citations
12.
Ames, Bruce N. & Mark K. Shigenaga. (1992). Oxidants Are a Major Contributor to Aginga. Annals of the New York Academy of Sciences. 663(1). 85–96. 235 indexed citations
13.
Storz, Gisela, Louis A. Tartaglia, S B Farr, & Bruce N. Ames. (1990). Bacterial defenses against oxidative stress. Trends in Genetics. 6(11). 363–368. 262 indexed citations
14.
Baker, Jeffrey C. & Bruce N. Ames. (1988). Alterations in levels of 5′-adenyl dinucleotides following DNA damage in normal human fibroblasts and fibroblasts derived from patients with xeroderma pigmentosum. Mutation Research Letters. 208(2). 87–93. 18 indexed citations
15.
Nishimura, Susumu & Bruce N. Ames. (1986). U.S.-JAPAN MEETING ON “OXYGEN RADICALS IN CANCER”. Cancer Science. 77(8). 843–848. 7 indexed citations
16.
Cathcart, Richard, et al.. (1984). [44] Detection of picomole levels of lipid hydroperoxides using a dichlorofluorescein fluorescent assay. Methods in enzymology on CD-ROM/Methods in enzymology. 105. 352–358. 59 indexed citations
17.
Maron, Dorothy M. & Bruce N. Ames. (1983). Revised methods for the Salmonella mutagenicity test. Mutation Research/Environmental Mutagenesis and Related Subjects. 113(3-4). 173–215. 6435 indexed citations breakdown →
18.
Ames, Bruce N., Peter F. Infante, & Richard H. Reitz. (1980). Ethylene dichloride : a potential health risk?. 17 indexed citations
19.
Ames, Bruce N., E G Gurney, James A. Miller, & Helmut Bartsch. (1972). Carcinogens as Frameshift Mutagens: Metabolites and Derivatives of 2-Acetylaminofluorene and Other Aromatic Amine Carcinogens. Proceedings of the National Academy of Sciences. 69(11). 3128–3132. 291 indexed citations
20.
Silbert, David F., Gerald R. Fink, & Bruce N. Ames. (1966). Histidine regulatory mutants in Salmonella typhimurium. Journal of Molecular Biology. 22(2). 335–347. 124 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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