Brian Spencer

19.0k total citations · 3 hit papers
77 papers, 7.8k citations indexed

About

Brian Spencer is a scholar working on Neurology, Physiology and Cellular and Molecular Neuroscience. According to data from OpenAlex, Brian Spencer has authored 77 papers receiving a total of 7.8k indexed citations (citations by other indexed papers that have themselves been cited), including 31 papers in Neurology, 31 papers in Physiology and 30 papers in Cellular and Molecular Neuroscience. Recurrent topics in Brian Spencer's work include Parkinson's Disease Mechanisms and Treatments (31 papers), Alzheimer's disease research and treatments (27 papers) and Nuclear Receptors and Signaling (11 papers). Brian Spencer is often cited by papers focused on Parkinson's Disease Mechanisms and Treatments (31 papers), Alzheimer's disease research and treatments (27 papers) and Nuclear Receptors and Signaling (11 papers). Brian Spencer collaborates with scholars based in United States, South Korea and Germany. Brian Spencer's co-authors include Eliezer Masliah, Edward Rockenstein, Christina Patrick, Anthony Adame, Paula Desplats, Leslie Crews, Tony Wyss‐Coray, He-Jin Lee, Seung‐Jae Lee and Eun-Jin Bae and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Brian Spencer

74 papers receiving 7.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein

2009 1.2k citations Paula Desplats, He-Jin Lee et al. Proceedings of the National Academy of Sciences profile →
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

2008 898 citations Eliezer Masliah, Brian Spencer et al. profile →
Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases

2009 501 citations Brian Spencer, Rewati Potkar et al. Journal of Neuroscience profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Brian Spencer United States	43	3.0k	2.8k	2.5k	1.8k	1.7k	77	7.8k
Han Seok Ko United States	33	4.0k 1.3×	4.2k 1.5×	2.0k 0.8×	2.1k 1.2×	2.2k 1.3×	58	8.5k
Anthony Adame United States	59	3.1k 1.0×	3.2k 1.1×	3.6k 1.5×	953 0.5×	2.8k 1.6×	110	9.4k
Shinji Saiki Japan	36	3.2k 1.1×	2.0k 0.7×	1.2k 0.5×	2.9k 1.6×	1.2k 0.7×	139	7.2k
Ken Nakamura Japan	34	2.7k 0.9×	2.4k 0.8×	1.5k 0.6×	999 0.5×	1.6k 0.9×	116	6.1k
Philipp J. Kahle Germany	56	5.0k 1.6×	6.9k 2.5×	3.0k 1.2×	2.6k 1.4×	3.7k 2.1×	124	11.9k
Fumiaki Mori Japan	50	2.2k 0.7×	4.2k 1.5×	1.5k 0.6×	785 0.4×	2.2k 1.3×	212	7.2k
Hideki Shimura Japan	29	2.2k 0.7×	2.5k 0.9×	1.1k 0.5×	915 0.5×	1.7k 1.0×	83	5.3k
Edward A. Fon Canada	42	6.2k 2.1×	3.0k 1.1×	1.6k 0.6×	4.1k 2.3×	2.2k 1.3×	124	10.1k
Asok Kumar United States	36	2.8k 0.9×	1.1k 0.4×	3.7k 1.5×	2.5k 1.4×	945 0.5×	73	7.5k
Leslie Crews United States	49	3.1k 1.0×	2.4k 0.8×	3.2k 1.3×	435 0.2×	2.1k 1.2×	90	8.8k

Countries citing papers authored by Brian Spencer

Since Specialization

Citations

This map shows the geographic impact of Brian Spencer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Brian Spencer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Brian Spencer more than expected).

Fields of papers citing papers by Brian Spencer

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Brian Spencer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Brian Spencer. The network helps show where Brian Spencer may publish in the future.

Co-authorship network of co-authors of Brian Spencer

This figure shows the co-authorship network connecting the top 25 collaborators of Brian Spencer. A scholar is included among the top collaborators of Brian Spencer based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Brian Spencer. Brian Spencer is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Spencer, Brian, et al.. (2025). Differential roles of human tau isoforms in the modulation of inflammation and development of neuropathology. Neurobiology of Disease. 211. 106942–106942.

Spencer, Brian, et al.. (2023). Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer's disease. Neurobiology of Disease. 186. 106285–106285. 5 indexed citations

Spencer, Brian, Floyd Sarsoza, Jennifer Ngolab, et al.. (2023). Hippocampal Reduction of α-Synuclein via RNA Interference Improves Neuropathology in Alzheimer’s Disease Mice. Journal of Alzheimer s Disease. 95(1). 349–361.

Nakamura, Tomohiro, Chang-ki Oh, Lujian Liao, et al.. (2020). Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer’s disease. Science. 371(6526). 67 indexed citations

Shen, Ruinan, Xiaobei Zhao, Lu He, et al.. (2020). Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease. Translational Neurodegeneration. 9(1). 26–26. 46 indexed citations

Spencer, Brian, et al.. (2018). Identification of Insulin Receptor Splice Variant B in Neurons by in situ Detection in Human Brain Samples. Scientific Reports. 8(1). 4070–4070. 12 indexed citations

Spencer, Brian, Sven Brüschweiler, Marco Sealey‐Cardona, et al.. (2018). Selective targeting of 3 repeat Tau with brain penetrating single chain antibodies for the treatment of neurodegenerative disorders. Acta Neuropathologica. 136(1). 69–87. 23 indexed citations

Fang, Fang, Wanlin Yang, Jazmin Florio, et al.. (2017). Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson’s disease. Scientific Reports. 7(1). 3868–3868. 68 indexed citations

Price, D. L., Edward Rockenstein, Michael Mante, et al.. (2016). Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson’s Disease/Dementia with Lewy Bodies. Scientific Reports. 6(1). 29523–29523. 42 indexed citations

10.

Kim, Changyoun, Edward Rockenstein, Brian Spencer, et al.. (2015). Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy. Cell Reports. 13(4). 771–782. 107 indexed citations

11.

Spencer, Brian & Eliezer Masliah. (2014). Immunotherapy for Alzheimerâ€™s disease: past, present and future. Frontiers in Aging Neuroscience. 6. 114–114. 62 indexed citations

12.

Vı́lchez, David, Leah Boyer, Margaret Lutz, et al.. (2013). FOXO4 is necessary for neural differentiation of human embryonic stem cells. Aging Cell. 12(3). 518–522. 40 indexed citations

13.

Tsigelny, Igor F., Yuriy Sharikov, Wolfgang Wrasidlo, et al.. (2012). Role of α‐synuclein penetration into the membrane in the mechanisms of oligomer pore formation. FEBS Journal. 279(6). 1000–1013. 139 indexed citations

14.

Lee, Seung‐Jae, Paula Desplats, He-Jin Lee, Brian Spencer, & Eliezer Masliah. (2012). Cell-to-Cell Transmission of α-Synuclein Aggregates. Methods in molecular biology. 849. 347–359. 45 indexed citations

15.

Tang, Bin, Kristina Bečanović, Paula Desplats, et al.. (2012). Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease. Human Molecular Genetics. 21(14). 3097–3111. 43 indexed citations

16.

Desplats, Paula, He-Jin Lee, Eun-Jin Bae, et al.. (2009). Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein. Proceedings of the National Academy of Sciences. 106(31). 13010–13015. 1156 indexed citations breakdown →

17.

Rose, J. Bart, Leslie Crews, Edward Rockenstein, et al.. (2009). Neuropeptide Y Fragments Derived from Neprilysin Processing Are Neuroprotective in a Transgenic Model of Alzheimer's Disease. Journal of Neuroscience. 29(4). 1115–1125. 78 indexed citations

18.

Spencer, Brian, Robert A. Marr, Edward Rockenstein, et al.. (2008). Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neuroscience. 9(1). 109–109. 71 indexed citations

19.

Crews, Leslie, Brian Spencer, & Eliezer Masliah. (2008). Immunotherapy Strategies for Lewy Body and Parkinson's Diseases. 599–613. 2 indexed citations

20.

Spencer, Brian. (1974). Industrial aspects of biochemistry. Elsevier eBooks. 109 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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